LOCUS       NM_001290651            4881 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Scm polycomb group protein like 2 (Scml2), transcript
            variant 1, mRNA.
ACCESSION   NM_001290651 XM_006528674
VERSION     NM_001290651.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4881)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4881)
  AUTHORS   Sakashita,A., Ooga,M., Otsuka,K., Maezawa,S., Takeuchi,C.,
            Wakayama,S., Wakayama,T. and Namekawa,S.H.
  TITLE     Polycomb protein SCML2 mediates paternal epigenetic inheritance
            through sperm chromatin
  JOURNAL   Nucleic Acids Res 51 (13), 6668-6683 (2023)
   PUBMED   37283086
  REMARK    GeneRIF: Polycomb protein SCML2 mediates paternal epigenetic
            inheritance through sperm chromatin.
REFERENCE   3  (bases 1 to 4881)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   4  (bases 1 to 4881)
  AUTHORS   Maezawa,S., Sakashita,A., Yukawa,M., Chen,X., Takahashi,K.,
            Alavattam,K.G., Nakata,I., Weirauch,M.T., Barski,A. and
            Namekawa,S.H.
  TITLE     Super-enhancer switching drives a burst in gene expression at the
            mitosis-to-meiosis transition
  JOURNAL   Nat Struct Mol Biol 27 (10), 978-988 (2020)
   PUBMED   32895557
  REMARK    GeneRIF: Super-enhancer switching drives a burst in gene expression
            at the mitosis-to-meiosis transition.
REFERENCE   5  (bases 1 to 4881)
  AUTHORS   Gan,P., Patterson,M., Watanabe,H., Wang,K., Edmonds,R.A.,
            Reinholdt,L.G. and Sucov,H.M.
  TITLE     Allelic variants between mouse substrains BALB/cJ and BALB/cByJ
            influence mononuclear cardiomyocyte composition and cardiomyocyte
            nuclear ploidy
  JOURNAL   Sci Rep 10 (1), 7605 (2020)
   PUBMED   32371981
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4881)
  AUTHORS   Hasegawa,K., Sin,H.S., Maezawa,S., Broering,T.J., Kartashov,A.V.,
            Alavattam,K.G., Ichijima,Y., Zhang,F., Bacon,W.C., Greis,K.D.,
            Andreassen,P.R., Barski,A. and Namekawa,S.H.
  TITLE     SCML2 establishes the male germline epigenome through regulation of
            histone H2A ubiquitination
  JOURNAL   Dev Cell 32 (5), 574-588 (2015)
   PUBMED   25703348
REFERENCE   7  (bases 1 to 4881)
  AUTHORS   Luo,M., Zhou,J., Leu,N.A., Abreu,C.M., Wang,J., Anguera,M.C., de
            Rooij,D.G., Jasin,M. and Wang,P.J.
  TITLE     Polycomb protein SCML2 associates with USP7 and counteracts histone
            H2A ubiquitination in the XY chromatin during male meiosis
  JOURNAL   PLoS Genet 11 (1), e1004954 (2015)
   PUBMED   25634095
  REMARK    GeneRIF: Our results demonstrate that the SCML2/USP7 complex
            constitutes a novel molecular pathway in modulating the epigenetic
            state of sex chromosomes during male meiosis
            GeneRIF: Scml2 is specifically expressed in germ cells. SCML2
            localizes to the XY body during male meiosis. SCML2 is associated
            with phosphorylated H2AX and USP7, a deubiquitinase. Loss of SCML2
            in mice causes defective spermatogenesis, resulting in sharply
            reduced sperm production. In the absence of SCML2, USP7 fails to
            accumulate on the XY body, whereas H2A monoubiquitination is
            dramatically augmented in the XY chromatin.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4881)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4881)
  AUTHORS   Wang,P.J., McCarrey,J.R., Yang,F. and Page,D.C.
  TITLE     An abundance of X-linked genes expressed in spermatogonia
  JOURNAL   Nat Genet 27 (4), 422-426 (2001)
   PUBMED   11279525
REFERENCE   10 (bases 1 to 4881)
  AUTHORS   Montini,E., Buchner,G., Spalluto,C., Andolfi,G., Caruso,A., den
            Dunnen,J.T., Trump,D., Rocchi,M., Ballabio,A. and Franco,B.
