LOCUS       NM_009134               6413 bp    mRNA    linear   ROD 12-DEC-2024
DEFINITION  Mus musculus sodium channel, voltage-gated, type X, alpha (Scn10a),
            transcript variant 2, mRNA.
ACCESSION   NM_009134
VERSION     NM_009134.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6413)
  AUTHORS   Ben-Shaanan,T.L., Knopper,K., Duan,L., Liu,R., Taglinao,H., Xu,Y.,
            An,J., Plikus,M.V. and Cyster,J.G.
  TITLE     Dermal TRPV1 innervations engage a macrophage- and
            fibroblast-containing pathway to activate hair growth in mice
  JOURNAL   Dev Cell 59 (21), 2818-2833 (2024)
   PUBMED   38851191
REFERENCE   2  (bases 1 to 6413)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6413)
  AUTHORS   Bangash,M.A., Cubuk,C., Iseppon,F., Haroun,R., Garcia,C.,
            Luiz,A.P., Arcangeletti,M., Gossage,S.J., Santana-Varela,S.,
            Cox,J.J., Lewis,M.J., Wood,J.N. and Zhao,J.
  TITLE     Analgesic targets identified in mouse sensory neuron somata and
            terminal pain translatomes
  JOURNAL   Cell Rep 43 (8), 114614 (2024)
   PUBMED   39163201
REFERENCE   4  (bases 1 to 6413)
  AUTHORS   Zhang,D., Turecek,J., Choi,S., Delisle,M., Pamplona,C.L.,
            Meltzer,S. and Ginty,D.D.
  TITLE     C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway
  JOURNAL   bioRxiv (2024)
   PUBMED   38915692
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6413)
  AUTHORS   Roy,D., Dion,E., Sepeda,J.A., Peng,J., Lingam,S.R., Townsend,K.,
            Sas,A., Sun,W. and Tedeschi,A.
  TITLE     alpha2delta1-mediated maladaptive sensory plasticity disrupts
            adipose tissue homeostasis following spinal cord injury
  JOURNAL   Cell Rep Med 5 (5), 101525 (2024)
   PUBMED   38663398
REFERENCE   6  (bases 1 to 6413)
  AUTHORS   Ma,Q., Fode,C., Guillemot,F. and Anderson,D.J.
  TITLE     Neurogenin1 and neurogenin2 control two distinct waves of
            neurogenesis in developing dorsal root ganglia
  JOURNAL   Genes Dev 13 (13), 1717-1728 (1999)
   PUBMED   10398684
REFERENCE   7  (bases 1 to 6413)
  AUTHORS   Akopian,A.N., Souslova,V., England,S., Okuse,K., Ogata,N., Ure,J.,
            Smith,A., Kerr,B.J., McMahon,S.B., Boyce,S., Hill,R., Stanfa,L.C.,
            Dickenson,A.H. and Wood,J.N.
  TITLE     The tetrodotoxin-resistant sodium channel SNS has a specialized
            function in pain pathways
  JOURNAL   Nat Neurosci 2 (6), 541-548 (1999)
   PUBMED   10448219
REFERENCE   8  (bases 1 to 6413)
  AUTHORS   Gallo,R.L., Kim,K.J., Bernfield,M., Kozak,C.A., Zanetti,M.,
            Merluzzi,L. and Gennaro,R.
  TITLE     Identification of CRAMP, a cathelin-related antimicrobial peptide
            expressed in the embryonic and adult mouse
  JOURNAL   J Biol Chem 272 (20), 13088-13093 (1997)
   PUBMED   9148921
REFERENCE   9  (bases 1 to 6413)
  AUTHORS   Souslova,V.A., Fox,M., Wood,J.N. and Akopian,A.N.
  TITLE     Cloning and characterization of a mouse sensory neuron
            tetrodotoxin-resistant voltage-gated sodium channel gene, Scn10a
  JOURNAL   Genomics 41 (2), 201-209 (1997)
   PUBMED   9143495
REFERENCE   10 (bases 1 to 6413)
  AUTHORS   Kozak,C.A. and Sangameswaran,L.
  TITLE     Genetic mapping of the peripheral sodium channel genes, Scn9a and
            Scn10a, in the mouse
  JOURNAL   Mamm Genome 7 (10), 787-788 (1996)
   PUBMED   8854872
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK157866.1 and AC171201.1.
