LOCUS       NM_011325               2694 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus sodium channel, nonvoltage-gated 1 beta (Scnn1b),
            transcript variant 1, mRNA.
ACCESSION   NM_011325
VERSION     NM_011325.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2694)
  AUTHORS   Hamby,M., Stec,D.E., Hildebrandt,E., Stec,D.F. and Drummond,H.A.
  TITLE     Mice lacking ASIC2 and betaENaC are protected from
            high-fat-diet-induced metabolic syndrome
  JOURNAL   Front Endocrinol (Lausanne) 15, 1449344 (2024)
   PUBMED   39224121
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2694)
  AUTHORS   Wasson,R., Fleming,A.B., McLin,J., Hildebrandt,E. and Drummond,H.A.
  TITLE     Bone marrow monocytes and macrophages from mice lacking betaENaC
            and ASIC2 have a reduced chemotactic migration response and
            polarization
  JOURNAL   Physiol Rep 12 (14), e16139 (2024)
   PUBMED   39016176
  REMARK    GeneRIF: Bone marrow monocytes and macrophages from mice lacking
            betaENaC and ASIC2 have a reduced chemotactic migration response
            and polarization.
REFERENCE   3  (bases 1 to 2694)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2694)
  AUTHORS   Hayashi,T., Eto,K. and Kadoya,Y.
  TITLE     Downregulation of ten-eleven translocation-2 triggers epithelial
            differentiation during organogenesis
  JOURNAL   Differentiation 125, 45-53 (2022)
   PUBMED   35569195
REFERENCE   5  (bases 1 to 2694)
  AUTHORS   Choudhary,I., Vo,T., Paudel,K., Yadav,R., Mao,Y., Patial,S. and
            Saini,Y.
  TITLE     Postnatal Ozone Exposure Disrupts Alveolar Development, Exaggerates
            Mucoinflammatory Responses, and Suppresses Bacterial Clearance in
            Developing Scnn1b-Tg+ Mice Lungs
  JOURNAL   J Immunol 207 (4), 1165-1179 (2021)
   PUBMED   34330754
  REMARK    GeneRIF: Postnatal Ozone Exposure Disrupts Alveolar Development,
            Exaggerates Mucoinflammatory Responses, and Suppresses Bacterial
            Clearance in Developing Scnn1b-Tg(+) Mice Lungs.
REFERENCE   6  (bases 1 to 2694)
  AUTHORS   Hummler,E., Barker,P., Gatzy,J., Beermann,F., Verdumo,C.,
            Schmidt,A., Boucher,R. and Rossier,B.C.
  TITLE     Early death due to defective neonatal lung liquid clearance in
            alpha-ENaC-deficient mice
  JOURNAL   Nat Genet 12 (3), 325-328 (1996)
   PUBMED   8589728
REFERENCE   7  (bases 1 to 2694)
  AUTHORS   Brooker,D.R., Kozak,C.A. and Kleyman,T.R.
  TITLE     Epithelial sodium channel genes Scnn1b and Scnn1g are closely
            linked on distal mouse chromosome 7
  JOURNAL   Genomics 29 (3), 784-786 (1995)
   PUBMED   8575777
REFERENCE   8  (bases 1 to 2694)
  AUTHORS   Hansson,J.H., Nelson-Williams,C., Suzuki,H., Schild,L.,
            Shimkets,R., Lu,Y., Canessa,C., Iwasaki,T., Rossier,B. and
            Lifton,R.P.
  TITLE     Hypertension caused by a truncated epithelial sodium channel gamma
            subunit: genetic heterogeneity of Liddle syndrome
  JOURNAL   Nat Genet 11 (1), 76-82 (1995)
   PUBMED   7550319
REFERENCE   9  (bases 1 to 2694)
  AUTHORS   Shimkets,R.A., Warnock,D.G., Bositis,C.M., Nelson-Williams,C.,
            Hansson,J.H., Schambelan,M., Gill,J.R. Jr., Ulick,S., Milora,R.V.,
            Findling,J.W. et al.
