LOCUS       NM_172938               4745 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Scm polycomb group protein like 4 (Scml4), transcript
            variant 2, mRNA.
ACCESSION   NM_172938
VERSION     NM_172938.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Feng,M., Liu,X., Hao,X., Ren,Y., Dong,G., Tian,J., Wang,Y., Du,L.,
            Wang,Y. and Wang,C.
  TITLE     Fatty Acids Support the Fitness and Functionality of Tumor-Resident
            CD8+ T Cells by Maintaining SCML4 Expression
  JOURNAL   Cancer Res 83 (20), 3368-3384 (2023)
   PUBMED   37610617
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Tedeschi,A., Dupraz,S., Laskowski,C.J., Xue,J., Ulas,T., Beyer,M.,
            Schultze,J.L. and Bradke,F.
  TITLE     The Calcium Channel Subunit Alpha2delta2 Suppresses Axon
            Regeneration in the Adult CNS
  JOURNAL   Neuron 92 (2), 419-434 (2016)
   PUBMED   27720483
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125206.3, AK034171.1 and AK220309.1.
            
            On Apr 8, 2009 this sequence version replaced NM_172938.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034171.1, BC043310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AC125206.3         53452-53793
            343-3899            AK034171.1         182-3738
            3900-4745           AK220309.1         3284-4129
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.89 cM"
     gene            1..4745
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /note="Scm polycomb group protein like 4"
                     /db_xref="GeneID:268297"
                     /db_xref="MGI:MGI:2446140"
     exon            1..342
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            343..421
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            422..636
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..1707
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /note="isoform 2 is encoded by transcript variant 2; sex
                     comb on midleg-like protein 4; sex comb on midleg-like 4"
                     /codon_start=1
                     /product="sex comb on midleg-like protein 4 isoform 2"
                     /protein_id="NP_766526.3"
                     /db_xref="CCDS:CCDS23816.1"
                     /db_xref="GeneID:268297"
                     /db_xref="MGI:MGI:2446140"
                     /translation="MQTQRVPGRKRGRPPLHSTRVQMAVHNLYSASAASVPAVTIPKK
                     RGRKPRYKIKSPVLMTPLALSPPRSTPEPDLSSIPQDAATIPSLVVPEALTVCLYINK
                     QADVGPYLERRKLQQLPERLGPERPATVLQQAVQACIDCAHQPRLVFSLVKQGYRGEL
                     VSVSASFDGKQHLRSLPVVNSVGYVLRFLTKLCRSLLCDNLFSHLPFPGSIGASDKAQ
                     EREDGRTESAKVATAEECLANAVGMNRYAMDFSHRGSVTHSSSLYKRLTCGDSHLAGG
                     PATTTSGSRTNPVPSGGSSSPGLRLPASSPKRNGTAIEGNRCAPSPSPEVQDTRRPSS
                     RNPSTWTVEDVVRFVKDADPEALGPHVELFRKHEIDGNALLLLRSDMIMKYLGLKLGP
                     ALKLCYHIDKLKQAKF"
     exon            637..766
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            767..967
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1162
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1435
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1581