            
            On Apr 15, 2011 this sequence version replaced NM_009134.2.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157866.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849379 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1123              AK157866.1         1-1123
            1124-1124           AC171201.1         65307-65307
            1125-4813           AK157866.1         1125-4813
            4814-6413           AC171201.1         121653-123252
FEATURES             Location/Qualifiers
     source          1..6413
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..6413
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /note="sodium channel, voltage-gated, type X, alpha"
                     /db_xref="GeneID:20264"
                     /db_xref="MGI:MGI:108029"
     exon            1..35
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            36..340
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            341..459
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            460..540
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            541..669
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            670..761
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            762..953
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1017
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1159
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1357
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1528
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1822
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1934
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..2173
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2347
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2707
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            2708..3160
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3161..3298
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3422
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3577
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3751
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3752..3874
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            3875..4159
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4160..4213
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4351
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4352..4456
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4457..4727
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     exon            4728..6413
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6379..6384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /note="hexamer: ATTAAA"
     polyA_site      6403
                     /gene="Scn10a"
                     /gene_synonym="Nav1.8; PN3; SNS"
                     /note="major polyA site"
ORIGIN      
        1 gcccagccac cttcgtggag gagccccgga caagtaagag tgtaaatcct tccccaagaa
       61 gaatgagaag atggagttcc cctttgggtc cgtgggaact accaacttca gacggttcac
      121 tccagagtcg ctggcagaga tcgagaagca gatcgctgcc caccgcgccg ccaagaaggg
      181 cagacctaag caaagaggac agaaggacaa gagtgagaag cccaggcctc agttggactt
      241 gaaggcctgt aaccagctgc ccaggttcta tggcgagctc ccagcagagc tggtcgggga
      301 gcccctggag gacctggatc ctttctacag cacacaccgg acattcatag tgttggataa
      361 aagcaggacc atttccagat tcagtgccac ttgggctctg tggctcttca gtcccttcaa
      421 cctgatcaga agaacagcca tcaaagtgtc cgtccactcc tggttctcca tatttatcac
      481 tgtcactatt ttggtcaact gtgtgtgcat gacccgaact gatcttccag agaaactcga
      541 gtatgccttc actgttgttt acaccttcga ggctctgata aagatactgg caagagggtt
