LOCUS       NM_001040026            4280 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SCO1 cytochrome c oxidase assembly protein (Sco1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001040026 XM_618888
VERSION     NM_001040026.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4280)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4280)
  AUTHORS   Jett,K.A., Baker,Z.N., Hossain,A., Boulet,A., Cobine,P.A.,
            Ghosh,S., Ng,P., Yilmaz,O., Barreto,K., DeCoteau,J., Mochoruk,K.,
            Ioannou,G.N., Savard,C., Yuan,S., Abdalla,O.H., Lowden,C.,
            Kim,B.E., Cheng,H.M., Battersby,B.J., Gohil,V.M. and Leary,S.C.
  TITLE     Mitochondrial dysfunction reactivates alpha-fetoprotein expression
            that drives copper-dependent immunosuppression in mitochondrial
            disease models
  JOURNAL   J Clin Invest 133 (1), e154684 (2023)
   PUBMED   36301669
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4280)
  AUTHORS   Xie,L., Yuan,Y., Xu,S., Lu,S., Gu,J., Wang,Y., Wang,Y., Zhang,X.,
            Chen,S., Li,J., Lu,J., Sun,H., Hu,R., Piao,H., Wang,W., Wang,C.,
            Wang,J., Li,N., White,M.F., Han,L., Jia,W., Miao,J. and Liu,J.
  TITLE     Downregulation of hepatic ceruloplasmin ameliorates NAFLD via
            SCO1-AMPK-LKB1 complex
  JOURNAL   Cell Rep 41 (3), 111498 (2022)
   PUBMED   36261001
  REMARK    GeneRIF: Downregulation of hepatic ceruloplasmin ameliorates NAFLD
            via SCO1-AMPK-LKB1 complex.
REFERENCE   4  (bases 1 to 4280)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4280)
  AUTHORS   Baker,Z.N., Jett,K., Boulet,A., Hossain,A., Cobine,P.A., Kim,B.E.,
            El Zawily,A.M., Lee,L., Tibbits,G.F., Petris,M.J. and Leary,S.C.
  TITLE     The mitochondrial metallochaperone SCO1 maintains CTR1 at the
            plasma membrane to preserve copper homeostasis in the murine heart
  JOURNAL   Hum Mol Genet 26 (23), 4617-4628 (2017)
   PUBMED   28973536
REFERENCE   6  (bases 1 to 4280)
  AUTHORS   Wei,X.B., Guo,L., Liu,Y., Zhou,S.R., Liu,Y., Dou,X., Du,S.Y.,
            Ding,M., Peng,W.Q., Qian,S.W., Huang,H.Y. and Tang,Q.Q.
  TITLE     Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin
            sensitivity by decreasing copper levels in adipocytes
  JOURNAL   Biochem Biophys Res Commun 491 (3), 814-820 (2017)
   PUBMED   28647369
  REMARK    GeneRIF: Our results demonstrated a novel role of SCO1 in
            modulating insulin sensitivity via the regulation of copper
            concentration in WAT and suggested a potential therapeutic target
            for T2DM.
REFERENCE   7  (bases 1 to 4280)
  AUTHORS   Hlynialuk,C.J., Ling,B., Baker,Z.N., Cobine,P.A., Yu,L.D.,
            Boulet,A., Wai,T., Hossain,A., El Zawily,A.M., McFie,P.J.,
            Stone,S.J., Diaz,F., Moraes,C.T., Viswanathan,D., Petris,M.J. and
            Leary,S.C.
  TITLE     The Mitochondrial Metallochaperone SCO1 Is Required to Sustain
            Expression of the High-Affinity Copper Transporter CTR1 and
            Preserve Copper Homeostasis
  JOURNAL   Cell Rep 10 (6), 933-943 (2015)
   PUBMED   25683716
REFERENCE   8  (bases 1 to 4280)
  AUTHORS   Brosel,S., Yang,H., Tanji,K., Bonilla,E. and Schon,E.A.
  TITLE     Unexpected vascular enrichment of SCO1 over SCO2 in mammalian
            tissues: implications for human mitochondrial disease
  JOURNAL   Am J Pathol 177 (5), 2541-2548 (2010)
   PUBMED   20864674
  REMARK    GeneRIF: Results describe the tissue distribution of SCO1 and SCO2
            in mouse and human tissues.
REFERENCE   9  (bases 1 to 4280)
  AUTHORS   Yang,H., Brosel,S., Acin-Perez,R., Slavkovich,V., Nishino,I.,
            Khan,R., Goldberg,I.J., Graziano,J., Manfredi,G. and Schon,E.A.
  TITLE     Analysis of mouse models of cytochrome c oxidase deficiency owing
            to mutations in Sco2
  JOURNAL   Hum Mol Genet 19 (1), 170-180 (2010)
   PUBMED   19837698
REFERENCE   10 (bases 1 to 4280)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011251.1, AK139512.1, AK083729.1 and AK018523.1.
