LOCUS       NM_001014761            4562 bp    mRNA    linear   ROD 19-MAR-2025
DEFINITION  Mus musculus sodium channel, voltage-gated, type II, beta (Scn2b),
            mRNA.
ACCESSION   NM_001014761 XM_134787
VERSION     NM_001014761.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4562)
  AUTHORS   Huikang,W., Shiya,C., Di,P., Kiani,F.A., Hao,L., Sha,N., Xuan,L.,
            Abouelfetouh,M.M., Ahmed,Z., Mingxing,D. and Yi,D.
  TITLE     Elucidation of Dexmedetomidine-Induced Analgesic Tolerance
            Mechanisms in Neuropathic Pain With Modulation of SGK1, NR2A, and
            NR2B Expression via the Spinal SGK1/NF-kappaB Signalling Pathway
  JOURNAL   J Cell Mol Med 29 (6), e70372 (2025)
   PUBMED   40099662
REFERENCE   2  (bases 1 to 4562)
  AUTHORS   Liu,F., Liao,H., Fang,Z., Tang,Q., Liu,Y., Li,C., Zhou,C., Zhang,Y.
            and Shen,J.
  TITLE     MicroRNA-6954-3p Downregulation Contributes to Orofacial
            Neuropathic Pain in Mice Via Targeting Voltage-Gated Sodium Channel
            beta2 Subunit Protein
  JOURNAL   J Pain 25 (10), 104598 (2024)
   PUBMED   38866121
  REMARK    GeneRIF: MicroRNA-6954-3p Downregulation Contributes to Orofacial
            Neuropathic Pain in Mice Via Targeting Voltage-Gated Sodium Channel
            beta2 Subunit Protein.
REFERENCE   3  (bases 1 to 4562)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4562)
  AUTHORS   Tan,Y.X., Hong,Y., Jiang,S., Lu,M.N., Li,S., Chen,B., Zhang,L.,
            Hu,T., Mao,R., Mei,R. and Xiyang,Y.B.
  TITLE     MicroRNA-449a regulates the progression of brain aging by targeting
            SCN2B in SAMP8 mice
  JOURNAL   Int J Mol Med 45 (4), 1091-1102 (2020)
   PUBMED   32124967
  REMARK    GeneRIF: MicroRNA449a regulates the progression of brain aging by
            targeting SCN2B in SAMP8 mice.
REFERENCE   5  (bases 1 to 4562)
  AUTHORS   Hu,T., Li,S.S., Lu,M.N., Zhang,L., Chen,B., Mao,R., Mei,R.,
            Tan,Y.X., Li,S. and Xiyang,Y.B.
  TITLE     Neuroprotection induced by Navbeta2-knockdown in APP/PS1 transgenic
            neurons is associated with NEP regulation
  JOURNAL   Mol Med Rep 20 (2), 2002-2011 (2019)
   PUBMED   31257483
  REMARK    GeneRIF: the present findings suggested that knockdown of Navb2
            reversed the APP/PS1 mutationinduced deficiency in amyloid b
            degradation by regulating NEP.
REFERENCE   6  (bases 1 to 4562)
  AUTHORS   Kim,D.Y., Ingano,L.A., Carey,B.W., Pettingell,W.H. and Kovacs,D.M.
  TITLE     Presenilin/gamma-secretase-mediated cleavage of the voltage-gated
            sodium channel beta2-subunit regulates cell adhesion and migration
  JOURNAL   J Biol Chem 280 (24), 23251-23261 (2005)
   PUBMED   15833746
  REMARK    GeneRIF: beta2 is a PS/gamma-secretase substrate, gamma-secretase
            mediated cleavage of beta2-C-terminal fragment is required for
            cell-cell adhesion and migration of beta2-expressing cells
            Erratum:[J Biol Chem. 2005 Aug 19;280(33):29988]
REFERENCE   7  (bases 1 to 4562)
  AUTHORS   Grieco,T.M., Malhotra,J.D., Chen,C., Isom,L.L. and Raman,I.M.
