LOCUS       NM_011326               3016 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus sodium channel, nonvoltage-gated 1 gamma (Scnn1g),
            mRNA.
ACCESSION   NM_011326 XM_914099
VERSION     NM_011326.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3016)
  AUTHORS   Ray,E.C., Nickerson,A., Sheng,S., Carrisoza-Gaytan,R., Lam,T.,
            Marciszyn,A., Zhang,L., Jordahl,A., Bi,C., Winfrey,A., Kou,Z.,
            Gingras,S., Kirabo,A., Satlin,L.M. and Kleyman,T.R.
  TITLE     Influence of proteolytic cleavage of ENaC's gamma subunit upon Na+
            and K+ handling
  JOURNAL   Am J Physiol Renal Physiol 326 (6), F1066-F1077 (2024)
   PUBMED   38634134
  REMARK    GeneRIF: Influence of proteolytic cleavage of ENaC's gamma subunit
            upon Na[+] and K[+] handling.
REFERENCE   2  (bases 1 to 3016)
  AUTHORS   Akkuratova,N., Faure,L., Kameneva,P., Kastriti,M.E. and Adameyko,I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3016)
  AUTHORS   Ray,E.C., Pitzer,A., Lam,T., Jordahl,A., Patel,R., Ao,M.,
            Marciszyn,A., Winfrey,A., Barak,Y., Sheng,S., Kirabo,A. and
            Kleyman,T.R.
  TITLE     Salt sensitivity of volume and blood pressure in a mouse with
            globally reduced ENaC gamma-subunit expression
  JOURNAL   Am J Physiol Renal Physiol 321 (6), F705-F714 (2021)
   PUBMED   34632813
  REMARK    GeneRIF: Salt sensitivity of volume and blood pressure in a mouse
            with globally reduced ENaC gamma-subunit expression.
REFERENCE   4  (bases 1 to 3016)
  AUTHORS   Mutchler,S.M., Hasan,M., Kohan,D.E., Kleyman,T.R. and Tan,R.J.
  TITLE     Deletion of the Gamma Subunit of ENaC in Endothelial Cells Does Not
            Protect against Renal Ischemia Reperfusion Injury
  JOURNAL   Int J Mol Sci 22 (20), 10914 (2021)
   PUBMED   34681576
  REMARK    GeneRIF: Deletion of the Gamma Subunit of ENaC in Endothelial Cells
            Does Not Protect against Renal Ischemia Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3016)
  AUTHORS   Rossier,B.C.
  TITLE     Epithelial sodium channel (ENaC) and the control of blood pressure
  JOURNAL   Curr Opin Pharmacol 15, 33-46 (2014)
   PUBMED   24721652
  REMARK    Review article
REFERENCE   6  (bases 1 to 3016)
  AUTHORS   Ahn,Y.J., Brooker,D.R., Kosari,F., Harte,B.J., Li,J., Mackler,S.A.
            and Kleyman,T.R.
  TITLE     Cloning and functional expression of the mouse epithelial sodium
            channel
  JOURNAL   Am J Physiol 277 (1), F121-F129 (1999)
   PUBMED   10409305
REFERENCE   7  (bases 1 to 3016)
  AUTHORS   Hummler,E., Barker,P., Gatzy,J., Beermann,F., Verdumo,C.,
            Schmidt,A., Boucher,R. and Rossier,B.C.
  TITLE     Early death due to defective neonatal lung liquid clearance in
            alpha-ENaC-deficient mice
  JOURNAL   Nat Genet 12 (3), 325-328 (1996)
   PUBMED   8589728
REFERENCE   8  (bases 1 to 3016)
  AUTHORS   Brooker,D.R., Kozak,C.A. and Kleyman,T.R.
  TITLE     Epithelial sodium channel genes Scnn1b and Scnn1g are closely
            linked on distal mouse chromosome 7
  JOURNAL   Genomics 29 (3), 784-786 (1995)
   PUBMED   8575777
REFERENCE   9  (bases 1 to 3016)
  AUTHORS   Hansson,J.H., Nelson-Williams,C., Suzuki,H., Schild,L.,
            Shimkets,R., Lu,Y., Canessa,C., Iwasaki,T., Rossier,B. and
            Lifton,R.P.
  TITLE     Hypertension caused by a truncated epithelial sodium channel gamma
            subunit: genetic heterogeneity of Liddle syndrome
  JOURNAL   Nat Genet 11 (1), 76-82 (1995)
   PUBMED   7550319
REFERENCE   10 (bases 1 to 3016)
  AUTHORS   Canessa,C.M., Schild,L., Buell,G., Thorens,B., Gautschi,I.,
            Horisberger,J.D. and Rossier,B.C.