  TITLE     Identification of SCML2, a second human gene homologous to the
            Drosophila sex comb on midleg (Scm): A new gene cluster on Xp22
  JOURNAL   Genomics 58 (1), 65-72 (1999)
   PUBMED   10331946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040521.1, AK031490.1, BC056382.1, CK341235.1 and AL672233.18.
            
            On Mar 15, 2014 this sequence version replaced XM_006528674.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN02146467
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AK040521.1         2-23
            23-1933             AK031490.1         2-1912
            1934-2269           BC056382.1         1621-1956
            2270-3854           AK031490.1         2251-3835
            3855-3855           CK341235.1         219-219             c
            3856-4864           AK031490.1         3837-4845
            4865-4881           AL672233.18        156230-156246
FEATURES             Location/Qualifiers
     source          1..4881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..4881
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="Scm polycomb group protein like 2"
                     /db_xref="GeneID:107815"
                     /db_xref="MGI:MGI:1340042"
     exon            1..499
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            500..545
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..3241
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="isoform 1 is encoded by transcript variant 1; sex
                     comb on midleg-like 2"
                     /codon_start=1
                     /product="sex comb on midleg-like protein 2 isoform 1"
                     /protein_id="NP_001277580.1"
                     /db_xref="CCDS:CCDS72460.1"
                     /db_xref="GeneID:107815"
                     /db_xref="MGI:MGI:1340042"
                     /translation="MGQTANEDHFDWDKYLKETGSISAPSEYFRQSKTPPTNEFKIGM
                     KLEARDPRNIDSVCVASVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPVGTCEQGG
                     DLLQPPLGYTLNTSSWPMFLLRVLTGSELAPAVFFKEEPPRPLQNNFIVGMKIEAVDR
                     KNPFMICPATIGAVCGDQLHITFDGWSGAFDYWCDYDSRDIFPVGWCRLTGDVLQPPG
                     KIVEKRPRRKRRTRLWRLRTALLGNEEEAPEAAEEPGTSVLTFGDENRTLKDCRGEAA
                     EEPGTSAFTFGDENRTLKDCQGGWKKPKGRGFIKPGKDETRPGKHDQGAPAGKKPRGR
                     GFTQPLEDEARPGRDVQVAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTV
                     TTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGAAPAEKKRKGKTVTT
                     PWTEDPRLFADQGDAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPW
                     TEDPRLFADQGAAPAEKKRKGKTVTTPWTEDPRLFADQGDAPAEKKRKGKTVTTPWTE
                     DPRLFADQGDAPAEKKPKGKRVTKSRKDQAQFLADEEAMPALFSALSVSSTERTPPSS
                     SEQPKSSTSGKTKSTSRGAQTSRKSPRKTSVVQPVPKTSKKAGKSKSTGNTSSPKKGI
                     TIKIVLPKKKGGKSGKKEKSIPVISSTSSASLSTLMKSSSSNKTSAGPSKIVMSTVCV
                     YINKHGDCGPFLDPQKVQQLPNHFGPGPVNVILQRTVQACVNCAFQAKDVFLFLKTDN
                     RGGEMITAFFDGKVHTVQLPPVNSASFALRFLENFCQSLQCDNFLSSQPFRREAQVPT
                     PDTGTDQSKPENGEPKEKRSLKRLSLHPHRSAPVSSKVPRKSGQASKGN"
     exon            546..616
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            617..851
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            852..940
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1184
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1268
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1343
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1418
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1502
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1586
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1670