            
            On Apr 5, 2006 this sequence version replaced XM_618888.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139008.1, AK139512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK011251.1         3-32
            31-1735             AK139512.1         2-1706
            1736-2171           AK083729.1         160-595
            2172-4280           AK018523.1         379-2487
FEATURES             Location/Qualifiers
     source          1..4280
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 40.59 cM"
     gene            1..4280
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="SCO1 cytochrome c oxidase assembly protein"
                     /db_xref="GeneID:52892"
                     /db_xref="MGI:MGI:106362"
     exon            1..247
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..880
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="SCO cytochrome oxidase deficient homolog 1"
                     /codon_start=1
                     /product="protein SCO1 homolog, mitochondrial"
                     /protein_id="NP_001035115.1"
                     /db_xref="CCDS:CCDS36183.1"
                     /db_xref="GeneID:52892"
                     /db_xref="MGI:MGI:106362"
                     /translation="MAALVRAAVVRSQCRQLWRLFPRGHGLRDVAERPRPEEACSCLR
                     SRAFSAGPPPPGAGPEPKGGQAGSHRPKPGPVSWKSLALTFAIGGSLLAGMKYFKKEK
                     IEKLEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEEL
                     EKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEID
                     GVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAH
                     MRSHMKKR"
     exon            248..338
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     exon            339..536
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     exon            537..629
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     exon            630..745
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     exon            746..4280
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1717..1722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="hexamer: AATAAA"
     polyA_site      1742
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="major polyA site"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="hexamer: ATTAAA"
     polyA_site      2265
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
                     /note="hexamer: AATAAA"
     polyA_site      2402
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
     polyA_site      3917
                     /gene="Sco1"
                     /gene_synonym="2610001C07Rik; D11Bwg1310e"
ORIGIN      
        1 aaaggaggcg cggtctccta aactcatggc agcacttgta cgcgccgcag tggtgaggtc
       61 gcagtgtcgc cagctctggc gtctgttccc tcgcggccat gggctcaggg atgtggcgga
      121 gaggccgaga ccggaggaag cgtgctcctg cctgcggagc agagccttca gcgctgggcc
      181 gccaccgccg ggggccggtc cggagcccaa gggcggtcaa gccgggtctc accgcccgaa
      241 gcctgggcct gtttcttgga agtctttagc tctcaccttt gccattggag gctctttatt
      301 ggctggaatg aagtacttca agaaagaaaa gatagaaaag ctggagaaac aacggcatcg
      361 cagcattggg aagcctttac taggggggcc attttccctt acaactcaca atggagagcc
      421 caaaaccgac aaggactacc tgggtcaatg ggtattgatt tattttggct tcactcattg
      481 ccctgatatc tgtccagaag aactagaaaa aatgattgaa gtcgtggagg agatagacag
      541 tattccatcc ctgccaaatt taactccact tttcatcacc attgacccag aaagggacac
      601 caaagaagcc attgcgactt atgtgaaaga attttctccc aaattggttg gtttgactgg
      661 cacaaaagaa gagattgatg gagtggccag agcatacagg gtgtattaca gccctggccc
      721 gaaggatgag gatgaagact acatagtgga tcatacaata ataatgtact tgattggacc
      781 agatggagaa tttcttgatt attttggaca aaacaagaag aaggcagaaa tagccggctc
      841 aattgctgca cacatgaggt cacacatgaa gaagaggtag ccagagccgt gtcaccagat
      901 gcaggattgg cttgctgaag aggaagcttt gtctcccaga ggaacctcta tatactgtaa
      961 catacaacat ggacttcata ccctgagaac atcattctac atgagatgtt accctggggc
     1021 tcagccaacc cagtctgcca ggaaactacc atgagttaaa gggccagggt ggtcagagcc
