LOCUS       NM_001313997            8320 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus sodium channel, voltage-gated, type I, alpha (Scn1a),
            transcript variant 1, mRNA.
ACCESSION   NM_001313997 XM_011239389
VERSION     NM_001313997.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8320)
  AUTHORS   Espino,C.M., Nagaraja,C., Ortiz,S., Dayton,J.R., Murali,A.R.,
            Ma,Y., Mann,E.L., Garlapalli,S., Wohlgemuth,R.P., Brashear,S.E.,
            Smith,L.R., Wilkinson,K.A. and Griffith,T.N.
  TITLE     Differential encoding of mammalian proprioception by voltage-gated
            sodium channels
  JOURNAL   Sci Adv 11 (2), eads6660 (2025)
   PUBMED   39772670
REFERENCE   2  (bases 1 to 8320)
  AUTHORS   Tsai,C.W., Ho,S.Y., Chen,I.C., Chang,K.C., Chen,H.J., Tsai,F.C. and
            Liou,H.H.
  TITLE     Abnormal increased mTOR signaling regulates seizure threshold in
            Dravet syndrome
  JOURNAL   Neuropharmacology 262, 110166 (2025)
   PUBMED   39374769
REFERENCE   3  (bases 1 to 8320)
  AUTHORS   Jones,S.P., O'Neill,N., Carpenter,J.C., Muggeo,S., Colasante,G.,
            Kullmann,D.M. and Lignani,G.
  TITLE     Early developmental alterations of CA1 pyramidal cells in Dravet
            syndrome
  JOURNAL   Neurobiol Dis 201, 106688 (2024)
   PUBMED   39368670
REFERENCE   4  (bases 1 to 8320)
  AUTHORS   Hawkins,N.A., Speakes,N. and Kearney,J.A.
  TITLE     Fine mapping and candidate gene analysis of Dravet syndrome
            modifier loci on mouse chromosomes 7 and 8
  JOURNAL   Mamm Genome 35 (3), 334-345 (2024)
   PUBMED   38862622
REFERENCE   5  (bases 1 to 8320)
  AUTHORS   Peters,C., Aberle,T., Sock,E., Brunner,J., Kuspert,M.,
            Hillgartner,S., Wust,H.M. and Wegner,M.
  TITLE     Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10
            during Oligodendrocyte Development
  JOURNAL   Cells 13 (13), 1159 (2024)
   PUBMED   38995010
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8320)
  AUTHORS   Beckers,M.C., Ernst,E., Belcher,S., Howe,J., Levenson,R. and
            Gros,P.
  TITLE     A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells
            maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2
  JOURNAL   Genomics 36 (1), 202-205 (1996)
   PUBMED   8812438
REFERENCE   7  (bases 1 to 8320)
  AUTHORS   Spur,N.K., Bashir,R., Bushby,K., Cox,A., Cox,S., Hilde Brandt,F.,
            Hill,N., Kao,F.T., Krols,L., Marzella,R., Miller,N., Nothwang,H.G.,
            Rocchi,M., Sarfarazi,M., Stratakis,C.A., Wallgren-Petterson,C. and
            Naylor,S.
  TITLE     Report and abstracts of the Fourth International Workshop on Human
            Chromosome 2 Mapping 1996
  JOURNAL   Cytogenet Cell Genet 73 (4), 255-273 (1996)
   PUBMED   8751373
REFERENCE   8  (bases 1 to 8320)
  AUTHORS   Crabbe,J.C., Belknap,J.K., Mitchell,S.R. and Crawshaw,L.I.
  TITLE     Quantitative trait loci mapping of genes that influence the
            sensitivity and tolerance to ethanol-induced hypothermia in BXD
            recombinant inbred mice
  JOURNAL   J Pharmacol Exp Ther 269 (1), 184-192 (1994)
   PUBMED   8169823
REFERENCE   9  (bases 1 to 8320)
  AUTHORS   Malo,M.S., Blanchard,B.J., Andresen,J.M., Srivastava,K., Chen,X.N.,
            Li,X., Jabs,E.W., Korenberg,J.R. and Ingram,V.M.
