LOCUS       NM_011322               1581 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sodium channel, voltage-gated, type I, beta (Scn1b),
            transcript variant 1, mRNA.
ACCESSION   NM_011322 XM_994669
VERSION     NM_011322.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1581)
  AUTHORS   Aldridge,J.L., Alexander,E.D., Franklin,A.A. and Frasier,C.R.
  TITLE     Decreased ability to manage increases in reactive oxygen species
            may underlie susceptibility to arrhythmias in mice lacking Scn1b
  JOURNAL   Am J Physiol Heart Circ Physiol 327 (4), H723-H732 (2024)
   PUBMED   39120465
  REMARK    GeneRIF: Decreased ability to manage increases in reactive oxygen
            species may underlie susceptibility to arrhythmias in mice lacking
            Scn1b.
REFERENCE   2  (bases 1 to 1581)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1581)
  AUTHORS   Chancey,J.H., Ahmed,A.A., Guillen,F.I., Ghatpande,V. and
            Howard,M.A.
  TITLE     Complex Synaptic and Intrinsic Interactions Disrupt Input/Output
            Functions in the Hippocampus of Scn1b Knock-Out Mice
  JOURNAL   J Neurosci 43 (49), 8562-8577 (2023)
   PUBMED   37845033
  REMARK    GeneRIF: Complex Synaptic and Intrinsic Interactions Disrupt
            Input/Output Functions in the Hippocampus of Scn1b Knock-Out Mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1581)
  AUTHORS   Helbig,I.
  TITLE     Genetic Causes of Generalized Epilepsies
  JOURNAL   Semin Neurol 35 (3), 288-292 (2015)
   PUBMED   26060908
  REMARK    Review article
REFERENCE   5  (bases 1 to 1581)
  AUTHORS   Brackenbury,W.J. and Isom,L.L.
  TITLE     Na Channel beta Subunits: Overachievers of the Ion Channel Family
  JOURNAL   Front Pharmacol 2, 53 (2011)
   PUBMED   22007171
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1581)
  AUTHORS   Taketo,M.M., Araki,Y., Matsunaga,A., Yokoi,A., Tsuchida,J.,
            Nishina,Y., Nozaki,M., Tanaka,H., Koga,M., Uchida,K., Matsumiya,K.,
            Okuyama,A., Rochelle,J.M., Nishimune,Y., Matsui,M. and Seldin,M.F.
  TITLE     Mapping of eight testis-specific genes to mouse chromosomes
  JOURNAL   Genomics 46 (1), 138-142 (1997)
   PUBMED   9403069
REFERENCE   7  (bases 1 to 1581)
  AUTHORS   Grosson,C.L., Cannon,S.C., Corey,D.P. and Gusella,J.F.
  TITLE     Sequence of the voltage-gated sodium channel beta1-subunit in
            wild-type and in quivering mice
  JOURNAL   Brain Res Mol Brain Res 42 (2), 222-226 (1996)
   PUBMED   9013777
REFERENCE   8  (bases 1 to 1581)
  AUTHORS   Fozzard,H.A. and Hanck,D.A.
  TITLE     Structure and function of voltage-dependent sodium channels:
            comparison of brain II and cardiac isoforms
  JOURNAL   Physiol Rev 76 (3), 887-926 (1996)
   PUBMED   8757791
  REMARK    Review article
REFERENCE   9  (bases 1 to 1581)
  AUTHORS   Dib-Hajj,S.D. and Waxman,S.G.
  TITLE     Genes encoding the beta 1 subunit of voltage-dependent Na+ channel
            in rat, mouse and human contain conserved introns
  JOURNAL   FEBS Lett 377 (3), 485-488 (1995)
   PUBMED   8549781
REFERENCE   10 (bases 1 to 1581)
  AUTHORS   Tong,J., Potts,J.F., Rochelle,J.M., Seldin,M.F. and Agnew,W.S.
  TITLE     A single B1 subunit mapped to mouse chromosome 7 may be a common
            component of Na channel isoforms from brain, skeletal muscle and
            heart
  JOURNAL   Biochem Biophys Res Commun 195 (2), 679-685 (1993)
   PUBMED   7690558
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158993.2.