  TITLE     Amiloride-sensitive epithelial Na+ channel is made of three
            homologous subunits
  JOURNAL   Nature 367 (6462), 463-467 (1994)
   PUBMED   8107805
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC165081.3, AF112187.1 and
            BP767443.1.
            
            On Oct 27, 2015 this sequence version replaced NM_011326.2.
            
            Summary: This gene encodes the gamma subunit of the epithelial
            sodium channel, a member of the amiloride-sensitive sodium channel
            family of proteins. This channel regulates sodium homeostasis and
            blood pressure, by controlling sodium transport in the kidney,
            colon and lung. Proteolytic processing of the encoded protein
            results in the release of an inhibitory peptide and channel
            activation. Homozygous knockout mice for this gene exhibit
            perinatal lethality, likely due to excess serum potassium.
            [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021338.1, AF112187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC165081.3         110915-110951       c
            38-2993             AF112187.1         10-2965
            2994-3016           BP767443.1         20-42               c
FEATURES             Location/Qualifiers
     source          1..3016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.07 cM"
     gene            1..3016
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /note="sodium channel, nonvoltage-gated 1 gamma"
                     /db_xref="GeneID:20278"
                     /db_xref="MGI:MGI:104695"
     exon            1..65
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            66..414
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2065
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /note="amiloride-sensitive sodium channel subunit gamma;
                     gamma-ENaC; gamma-NaCH; epithelial Na(+) channel subunit
                     gamma; nonvoltage-gated sodium channel 1 subunit gamma;
                     ENaC gamma"
                     /codon_start=1
                     /product="epithelial sodium channel subunit gamma"
                     /protein_id="NP_035456.1"
                     /db_xref="CCDS:CCDS21803.1"
                     /db_xref="GeneID:20278"
                     /db_xref="MGI:MGI:104695"
                     /translation="MAPGEKIKAKIKKNLPVRGPQAPTIKDLMHWYCLNTNTHGCRRI
                     VVSRGRLRRLLWIAFTLTAVALIIWQCALLVFSFYTVSVSIKVHFQKLDFPAVTICNI
                     NPYKYSAVSDLLTDLDSETKQALLSLYGVKDVLDSTPRKRREAGSMRSTWEGTPPRFL
                     NLIPLLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTS
                     DCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGMSCDAR
                     NFTLFHHPMYGNCYTFNNRENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTGAK
                     VLVHQQNEYPFIEDVGTEIETAMSTSIGMHLTESFKLSEPYSQCTEDGSDVPVTNIYN
                     AAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLYQAFVR
                     EELGCQSVCKQSCSFKEWTLTTSLAQWPSEASEKWLLNVLTWDQSQQINKKLNKTDLA
                     KLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEVFFIDFFSI
                     IARRQWQKAKDWWARRRTPPSTETPSSQQGQDNPALDTDDDLPTFTSAMRLPPAPEAP
                     VPGTPPPRYNTLRLDSAFSSQLTDTQLTNEF"
     exon            415..733
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            734..924
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1028
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1192
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1291
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1409
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1488
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1546
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1608
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1684
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..2998
