LOCUS       NM_001083917            4177 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus sodium channel, voltage-gated, type III, beta (Scn3b),
            transcript variant 3, mRNA.
ACCESSION   NM_001083917
VERSION     NM_001083917.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4177)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 4177)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4177)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4177)
  AUTHORS   Nakano,Y., Wiechert,S., Fritzsch,B. and Banfi,B.
  TITLE     Inhibition of a transcriptional repressor rescues hearing in a
            splicing factor-deficient mouse
  JOURNAL   Life Sci Alliance 3 (12), e202000841 (2020)
   PUBMED   33087486
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4177)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4177)
  AUTHORS   Hodge,L.K., Klassen,M.P., Han,B.X., Yiu,G., Hurrell,J., Howell,A.,
            Rousseau,G., Lemaigre,F., Tessier-Lavigne,M. and Wang,F.
  TITLE     Retrograde BMP signaling regulates trigeminal sensory neuron
            identities and the formation of precise face maps
  JOURNAL   Neuron 55 (4), 572-586 (2007)
   PUBMED   17698011
REFERENCE   7  (bases 1 to 4177)
  AUTHORS   Harrell,M.D., Harbi,S., Hoffman,J.F., Zavadil,J. and Coetzee,W.A.
  TITLE     Large-scale analysis of ion channel gene expression in the mouse
            heart during perinatal development
  JOURNAL   Physiol Genomics 28 (3), 273-283 (2007)
   PUBMED   16985003
REFERENCE   8  (bases 1 to 4177)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   9  (bases 1 to 4177)
  AUTHORS   Adachi,K., Toyota,M., Sasaki,Y., Yamashita,T., Ishida,S.,
            Ohe-Toyota,M., Maruyama,R., Hinoda,Y., Saito,T., Imai,K., Kudo,R.
            and Tokino,T.
  TITLE     Identification of SCN3B as a novel p53-inducible proapoptotic gene
  JOURNAL   Oncogene 23 (47), 7791-7798 (2004)
   PUBMED   15334053
  REMARK    GeneRIF: SCN3B mediates a p53-dependent apoptotic pathway and may
            be a candidate for gene therapy combined with anticancer drugs.
REFERENCE   10 (bases 1 to 4177)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB520894.1 and BC053919.1.
            
            Transcript Variant: This variant (3) differs in the 3' UTR,
            compared to variant 2. Variants 2, 3 and 5 encode the same protein
            (isoform a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058636.1, AK173115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-387               CB520894.1         1-387
            388-4177            BC053919.1         283-4072
FEATURES             Location/Qualifiers
     source          1..4177
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 21.42 cM"
     gene            1..4177
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /note="sodium channel, voltage-gated, type III, beta"
                     /db_xref="GeneID:235281"
                     /db_xref="MGI:MGI:1918882"
     exon            1..387
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..467
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             413..1060
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; sodium channel subunit beta-3; brain and heart
                     sodium channel beta 3 subunit; sodium channel regulatory
                     subunit beta-3"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-3 isoform
                     a precursor"
                     /protein_id="NP_001077386.1"
                     /db_xref="CCDS:CCDS23080.1"
                     /db_xref="GeneID:235281"
                     /db_xref="MGI:MGI:1918882"
                     /translation="MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNSMKLR
                     CISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQD
                     VSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEI
                     MMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE"
     exon            468..631
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            632..857
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            858..996
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1076
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..4151
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /note="hexamer: AATAAA"
     polyA_site      4151
                     /gene="Scn3b"
                     /gene_synonym="1110001K16Rik; 4833414B02Rik; Scnb3"
                     /note="major polyA site"
ORIGIN      
        1 gcggcagaga gctgcctgcg catgtcaagg ctagcaacac attcagctag ggggtggccc
       61 tggagagggg cggcttgatc acccaatcgc ccagcatcgg ggcttcgcag gatccagaga
      121 cgcgccccgc ggaagggggt ccccccctct acccagcctc cacctctgag atcgccagtc
      181 ccaccgaagc tcccgcctct ttccacgcct ggtggacctc atgggagccc ggggctgctg
      241 tgtacaagac tgaagtggaa cacattctgt agcccagacg acggctggag tggggacacg
