LOCUS       NM_001081411            3020 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus sodium channel and clathrin linker 1 (Sclt1),
            transcript variant 1, mRNA.
ACCESSION   NM_001081411 XM_982541
VERSION     NM_001081411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3020)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3020)
  AUTHORS   Lee,H., Moon,K.H., Song,J., Je,S., Bok,J. and Ko,H.W.
  TITLE     Tissue-specific requirement of sodium channel and clathrin linker 1
            (Sclt1) for ciliogenesis during limb development
  JOURNAL   Front Cell Dev Biol 10, 1058895 (2022)
   PUBMED   36407107
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3020)
  AUTHORS   Ding,W., Wu,Q., Sun,L., Pan,N.C. and Wang,X.
  TITLE     Cenpj Regulates Cilia Disassembly and Neurogenesis in the
            Developing Mouse Cortex
  JOURNAL   J Neurosci 39 (11), 1994-2010 (2019)
   PUBMED   30626697
REFERENCE   4  (bases 1 to 3020)
  AUTHORS   Li,J., Lu,D., Liu,H., Williams,B.O., Overbeek,P.A., Lee,B.,
            Zheng,L. and Yang,T.
  TITLE     Sclt1 deficiency causes cystic kidney by activating ERK and STAT3
            signaling
  JOURNAL   Hum Mol Genet 26 (15), 2949-2960 (2017)
   PUBMED   28486600
REFERENCE   5  (bases 1 to 3020)
  AUTHORS   Ye,X., Zeng,H., Ning,G., Reiter,J.F. and Liu,A.
  TITLE     C2cd3 is critical for centriolar distal appendage assembly and
            ciliary vesicle docking in mammals
  JOURNAL   Proc Natl Acad Sci U S A 111 (6), 2164-2169 (2014)
   PUBMED   24469809
REFERENCE   6  (bases 1 to 3020)
  AUTHORS   Geurts,A.M., Collier,L.S., Geurts,J.L., Oseth,L.L., Bell,M.L.,
            Mu,D., Lucito,R., Godbout,S.A., Green,L.E., Lowe,S.W., Hirsch,B.A.,
            Leinwand,L.A. and Largaespada,D.A.
  TITLE     Gene mutations and genomic rearrangements in the mouse as a result
            of transposon mobilization from chromosomal concatemers
  JOURNAL   PLoS Genet 2 (9), e156 (2006)
   PUBMED   17009875
REFERENCE   7  (bases 1 to 3020)
  AUTHORS   Geurts,A.M., Wilber,A., Carlson,C.M., Lobitz,P.D., Clark,K.J.,
            Hackett,P.B., McIvor,R.S. and Largaespada,D.A.
  TITLE     Conditional gene expression in the mouse using a Sleeping Beauty
            gene-trap transposon
  JOURNAL   BMC Biotechnol 6, 30 (2006)
   PUBMED   16800892
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3020)
  AUTHORS   Collier,L.S., Carlson,C.M., Ravimohan,S., Dupuy,A.J. and
            Largaespada,D.A.
  TITLE     Cancer gene discovery in solid tumours using transposon-based
            somatic mutagenesis in the mouse
  JOURNAL   Nature 436 (7048), 272-276 (2005)
   PUBMED   16015333
REFERENCE   9  (bases 1 to 3020)
  AUTHORS   Carlson,C.M., Dupuy,A.J., Fritz,S., Roberg-Perez,K.J.,
            Fletcher,C.F. and Largaespada,D.A.
  TITLE     Transposon mutagenesis of the mouse germline
  JOURNAL   Genetics 165 (1), 243-256 (2003)
   PUBMED   14504232
REFERENCE   10 (bases 1 to 3020)
  AUTHORS   Dupuy,A.J., Fritz,S. and Largaespada,D.A.
  TITLE     Transposition and gene disruption in the male germline of the mouse
  JOURNAL   Genesis 30 (2), 82-88 (2001)
   PUBMED   11416868
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102795.28, AC154098.6 and AC161235.6.