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1754
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1838
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1922
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2006
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2090
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2174
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..2258
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2342
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..2620
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2621..2735
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2939
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2940..3122
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3233
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3234..4881
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3550..3555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3570
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="major polyA site"
     regulatory      4849..4854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="hexamer: AATAAA"
     regulatory      4858..4863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4871
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
     polyA_site      4875
                     /gene="Scml2"
                     /gene_synonym="4932420G07Rik"
ORIGIN      
        1 gcggctctgc gcgcggcttc tcaaaaatgg cggctgcaat gtgaagtctg gtgcctgctc
       61 cctgagctag catgacagaa gtgcttttgc tcgggcggag aagacccgag gtgcttggtg
      121 gccctggtcc cccttgggaa gtggagatgg agtcctgatg ttggagtcct gatggctgtc
      181 tgcagggcag gggagcctta ggggcaagtc ctgcgctggg aacgccccct tactgccgcg
      241 ccagcgtccc gcctcagttt gtcccaacac tcctgcctca cacccctgga agctttaccc
      301 cagatgccaa ggctgctgtg tctaaattag tgttctctgt gggccatctc cgctgctagc
      361 actcgctgct gaccttcaca cttattcgga ccctcttcac tggctcatct tgctagaggt
      421 attcggcccc tggcccagct cccctcaaca ggccccctcc ccaggagcac cgacagcgcc
      481 ctctgcaatt ctccccaggg aaaatacaga agaggcgaat accatggggc aaacagcgaa
      541 tgaagatcat tttgactggg acaagtactt gaaagagact ggatcgataa gtgctccttc
      601 tgaatatttc agacagtcta agactccacc aactaatgaa ttcaaaattg gtatgaaatt
      661 ggaagcccgt gaccctcgca atattgattc ggtgtgtgtt gcttcggtca ttggaattac
      721 tggagccagg ttacgtctac gactggatgg tagtgacaat aagaatgatt tttggagact
      781 tgtggattca tcagacatac aacctgttgg gacgtgtgaa caaggaggag atttacttca
      841 gcctccactg gggtacacac tgaatacttc atcatggccc atgttcttac tacgtgtact
      901 aactggatct gaactggcac ctgcagtgtt ctttaaggag gaaccaccac gtccactcca
      961 aaataatttc atagttggga tgaagattga agctgtcgat agaaaaaatc catttatgat
     1021 ctgtcctgcc acaattggag ctgtctgtgg agatcaactt catatcactt ttgatggatg
     1081 gagtggagca tttgattatt ggtgtgacta tgactcccga gacatcttcc cagttggatg
     1141 gtgtcgcctc acaggagatg tattacagcc accaggaaaa attgttgaaa aaagaccaag
     1201 gcgcaaaaga agaaccagac tatggagact tagaactgct cttttgggaa atgaagaaga
     1261 ggccccagaa gctgcagaag aacctgggac cagtgtactt acttttggag atgaaaacag
     1321 aactttgaaa gattgccgag gagaagctgc agaagaacct gggaccagtg catttacttt
     1381 tggagatgaa aacagaactt tgaaagattg ccaaggaggt tggaaaaaac ccaagggcag
     1441 aggattcatc aaacctggaa aagatgaaac cagacctggg aaacatgacc aaggagcccc
     1501 agctgggaaa aaacccaggg gcagaggatt cacccaacct ttggaagatg aagccagacc
     1561 aggaagagat gtccaagtag ccccagctga gaaaaaacgc aagggcaaaa cagtcaccac
     1621 accttggact gaggatccca gactttttgc agatcaagga gatgccccag ctgagaaaaa
     1681 acgcaagggc aaaacagtca ccacaccttg gactgaggat cccagacttt ttgcagatca
     1741 aggagatgcc ccagctgaga aaaaacgcaa gggcaaaaca gtcaccacac cttggactga
     1801 ggatcccaga ctttttgcag atcaaggagc agccccagct gagaaaaaac gcaagggcaa
     1861 aacagtcacc acaccttgga ctgaggatcc cagacttttt gcagatcaag gagatgcccc
