LOCUS       NM_001379185            3553 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus Scm polycomb group homolog 1 (Scmh1), transcript
            variant 6, mRNA.
ACCESSION   NM_001379185 NM_001355423 XM_030253598
VERSION     NM_001379185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Kumar,S., Alam,S.S., Bareke,E., Beauchamp,M.C., Dong,Y., Chan,W.,
            Majewski,J. and Jerome-Majewska,L.A.
  TITLE     Sf3b4 regulates chromatin remodeler splicing and Hox expression
  JOURNAL   Differentiation 131, 59-73 (2023)
   PUBMED   37167859
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   He,Y., Hou,X.T., Guan,Y.X. and Chen,Y.
  TITLE     CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling axis to
            promote diabetes-induced retinal epithelial-mesenchymal transition
  JOURNAL   Exp Eye Res 224, 109264 (2022)
   PUBMED   36162459
  REMARK    GeneRIF: CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling
            axis to promote diabetes-induced retinal epithelial-mesenchymal
            transition.
REFERENCE   5  (bases 1 to 3553)
  AUTHORS   Yasunaga,S., Ohtsubo,M., Ohno,Y., Saeki,K., Kurogi,T.,
            Tanaka-Okamoto,M., Ishizaki,H., Shirai,M., Mihara,K., Brock,H.W.,
            Miyoshi,J. and Takihara,Y.
  TITLE     Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A
            and regulates geminin stability directly or indirectly via
            transcriptional repression of Hoxa9 and Hoxb4
  JOURNAL   Mol Cell Biol 33 (4), 644-660 (2013)
   PUBMED   23207902
  REMARK    GeneRIF: Loss of Scmh1 caused derepression of Hoxb4 and Hoxa9,
            direct targets of Polycomb-group complex 1-mediated transcriptional
            silencing in hematopoietic cells.
REFERENCE   6  (bases 1 to 3553)
  AUTHORS   Yahata,T., Takedatsu,H., Dunwoodie,S.L., Braganca,J., Swingler,T.,
            Withington,S.L., Hur,J., Coser,K.R., Isselbacher,K.J.,
            Bhattacharya,S. and Shioda,T.
  TITLE     Cloning of mouse Cited4, a member of the CITED family
            p300/CBP-binding transcriptional coactivators: induced expression
            in mammary epithelial cells
  JOURNAL   Genomics 80 (6), 601-613 (2002)
   PUBMED   12504852
REFERENCE   7  (bases 1 to 3553)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   8  (bases 1 to 3553)
  AUTHORS   Yamaki,M., Isono,K., Takada,Y., Abe,K., Akasaka,T., Tanzawa,H. and
            Koseki,H.
  TITLE     The mouse Edr2 (Mph2) gene has two forms of mRNA encoding 90- and
            36-kDa polypeptides
  JOURNAL   Gene 288 (1-2), 103-110 (2002)
   PUBMED   12034499
REFERENCE   9  (bases 1 to 3553)
  AUTHORS   Koga,H., Kaji,Y., Nishii,K., Shirai,M., Tomotsune,D., Osugi,T.,
            Sawada,A., Kim,J.Y., Hara,J., Miwa,T., Yamauchi-Takihara,K.,
            Shibata,Y. and Takihara,Y.
  TITLE     Overexpression of Polycomb-group gene rae28 in cardiomyocytes does
            not complement abnormal cardiac morphogenesis in mice lacking rae28
            but causes dilated cardiomyopathy
  JOURNAL   Lab Invest 82 (4), 375-385 (2002)
   PUBMED   11950896
REFERENCE   10 (bases 1 to 3553)
  AUTHORS   Tomotsune,D., Takihara,Y., Berger,J., Duhl,D., Joo,S., Kyba,M.,
            Shirai,M., Ohta,H., Matsuda,Y., Honda,B.M., Simon,J., Shimada,K.,
            Brock,H.W. and Randazzo,F.
  TITLE     A novel member of murine Polycomb-group proteins, Sex comb on
            midleg homolog protein, is highly conserved, and interacts with
            RAE28/mph1 in vitro
  JOURNAL   Differentiation 65 (4), 229-239 (1999)
   PUBMED   10653359
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626767.15 and AL611924.14.