            
            On Feb 6, 2007 this sequence version replaced XM_982541.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.18994.1,
                                           SRR7345562.1250948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-520               AC102795.28        160634-161153
            521-588             AC102795.28        168913-168980
            589-647             AC102795.28        172229-172287
            648-720             AC102795.28        172785-172857
            721-776             AC102795.28        176000-176055
            777-912             AC102795.28        185284-185419
            913-1035            AC102795.28        191943-192065
            1036-1101           AC102795.28        193614-193679
            1102-1172           AC154098.6         197226-197296       c
            1173-1263           AC154098.6         176122-176212       c
            1264-1355           AC154098.6         175536-175627       c
            1356-1533           AC154098.6         169168-169345       c
            1534-1632           AC154098.6         165225-165323       c
            1633-1704           AC154098.6         160951-161022       c
            1705-1779           AC154098.6         157792-157866       c
            1780-1925           AC154098.6         155412-155557       c
            1926-2118           AC154098.6         151044-151236       c
            2119-2315           AC161235.6         5037-5233
            2316-2394           AC161235.6         20947-21025
            2395-2490           AC161235.6         23065-23160
            2491-3020           AC161235.6         25444-25973
FEATURES             Location/Qualifiers
     source          1..3020
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 19.91 cM"
     gene            1..3020
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="sodium channel and clathrin linker 1"
                     /db_xref="GeneID:67161"
                     /db_xref="MGI:MGI:1914411"
     exon            1..520
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     CDS             487..2553
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="sodium channel-associated protein 1"
                     /codon_start=1
                     /product="sodium channel and clathrin linker 1"
                     /protein_id="NP_001074880.1"
                     /db_xref="CCDS:CCDS38425.1"
                     /db_xref="GeneID:67161"
                     /db_xref="MGI:MGI:1914411"
                     /translation="MATEIDLLRDQKDKLNDILRQHQIEHIFRDPTMQNSMSKGGRGD
                     TLVDSINEQSSLPPLIAEYEKHLEELNRQLTYYQKHMGEMKLQLETVITENERLHSKL
                     KDAVEKQLEALPFGTGIGNDICADDETVRILQEQLQLANQEKTWALELWQTASQELQS
                     VQKLYQEHMTEAQIHEFENRKQKDQLNNFQQLTKKLHVANENIEMTNHHFLKTVTEQN
                     MEIEKLRKHLRQARLDLRVAVSKVEELTKVTEGLQEQMLKKEEDIMSAQGKEEASDRR
                     VQQLQSSIKQLESRLCVAIEEADVLKTGKSNLEKQIKELQAKCSESENEKYEAISRAR
                     DSMQLLEEANIKQNQILLEEKQKEVDREKMKKTMSQLIQDAAIKARKEVESTKKQYEI
                     LISQLKEELSTLQMDCDEKQGQIDRAIRGKRAVEEELEKIYREGKQDESDYRKLEEMH
                     QRCLAAERSKDDLQLRLKSAENRIKQLEINSSEEMSRSHEMIQKLQTVLESERENCGF
                     VSEQRLKLQQENEQLQKETEDLRKVALEAQKKAKLKVSTMEHQFSIKEHGFEVQLREM
                     EDSNRNSIVELRHLLAAQQKTANRWKEETKKLTESAEMRISSLKSELSRQKLHTQELL
                     SQLEMANEKVAENEKLILEHQEKANRLQRRLSQAEERAASASQQLSVITVQRRKAASM
                     MNLENI"
     exon            521..588
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            589..647
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            648..720
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            721..776
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            777..912
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1035
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1101
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1172
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1263
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1355
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1533
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1632
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1704
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1779
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1925
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2118
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2315
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2394
