LOCUS       NM_001013390            4771 bp    mRNA    linear   ROD 15-DEC-2024
DEFINITION  Mus musculus sodium channel, type IV, beta (Scn4b), mRNA.
ACCESSION   NM_001013390 XM_357946
VERSION     NM_001013390.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4771)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4771)
  AUTHORS   Martinez,M.E., Pinz,I., Preda,M., Norton,C.R., Gridley,T. and
            Hernandez,A.
  TITLE     DIO3 protects against thyrotoxicosis-derived cranio-encephalic and
            cardiac congenital abnormalities
  JOURNAL   JCI Insight 7 (21), e161214 (2022)
   PUBMED   36166296
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4771)
  AUTHORS   Wang,N., Langfelder,P., Stricos,M., Ramanathan,L., Richman,J.B.,
            Vaca,R., Plascencia,M., Gu,X., Zhang,S., Tamai,T.K., Zhang,L.,
            Gao,F., Ouk,K., Lu,X., Ivanov,L.V., Vogt,T.F., Lu,Q.R.,
            Morton,A.J., Colwell,C.S., Aaronson,J.S., Rosinski,J., Horvath,S.
            and Yang,X.W.
  TITLE     Mapping brain gene coexpression in daytime transcriptomes unveils
            diurnal molecular networks and deciphers perturbation gene
            signatures
  JOURNAL   Neuron 110 (20), 3318-3338 (2022)
   PUBMED   36265442
REFERENCE   4  (bases 1 to 4771)
  AUTHORS   Patel,T., Hammelman,J., Aziz,S., Jang,S., Closser,M.,
            Michaels,T.L., Blum,J.A., Gifford,D.K. and Wichterle,H.
  TITLE     Transcriptional dynamics of murine motor neuron maturation in vivo
            and in vitro
  JOURNAL   Nat Commun 13 (1), 5427 (2022)
   PUBMED   36109497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4771)
  AUTHORS   Ransdell,J.L., Moreno,J.D., Bhagavan,D., Silva,J.R. and
            Nerbonne,J.M.
  TITLE     Intrinsic mechanisms in the gating of resurgent Na+ currents
  JOURNAL   Elife 11, e70173 (2022)
   PUBMED   35076394
  REMARK    GeneRIF: Intrinsic mechanisms in the gating of resurgent Na(+)
            currents.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4771)
  AUTHORS   Lopez-Santiago,L.F., Meadows,L.S., Ernst,S.J., Chen,C.,
            Malhotra,J.D., McEwen,D.P., Speelman,A., Noebels,J.L., Maier,S.K.,
            Lopatin,A.N. and Isom,L.L.
  TITLE     Sodium channel Scn1b null mice exhibit prolonged QT and RR
            intervals
  JOURNAL   J Mol Cell Cardiol 43 (5), 636-647 (2007)
   PUBMED   17884088
REFERENCE   7  (bases 1 to 4771)
  AUTHORS   Oyama,F., Miyazaki,H., Sakamoto,N., Becquet,C., Machida,Y.,
            Kaneko,K., Uchikawa,C., Suzuki,T., Kurosawa,M., Ikeda,T.,
            Tamaoka,A., Sakurai,T. and Nukina,N.
  TITLE     Sodium channel beta4 subunit: down-regulation and possible
            involvement in neuritic degeneration in Huntington's disease
            transgenic mice
  JOURNAL   J Neurochem 98 (2), 518-529 (2006)
   PUBMED   16805843
  REMARK    GeneRIF: down-regulation of Scn4b may lead to abnormalities of
            sodium channel and neurite degeneration in the striatum of
            Huntington's disease transgenic mice
REFERENCE   8  (bases 1 to 4771)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   9  (bases 1 to 4771)
  AUTHORS   Grieco,T.M., Malhotra,J.D., Chen,C., Isom,L.L. and Raman,I.M.