            
            On or before Apr 20, 2022 this sequence version replaced
            NM_001355423.1, XM_030253598.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.5778.1,
                                           SRR9219382.11273.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL626767.15        183069-183177
            110-238             AL611924.14        27060-27188
            239-301             AL611924.14        33271-33333
            302-325             AL611924.14        33779-33802
            326-550             AL611924.14        36312-36536
            551-693             AL611924.14        42040-42182
            694-764             AL611924.14        43102-43172
            765-999             AL611924.14        48262-48496
            1000-1088           AL611924.14        58029-58117
            1089-1332           AL611924.14        63617-63860
            1333-1562           AL611924.14        85311-85540
            1563-1689           AL611924.14        88113-88239
            1690-1890           AL611924.14        95101-95301
            1891-2082           AL611924.14        96913-97104
            2083-2277           AL611924.14        102482-102676
            2278-2343           AL611924.14        105025-105090
            2344-2486           AL611924.14        108183-108325
            2487-3553           AL611924.14        109161-110227
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 56.52 cM"
     gene            1..3553
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /note="Scm polycomb group homolog 1"
                     /db_xref="GeneID:29871"
                     /db_xref="MGI:MGI:1352762"
     exon            1..109
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            110..238
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            239..301
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            302..325
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            326..550
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..693
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..2612
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /note="isoform 1 is encoded by transcript variant 6; sex
                     comb on midleg 1; polycomb protein SCMH1; sex comb on
                     midleg-like 3; sex comb on midleg-like 1; sex comb on
                     midleg homolog 1"
                     /codon_start=1
                     /product="polycomb protein SCMH1 isoform 1"
                     /protein_id="NP_001366114.1"
                     /db_xref="CCDS:CCDS18589.1"
                     /db_xref="GeneID:29871"
                     /db_xref="MGI:MGI:1352762"
                     /translation="MLVCYSVLACESLWDLPCSIMGSPLGHFTWDKYLKETCSVPAPV
                     HCFKQSYTPPSNEFKISMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFW
                     RLVDSSEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPIKIFHKEPP
                     SPSHNFFKMGMKLEAVDRKNPHFICPATIGEVRGAEVLVTFDGWRGAFDYWCRFDSRD
                     IFPVGWCSLTGDNLQPPGTKVVIPKNPSPSSDVSTEKPSIHSTKTVLEHQPGQRGRKP
                     GKKRGRTPKILIPHPTSTPSKSAEPLKFPKKRGPKPGSKRKPRTLLSPPPTSPTTSTP
                     EPDTSTVPQDAATVPSSAMQAPTVCIYLNKSGSTGPHLDKKKIQQLPDHFGPARASVV
                     LQQAVQACIDCAYHQKTVFSFLKQGHGGEVISAVFDREQHTLNLPAVNSITYVLRFLE
                     KLCHNLRSDNLFGNQPFTQTHLSLTATEYNHNHDRYLPGETFVLGNSLARSLETHSDL
                     MDSALKPANLVSTSQNLRTPGYRPLLPSCGLPLSTVSAVRRLCSKGVLKGKKERRDVE
                     SFWKLNHSPGSDRHLESRDPPRLSGRDPSSWTVEDVMQFVREADPQLGSHADLFRKHE
                     IDGKALLLLRSDMMMKYMGLKLGPALKLSFHIDRLKQGKF"
     exon            694..764
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            765..999
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1088
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1332
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1562
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1689
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1890
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2082
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2277
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2343
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2486
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..3553
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3519..3524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /note="hexamer: AATAAA"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /note="hexamer: AATACA"
     polyA_site      3536
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