      601 ttgtctaaat gaattcactt atcttcgaga tccctggaac tggctggact tcagtgtcat
      661 taccctggcg tatgtgggtg cagcgataga cctccgagga atctcaggcc tgcggacatt
      721 ccgagttctc agggccctga agactgtttc tgtgatccca ggactgaagg tcatcgtggg
      781 agccctgatc cactcagtga ggaagctggc cgacgtgacc atcctcacag tcttctgcct
      841 gagtgtcttt gccttggtgg gcctgcagct cttcaagggg aacctcaaga ataaatgcat
      901 taagaacggc acagatccgc acaaggctga caatctctca tctgaaatgg caggagacat
      961 cttcatcaag cccggtacta cggatccctt gttgtgtggc aatggatctg atgctggcca
     1021 ctgccctaat gattatgtct gccggaaaac ttctgacaac ccggatttta actacaccag
     1081 ctttgattcc ttcgcgtggg cgttcctctc actgttccgt ctcatgacgc aggactcctg
     1141 ggaacggctg taccagcaga cactccgggc ttccgggaaa atgtacatgg tcttttttgt
     1201 gctggtcatc ttccttggat cattctacct ggtcaatttg atcttggctg tggtcaccat
     1261 ggcatatgag gaacagagcc aggcaacaat tgcagaaatc gaagccaagg agaagaagtt
     1321 caaggaagcc ctcgaggtgc tgcagaaaga acaggaggtg ctggcagcgc tgggcattga
     1381 cacaacctcg ctctattccc acaacggatc acccttagcc cccaaaaacg ccaatgagag
     1441 aagacccagg gtgaaatcaa ggatgtcaga aggctcgaca gatgacaaca gatcactaca
     1501 atccgaccct tacaaccagc gcaggatgtc tttcctaggc ctttcttctg gaagacgcag
     1561 ggctagccac agcagtgtgt tccacttccg agcacccagc caagacgtct catttcctga
     1621 tgggatcttg gatgacgggg tctttcatgg agatcaggaa agccgtcgaa gttccatatt
     1681 gctgggcagg ggtgccgggc aggcaggtcc tctccccagg agtccactgc ctcagtcccc
     1741 caaccctggc cctagacgtg gagaagaggg acagcgtgga gtgcccactg gtgagcttgc
     1801 cactggagcg cctgaaggcc cggcactcga tgctgcagga cagaagaact tcctgtctgc
     1861 agactacttg aatgaacctt tccgagcaca gagggcaatg agtgttgtca gtattatgac
     1921 ttctgtcatt gaggagctgg aagagtctaa gctgaagtgc ccaccctgct tgatcagctt
     1981 agcccagaag tacctgatat gggagtgctg ccccaagtgg aagaaattca agatggtgct
     2041 cttcgagctg gtgactgacc ccttcgcaga gctcaccatc accctgtgca ttgtggtgaa
     2101 taccgtcttc atggccatgg aacactaccc catgactgat gccttcgatg ccatgctcca
     2161 agccggcaac attgtcttta ctgtgttttt tacaatggag atggccttca agatcattgc
     2221 cttcgacccc tactactact tccagaagaa gtggaacatc ttcgactgtg tcatcgtcac
     2281 cgtgagcctg ctggagctga gcacatccaa gaagggcagc ttgtctgtgc tccgcacctt
     2341 ccgcttgctt cgggtcttca agctggccaa gtcctggccc accctgaaca tgctcatcaa
     2401 gatcatcggg aactctgtgg gggccctggg caacctgacc ttcatcctgg ccatcatcgt
     2461 ctttatcttc gccctggtgg gaaagcagct cctctcagag aactatgggt gccgcaggga
     2521 tggcatctcc gtgtggaatg gtgagaggct gcgctggcac atgtgtgact tcttccattc
     2581 cttcctcgtc gtcttccgga tcctctgcgg ggagtggatc gagaacatgt gggtctgcat
     2641 ggaggtcagc caggactaca tctgcctcac cctcttcttg acagtgatgg tgctaggcaa
     2701 cctggtggtg ctcaacctat tcatcgcttt actgctgaac tccttcagtg cggacaacct
     2761 cacagcccca gaggatgacg gggaggtgaa caacttgcag gtagcactgg cccggattca
     2821 ggtatttggc catcgggcca gtcgggccat taccagttac atcagaagcc actgccggct
     2881 ccgctggccc aaggtggaga cccagctggg gatgaaaccc ccactcacca gctgcaaagc
     2941 tgagaaccac attgctactg atgctgtcaa tgctgcagtg gggaacctgg caaagccagc
     3001 tcttggtggc cccaaggaga accacgggga cttcatcact gatcctaacg tgtgggtctc
     3061 tgtgcccatt gctgaggggg agtccgacct tgatgagctc gaggaagatg tggagcatgc
     3121 ttctcagagc tcctggcagg aagagagccc caaagggcag gagctgctgc agcaagtcca
     3181 aaagtgtgaa gatcaccagg cagcccgaag cccaccctcc gggatgtcct ctgaggacct
     3241 ggctccatac ctgggggaga gatggcagag ggaggagagc cctcgggtcc ctgccgaggg
     3301 agtggatgac acaagctcct ccgagggcag cacggtggac tgcccggacc cagaggagat
     3361 cctgaggaag atccctgagc tggcggagga gctggacgag cccgatgact gtttcccaga
     3421 aggctgcact cgccgctgtc cctgctgcaa agtgaacacc agtaagtttc cttgggccac
     3481 gggctggcag gtgcgcaaaa cctgttaccg cattgtggag cacagctggt ttgagagttt