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2490
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..3020
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2763..2768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="hexamer: AATAAA"
     polyA_site      2783
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="major polyA site"
     regulatory      2983..2988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="hexamer: AATAAA"
     polyA_site      3005
                     /gene="Sclt1"
                     /gene_synonym="2610207F23Rik; 4931421F20Rik; CAGGS-SB10;
                     Tg(ACTB-sb10)1Dla; Tg(CAG-sb10)1Dla"
                     /note="major polyA site"
ORIGIN      
        1 tccaaggaac ggtctggggc accgctttca aagtcgcagg gcgggccgag tggactccgc
       61 ggccgctcct gctttcccgc ggccctggcg tcgcccctca gccggcgggg acgctgccgc
      121 ccagccaggc gcgtcgcagg gtcatcctcc cgcgcggtct gacgggaact cggcgccctc
      181 cggccgcgcg cggctccgcg gcccttctcg tccggccggg tccggccgag cgcggaacgg
      241 agtctgaggc gcgtcgcctg ggttccgcgg agcggcgggc cgggctgcgc cgccgcgtga
      301 gtgggatgct gatgtctccg cgccagggct cggctgcccc tgcgacccct tagctttttg
      361 tttgccctca cagcgggagg ctgctttttt gttgttgttc gattgcttgc ttgtttgaga
      421 aataccttct ttcccccctg cgaggaatcg ataaacgtga tgaaaactcc aaactaaaat
      481 atcgaaatgg ccacagaaat cgacttactg agagaccaaa aagataaact aaatgatatt
      541 cttaggcagc atcaaatcga acatattttc agagacccaa ctatgcagaa cagcatgtcc
      601 aaaggaggca gaggtgacac actagtagac tcaataaatg agcaaagttc tttacctcct
      661 ctcattgctg agtatgagaa acatctggaa gagctaaaca ggcagctgac ctattaccag
      721 aagcacatgg gtgagatgaa actacaactt gaaactgtca tcacagaaaa tgaaaggttg
      781 cacagtaaat taaaagatgc tgttgaaaag caattggaag cccttccctt tggcacaggg
      841 ataggaaatg acatctgtgc agatgatgag accgtgagga tccttcaaga acaattgcaa
      901 ctagccaatc aagagaaaac ttgggctctg gaactctggc agactgcttc tcaggagttg
      961 caaagtgtac agaaactcta tcaggagcat atgactgaag cccagattca tgaatttgaa
     1021 aaccgaaagc aaaaagatca gctgaacaat tttcaacaac taaccaagaa actccatgtt
     1081 gctaatgaga acatagaaat gactaaccac cacttcctga aaacagtaac tgaacaaaac
     1141 atggagattg agaaacttcg aaaacatctt aggcaagcca gattagatct gagagttgca
     1201 gtatcgaaag tggaagagtt aactaaagtg actgaaggtc ttcaagagca gatgctgaag
     1261 aaggaggaag atattatgtc tgcacaagga aaagaagaag cgtcggatag acgagtacag
     1321 cagttacaat ctagtataaa acagttagag tcaagattgt gtgtagcaat tgaagaagcc
     1381 gatgtactaa aaacagggaa atcaaatttg gaaaagcaaa tcaaagaact acaagcaaaa
     1441 tgtagtgaat cagaaaatga gaaatatgag gctatttcaa gagccagaga tagcatgcag
     1501 ctcttagaag aagctaacat taaacaaaat cagattctcc ttgaagagaa acaaaaagag
     1561 gttgacagag aaaaaatgaa gaaaacaatg tctcagctta tacaagatgc agctatcaaa
     1621 gcaaggaaag aggttgaaag cacaaaaaaa caatatgaaa ttctgatttc acaattaaag
     1681 gaagaactct caacccttca aatggactgt gatgaaaagc aaggtcaaat tgatcgagcc
     1741 attagaggga aaagagccgt ggaagaagaa ctggagaaga tttaccgtga aggcaaacag
     1801 gatgaaagtg attacagaaa attggaagaa atgcatcaaa gatgtcttgc tgcagaacgt
     1861 tcaaaagatg atcttcagct aagactcaag agtgcagaaa atagaataaa acaacttgaa
     1921 attaattcct cagaagagat gtcacgttcc catgaaatga tccagaaact tcaaactgta
     1981 ttggagtcag agagggagaa ctgtggcttt gtcagcgagc agaggctgaa gcttcagcag
     2041 gaaaacgagc aactacagaa ggagaccgag gatctcagaa aagttgctct ggaggcccaa
     2101 aaaaaagcaa aattaaaggt cagtacaatg gagcatcagt tctcaattaa ggagcatggg
     2161 tttgaagttc agctgagaga aatggaggac agtaatcgga attccattgt tgaactgagg
     2221 catcttttgg cagctcaaca aaagacagcc aataggtgga aagaagaaac caagaaactt
     2281 actgaaagtg cagaaatgag gatcagcagt ctaaagagtg agctgagccg acagaagctt
     2341 catacccagg agctactttc tcaactggaa atggcaaatg aaaaggtggc tgagaatgaa
     2401 aagttaattc tggaacatca agaaaaagca aacagacttc aaaggcgtct aagtcaggca
     2461 gaagagagag ctgcttcagc gtcccagcag ctcagtgtga ttacagtgca gagaagaaaa
     2521 gcagcttcca tgatgaatct ggaaaatatt taaacatatt catagttcac tgacagaact
     2581 gtagagttgg gaaagctgtt gtaccaaacg tattgacatg gagaagcctg ctgagaatgg
     2641 ggaaggcttg tgtcattttg cataagcatt ttccattctg ttttgagggt tattggaaaa
     2701 cagaacagtg acagcttctt gtaagtagaa aactataatc ctatatttga gattcagtag
     2761 agaataaagc cagctgagaa gaactcactg ccttcatcaa tgtctatttt taattccttt
     2821 ttccccctcc ttggaagaac ataatatttt caagaggttt aattaaatcc ctagaatttg
     2881 atatttcagg ttctaagatt tggagattta atgtctcatt ttttactctt aattcatttt
     2941 tataattctt aagattctat tttactatga attcataaat gtaataaatt atgtattttg
     3001 taaaattatg ttgtcatgta
//