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..4745
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2685
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /note="major polyA site"
     regulatory      4300..4305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
                     /note="hexamer: ATTAAA"
     polyA_site      4331
                     /gene="Scml4"
                     /gene_synonym="9330161D17; mFLJ00197"
ORIGIN      
        1 cgctttctgc atgtaaaatg tgtgtgtgtt ctttagaagc cagcggttgg ctggttttcc
       61 ggacatgatg tggttgaagc tgtcatcgta atggaaattc actgctgtag ctatggtaaa
      121 tcgagtgttc tgcctgtact gaatgcatta gtctaatgag atgtttgcag cggcggcgag
      181 ctgggctgct ggcgactagc tgtgaggcag gcgtagcaca cgggtggaag atagcttgtg
      241 ccatactcgc agtgtgtgtg caggaagtca cctgtcttct aagccaccac tccagacctc
      301 agcaagcaac accctggtca gggctctgtg accaagctgt agcatagttt tgggaaggaa
      361 gattttggaa acctgcattc cccctccccc atttccaaag tatctggacc tgttattgaa
      421 ggacctctct tgcctgcgtg tggtttgcct tctcacgcag taagactggc accagcagag
      481 atgcagacac agagggtgcc agggaggaaa cgtggccggc ctccacttca ctccacacgg
      541 gtgcagatgg ccgtccataa cctctattct gcttctgctg cctctgtgcc agcagtgaca
      601 atcccaaaga agagaggacg gaagcccagg tacaagatca agtctccagt gctcatgact
      661 cccttggccc tgtcacctcc acggagtacc ccggaacccg atctcagctc catccctcag
      721 gatgcagcca ccattcccag cctggtggtc ccagaggctc tcacagtatg cctctacata
      781 aacaaacagg ccgatgtggg gccgtacctg gagaggagga agctacagca gcttccggag
      841 cgcctgggac ctgagcggcc cgccaccgtc ctgcagcagg cggtgcaagc atgcatcgat
      901 tgtgcgcacc agcctcggct ggtcttctcc ctcgtcaagc agggataccg aggcgagctg
      961 gtgtcagtct ctgcttcctt cgatggaaag cagcacttga ggagtctgcc tgtggtgaac
     1021 agtgtgggct atgtcctccg tttcctgacc aaactgtgcc gcagcctcct gtgtgacaac
     1081 ctcttcagcc acctgccttt tcccgggagc atcggcgcct ctgacaaggc gcaggagaga
     1141 gaggatggga ggactgagtc agccaaggta gccacggctg aagagtgtct ggcaaacgca
     1201 gtgggcatga accgctacgc catggacttt agccacaggg gctccgtaac ccactcttcc
     1261 tcactgtaca agaggctgac ctgcggagac agccaccttg ccggaggccc cgccaccacc
     1321 accagtggtt cccgcaccaa ccctgttccc tctggaggtt cgtcgtcacc tggactgagg
     1381 ctgccagcct ccagccccaa gaggaatgga acagccatcg aaggaaacag atgtgccccg
     1441 agcccctctc cggaggtgca ggataccagg cgaccaagca gcagaaaccc ttctacctgg
     1501 accgtggagg acgtggtccg gtttgtgaaa gatgctgatc ccgaggctct gggacctcat
     1561 gtggagctct tcagaaagca cgagattgat ggcaatgcct tgttgttgct gaggagcgac
     1621 atgatcatga agtacctggg actgaagctg ggacccgcac tgaaactctg ctatcacatt
     1681 gacaagctaa agcaagctaa attctaaaga gttggaaaca aagccccaca tctccaggtt
     1741 acttctgcca gaccagcatc cggccaacat catgagtaga ctgtcctctt aaacgtcgca
     1801 gccacaacga ctgtgtcttc ttatagaacg tgtgcatcct tgccttttct aatattccta
     1861 gtggcccctt tcagacactc aaccgtgtgc tagacttgtc agaaaaatca caaaaaggct
     1921 attacagtgt tcctgacgtg ctggtcactc tttacgggtg ctatttgtgc cgcgacagag
     1981 tggataactg aatgctgtca cacaaggaga gccctggagg gggctcacaa agtccctgca
     2041 ggggctgtgg ggacgccccc agtggcggtg gcaactgctc cctgttcttg ggaccgatca
     2101 gcatgagttt ccctggactc agccctggaa gttgtcttct gatgaccacc tcgccttgca
     2161 ctatctggaa aacttgaatt tttgttgctg tttttttgtc cgtttgtttg tttttgtttt