      301 cccagctgga gaagcctgcc ccgccgtaga agcccgagat tctgagtctc ggtggatcga
      361 agtcgctgtc cctaggggag gcgagagttc cagaaaccac ttacgagaaa agatgcctgc
      421 cttcaacaga ttgcttcccc tagcttctct agtgctcatc tactgggtca gagtctgctt
      481 ccctgtgtgt gtagaagtac cctcggagac agaagccgtg cagggcaatt ccatgaagct
      541 gagatgcatc tcctgcatga agagggagga ggtggaggcc accactgtag tggagtggtt
      601 ctacaggcct gagggcggta aagatttcct tatatatgag tatcgaaatg gccaccagga
      661 ggtggagagc cccttccaag gtcgtctgca gtggaatggg agcaaagacc tgcaggacgt
      721 atccatcact gttctcaatg tcactctgaa tgactctggc ctctacacat gtaatgtgtc
      781 cagggagttt gagttcgaag cacaccggcc ctttgtgaag accacaagac taatacccct
      841 gcgagtcact gaagaggcgg gagaagactt cacctccgtg gtctcggaaa tcatgatgta
      901 catcctcctg gtcttcctca ccttgtggct gtttattgag atgatctatt gctacagaaa
      961 ggtctctaag gccgaagagg cagctcagga aaatgcgtct gactaccttg ctatcccttc
     1021 agagaacaag gagaactctg tggtacccgt ggaggaataa agtggtgtga cttgagcaat
     1081 ctcgtccttc gggtactcta cgttaatggt cacatcacaa tgctctctat tatatcaaac
     1141 ccttcagaag ctgaatcact ttggcctgaa tattgagcaa accaaacccc ttgctcatga
     1201 tagcaaaggc acaataattc tctcgttccc tgtttcctcc gtatgtgttt ggagagggtt
     1261 gccctggaca ttctcaatga gttcttctat tgttggtggg tgagctgagt gctgagcaac
     1321 tggctatccc cagttcagca atgccagcaa catcaggaag tgccccaggt gtcccaacac
     1381 atccatcttt ctattcacca accacccacc caactgtgag atttttacct gacttccgga
     1441 ctctatcaga actcctatac atcttgacct tgcctgaact gaagagccaa catctctcca
     1501 tggactaaac ctcactctat ccttgcttcc aatcaagtag ctcccaactc aactagagtt
     1561 gtcccctgtg ctccaaatga ctttagataa gtactggaga gtagtagtct ctgtgtcctg
     1621 tctgcaattg ggttgtcctt cactgcagca aaaggatgaa tgtatattgg aaggaagccc
     1681 tgattagttt gtttaaaagc caaagtgtgg cattcacttt gattcattga agtcattctt
     1741 ttcctgcctc ttagaacaca agagagcagc atgcccgccc ctaaactttc cagagacatc
     1801 ttctgtgtgc actggaatac attctggagc tcagtgtttc gaggctatgt ctccataatc
     1861 ccaaaggcct ggaacaaacc cagaacttcc aagaagccaa ggaagcatcc aggacgattt
     1921 cagtaggttt tgaaagcgat ataacactcc cgagattgga aacacggatg agtgaatttt
     1981 ctgggttgaa atgcctcact tcttcatttc tcagtgtctg tggatcagta ttagtcctcg
     2041 ttttacagga ggcatctgag actcacacaa ggctgaacag gatattgagg ggattaaact
     2101 ggccgagaga tgagtttcat gcctccactc ttacactccc taagctgaaa gatgtttttg
     2161 aggactctta acaatcagca gggcagaagc atggcatttg tccagcagag gctacaggtg
     2221 acatgagaca gactttagga tttcacacaa agatttgtga atctgaagca tcctccaaga
     2281 gacatggcac ctgagggcaa tagctatatg gcaaaaaatg tttttagtct gaaatggaca
     2341 atgaacaaag agacaaagat aggtgtgtag cttctaaata cctcacctgt agatgtcatg
     2401 tttgggtatt ggtgtttgta aagtccccca cccctaccct catccccacc caagagagca
     2461 gggaacaagt gacaagattc ttagtcaata tctctttttt aatgactgtt ctaagtgcaa
     2521 tattctttag cccctacaga tagcaagggc aggaggcctt atggtatata aaaagatgca
     2581 agtgagactc agtaagagag ttgtcctcac tctgaggagc tctataagaa agacccttct
     2641 ccacccccat cgggctttgt atggcaaact cccttttcac ccacaccgtt tccttctttg
     2701 tggatgccag acatccgcct tgggactccc atcccactct tttttatctg gtttgtttgt
     2761 acatgggggt ttatccagaa acacaattgc atttgcttat gggagatcat gactatgacc
     2821 tacaaggtat ggcactcacc agccaactta aaatcttcac catctccatc ttcttcccat
     2881 ccttctactt tgaatcccag actagacgtg cgcagctctg gagcctttcc tggtgtgcta
     2941 ctgcttacta aagggcttag aagagttctc aagggctata atcctctaga aaccccactg
     3001 tttgtcttgg tgctgggtat ttgctgtgac tgattctcaa taatttactg aaggtcaaac
     3061 taagctgagt ctaatttccc ctttattact gtctaacagc tgtgaacttg gttactcggt
     3121 tgggcctgaa agcatcttgc cctgttgact tggagtgtca gctaggtgtt ggatcaagcc
     3181 ccagtcccta agtggaaata ctcagtgctt gctatctcag gctttccttt caatttgttt
     3241 acacattatt ctttggttcc tccactctca attaactgca cacccatgct ttcttttgag
     3301 tttctgggtt tgctctagac atcaaaatag aattgcaagt agaaagggaa gttttcagag
     3361 caagattatg ctgagaaaga tagcagtggg cttaaaagtg gaaagggcta aggtgatagc
     3421 ccaataggta aagtgcttgc cacgccagcg ggagagtctc cgtatgatct ctagaatcca
     3481 tgtgaacagc cagacataca ttatggcaca cattggtcat cccagacctg gggaggcaga
     3541 gacaggaaga tctgagactc gctaaccagg tcaccaggcc aaacttactt acttggcaag
     3601 ctccaggaga gtgagagacc ctgtctccaa aaacaaaacc aaaaaaccaa caaggtggat
     3661 agtgcctgag gaatgacacc caaggttgac ttctggcctc cacatataca tgcacacaag
     3721 ttaaggccca taagcatact tacataaaga tgcacacgct tgtgtctgtg tatgtataca
     3781 tgtgcgtgca cacacacaca cacacacaca cacagagaca gagagagaca gagagagaga
     3841 cagagacctt cctctcactt gttttataaa tgagaaagcc ctggttctgt gaattcactc
     3901 agtcaatgca aatgtatgta accaggacct tggtgtgcct acgcatcatt ctgatcatct
     3961 actcacattg ttcaacactc tctgtgtcga gcactaggtt aggctctagt tagacccctt
     4021 ggttttaggt ctgtaaaagt gtgcaagcat gtgtgtgtgt gcgcgcacat gtgtgtgtgt
     4081 acactagtgc acaagcacat ggttccaata aagtctctct gttcatgtca ataaagcgtc
     4141 tctgaagacc aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