  TITLE     Open-channel block by the cytoplasmic tail of sodium channel beta4
            as a mechanism for resurgent sodium current
  JOURNAL   Neuron 45 (2), 233-244 (2005)
   PUBMED   15664175
REFERENCE   8  (bases 1 to 4562)
  AUTHORS   Chen,C., Bharucha,V., Chen,Y., Westenbroek,R.E., Brown,A.,
            Malhotra,J.D., Jones,D., Avery,C., Gillespie,P.J. 3rd,
            Kazen-Gillespie,K.A., Kazarinova-Noyes,K., Shrager,P.,
            Saunders,T.L., Macdonald,R.L., Ransom,B.R., Scheuer,T.,
            Catterall,W.A. and Isom,L.L.
  TITLE     Reduced sodium channel density, altered voltage dependence of
            inactivation, and increased susceptibility to seizures in mice
            lacking sodium channel beta 2-subunits
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 17072-17077 (2002)
   PUBMED   12481039
REFERENCE   9  (bases 1 to 4562)
  AUTHORS   Jones,J.M., Meisler,M.H. and Isom,L.L.
  TITLE     Scn2b, a voltage-gated sodium channel beta2 gene on mouse
            chromosome 9
  JOURNAL   Genomics 34 (2), 258-259 (1996)
   PUBMED   8661062
REFERENCE   10 (bases 1 to 4562)
  AUTHORS   Isom,L.L., Ragsdale,D.S., De Jongh,K.S., Westenbroek,R.E.,
            Reber,B.F., Scheuer,T. and Catterall,W.A.
  TITLE     Structure and function of the beta 2 subunit of brain sodium
            channels, a transmembrane glycoprotein with a CAM motif
  JOURNAL   Cell 83 (3), 433-442 (1995)
   PUBMED   8521473
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF533534.1 and AC122305.4.
            
            On Mar 14, 2007 this sequence version replaced NM_001014761.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CF533534.1, BC092225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-602               CF533534.1         1-602
            603-4562            AC122305.4         136158-140117
FEATURES             Location/Qualifiers
     source          1..4562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..4562
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /note="sodium channel, voltage-gated, type II, beta"
                     /db_xref="GeneID:72821"
                     /db_xref="MGI:MGI:106921"
     exon            1..218
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..796
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /note="sodium channel subunit beta-2; sodium channel,
                     voltage-gated, type II, beta polypeptide; sodium channel
                     regulatory subunit beta-2"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-2
                     precursor"
                     /protein_id="NP_001014761.1"
                     /db_xref="CCDS:CCDS40606.1"
                     /db_xref="GeneID:72821"
                     /db_xref="MGI:MGI:106921"
                     /translation="MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGS
                     DTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFS
                     GNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAV
                     IVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK"
     exon            219..385