  TITLE     Open-channel block by the cytoplasmic tail of sodium channel beta4
            as a mechanism for resurgent sodium current
  JOURNAL   Neuron 45 (2), 233-244 (2005)
   PUBMED   15664175
REFERENCE   10 (bases 1 to 4771)
  AUTHORS   Yu,F.H., Westenbroek,R.E., Silos-Santiago,I., McCormick,K.A.,
            Lawson,D., Ge,P., Ferriera,H., Lilly,J., DiStefano,P.S.,
            Catterall,W.A., Scheuer,T. and Curtis,R.
  TITLE     Sodium channel beta4, a new disulfide-linked auxiliary subunit with
            similarity to beta2
  JOURNAL   J Neurosci 23 (20), 7577-7585 (2003)
   PUBMED   12930796
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ057833.1, CJ146846.1, BK001031.1 and AI844796.1.
            
            On Jun 21, 2018 this sequence version replaced NM_001013390.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB118946.1, BK001031.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-192               CJ057833.1         2-193
            193-418             CJ146846.1         1-226
            419-4662            BK001031.1         1-4244
            4663-4771           AI844796.1         1-109               c
FEATURES             Location/Qualifiers
     source          1..4771
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..4771
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /note="sodium channel, type IV, beta"
                     /db_xref="GeneID:399548"
                     /db_xref="MGI:MGI:2687406"
     exon            1..479
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..1105
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /note="sodium channel, type IV, beta polypeptide; sodium
                     channel subunit beta-4; voltage gated sodium channel beta
                     4 subunit; sodium channel accessory subunit; sodium
                     channel regulatory subunit beta-4"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-4
                     precursor"
                     /protein_id="NP_001013408.1"
                     /db_xref="CCDS:CCDS23130.1"
                     /db_xref="GeneID:399548"
                     /db_xref="MGI:MGI:2687406"
                     /translation="MSRAGNRGNTQARWLGTGLLGLFLLPMYLSLEVSVGKATTIYAI
                     NGSSILLPCTFSSCYGFENLYFKWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRIT
                     LEGSTKEKTNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEKVDN
                     TVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGS
                     KAEEKPPTKV"
     exon            480..652
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /inference="alignment:Splign:2.1.0"
     exon            653..881
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1011
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..4756
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4735..4740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /note="hexamer: AATAAA"
     polyA_site      4756
                     /gene="Scn4b"
                     /gene_synonym="Gm1471"