  TITLE     Liddle's syndrome: heritable human hypertension caused by mutations
            in the beta subunit of the epithelial sodium channel
  JOURNAL   Cell 79 (3), 407-414 (1994)
   PUBMED   7954808
REFERENCE   10 (bases 1 to 2694)
  AUTHORS   Canessa,C.M., Schild,L., Buell,G., Thorens,B., Gautschi,I.,
            Horisberger,J.D. and Rossier,B.C.
  TITLE     Amiloride-sensitive epithelial Na+ channel is made of three
            homologous subunits
  JOURNAL   Nature 367 (6462), 463-467 (1994)
   PUBMED   8107805
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036819.1, AF112186.1 and AK087055.1.
            
            On Dec 27, 2012 this sequence version replaced NM_011325.1.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036819.1, AK028909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AK036819.1         2-74
            74-2482             AF112186.1         1-2409
            2483-2694           AK087055.1         2446-2657
FEATURES             Location/Qualifiers
     source          1..2694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.07 cM"
     gene            1..2694
                     /gene="Scnn1b"
                     /note="sodium channel, nonvoltage-gated 1 beta"
                     /db_xref="GeneID:20277"
                     /db_xref="MGI:MGI:104696"
     exon            1..100
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            101..419
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2025
                     /gene="Scnn1b"
                     /note="amiloride-sensitive sodium channel subunit beta;
                     SCNEB; beta-ENaC; beta-NaCH; epithelial Na(+) channel
                     subunit beta; nonvoltage-gated sodium channel 1 subunit
                     beta; ENaC beta"
                     /codon_start=1
                     /product="epithelial sodium channel subunit beta"
                     /protein_id="NP_035455.1"
                     /db_xref="CCDS:CCDS21804.1"
                     /db_xref="GeneID:20277"
                     /db_xref="MGI:MGI:104696"
                     /translation="MPVKKYLLKCLHRLQKGPGYTYKELLVWYCNNTNTHGPKRIICE
                     GPKKKAMWFLLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMNFPAVTVCNSSP
                     FQYSKVKHLLKDLDELMEAVLEKILAPEASHSNTTRTLNFTIWNHTPLVLIDERNPDH
                     PVVLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSANGTVCTLRNFTSATQAVTEWYI
                     LQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPIFYPDYGNCYIFNWG
                     MTEETLPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLMLHEQRTYPFIREEGIYA
                     MAGTETSIGVLVDKLQRKGEPYSPCTMNGSDVAIKNLYSVYNTTYSIQACLHSCFQDH
                     MIRNCSCGHYLYPLPEGEKYCNNRDFPDWAYCYLNLQMSVTQRETCLSMCKESCNDTQ
                     YKMTISMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEES
                     PANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFIWITIIKLVASCKGLRRRRPQ
                     APYTGPPPTVAELVEAHTNFGFQPDTTSCRPHGEVYPDQQTLPIPGTPPPNYDSLRLQ
                     PLDTMESDSEVEAI"
     exon            420..687
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            688..878
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            879..982
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1146
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1254
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1372
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1448
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1506
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1568
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1644
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2694