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /inference="alignment:Splign:2.1.0"
     exon            386..596
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /inference="alignment:Splign:2.1.0"
     exon            597..4562
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4539..4544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="Scn2b"
                     /gene_synonym="2810451E09Rik; Gm183"
                     /note="major polyA site"
ORIGIN      
        1 gaaataaagc ttcctcaatg ttgcatatgt ctttgaagta catccgtgca ttttcttttt
       61 tagcatttaa ccattcctac cttgtggtcc ttggtccctc aatcaccctt tcccacagcc
      121 cacccgccta acgtcacagt ctctgaaaat gcacagggat gcctggctac ctcgccctgc
      181 cttcagtctc acggggctca gtctgttttt ctctttggtg cccccggggc ggagcatgga
      241 agtcacagcg cccaccactc ttagtgtcct caatgggtcc gatacccgcc tgccctgtac
      301 cttcaactcc tgctacaccg tgaaccacaa gcagttctct cttaactgga cttaccagga
      361 gtgtaacaat tgcacagagg agatgttcct ccagttccga atgaagatca ttaacctgaa
      421 gctggagcgg tttggagacc gcgtggagtt ctcagggaac cccagtaagt acgacgtgtc
      481 agtgactcta aagaacgtgc agctagaaga cgaaggcatt tacaactgct acattaccaa
      541 ccctccagac cgccaccgcg gccacggcaa gatttacctg caggtccttc tagaagtacc
      601 cccagagcgg gactccacgg tggcggtcat cgtgggtgcc tcagtggggg gtttcctggc
      661 tgtggtcatc ttggtgctga tggtggtcaa atgtgtgagg aggaaaaaag agcagaagct
      721 gagcacggat gacctgaaga ctgaagagga aggcaagatg gatggtgagg gcaacgcgga
      781 agatggcacc aagtaaccgg aagcctgccc tgaagcccct ccccgtgccc tatctcctct
      841 cactctctgc cctgtacagt gtgaccccgc ctgctctctc ttggtgtgct tctcttgaat
      901 aggaccccag aatcgacctg gggcctcact tcccatgccc ccacccctat accaagggtg
      961 atcgccctcc ctttcatctg aaaactgcct tggtatctga gattcgggag tcccagggag
     1021 aacagagaag ggctgtagcc tgtcagtctt tgaggaagaa agacttgtgt ggtcccaaag
     1081 acaggatggg ggagggaggg cagtgggaga agaggtctgc tgaccatctt gtctaaggct
     1141 tggtctggtg gcgatttaaa ctgtgggagt agcagtgtgt gtggtggcgg ggttctgtgc
     1201 tgaccagagg caccatggga atgacttgtg aagatggcta gggaacagcc atcagctgga
     1261 gatgaaggtg gggtcctacc atttgtgaaa gcactattta aagggatgac tgtgcatttc
     1321 cagggtactc aaggaaaaag gaaagatagg gctgagtcgt ttctggatgc gagccttggc
     1381 ccagagaact ctgttctggc ctcgtttcta tcactagcca ctcccagaga ggctctggtt
     1441 actgtaggct gctgctccat gggggatgct ggcgagaggt aggatcctat cctaccctag
     1501 ggctgcccct taagagacct gtgaggaact gccgggtgca ggcttcactg catacacatg
     1561 gctgccttct caaacaagat gctcaccttg gcctctgcag cagccatcaa ccctcagaac
     1621 tggggtgtgt ttgggggagc ggaactgtgt ataggggcaa cttcctgtgt ggctttagtt
     1681 tggggatttt cgagcagggt ttctctgcct ggcttttggc aagatggaag agaaagctgg
     1741 aacgctttaa atatgagagc atatgctgaa ggagcctctg aaccctgccc cgcccccacc
     1801 ccacccccac ctccaccccc accccggaac tccctttgta cgggagaaag tcactcctgt
     1861 ggtaagccta cattcactgc cgttttacta tcattataag ggacttaagt ccagagacat
     1921 tttactatca ttataagaaa cttgttataa gtccagagat gggagaaagg cagggtagaa
     1981 atggctaatc ggagagtatc ctgttgggac gtgctcagag aactggcaca aagcctcctg
     2041 cagatgggga gactgaagtt ccaagtgacc aacagaggct gaaagcattg cccatgttct