  TITLE     Localization of a putative human brain sodium channel gene (SCN1A)
            to chromosome band 2q24
  JOURNAL   Cytogenet Cell Genet 67 (3), 178-186 (1994)
   PUBMED   8062593
REFERENCE   10 (bases 1 to 8320)
  AUTHORS   Malo,D., Schurr,E., Dorfman,J., Canfield,V., Levenson,R. and
            Gros,P.
  TITLE     Three brain sodium channel alpha-subunit genes are clustered on the
            proximal segment of mouse chromosome 2
  JOURNAL   Genomics 10 (3), 666-672 (1991)
   PUBMED   1679748
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928726.5 and AL844526.5.
            
            On Sep 22, 2015 this sequence version replaced XM_011239389.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMN00849374,
                              SAMN00849376 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AL928726.5         32880-33017         c
            139-451             AL844526.5         145492-145804       c
            452-570             AL844526.5         132456-132574       c
            571-660             AL844526.5         130018-130107       c
            661-789             AL844526.5         128786-128914       c
            790-881             AL844526.5         126785-126876       c
            882-1151            AL844526.5         125817-126086       c
            1152-1215           AL844526.5         123609-123672       c
            1216-1357           AL844526.5         122983-123124       c
            1358-1564           AL844526.5         122229-122435       c
            1565-1849           AL844526.5         120480-120764       c
            1850-2230           AL844526.5         119149-119529       c
            2231-2363           AL844526.5         117890-118022       c
            2364-2602           AL844526.5         116832-117070       c
            2603-2776           AL844526.5         115446-115619       c
            2777-3133           AL844526.5         113964-114320       c
            3134-3616           AL844526.5         112382-112864       c
            3617-3737           AL844526.5         98170-98290         c
            3738-3892           AL844526.5         96944-97098         c
            3893-4066           AL844526.5         94202-94375         c
            4067-4189           AL844526.5         91331-91453         c
            4190-4471           AL844526.5         83452-83733         c
            4472-4525           AL844526.5         82301-82354         c
            4526-4663           AL844526.5         80489-80626         c
            4664-4768           AL844526.5         75274-75378         c
            4769-5039           AL844526.5         72140-72410         c
            5040-8320           AL844526.5         65360-68640         c
FEATURES             Location/Qualifiers
     source          1..8320
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 39.13 cM"
     gene            1..8320
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /note="sodium channel, voltage-gated, type I, alpha"
                     /db_xref="GeneID:20265"
                     /db_xref="MGI:MGI:98246"
     exon            1..138
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..451
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..6217
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium channel protein type I subunit alpha; sodium
                     channel protein brain I subunit alpha; voltage-gated
                     sodium channel subunit alpha Nav1.1; sodium channel
                     protein type 1 subunit alpha"
                     /codon_start=1
                     /product="sodium channel protein type 1 subunit alpha
                     isoform 1"
                     /protein_id="NP_001300926.1"
                     /db_xref="CCDS:CCDS84530.1"