     3541 cattatcttc atgatcctgc tcagcagtgg agcgctggcc tttgaggata actacctgga
     3601 agaaaagccc cgagtgaagt ctgtgctgga gtacactgac agagtgttca ccttcatctt
     3661 tgtattcgag atgttgctca agtgggtagc ttatggcttc aaaaaatatt tcaccaatgc
     3721 ctggtgctgg ctggacttcc tcatcgtgaa tatctccctc acaagcctca tagccaagat
     3781 cctcgagtat tcagacgtgg cgtccatcaa agcccttcgg actctccgtg ccctccggcc
     3841 gctgcgggct ctgtctcgat tcgaaggcat gagggtagtg gtggatgcct tggtgggcgc
     3901 cattccctcc atcatgaacg tcctcctcgt ctgcctcatc ttctggctca tcttcagcat
     3961 catgggtgtg aacctcttcg ccgggaaatt ttcgagatgt gtcgacacca gaagcaaccc
     4021 attttccgtc gtgaattcga cattcgtgac taacaagtct gactgttaca atcaaaacaa
     4081 tactggccac ttcttctggg ttaacgtcaa agtcaacttc gacaacgttg ctatgggcta
     4141 cctcgcgctt ctccaggtgg caaccttcaa aggctggatg gacattatgt atgcagctgt
     4201 cgattctcga gatatcaaca gtcagcccaa ttgggaggag agcctgtaca tgtacctata
     4261 cttcgtcgtc ttcatcattt tcggtggctt cttcacgctg aatctctttg tcggggtcat
     4321 cattgacaac ttcaatcaac agaaaaaaaa gctagggggc caggacatct tcatgacaga
     4381 ggagcagaag aagtactaca atgccatgaa gaagctgggc tccaagaaac cccagaagcc
     4441 catcccacgg cctttgaata agtaccaggg cttcgtgttt gacattgtga ccaggcaagc
     4501 atttgacatc atcatcatgg ctctcatctg cctcaacatg atcaccatga tggtggagac
     4561 cgacaatcag agcgaggaga agacgaaggt cctgggcaga atcaaccagt tcttcgtggc
     4621 cgtcttcacg ggcgagtgtg tgatgaagat gttcgccctt cggcagtatt acttcaccaa
     4681 cggctggaat gtgttcgact tcattgtggt gattctgtcc atttctagtc tgttgttttc
     4741 tgcgatcctt agctcactag aaagttactt ctcccccacg ctcttacgcg tcatccgtct
     4801 ggccaggatc ggccgcatcc tcaggctgat tcgagcagcc aaggggattc gcacgctgct
     4861 cttcgccctc atgatgtccc tgcccgccct cttcaacatc ggcctcctcc tcttcctcgt
     4921 catgttcatc tactccatct tcggcatggc cagcttcgct aatgtcatag atgaggctgg
     4981 catcgacgac atgttcaact tcaagacctt tggcaacagc atgctgtgcc ttttccagat
     5041 caccacgtcg gctggctggg atggcctcct cagccccatc ctcaacacag gaccccccta
     5101 ctgcgacccc aaccggccca acagcaatgg ctccaagggg aattgtggaa gcccagcggt
     5161 gggcatcctc ttcttcacca cctacatcat catctccttc ctcatcgtgg tcaacatgta
     5221 cattgcagtg attctggaga acttcaatgt ggccacagaa gagagcacgg agcccctgag
     5281 cgaggacgac tttgacatgt tctatgagac ctgggagaag tttgacccgg aggccaccca
     5341 gttcattgcc ttttctgccc tctcagactt tgcagacaca ctctctggcc ctcttagaat
     5401 cccaaaacct aatcagaata tattaatcca gatggacctg ccgttggtcc ccggagataa
     5461 gatccactgt ttggacatcc tctttgcctt cacaaagaat gtcttgggag aatctgggga
     5521 gttggattct ctgaagacta atatggaaga gaagtttatg gcaactaatc tttccaaagc
     5581 atcctatgaa ccaatagcaa ccaccctccg gtgcaagcag gaagacatct cagccaccat
     5641 tattcaaaag gcctatcgga actacatgtt gcaacgctcc ttgatgctct ccaaccccct
     5701 gcatgtgccc agggctgagg aggatggcgt gtcactcccc agggaaggct atgttacatt
     5761 catggcaaat gacaacggtg ggctcccaga caaatcggaa actgcttctg ctacgtcttt
     5821 cccaccatcc tatgacagcg tcaccagggg cctgagtgac agggccaaca ttagcacatc
     5881 tagctcaatg caaaatgaag atgaagtcac tgctaaggaa gggaagagcc ctggacctca
     5941 gtgaagacac tccagcatgc acggggcggg ttctaatgtc tttctctgct gtgctgaccc
     6001 tttccctcca gagatggcac caacctacag cctcaccgat gcatgtcact ggtcatggtg
     6061 tcagagctga atagggatat ccttgagaaa gcccccaccc caataggaat caaaagccaa
     6121 gaatactccc ccactttgac atctcttctg aactttcaga agatgacatc gctttgtgtt
     6181 gtttgtgacc agagatgtga tttaccaact tctcagaacc agaacttcca gagacacatg
     6241 gcaaggacat ttctggtggt ctcaggcaat cttggagaag ttgcataggg gtggcactgt
     6301 cgcatagggg tggcactgct aatgagggtt tgcatgactg catgctcgca gttgccggac
     6361 aatacctgag ggtcggccat taaaattgat atttttaaag gtatagcaag agt
//