     2101 ggctccttgg tcctcagtta gaacaaatag agcttcctgg tgggagaacc tcaagccttg
     2161 gatgtgtttt gtgcacagta gtggtggggt tcatctagcc ccgctcccct tccaggaact
     2221 caacccccac aagctcaggg agttagctgt tcagggtagg gaaagagtgt ggtaggagac
     2281 aggactaaga cagtctcagg gaccaatact tgcctctgtt tatcagatag ccactcgaag
     2341 agacaatggt ggccgatgga aagttcaact taattcactt caaccaccat ttactgagtt
     2401 tatgctgtat gccaggcacc gtgctgggtg tcaggggtgc ctacaaagcc ataacagagt
     2461 cagggactgc caaatcggta ctataggacc aagaatatta ttactattta ttattattat
     2521 tgttattgtt attgttatta ttttggtgca tctacttcca cctccatagc cactgcttcc
     2581 acaagagact cagaagggtg agactcttga atctggggtt tgggaaagtg agggtgcaag
     2641 gggaggggga aggtactgct gggaagggtg caggggtcag gtaggttggg catggagtaa
     2701 ggaatgatgg atagccagcc agagaactcc tgggtaaggg gaatctaacc cttctggaag
     2761 ttctaatctc tttggctcag tacctaactg ccaaacaaca cactgccaat gggagtgggt
     2821 gagaccaccg gggtgcctgg agcaggtgaa tactgcccat ccttcaagca agccaaccag
     2881 gagtagagag atgagttgtg ggctccccaa gccggctgaa accaagggtg gtggtgtata
     2941 tatagttctg cagctttgag tggccagttt tcatcacctg gcatgtgtcc tcttctttca
     3001 cagtgcacag acaagggact tggcttttgc ggacggtctt ctaacatctt ttgggtgggt
     3061 gggtggttac ttgtgaaatc cccctacagg gttgtactaa taagctgtct ctttttttgt
     3121 ttggttgggt ttctttcttt ctttctttct ttctttcttt ctttctttct tttttttttt
     3181 tttttttttt ttttgagaca gggtttctct gtgtagccct ggctgtcctg gcactcactt
     3241 tgtagaccag gttggcctcg aactcataca tccgcctgcc tctgcctccc aagtgctggg
     3301 attaaaggca tacaccacca ccgcccagct aagctgtccc ttaaagaagt aaagtttctt
     3361 ggggtctttt tcttttctgc cctgacggaa tgaggcccag ggaaagcaat gcctgcctct
     3421 ggacctcatg gactgggtca ggagccattt ctgccccagg tagttgtcct catgtgcact
     3481 ttcttttgga gccacttgga ccctcctcca gggtctctgg gcttgtgctt gggaacaaaa
     3541 ctaggcttct gtgagatggg gtgagaaact gtgagatgtt cctacaggag ccattgctca
     3601 agcttgcttc ttagcttatg ccagcaaact gctctcttgc tgcagtgtgg gctctgagcg
     3661 ctgctcctgg ctgaatgctt ccactacagt gctctcagtc tctcctgcct ctcctgctct
     3721 cccagaagcc cctcctcaca ccccctctgc ctctgcctgc taattaaggg ccactgcaaa
     3781 gaaaggctgg ctggccaacc tgcgggattc agctcatgag aacaaagcac aatatttcag
     3841 gactgaaagt gccttgcggt gccttggaac tggctttgga aatagctgtt tgcccctcca
     3901 gctgtgggca gactcatcac ctagtcccac tttatcaaat gggagaagct gattgggtcc
     3961 acgtttccct gtgagtctcc ttgggaaagt tggagtgcta catacctaca agatcaggct
     4021 aagcaggtag ataggtggaa ataccaacca ggtccaaaga agttaatccc aggccatagg
     4081 aatggcttgg tgcagttgga acgggtgaca aattaagaga acttttttcc tacatatgtc
     4141 ttaagaatag acagccttgc tgtgcctcct gctgatgtct tcctttattg aagcttgctg
     4201 atgcgattgt acatagcctt tctatacagg tagagatata ttatatatat acatataaaa
     4261 catctcacta tgcccacccc aaaagttaca ctgtggggtg gagggtgaaa tcacctctca
     4321 gtgtttccaa gtaccaaagg ttcattatgg aatgttcttt atgcttttta ggggagaacc
     4381 cagctgcata catagcaagt gcttatgcag gtctaggtac tacttcctgt ctgttggttg
     4441 ggaggggaga gaagcttaaa tggtcttctg tgacccagct gcgggggcag gctggatttc
     4501 tatagcagtt tgtcagattg cttggatcta ttggctgcaa taaacacact gtctccccgg
     4561 aa
//