                     /db_xref="GeneID:20265"
                     /db_xref="MGI:MGI:98246"
                     /translation="MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDD
                     DENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRF
                     SATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYT
                     FTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTF
                     RVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNK
                     CVQWPPTNASLEEHSIEKNITMDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDAL
                     LCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTL
                     RAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQ
                     LKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKE
                     QSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSP
                     RRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQ
                     TSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNG
                     TTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYK
                     FSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNH
                     VLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLS
                     VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGK
                     SYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVF
                     MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGIAYVKRKI
                     YEFIQQSFVKKQKILDEIKPLDDLNNRKDNCISNHTTEIGKDLDCLKDVNGTTSGIGT
                     GSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLN
                     ESSSSSEGSTVDIGAPAEEQPVIEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQW
                     WNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYI
                     FILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRA
                     LRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVN
                     TTTGDIFEISEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMD
                     IMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG
                     GQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILIC
                     LNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV
                     VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP
                     ALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGW
                     DGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAV
                     ILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLP
                     QPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK
                     VSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKED
                     MLIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK"
     exon            452..570
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..660
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..789
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            790..881
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1151
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1215
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1357
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1564
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1849
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2230
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2363
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2602
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2776
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..3133
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..3616
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3617..3737
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3738..3892
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            3893..4066
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4189
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4190..4471
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4472..4525
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4526..4663
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4768
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            4769..5039
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     exon            5040..8320
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8279..8284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
                     /note="hexamer: ATTAAA"
     polyA_site      8305
                     /gene="Scn1a"
                     /gene_synonym="B230332M13; Nav1.1"
ORIGIN      
        1 atgtaagtct gtctaggtca agtgtaggag actcactacc ggcctgtgga aactcatgga
       61 actgtttctt cagattaaca cttcaggggc tatcgaggct gcaggaagct gagctttaac
      121 tacatacatc tttcggggga atctcacatg aagagtaaag agtaattaaa atgtgcagga
      181 tgacaagatg gagcaaacag tgcttgtacc accaggacct gacagcttca acttcttcac
      241 cagagaatcc cttgcagcta ttgaaaggcg cattgcagaa gagaaggcta agaatcccaa
      301 gccagacaaa aaagatgatg atgaaaatgg cccaaagcca aacagtgact tggaagctgg
      361 gaagaacctt ccatttatct atggagacat tcctccagag atggtgtcgg agcctctgga
      421 ggacctggac ccctactata tcaataagaa gacttttata gtattgaata aagggaaggc
      481 catcttccgg ttcagtgcca cctccgccct gtacatttta acacccttca atcctcttag
      541 gaaaatagct attaagattt tggtacactc attattcagc atgttaatca tgtgcactat
      601 tttgacaaac tgtgtattta tgacaatgag taaccctccc gactggacaa agaatgtgga
      661 gtacaccttc acaggaatat atacttttga atcactaata aaaattattg caaggggctt
      721 ctgtttagaa gattttactt tccttcgcga cccatggaac tggctggact tcactgtcat
      781 tacattcgca tatgtgacgg agtttgtgga cctgggcaat gtctcagcat tgagaacatt
      841 cagagttctt cgagcattga aaactatttc agtcattcca ggcctgaaga ccatcgtggg
      901 ggccctgatc cagtcggtga agaagctgtc tgacgtcatg atactcactg tgttctgtct
      961 cagtgtgttc gcactcatcg ggttgcagct cttcatgggc aacctgagga ataaatgtgt
     1021 acagtggcct cccaccaacg cttcccttga ggaacatagc atagagaaga atataactat
     1081 ggattacaat ggcacacttg taaatgaaac cgtgttcgag tttgactgga aatcatacat
     1141 tcaagactca agatatcatt atttcctgga gggtgtttta gatgcactgc tgtgtggaaa
     1201 tagctctgat gcaggccaat gtccagaagg atatatgtgt gtaaaagctg gtagaaaccc
     1261 taattatggt tacacaagct ttgatacctt cagttgggca tttttgtccc tgtttcgact
     1321 gatgactcag gacttctggg aaaatctata ccaactgaca ttgcgtgctg ctggcaaaac
     1381 ctacatgata ttttttgtgc tggtcatttt cttgggctca ttctacctga taaacttgat
     1441 cctggctgtg gtggccatgg cctatgagga gcagaatcag gccacactgg aggaggctga
     1501 acagaaagag gcagaatttc agcagatgtt ggagcaactt aagaagcagc aagaggctgc
     1561 acagcaggca gcggctacaa cagcctcaga acattccagg gagcccagtg cagcaggcag
     1621 gctctcagat agctcttcag aagcctctaa gttgagttcg aagagtgcta aagaaagacg
     1681 aaatcggagg aaaaaaagga aacagaaaga gcagtctgga ggagaagaga aagatgatga
     1741 tgaattccac aagtctgagt ctgaagacag catcaggagg aaggggtttc gcttctccat
     1801 agaagggaat agactgacat atgaaaagag gtactcttcc ccgcatcagt ctctgttaag
     1861 cattcgtggt tccctgttct ccccaagacg caatagcaga acaagtcttt tcagctttag
     1921 agggcgagcc aaggatgtgg ggtctgagaa tgactttgct gatgatgaac acagcacctt
     1981 tgaggataat gagagccgta gagactcact gttcgttccc cgaagacacg gagagcgacg
     2041 caacagtaac ctgagccaga ccagcaggtc ctcccgaatg ctggcggtgt ttccagccaa
     2101 tgggaagatg cacagcacgg tggattgcaa tggtgtggtt tccttggttg gtggaccctc
     2161 agttcccaca tcgccagttg gacagcttct gccagaggtg ataatagata agccagctac
     2221 tgatgacaat ggaacaacca ctgaaactga gatgagaaag aggaggtcga gctctttcca