                     /gene="Scnn1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2461..2466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scnn1b"
                     /note="hexamer: AATAAA"
     polyA_site      2480
                     /gene="Scnn1b"
                     /note="major polyA site"
ORIGIN      
        1 ctacagcgtc ccgggctcta caggtgaccc agctccacag ccactcggac gccaccacct
       61 tagctgccat cacctcacac tggagcagct tcctaaacag gtgccaccat gccagtgaag
      121 aagtacctcc tgaagtgcct gcaccggctg cagaagggcc caggctacac ctacaaggag
      181 ctgctagtgt ggtactgcaa taacaccaac acccacggcc ccaaacgcat catctgtgag
      241 gggcccaaga agaaggccat gtggttcctg cttacgctgc tcttcgcctg cctggtgtgc
      301 tggcagtggg gagtcttcat ccagacctac ctgagctggg aggtcagcgt ctcgctctcc
      361 atgggcttca agacgatgaa cttcccggcg gtcaccgtct gcaattccag ccccttccag
      421 tactccaagg tcaagcactt gctcaaggac ttggatgagc taatggaggc agtcctggaa
      481 aagattctgg ctccagaggc cagccacagc aacaccacca ggaccctgaa ctttaccatc
      541 tggaaccaca cacccctggt ccttattgat gagcggaacc ctgaccaccc ggtggttctc
      601 aatttgtttg gggacagcca caacagcagc aacccggctc caggaagcac ctgcaatgcc
      661 cagggatgca aagtggccat gaggctgtgc agtgccaatg gaactgtgtg taccttgcgg
      721 aacttcacca gtgccaccca ggccgtaact gagtggtaca tcctgcaggc caccaacatc
      781 ttctcacaag tgcttcctca ggacctggtg gggatgggct atgcccctga tcgcataatc
      841 ctagcttgcc tgtttggaac agagccctgc agtcatcgga acttcacgcc tatcttctac
      901 cctgattatg gcaactgcta catcttcaac tggggcatga cagaggagac acttccttct
      961 gccaaccctg ggactgaatt tggtctcaag ttgatcctgg acatcggtca ggaggactat
     1021 gtccccttcc ttgcgtccac agcaggggct aggctgatgc ttcatgagca gaggacgtac
     1081 cccttcatta gagaggaggg catctatgcc atggcaggaa ctgagacgtc tattggggtg
     1141 ctggtggaca agctgcaacg caagggggag ccctacagtc cctgcaccat gaacggctcc
     1201 gatgttgcca taaagaacct ctacagtgtc tacaacacca cctattccat ccaggcctgt
     1261 cttcattcct gtttccaaga ccacatgatc cgtaactgca gttgtggcca ctacttatac
     1321 ccactgcctg aaggagagaa atactgcaac aacagggact tcccagactg ggcctattgc
     1381 tatctaaacc tgcagatgag tgtgacccag agagagacct gcctcagcat gtgcaaggag
     1441 tcctgcaatg acacccagta taagatgacc atctccatgg ctgactggcc atctgaggcc
     1501 tctgaggatt ggatcttaca tgtcctgtct caggagcggg accagagctc gaatatcacc
     1561 ctgagcagga agggtattgt caagctcaat atctacttcc aagagttcaa ctaccgtacc
     1621 attgaggaat ctccagccaa caatattgtg tggctgctct ctaacctggg gggccagttt
     1681 ggcttctgga tggggggctc ggtgctgtgc ctcattgagt ttggggagat cattatcgac
     1741 ttcatttgga tcaccatcat caagctggtg gcctcctgca aaggcctgcg caggaggcgg
     1801 ccacaggcac cctacactgg cccaccgccc actgtggctg agctggtaga ggcccacacc
     1861 aactttggct tccagcctga cacaaccagc tgcaggcccc acggcgaggt ctaccctgac
     1921 caacagactc tgcccatccc ggggactcca ccccccaact atgactccct gaggctgcag
     1981 ccgctggaca ccatggagtc ggacagtgag gtggaggcca tctagatccc cacccccacc
     2041 cagcaactag tgaactcaaa actgaagagt tacaaccatt gtcagtgcct cgtttcatta
     2101 ggccttgtac aaagagccgg gggcaccgtt gcccaagcca gagcccatgt ctggtcagcc
     2161 ccaggctgca gggttcttag ggtcagatgc tggttccaga atacggaact tgtatccttt
     2221 tctggctctt gcgtacccta cccagtattt gctctctgtt gatctagcac acaggctcca
     2281 gagatggcta gagtccctct cctggttgat aggccacttt cctgtctgtt accacctcag
     2341 tctcccagaa tccttgccct agttggcatt ggttgacctc tgttaacaga cttggggggg
     2401 tgcagatcat agggagatca ggtaagaagt cttgaaaggg gaacacgtgc tttgttagaa
     2461 aataaagaga gaaaacactg gatggaggtt tgttctttat cccactgggt agctggggtg
     2521 cactgaagca aactgacttc agtaaaacca ggcatgggga tggagggcag acacctataa
     2581 tcccaggtcg gaagatccaa gttcaagacc agcttggact atacagattg tctcagaaaa
     2641 ccaaacagca caaacaaaaa ccccacaaaa caaataaatg ttctcaagca cccc
//