     1921 agctgagaaa aaacgcaagg gcaaaacagt caccacacct tggactgagg atcccagact
     1981 ttttgcagat caaggagatg ccccagctga gaaaaaacgc aagggcaaaa cagtcaccac
     2041 accttggact gaggatccca gactttttgc agatcaagga gcagccccag ctgagaaaaa
     2101 acgcaagggc aaaacagtca ccacaccttg gactgaggat cccagacttt ttgcagatca
     2161 aggagatgcc ccagctgaga aaaaacgcaa gggcaaaaca gtcaccacac cttggactga
     2221 ggatcccaga ctttttgcag atcaaggaga tgccccagct gaaaaaaaac ccaagggcaa
     2281 aagagtcacc aaatctcgga aagaccaagc ccagttttta gctgatgaag aagcaatgcc
     2341 agctcttttt tcagctctta gtgtgagcag tacagagaga acaccacctt cttcctctga
     2401 acaaccaaag tcttctacct ctgggaaaac aaaatccacc tctagagggg ctcaaacttc
     2461 aaggaagtct ccacggaaaa caagtgttgt gcaaccagta ccaaagacca gcaagaaagc
     2521 aggaaaatct aagtctactg gaaatacttc atcccctaag aagggcatta ctattaaaat
     2581 tgtcctacca aagaaaaagg gtggaaagtc tggaaaaaag gaaaaaagta ttccagttat
     2641 ttcttctaca tcttcagctt ctttaagtac actgatgaaa agttcttcat ctaataagac
     2701 ttctgcgggg ccatctaaaa tagtgatgtc tacagtttgt gtgtatataa ataaacatgg
     2761 agattgtggc cccttcctgg atccacagaa ggttcagcag ctacctaacc acttcggtcc
     2821 aggccctgtg aatgtcattc tccagcggac tgtgcaggcc tgtgtcaatt gtgcctttca
     2881 ggccaaggat gtgtttctat ttcttaaaac agataataga ggaggagaaa tgataactgc
     2941 cttctttgat gggaaagttc atactgttca gctccctcca gtgaatagtg catcatttgc
     3001 acttcgcttt cttgaaaatt tctgccaaag cctgcagtgt gataactttt tgagtagcca
     3061 gcctttcaga cgtgaggctc aagttcctac cccagataca ggcactgatc aaagcaaacc
     3121 agaaaatggg gaaccaaagg aaaagagaag cctcaaacga ttgtctctgc atcctcatcg
     3181 ttctgctcct gtctcatcta aggttcccag aaagtctggg caagcgtcta aaggaaattg
     3241 atgggaaagc tctgctacta ctgaagagtg agctgctgat gaagtatatg gggctgaaac
     3301 taggaccagc agtaaaactt tgttattaca ttgaaaaact taaagaaata aaccataatt
     3361 gaaaatgtgc aaatttagtt tagagataat tctcaggtat actgaaaaca ttttacttta
     3421 atagtagttt tcatctcatc cgtttttatt ttatagaatg tttttataga aatattttat
     3481 gaaagttgta gtacattaat agtatactct tattctttaa attccatcta atacgtttgt
     3541 attagcatga ttaaaactgg ctgttcatta tttatgtctt cagttatttt tattgtgttt
     3601 acaagtgtac ttcatgtggc aaagagaaga aacattttta tttggattaa tctttatatc
     3661 tagaaccaaa cagctaagtc caaggaggaa aataccagca cttctaaaaa caggagaaat
     3721 tttttcttca aaagagaatt tcaagatgca cttaagctct cgtcagctca attattttag
     3781 tctggtttta tgatgttttg ttcctgatct actagtagaa agggaagagc catctaaatt
     3841 attctttttt ctgtcagtgc ccttttttgt tcatactaca gggggaaagc aattttataa
     3901 gcttatataa agtgttctta ctagtttttg atatttttta aactgtaggc tagattaaaa
     3961 ttgataattt tgtgcaggag atgtttattt taccagagtg aattggagag aattggataa
     4021 attttatacc tattttacaa ctttctatat ttttgctaaa cttgaacatt agacacccaa
     4081 ttctgacatc tttattttct aagatatttg tgtccagatt ttaaatttgt gttttatttt
     4141 gtgtttatta ctcatacaga tactttagca tatttatata ctattatata tatgtgagaa
     4201 gacacaagtg actttttgaa ttgaatatgg cactttacac tgccacagag gtaataaagg
     4261 tatatataga tgtttaatcc ctgaaaaaat atatacatca tttttctatc atcagtacct
     4321 ctcagcgtat tattcaggtg ataagaaact gcccataaat tggctcccac atagggaagc
     4381 tctttatcct atgcaatatt tctaattatt tttcttagtt ctgagccatc aactttgcta
     4441 cattttgaaa ggtgcattaa ttctgacatt gagggttttg tttttccaaa taatagcttt
     4501 caaagtaaaa tggtgctgca tgttataact ttatatgatg gtgtagtgca tataagctat
     4561 gagaatcagt tatacatgta ttagagtcag ttatacatgt attatctatt ctaagtctca
     4621 acaaaatgtt caaccagaca agaatgtaat tttctcttta gaatgccaaa tgtgctttag
     4681 acaacaatgc aaaagtttaa aagactattt cacttatgtc atttctgaca caactagaat
     4741 acttaaactt tatcttcttg caaattgctt gtatgaagat gctctttcca gttgattgga
     4801 cctcaggtgt ttataatatt gtttataacc ttaagatttt aagaatataa taaagttatt
     4861 aaataaccac agcaattaac a
//