                     /note="major polyA site"
ORIGIN      
        1 attcccgtcc cgctggagag gaagagggct gcccaggctg gaccctacgg ccgtgataca
       61 cggcgcaacg ggcactgtgc gaaaccgacg gggacgccgc ccctcctgcg gctggagcgc
      121 ttccagagca gaggcgcatc gcagtgccgc tcgccccggc gtcctccctt cagctccggc
      181 tcctcctccc ccttccagcc ccggctcctg cagccggctc caagaggcgg cgggcgcgcc
      241 tccccctcct tggtctcccc ctcgtctcgc tctctcgcgg ctaactttcc ggagccccga
      301 cccgcggctc ggagctcccc tggcagctgc ggggcccaca gacgacctcg ggtggagagc
      361 ccggctgtcc ccactattcc atcccaagcc cccggagcgc tccagagaga acaggaccat
      421 gtcccgggct gggaaccgag gcaatactca ggcgagatgg ctgggcactg ggcttttggg
      481 tctcttcctg cttcccatgt acctgtcgtt ggaggtatct gtgggaaagg ccaccaccat
      541 ctacgctatt aacggctcat cgatcctgct gccctgcacc ttctccagct gttatggctt
      601 tgagaacctc tacttcaagt ggtcctacaa taacagcgaa acatccagga ttctcatcga
      661 cgggatcgtg aagaacgata agtctgaccc taaggtgaga gtgaaggatg atgatcgaat
      721 caccctagag ggctccacca aggagaagac gaataacatc tccatcctct tgagtgacct
      781 ggagttcagt gacacgggca gatacacctg cttcgtgagg aaccccaagg agaaggactt
      841 gaacaactct gccaccatct tcctccaagt ggttgataaa ttggaaaaag tggacaacac
      901 ggtgactctc atcatcctgg ctgtggtggg cggggtcatt ggacttcttg tttgcatcct
      961 tctgctgaag aagctcatca ccttcatcct gaagaagacc cgagagaaga agaaggagtg
     1021 tctcgtgagt tcctctggga atgacaacac agagaacggg ttgcctggct ccaaggcaga
     1081 agagaagcca cccacaaaag tgtgaggccc tgctcgggcc aagcagggca gggagcctcg
     1141 ctttctgatg gtgatcctga tgccaagtcc tatctgagat gtgtgctgct tggcccaaac
     1201 tgttctttct gagcaggaag gacctggccc tgcccagctg ccgttctctc cccagccagg
     1261 gcttcctagg gacaagggtt ggttgactgg gggaggaagc ctacaggaga ttgaagacag
     1321 ggaagggagg ggctggagtg gtgtggaagg ttggttcccg gatcctgggc acgtggggtc
     1381 tcctttagat tttcccctct gtgaagcctt gttttctcct cagttttcct tctgatcttt
     1441 caccaggaaa tcggggtgac cagtgagggc tgcttccaaa gctggggtct ggagatgggt
     1501 agagggtgac cgcttcagaa gctgggaatg cacaagaagt ctagaatggt gtcttctggg
     1561 gggggggggg gcagttgtga gaggcaagct gggctctgaa gaatatcagg cttctggaag
     1621 ttcctttaga gaggacttct ctttccctta ccctagaaca cctgcccaca ctgtcctggc
     1681 tccccgacca gcctcctcct gctgcctgcc tagtctgtct ttgctctctg ggctgcagct
     1741 gctgaggagg cttgtgggga gggggcagcc tccactctcc tggagcactg gggtgctatt
     1801 tgcagctata ctggctttgc tctttgggtt tcagaggcag gagaacagtg cccctggtct
     1861 cctagccttt ggaatgtcta ccccagccct acaagactga cagcccttgt ccttggcatg
     1921 gcaggaccat gccaccctgg cacttccgga gctcagtttt tcactcttct tcccttccct
     1981 tgaaacagct ggcattgcca ccttccctga gggatgcttt cctaggactt gtcatcccat
     2041 acctttgctc cttctgtgtc catccagcat gcctggcctt cccctgctcc tggcccccca
     2101 gctctgggtc tgcctttgcc tcagggaccc ttgtttccag atgagaaggc ccttggcttt
     2161 tccagcttct tttttgccca gctgggctga ctcctcacct agcctgaggc tgaggaggag
     2221 ctgggagaag gtactcacac cttctcttga cttctggcag agccggcttg cacaccccct
     2281 gagtgtgggg ctagattgtg ccttagttcc tcgagtcctg gttctgagcc ccttttcttt