     2281 tgtttccatg gactttctag aagatccttc ccagaggcaa agggcaatga gcatagccag
     2341 catcttaaca aatacagtag aagaactaga agaatccagg cagaaatgtc caccctgttg
     2401 gtataaattt tccaacatat tcttaatttg ggactgttct ccatattggc tgaaagttaa
     2461 acatattgtc aacctggtgg tgatggaccc atttgttgat ctggccatta ccatctgcat
     2521 tgtgttaaat acgctcttca tggctatgga gcactacccc atgactgaac atttcaacca
     2581 tgttcttaca gtgggaaact tggtcttcac tgggattttc acagcagaaa tgttcctgaa
     2641 aatcatcgca atggatcctt actattactt ccaagaaggc tggaatatct ttgatggttt
     2701 cattgtgaca ctcagcctgg tagaacttgg ccttgccaat gtggaaggat tgtcagttct
     2761 ccgttcattt cgactgctcc gagtgttcaa gttggcaaag tcttggccca cactgaatat
     2821 gctcattaag atcattggta actcggtggg agcactgggc aacctgactc tggtgttggc
     2881 catcattgtc tttatttttg ccgtggttgg catgcagctg tttggaaaaa gttacaaaga
     2941 ttgtgtctgc aaaattgcca ctgactgcaa actcccacgt tggcacatga acgacttctt
     3001 ccactcgttc ctgatcgtgt tccgcgtgct gtgtggggag tggatagaga ccatgtggga
     3061 ctgcatggag gtggcaggac aagctatgtg ccttactgtc ttcatgatgg tcatggtgat
     3121 tgggaacctt gtggtcttga acctctttct ggccttgctt ctgagctcat ttagtgcaga
     3181 caaccttgca gccactgatg atgacaatga gatgaacaac ctgcagattg ctgtggacag
     3241 gatgcacaaa ggaatagctt atgtaaaaag aaaaatatat gaattcattc aacaatcctt
     3301 tgttaagaaa cagaagattc tagatgaaat taagccactt gatgatctaa acaacagaaa
     3361 agacaattgt atctctaacc acacaacaga aattgggaaa gatctggact gtctgaaaga
     3421 tgtgaatgga accacaagtg gcatagggac gggcagcagt gtggagaagt acatcattga
     3481 tgagagtgat tatatgtcat tcataaacaa ccccagcctc actgtgactg tgcccattgc
     3541 tgtgggagag tctgactttg agaacttaaa cacagaagac tttagcagtg aatcagatct
     3601 agaagaaagc aaagagaaac tcaacgaaag cagtagctcc tcagagggaa gcacagtaga
     3661 cattggggcg cctgcagagg aacagcctgt cattgaacca gaagaaaccc ttgagcccga
     3721 agcttgcttc actgaaggct gtgtccagag attcaagtgc tgtcaaatca gcgtggaaga
     3781 aggaagaggg aaacagtggt ggaacctacg gaggacgtgc ttccgaatag ttgaacacaa
     3841 ctggtttgag accttcattg tgttcatgat tctcctgagt agtggtgccc tggcctttga
     3901 ggatatatat attgatcagc gaaagacgat caaaaccatg ctggagtatg ctgacaaagt
     3961 cttcacttac attttcatcc tggagatgct cctcaaatgg gtggcctatg gctatcaaac
     4021 atacttcacc aatgcctggt gttggctaga cttcttaatt gttgatgttt cattggtcag
     4081 tttaacagca aatgccttgg gttactctga actcggggcc atcaaatccc taaggacact
     4141 aagagctctg agacccctaa gagccttatc acgatttgaa gggatgaggg tggttgtgaa
     4201 tgccctgtta ggagcaattc catccatcat gaatgtgctt ctggtttgcc ttatattctg
     4261 gctaattttc agcatcatgg gcgtaaattt gtttgctggc aaattctacc actgtgttaa
     4321 caccacaact ggtgacatat ttgagatcag cgaagtcaat aatcattctg attgcctaaa
     4381 actaatagaa agaaatgaga ccgcccggtg gaaaaatgtg aaagtaaact ttgataatgt
     4441 aggatttggg tatctttctt tgcttcaagt tgccacattt aagggctgga tggatatcat
     4501 gtatgctgca gttgattcca gaaatgttga actacagcct aagtatgagg aaagcctgta
     4561 catgtatttg tacttcgtca tcttcatcat cttcgggtcc ttctttaccc tgaacctgtt
     4621 tattggtgtc attatcgaca atttcaacca gcaaaagaag aagtttggag gtcaagacat
     4681 ctttatgaca gaagaacaga agaaatacta taatgcaatg aagaaattag gatcaaaaaa
     4741 gccacaaaag cctatccctc gacctggaaa caaatttcaa ggaatggttt ttgactttgt
     4801 aaccagacaa gtgtttgata tcagcatcat gatcctcatc tgtctgaaca tggtgaccat
     4861 gatggtggaa acggatgacc agagcgatta tgtgacaagc attttgtcac gcatcaacct
     4921 ggtgttcatc gtcctgttca ccggcgagtg tgtgctcaag ctcatctcgc tccgccatta
     4981 ttatttcacc attggatgga acattttcga ttttgtggtg gtcatcctct ccattgtagg
     5041 gatgtttctt gcggagctaa tagaaaagta ttttgtgtct cctaccctgt tccgagtcat
     5101 ccgcctggcc aggattggac gaatcctacg cctgatcaaa ggtgccaagg ggatccgcac
     5161 gctgctcttt gctctgatga tgtcccttcc tgcgctgttt aacatcggcc tcctgctttt
     5221 tctcgtcatg ttcatctacg ccatctttgg gatgtccaac tttgcctatg ttaagaggga