            
            On Mar 11, 2022 this sequence version replaced NM_011322.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009652.1, U85786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-346               AC158993.2         88820-89165         c
            347-513             AC158993.2         87209-87375         c
            514-754             AC158993.2         85060-85300         c
            755-896             AC158993.2         79860-80001         c
            897-968             AC158993.2         79378-79449         c
            969-1581            AC158993.2         78678-79290         c
FEATURES             Location/Qualifiers
     source          1..1581
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.3 cM"
     gene            1..1581
                     /gene="Scn1b"
                     /note="sodium channel, voltage-gated, type I, beta"
                     /db_xref="GeneID:20266"
                     /db_xref="MGI:MGI:98247"
     exon            1..346
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..963
                     /gene="Scn1b"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; sodium channel, voltage-gated, type I, beta
                     polypeptide; sodium channel subunit beta-1; sodium channel
                     regulatory subunit beta-1"
                     /codon_start=1
                     /product="sodium channel regulatory subunit beta-1 isoform
                     1 precursor"
                     /protein_id="NP_035452.1"
                     /db_xref="CCDS:CCDS21126.1"
                     /db_xref="GeneID:20266"
                     /db_xref="MGI:MGI:98247"
                     /translation="MGTLLALVVGAALVSSAWGGCVEVDSDTEAVYGMTFKILCISCK
                     RRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQ
                     DLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSE
                     IMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
                     "
     exon            347..513
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            514..754
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            755..896
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            897..968
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1581
                     /gene="Scn1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn1b"
                     /note="hexamer: AATAAA"
     polyA_site      1581
                     /gene="Scn1b"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgcgca ggagcccgcg gtccgcaccc cagcgccggg agcccgagcg cgagcaacgt
       61 ccggagccag gcaggggtcg ccgcagcctg gatgcgccct gtggcgcgcg cgcacgcagc
      121 atcccgagcc tcccgccgcg cggcggggat gcctgctctc cgagccccgg ggctgggccc
      181 ccggcggtaa ccggagcggg ggggcgcgcc cccccagcag cagctgccgc gcccgcgccc
      241 gggccagtcg ccgccggggc ccatcgcctg tcgccgcgct ctgcgcaccc accgccttgc
      301 gcggccatgg ggacgctgct ggctctcgtg gtgggcgcgg cgctggtatc ctcagcctgg
      361 gggggctgcg tggaggtgga ttccgatacc gaggctgtgt atgggatgac cttcaaaatc
      421 ctgtgcatct cctgtaagcg tcgtagtgag accaccgccg aaaccttcac ggagtggacc
      481 ttccgccaga aggggacaga ggaatttgtc aagatcctac gctatgagaa tgaggtgctg
      541 cagctggagg aagatgagcg ctttgagggc cgagtggtgt ggaacggtag tcggggcacc
      601 aaggacctgc aggacctgtc catcttcatc accaacgtca cctacaacca ctctggcgac
      661 tacgaatgtc acgtctaccg tctcctcttc tttgataatt atgagcacaa caccagcgtc
      721 gtcaagaaga tccacctgga ggtggtggac aaggccaaca gagatatggc atccatcgtg
      781 tcagagatca tgatgtacgt gctcattgtg gtgttgacca tatggcttgt ggcagagatg
      841 gtgtactgct acaagaagat tgctgctgct acggaggctg ctgcacaaga gaacgcctca
      901 gaatacctgg ccattacatc cgagagcaaa gaaaactgta caggcgtcca ggtggctgaa
      961 tagcgctggc tctgggctcc gcctcatgga agagccagcc cctacgggta ccctcccgcc
     1021 ctgcagtggg gatcagcccc tggtgggtac cctcccccgg cagtggggat cagcccttcg
     1081 gtctccccag cctcacagtt ctgcagtgga gccacgaggg tgggagcggg cagggactga
     1141 tcccacctca cccaccgcct cccacctacc ctcccaccgc catgcatgat gggtgaagca
     1201 atatggccgc cccaccctgc ttttgctgcc tgtttggggg agggggcggt gaggcgaggg
     1261 ggcaggcccc gccccttctt tttgctgatt tgcacatagg ccacttccca cacgcactgc
     1321 caggccagcc ggccccaccc ctgcttgatg gggtcaagag gggtcgggac agggacagta
     1381 gtgggcagga ggttctgggc ctcatctccc ctccgcttcc tccggctgga cctggggttc
     1441 ccttcctgtg acacctccta gccctggccc acccgccctc tctcaccagc cttcaattgt
     1501 ggtctcttgg gaagggcctc ttcggcctcc tctctttaca gaagtagttt ttgttcatga
     1561 aataaagatt cttggactcg a
//