     2341 cggctcacac tccctgaatt aattgcacag cttggtgtga ctttggcggg gctccccagc
     2401 tccttacccc aaagccatgg aagagaccat gaagccgggg ttggtggcag ccttgatgac
     2461 acctgagggc accctttctt gtccctgaca tggagatagg atggcatttg atgtgggacc
     2521 ttcagatggg tttgaccgtg tacaaaccgt agtgctagct agggtttctg tgatgtatga
     2581 aatgggatac ccaaagtccc tcttcctcat cagatttctg atacccttaa tgtcagaaga
     2641 tggagattag tcctcttttc aggggggtgt aaggactgct acaggctctg cccaggagta
     2701 gctgaaggtt ccccccccca aatggaagtt gggggagact aaggcacagt aggatctgta
     2761 ggtgactgtg gctttggcta gtgtctgttg cccaagccaa ggggctcttg gggttgcctc
     2821 cactcttccc attcttcttt acccagaact cattgtgagc tgggtaaaaa ttgcccgtct
     2881 cctgcttttt aaatatttat ttgagcagag tctcatgtgt ggcccaggcg ggcctccacc
     2941 tctctatgta gccaagactg gccttgaact cccaatctcc tgcctccatt gccacagtgc
     3001 tggtatgaca ggtgtgagcc cacaccctgc ttagagtaac ctggctctga gaaccaacat
     3061 ggcacccgag cctccagcca ttcaggaaac ttccagctgc cttcatgtaa aactgctttc
     3121 tcccccaaca ctggaagagg ccaagtgttg ggggttcttc ttgctttcct gagaggaagc
     3181 caaggcatag agcagaagag agggagggac tctcccttcc cagcttcctg ctcactgtca
     3241 gcttataggc agcccttgca gcttctccca tctacccaaa gggtgaaata atacctacct
     3301 cacaggactg cagtgaggct tggtgagatt tttgtgtttt ttgttttttt ggcctggctt
     3361 ggaaaggcac tgggaaacaa ggctaataac cagcgagaat gttccacatc tatcctgtcc
     3421 tcatctctgg tttgcatccc aataatatgc atatgcctca ttcttcttcc tttagcaacc
     3481 ttaggcatca tgactcagat gcttaaagca tctttgtccc cagttctttt ttttttttga
     3541 tggaggtacc tgggactatg ggagtacttt tttatattgt tgttgcccca atgcctgtga
     3601 taaatactag cgtttaatgg atagggatta agagcacaaa tctcagtcct cttaacaaag
     3661 aatgtctggc ctagtgctag cggcatgcct gtgcaggcat taccacggat tgtgttagaa
     3721 tgtatatttg caaagccatt ttctctagcc agaccctctg acaggcaagt cttcaaatag
     3781 cgatctcagg gttgctgagg ttggtcccgg tgccagtggg ctacagcacc tctcatacgg
     3841 ttgactttgg ggaaacctgg acccatgcag ttgtgttgac cttgatgtca gtgagaccaa
     3901 agacaaagca caagtacctt actcttgact tccaaataaa cttctgccct tgagggctca
     3961 gatcccttgg tgtagaaact aagcagaggg caactggaat caacctgcag tgtggaaggc
     4021 ccaggagaat gacagacagg agggcagcag aatgtcacgt atctgactga ctcgcttctg
     4081 tggagccagg gaggcaagag catcctgctg gtgggaggtg agggtgcact tgtgtggagt
     4141 gcttgtggtg tgtgggaggt ggaaaggcgt gcctagtcag tctgcgggtg cagaggcatg
     4201 acagaagagg gtgggctgtg cacgcgaggg gtgatgtggg atgaaggggt tgggggtggg
     4261 gctctgcatc ttcagtagcc tgaactggag actgaagaag ggttaagaga cataaatgaa
     4321 cggctatgct cctggattct actgggtgac tccatgtcag ggtgacagac gactgccacc
     4381 ggagggctgg ggcaaggatg cccaaatgag ggatttgtgg ggaagtcctc tagcttgcta
     4441 cattttattt tgtcccaggt tggagtccct gctctcccat ctcccactgg atgtgcagtg
     4501 cttttgacta tcttatgcat ggtttagtcc tctggcttgg ataacagtac ccatagtcaa
     4561 ttttcctatc taactttata ggcaatacag tggtgggccg tgggagcctc caggaggcac
     4621 cgacctgcac atgcccagcg cttgcgtcta agcacagatc gaatgccatt aggttgtctt
     4681 gcctctacaa tacattttgc attgcagact tggatttagc ttcgctttgg atgaaataaa
     4741 aattattttt taataaaaaa aaaaaaaaaa a
//