     5281 agttgggatt gatgacatgt tcaactttga gaccttcggc aacagcatga tctgcctgtt
     5341 ccaaatcacc acctctgcgg gctgggatgg actgctggcc cccatcctca acagcaaacc
     5401 ccctgactgt gaccctaata aagttaaccc tggaagctcg gtgaagggag actgtgggaa
     5461 cccatctgtg gggattttct tttttgtcag ctacatcatc atatccttcc tggttgtggt
     5521 gaacatgtac attgctgtca tcctggagaa cttcagcgtt gccacagaag aaagtgcaga
     5581 gcctctgagt gaggacgact ttgagatgtt ctacgaggtc tgggagaagt tcgaccctga
     5641 cgccacccag ttcatggaat ttgaaaaatt atctcagttt gcagctgctc tagaaccccc
     5701 tctcaatttg ccacaaccaa acaaacttca gctcattgcc atggacctgc ccatggtgag
     5761 tggagaccgc atccactgcc tggacatctt atttgctttt acaaagcggg tgttgggtga
     5821 gagtggagag atggatgctc ttcgaatcca gatggaagag cggttcatgg cttccaaccc
     5881 ctccaaggtc tcttatcagc ccatcactac tacattaaaa cgcaaacaag aggaggtgtc
     5941 agctgttatc attcagcgag cttataggcg ccaccttttg aagcgaacag taaaacaagc
     6001 ttcattcaca tacaataaga acaaactcaa aggtggggct aatcttcttg taaaagaaga
     6061 catgctcatt gacagaataa acgaaaactc tattacggag aaaactgacc tgacaatgtc
     6121 cacagcagct tgtccgccct cctacgatcg ggtgacaaag ccaatcgtgg agaaacacga
     6181 gcaggaaggg aaggatgaaa aagccaaagg gaaatgaaca aaaacaacaa aaaaaaataa
     6241 taaattgggt gacaaattgt ttacagcctg tgaagtcaaa aggactcctt taagaagtca
     6301 atgccaaact gactgttttt acacaaattc actttaaggt cagtgcctca ataagacagt
     6361 gacccccttg tcggcaaact ctgtgactgt gtaaagggga gataaccttg acaggagggt
     6421 actgttctaa ctaccagctg acactgctga agacaagaga caaatggcta tgcagactgt
     6481 agggatcagt ctaaaggggt gcagagctat aatttggggg ttaatgtgaa acactttagt
     6541 gtagtaactc tatccaccgt ttgcatttca actgccacat ttgtcaggtt ttttacaaac
     6601 tctgttagtg gattcatctt ttttttaatc catgtgttgt ttgttacatg tgactatttt
     6661 tgtaagcagg gtttctgttg ggaaatagac taaaggaact cttttcccgg tgtgtcacct
     6721 gggagtgttg acatccttat ggccctcccg tctgcacaac ggtgtggttt cgcatgaggg
     6781 catgttgcac cttaggatca tgcatgagaa aaagtcgaaa ggaaagcaaa gacagttctt
     6841 caacagttct atgtcatctg tgtttctgcg gggggagggg gcggtacgga ggtgatcgct
     6901 agatcgtggg ctttgctgag ctgggtttgt caaaatctag tccttagtcc aaggagattg
     6961 ttcagacagg tcatcaagtc ttaggaggtg caaacttcat tcaaatgtct ggagtcacgc
     7021 tacatttctg ttcactgtct ctgaaaggtc tctaaattat gactctgact ccctaccccc
     7081 aaccctagca gagcgaattg accaaaagaa ccctttataa atccccgctt cctcctgcac
     7141 tttgtttagc catcttcagc tctcagcaag gttgacactg tatgtgttaa tgaaatgcta
     7201 tttattatgt aaatagtcat tttactctgt ggtgcacgtt tgagcaaaca aataatgacg
     7261 taagcacagt atttattgca tcaaatatgt accacgagaa atgtagagtg caagctgtcc
     7321 accggaaata tactgtactc tgtaccattg tagatagtgt ggatgctgcc aatgcatgtc
     7381 gatattacca cgttgcggta tctagtttct ctcagcactc agaatctcac tcacgagaaa
     7441 ccataggtca gtggctaagt caaggaaact gttcagcaga cttcatttct ttaagtcatt
     7501 aagcaatagt ttgcagcact ttaacaatgt ttgggttgtt tttaaaattt aagtggataa
     7561 cgttcaatgt atagccagac tgtacatacg tgttcaaaag acaacactac tgcttaacct
     7621 gttaaaaaca tgtttagagt tttataagca aatataaata ctgtacaaag tcactttctt
     7681 ttacttttca gcattatgta catatgaaga ggaaattatc ttcaggttga tatcacaatc
     7741 acttttctta ctttctgtcc acagcagttt ttcatggaag atatttgcta actaagaaat
     7801 gaaactatga ctgggtagtg gtagatctct gcttttttat tacaattgtt aattttggat
     7861 tatttcataa ttttaagggg caaaatacac tcacaacttc acatccaaat tatgatttgc
     7921 aattggaaaa ggtataacat ttgatttata tttattgtag tgtttgtgct aacagatgac
     7981 cagagtgctt ttttttctca tttttttctt tatttcccca atttctgttt atttttcttt
     8041 gctttgaaat catgcttctt tagattgttc taaatataaa tgtgggcttc agaatttctt
     8101 ttcctcaaaa tcagagagga ttacacttat atagtcaatt acatcaagat atttgtgttt
     8161 cttacagaag cagaccgtag gcacctcttt ttcttaaaaa aaaaatattt aggcaaaccg
     8221 tattcatgaa ctgcatgttg gaaaatgcta ctattagccc aaaatgatgc taatcacaat
     8281 taaaaaatgt gcaaatctaa taaaattaat tttttatttt
//