                     /note="major polyA site"
     polyA_site      3553
                     /gene="Scmh1"
                     /gene_synonym="Scml1; Scml3"
ORIGIN      
        1 agagccgtcg cccgcccctg ccggcgtcct cgctcgctcc ctgcgcagcg gaaacatggc
       61 ggctggatgg gagtgagccg cccgcgcccc gcgccgctgt cgccctcaga tggagagatt
      121 aaatcacaga gaaactaact tgtcagaggt cagagcaagg tgtaggtgga tccaggaata
      181 agtctcaagc ttcatcactc cttgcttagt tttaggccat tgactatgca gcctagtgac
      241 tggaatgatg tgaaaaaacc taagtatggt cacttgtcag agtctgcatc tcaatatcaa
      301 gaatctgttg acatcctgga gctaggagcc cgaatgttat tgcctctggg aagccttcca
      361 caaaccttct gcgtgctcct acagcaccct ccacctctcc aagtgcagcc ctcaccacac
      421 ctttctgcca tggatcactt agtttctgtc cctcactaga ctgaagctca caagaatgag
      481 ggcaatattt tgatcatggt tgtatctgca gtgcccagca caatactgta aataagtctt
      541 ggaagaatgg catctagtgc tttttgcatg gcccaaaggg gccctgtgct gctccactac
      601 agaggaaaat tcaagaaatg ctggtttgct acagtgtttt agcttgtgag agtctctggg
      661 accttccctg ctccatcatg gggtcacctc taggtcattt tacctgggac aaatacctaa
      721 aagaaacatg ttcagtccca gcgcctgtcc attgcttcaa gcagtcctac acacctccaa
      781 gtaatgagtt caagatcagc atgaaattgg aagcacagga tcccaggaac accacatcca
      841 cctgtattgc cacggtcgtt ggattgacag gtgcccgact tcgtctgcgc cttgatggca
      901 gtgacaacaa gaatgacttc tggagactgg ttgactcctc tgaaatccag ccaattggaa
      961 actgtgagaa gaatggcggg atgctgcagc cccctctagg atttcggctg aatgcctcct
     1021 cttggcccat gttccttttg aagacactaa atggagcaga gatggctccc atcaagattt
     1081 tccataagga gccaccatca ccttcccaca acttcttcaa aatgggaatg aagttagaag
     1141 ctgtagacag aaagaaccct catttcattt gcccagccac tattggagaa gttcgaggcg
     1201 cagaagtgct agtcaccttt gatgggtggc gaggcgcatt tgactactgg tgccgctttg
     1261 actcccggga catctttcct gtgggctggt gttctttgac tggagataac ctgcagccac
     1321 ctggcaccaa agttgtgatt ccaaagaatc cgtccccttc atctgatgtg agcactgaga
     1381 agcccagcat ccacagcacc aaaactgtct tggagcatca gccagggcag aggggccgca
     1441 aaccaggaaa gaagcggggc cgaacaccca agatccttat tccccatccc acctctaccc
     1501 catccaagtc agctgaacct ttgaaatttc caaagaagag aggtcccaag cctggcagta
     1561 agaggaaacc tcggactttg ctgagcccac cacccacctc accaacaacc agcacccctg
     1621 aaccggacac cagcactgtt cctcaagatg ctgccaccgt cccaagttca gccatgcagg
     1681 cccccacagt ttgtatctac ttgaacaaga gcggcagcac gggcccccac ctggataaga
     1741 agaagatcca acaactccct gaccattttg ggccagcccg tgcctctgtg gtgctgcagc
     1801 aggctgtcca ggcttgcatt gactgtgctt atcaccagaa aactgtcttc agcttcctca
     1861 aacagggcca cggcggtgaa gtcatttcag ccgtgtttga ccgggaacag cacactctga
     1921 acctcccagc agtcaacagc atcacctatg tcctccgttt cctggagaag ctctgccaca
     1981 accttcgaag tgacaatctg tttggcaacc agccctttac acagactcac ttatcactca
     2041 ctgccacaga gtataatcac aaccacgaca ggtacctacc aggtgaaacc tttgtcctgg
     2101 ggaatagcct ggcccggtcc ttggagacac actcagacct gatggattct gccttgaagc
     2161 ctgccaacct tgtcagcaca tcccaaaacc ttcggactcc tggctatcgg cccttgcttc
     2221 cctcctgtgg cctcccatta agcactgtct ctgctgtgcg taggctctgc tctaagggag
     2281 tgttaaaagg aaaaaaggaa agaagggatg tggagtcatt ttggaaacta aatcattccc
     2341 cagggtcaga tcgacatctg gagagccgag atccccctcg cctgagtggc cgggacccct
     2401 cctcatggac agtggaggat gtgatgcagt ttgtccggga agccgatcct cagcttggat
     2461 cccatgctga cctcttccga aaacatgaaa tcgatggcaa ggccctgctc ctgctgcgca
     2521 gtgacatgat gatgaagtac atgggcctga agctggggcc cgccctcaag ctctcctttc
     2581 acattgaccg gctgaagcag ggcaagttct gaacaggagg cactcttctc ccaggaagcc
     2641 gcccgccagc tcccaggcac cttagtaggg ctctgggtga cctcaggact ctaggaggct
     2701 ggaaagccac cactgctacc cttcctgccc tgatgtgtcc ttccatgaag gactgaggag
     2761 ggaacagtgg gcccggggct ggtgctgctc ttccccttag cctgctgtgg ctcccaggcc
     2821 cttctattta tttctcaagg ctagccagcc tctctccaca agtttagacg agcacctttc
     2881 aagagatgag gaagacgcca gccctaggac cttgaaaggc cctggtaccc aggccccttg
     2941 ccacctcctg ggcttggcat agtgtcccaa ggcccccagc tcatgccttc tcactggatc
     3001 cccagactct gaacttatgg tgcagacctt ttttaaagag atcctttctt attgctaatt
     3061 tattgcttct ggcgtttgga cttaatgctt ctcttgcacc aaacagtttt ttggaagagg
     3121 gagaccatcc tctggtccag agagggcctc tccagagaag tgtggcctat ttcagaagac
     3181 actgccctag ggcacttctt ctctggaatg gacaaagtat ttggctcact gagcaaaagg
     3241 tgagggtctc tcttcctaca ctgggtcctt tgtagcccca gtcttcatct ctgatggagt
     3301 ttcccctctc cctgccccca cagctccctg ccctggtcag aattgctgca aaagatgggg
     3361 cctaatgcaa ttaggtcacg gggccccaat ggtgggagga ggacctcaag gctggaggag
     3421 ttctgccctc tgctagctcc tgtgctttcc tcctaagcaa gtcagcagca ctgctgcccc
     3481 cactgccatc tgaactattt tgtgtccgtt tgtttataaa taaaaaccaa tacaaatgcc
     3541 cgtgtctttt taa
//