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="Scnn1g"
                     /gene_synonym="SCNEG"
                     /note="major polyA site"
ORIGIN      
        1 ggccagaaga agaggagcgt ctccagactg tacacaggcc agccgtgacc cttcagttca
       61 gaaagaactc tgcaggctgc aaagtcctgt ccttaccatg gcgcctggag agaagatcaa
      121 agccaaaatc aaaaagaatc tgccagttcg aggcccccag gcaccgacca ttaaggacct
      181 gatgcattgg tactgcctga acaccaacac ccacggctgc cggcgcatcg tggtgtcccg
      241 aggccgcctt cggcgcctgt tgtggattgc gttcacgctg acagcagtgg ccctcattat
      301 ctggcagtgc gccctcctcg tcttctcttt ctacaccgtc tctgtctcca tcaaagtcca
      361 cttccagaaa ctggatttcc ccgctgtcac tatctgcaat atcaacccct acaagtacag
      421 tgctgtgagt gacctcctga ctgacttgga cagtgagaca aaacaggcct tgctgtcctt
      481 gtatggggtc aaagatgttc tagacagtac acctcggaaa cgccgggaag caggatccat
      541 gcggtccacg tgggaaggca caccacccag atttctcaac ctgatcccat tgttggtctt
      601 caatgagaac gagaagggaa aggccaggga cttcttcact ggtcggaagc ggaaaatcag
      661 tgggaaaatc atacacaagg cttctaatgt catgcacgtt catgagtcga agaaactggt
      721 gggatttcag ttgtgctcaa atgacacctc tgactgtgcc acctacacct tcagctcagg
      781 aatcaatgcc atccaggagt ggtacaaact tcactacatg aatatcatgg cacaggtgcc
      841 tctagagaag aaaatcaaca tgagctattc tgccgaagaa ctgctggtga cctgcttctt
      901 cgatgggatg tcctgtgatg ccaggaactt cactcttttc caccatccaa tgtatgggaa
      961 ctgctacacg ttcaacaaca gagaaaacgc caccatcctc agcacctcca tgggaggcag
     1021 tgagtatggt ctgcaagtca tcttatacat aaacgaagat gagtacaacc ccttcctggt
     1081 gtcatccact ggagccaagg tgcttgtcca tcagcagaat gaataccctt tcatcgaaga
     1141 cgtggggacc gagatcgaga cagcaatgtc cacttccata ggaatgcacc tgacagaatc
     1201 cttcaagctg agcgaacctt acagccagtg cacagaggac ggcagcgatg tgcccgtcac
     1261 aaacatctac aatgctgcct attccctcca gatctgcctt tactcatgct tccaaacgaa
     1321 gatggtggaa aaatgtggct gtgcccagta cagtcagcct ctacctccag cagccaatta
     1381 ctgcaactac cagcaacacc ccaactggat gtattgctac taccagctgt accaggcctt
     1441 tgtccgggaa gaactgggct gccaatcagt gtgcaagcaa tcctgcagct ttaaggaatg
     1501 gacactgacc accagcttgg cacagtggcc atctgaggct tctgagaaat ggttgctgaa
     1561 tgttctcacc tgggaccaaa gccagcaaat aaacaaaaag ctcaacaaga ctgacctggc
     1621 caagctcttg atattctaca aagacctgaa ccaaagatcc atcatggaga gcccagccaa
     1681 cagtattgag atgctcctgt ctaactttgg tggacagctc ggcctgtgga tgagctgctc
     1741 ggtcgtctgt gtcatcgaaa tcatcgaagt cttcttcatt gatttcttct ctattattgc
     1801 ccgccgccag tggcagaaag ccaaggattg gtgggcccgt aggcggacac caccctccac
     1861 tgagactccc tccagccagc agggtcagga taatccagcc ctggatacgg acgatgatct
     1921 gcccactttt acctctgcta tgcgcctgcc tccagccccg gaggctccgg tgcctggcac
     1981 accacccccc agatacaata ccttgcgctt ggacagtgcc ttttcctccc agctcacaga
     2041 cactcagttg accaatgagt tctaagatag gattggaaaa cagtcatggt ttgaggagac
     2101 tctcttcctg acacaaatgg tcctcctatc ctcgttctgg cttttgatac atgtctaaca
     2161 gcctgctgtg aacaggatag ggcatggaaa tccacagaag gacctgatgg gccctgcccc
     2221 aacactcata acttccagca tgagctatat cctgcaacct ggactcagca cttataagct
     2281 aaagagccaa aggtaatgaa tgacctgggc caacagtgag ctcttcctgg ggtcctgaaa
     2341 gagaatggtg tttcagagcc ccaagctcag gagtttgccc acaataacct ggcccagctt
     2401 gtacctcaag cacatgatct tgggtagcaa ggctggccag ctattgcctg atgggtgtga
     2461 cagaagaaat tagcaccatc cttggatccc agcagttggt tgctgacctc agtcattgac
     2521 actgggacaa ggtgtcctct gtgtcctcag acagacagtt ggcccagagc ctggggatcg
     2581 tgtttggaga gggcacagta gagagaggac aaggggtgtg gtaagatgtc cccactctga
     2641 agcagggtgg ggcagtagag aagggccagt taaagggcat agctggacac tcctgccaaa
     2701 tggtactcct atcctaatct cagctcgagt ggtatgctgc gagctgtact aagcacttac
     2761 tctagggcat aacaaacacc agcctacagg cccaatcctt tattttgtct ttgaactgag
     2821 agtatgtgta tgtgtgagaa tgtgtgtatg aatgtgtata tatgtatgtg tttataattt
     2881 ttatattgct aatatataca tatatatata tcaaaaagat aatattttgt gacttgtgaa
     2941 aattataaga ttcaaatgct agtgtttata aataaagttt tattgataat cgatcataaa
     3001 aaaaaaaaaa aaaaaa
//