     2221 tgttttccgc tctcgaagag aaaagggaaa ggatgttttg gagccctagc tactgaagtc
     2281 cttccttgct ccactagagg gcagactgct aacgaggttt cgggatgcac agactgcgtg
     2341 gccggggtag ggtttttata agcaagacct cgcttgcaca gggacaggga atgaagtcca
     2401 cattgagcac cccagattgc cacttgggaa gaaatcaggc tctgtcaggc ggggtccagc
     2461 tcatatccat tacttactga cttactcggt acaaattccg aagcagccat ctgcctaaac
     2521 aaagactggt gtcccttctc tcccagagtc tcactgaggc tctgatatga cggcatgctg
     2581 aagaatcttg gtgacattta gctatgggta tttcttgaaa aaaaggcggg gggcgggaac
     2641 tgtctcgaca aagtttgaaa taggacatac tgatttctag tttcatggct gcgttcttag
     2701 ctgtgtgtct gtggctaatt tttctagtct tcaacaaata cgcagacgtg tttttattgg
     2761 gtttaattca atttacaaat aggtttttac tcttcactgt gaagtaatgg gaaaaaattg
     2821 attttctacc ctttgcagct gtgtccagag aggggggtgg agccagggtt tcctaggcag
     2881 aagggtgacc tctttactgc ctattcttta tggaatccct ccccctttgt ttattctcga
     2941 tgaatagaga actcatgggc acagcctttt ccttaaaggc acatctgggg aaggtgaggg
     3001 tcaaggataa cctagggtct cccttgacaa tagtatgaat tttagaaagg caccttccct
     3061 caggctgcag tctgagcaag atctcagctg gcaagtgtag ccagacgtcc tggactgtaa
     3121 caagataaat gcggtctctc agatggatct acctattgta ccaatcaggt agaatttagg
     3181 taaagagcac aggacatact ccatgctgtg ctataagggc ccactttgat gttccctgtt
     3241 tgtgggagtg tgacatgacc ctgcaagatc tttgttacat atacacgggt ggttggactt
     3301 aagtaagaca gagaaggaga aaattgtccc agagcttccc actgaatgga acttgatcag
     3361 gctgtggatg agccggatgt ctgttattgc tagcatgagg cagaaatgac cttgaattag
     3421 accttggaga gactctttaa gatgataaag caatgagcgg actctgccta gaagaagatt
     3481 tttaactctg ggtgctcgct gctgctctga agttagatcc ttgtctcaga aagcatcagg
     3541 cagttcccac atacagaact gcttgtgtga aagctttgag attagaccgg tcacttcaca
     3601 caaacgtttg cccttccctg gaggttcacg gtgcctcttc cagggacacg ggctccttag
     3661 tgagtggtgg tattaagctt gccaaatgtc ctgcctaaac ttacccatgt ctcactggtg
     3721 ccccaagtta aaacaaggcc aaacaagtca ggggaggcct ctaataattt ttgaaggaga
     3781 gctagaaccc agttcaagtc tgtggaggaa cggagctgtg tccccagaca tgatgtctta
     3841 tttcacacga agccttaaat tagctcaatt gtagaattcc agatatttaa ggtttggcca
     3901 aacaaaacaa aataaaacaa aacaccaaga agcaatctca ttagtcttgg aatgaggggc
     3961 tgccacatca cagaaggccc agcggaacca attcttcttg cctgtttttt catagaatct
     4021 aattagttga ccaaatcagc attgcaatac tgcaagtata attaattttc atccctctca
     4081 aaaatcttgt caaacagcgc agctaaatag cttctcaaat gtaaaacatg caaggccact
     4141 tcctctaaac agaccttcca gggtcagacc gtaagggtta ccctggccca gatgagcagg
     4201 acttgaactc acacctgata gttcacaggc ttgctcttcc agctgcacag cattgcttca
     4261 gcttggagtg gataatgatc acattttgca taattccaaa ttaaagagtg tgggtgctca
     4321 tgttccaaac atttccaatt acatttgtct gttaaacact tgggggaggg aggtttcaag
     4381 agagttctgt tgcctaaagc attttaaatg ttttatgaaa cacattattc cctttgtgaa
     4441 gattttagat aaaagatgtg gcctgtgtgt atgagtctgt gtgtgtattt gtgtatctct
     4501 ctctgtgtgt ctgtctgtgc ctctgtgtgt gtatgtgtct gtttatgggg ctggagagat
     4561 gactcagcag ttaagagcac tgactgccct tccgaaggtc ctgagttcaa atcccagcaa
     4621 ccacaccgtg actcacaacc ctctgtaatg ggatcctatg ccctcttctg gtgtgtttga
     4681 aaacagccta cagtgtgttt gaaaacagct acagtgtacc caaatataat aaataaatct
     4741 taagg
//