     1081 agtggagaac agacgtccag aaccatcaga gaggcacaca atgcacatct gtaggaatgg
     1141 cactcttgga gtagtgttgc ttccttgccg gtgtcttctt gctcaggggg gccaaattct
     1201 acaggaaggt gtcacttccg taatgttctt gctgtttcaa tttgtgtgct cagcataggc
     1261 attcaagtcc tctttatatt tgagagtaga agcttagctt ctttgaaaag gaatgtcacc
     1321 atcaggtctg catctctgtc acacagtagg tgctgctttg ggctggagga gaaaacttac
     1381 tgtttgcaca taacttttgg ttcattctcc acctttttat tttttatttt ttgttttttg
     1441 aggcagggtt tctctgtata gccctggcta tcctggaact cactctgtag accaggctgg
     1501 cctcgaactc agaaatctgc ctgcctctgc ctccccagtg ctgggattaa aggcgtgcac
     1561 caccactgcc cagctttttt ttttttttta atccttttta tttttttaat agctaagtgg
     1621 tttgactggt tttcagtggt agaccacgtg gaaatgagaa tatttatcat gtctatgatc
     1681 tggtaatttt tatgtaccag attacacaat gtatgaaata aaagatgtgg tcagtccagc
     1741 aacttggaca agcatggctt tgcttctgtg aagaatgggt ccctagcaca ccatggtagg
     1801 ggtagaggcc acagactgaa gtgcttgtta aatagataag tgcttgttaa aatgcagatt
     1861 cacaggccag gaactggcct ctcttgagtc agagtgggat acagagacct gggtctccag
     1921 gggcaagtga ctgagatctg aggacctgag cccacacctg ggtcatctgt tccatagaga
     1981 agtaacaagc ataaccagct cttaaaggtg tcagcagcta ctccagggaa tgtcgtctgg
     2041 ctgggtgtgg tgtgcacact gttagtccca gcactcggga ggcagaggca ggggcttctt
     2101 caagtttgag gctagcctgg tctaatagag agtcttgggc caaccaggct acctaataag
     2161 accctgtctc caaaaaaaaa aaaaaaaaaa gagagtaaga aagacgatgc ctgctgagta
     2221 atgaatcttg gctttgtttc tgaattaaac ttccctgata cctgggtttg gctatctcct
     2281 tttcaacttg aaccttttta atgaatccaa agatgctaca aatgagcctt gctggaaacc
     2341 attcttccca aacacagatt agtttatatg caagcaataa aggcttacct tctggttttt
     2401 aacttcttgg tacttacatg aagcctaatg aaaatactta tgtcaccatg aaagaacacc
     2461 tgtacttgtt ataggccaaa tcatgtcatt tacaatttat atattcaagt cctggatcag
     2521 tcacttcaga atgtgactga atgtggaaag aaggcattta tttatttgtt ggtttgtttt
     2581 taaatttttg aggcagggtt tctctgtaat cctggctgtc ctagaacttg taaggaccag
     2641 gctggccttg aactgagatc cacttgccac tgcctctggg tagtatttgg tgctgggact
     2701 aaaggcatca ccacccccac acagctggag agtaaggctt taaagaggta ataaggttta
     2761 aatgaagctg ttaggttttc tcttccttaa agcaaaccta ctgatatcct taaaagggta
     2821 ggaaattaga acacaggaga gcaggctgaa gcacagttgt ctgtccctgg cctcagaaga
     2881 aaccgactcc tgacaccccc atcattgatt gccagtctct agaaccttaa gaaaacaatt
     2941 attttctgtt aaatcagtca gctgcagtga accagtatag tccattcctt agttgtgagc
     3001 caccatgtgg ttactgagaa ttgaactcgg aactgctgaa agagcggtca gtgttcttta
     3061 accactgagc aatctctcca gccaccctgt tcagagacgt ttaagacatt aagtagccat
     3121 ttaatgtctt tatctcaggg ttctgcatcg gtcactctat atcatactgt aactgtgtgt
     3181 atactgcgct aaggtcaagg aagaagcaag tagagtaggg ttcagtgtag accagaacaa
     3241 atgcaacaac ctgcttgtta gggtttttct ttgtaaaacc aggattgcat taggaaggca
     3301 tcagatggtg ggagcacaaa ccagacgtgc acagctccag caggacttgg tgtgattggt
     3361 ttcaattgaa gcagacacaa agccccttcc agagtgagat gccttgaact atgtagtggc
     3421 ttacatacct ggaagtgtag gatgtatcct gccactgtct acaatctaca cctcaaaaca
     3481 catcagaaga attcctatga gtggccttga aagaaagcat gtctggggtg taagacttca
     3541 actcttagca acgtgctcta gcttagcaca atagcaaggg caggctaccc caggtgagag
     3601 agggacaaag agactgaaga aggcagagct ctcagcaaag tttaacaaac ccaaagggaa
     3661 gagaatggtt tattacttat tgcaaacatc accacccata atttccataa tttccctact
     3721 tgttctatgc aagagtcatc attaatgggt attattctga gacaaaattc cattgtttta
     3781 atttttacta ttgatcacta gtaatgccat gttttccatc tataatttac ttgttattct
     3841 tcttttttga actatgcact tatgttcttg ggctttttct gaagttattc atatataatt
     3901 tctttctgga ctcataatca tttcttatcc attggtgtta gtatttatgt ttttggtgaa
     3961 gcctagtgat gactgtatgt gttctgcctt tgctgtcatg tcataactgc attcctgggt
     4021 attacggttg taagaaacaa aggctcactc gttgaagctc tagagaaaga agacgggaag
     4081 aactaaaatc attgtgtaga ctagacctaa aactggatgc tcaagaacgc cagaggccag
     4141 agcatttccc ccaaattcag gctcacagca cagcagtgtg ggagaaaatt aggctgtcta
     4201 tacatttaca tttttagaca gtgtaaacat atatgactat gcaaaagtat gtacatcctg
     4261 tttataaagt ataaactgat
//
