LOCUS       NM_001146196            3008 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus scinderin (Scin), transcript variant 1, mRNA.
ACCESSION   NM_001146196
VERSION     NM_001146196.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3008)
  AUTHORS   Li,Y., Tang,L., Dang,G., Ma,M. and Tang,X.
  TITLE     Scinderin Promotes Hydrogen Peroxide-induced Lens Epithelial Cell
            Injury in Age-related Cataract
  JOURNAL   Curr Mol Med 24 (11), 1426-1436 (2024)
   PUBMED   37936437
  REMARK    GeneRIF: Scinderin Promotes Hydrogen Peroxide-induced Lens
            Epithelial Cell Injury in Age-related Cataract.
REFERENCE   3  (bases 1 to 3008)
  AUTHORS   Wang,K., Kong,F., Qiu,Y., Chen,T., Fu,J., Jin,X., Su,Y., Gu,Y.,
            Hu,Z. and Li,J.
  TITLE     Autophagy regulation and protein kinase activity of PIK3C3 controls
            sertoli cell polarity through its negative regulation on SCIN
            (scinderin)
  JOURNAL   Autophagy 19 (11), 2934-2957 (2023)
   PUBMED   37450577
  REMARK    GeneRIF: Autophagy regulation and protein kinase activity of PIK3C3
            controls sertoli cell polarity through its negative regulation on
            SCIN (scinderin).
REFERENCE   4  (bases 1 to 3008)
  AUTHORS   Chan,B., Glogauer,M., Wang,Y., Wrana,J., Chan,K., Beier,F.,
            Bali,S., Hinz,B., Parreno,J., Ashraf,S. and Kandel,R.
  TITLE     Adseverin, an actin-binding protein, modulates hypertrophic
            chondrocyte differentiation and osteoarthritis progression
  JOURNAL   Sci Adv 9 (31), eadf1130 (2023)
   PUBMED   37540756
  REMARK    GeneRIF: Adseverin, an actin-binding protein, modulates
            hypertrophic chondrocyte differentiation and osteoarthritis
            progression.
REFERENCE   5  (bases 1 to 3008)
  AUTHORS   Xie,Z., Ma,X.H., Bai,Q.F., Tang,J., Sun,J.H., Jiang,F., Guo,W.,
            Wang,C.M., Yang,R., Wen,Y.C., Wang,F.Y., Chen,Y.X., Zhang,H.,
            He,D.Z., Kelley,M.W., Yang,S. and Zhang,W.J.
  TITLE     ZBTB20 is essential for cochlear maturation and hearing in mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (24), e2220867120 (2023)
   PUBMED   37279265
REFERENCE   6  (bases 1 to 3008)
  AUTHORS   Svensson,C., Silverstone,A.E., Lai,Z.W. and Lundberg,K.
  TITLE     Dioxin-induced adseverin expression in the mouse thymus is strictly
            regulated and dependent on the aryl hydrocarbon receptor
  JOURNAL   Biochem Biophys Res Commun 291 (5), 1194-1200 (2002)
   PUBMED   11883943
  REMARK    GeneRIF: adseverin induction is a specific gene regulatory effect
            by TCDD on thymocytes.
REFERENCE   7  (bases 1 to 3008)
  AUTHORS   Arai,M. and Kwiatkowski,D.J.
  TITLE     Differential developmentally regulated expression of gelsolin
            family members in the mouse
  JOURNAL   Dev Dyn 215 (4), 297-307 (1999)
   PUBMED   10417819
REFERENCE   8  (bases 1 to 3008)
  AUTHORS   Kwiatkowski,D.J.
  TITLE     Functions of gelsolin: motility, signaling, apoptosis, cancer
  JOURNAL   Curr Opin Cell Biol 11 (1), 103-108 (1999)
   PUBMED   10047530
  REMARK    Review article
REFERENCE   9  (bases 1 to 3008)
  AUTHORS   Lueck,A., Brown,D. and Kwiatkowski,D.J.
  TITLE     The actin-binding proteins adseverin and gelsolin are both highly
            expressed but differentially localized in kidney and intestine
  JOURNAL   J Cell Sci 111 (Pt 24), 3633-3643 (1998)
   PUBMED   9819354
REFERENCE   10 (bases 1 to 3008)
  AUTHORS   Robbens,J., Louahed,J., De Pestel,K., Van Colen,I., Ampe,C.,
            Vandekerckhove,J. and Renauld,J.C.
  TITLE     Murine adseverin (D5), a novel member of the gelsolin family, and
            murine adseverin are induced by interleukin-9 in T-helper
            lymphocytes
  JOURNAL   Mol Cell Biol 18 (8), 4589-4596 (1998)
   PUBMED   9671468
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY201136.1, BC063328.1 and Y13971.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK133484.1, BC063328.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BY201136.1         2-46
            46-2512             BC063328.1         1-2467
            2513-2994           BC063328.1         2476-2957
            2995-3008           Y13971.1           2640-2653
FEATURES             Location/Qualifiers
     source          1..3008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 18.06 cM"
     gene            1..3008
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /note="scinderin"
                     /db_xref="GeneID:20259"
                     /db_xref="MGI:MGI:1306794"
     exon            1..319
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2268
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gelsolin-like protein"
                     /codon_start=1
                     /product="scinderin isoform 1"
                     /protein_id="NP_001139668.1"
                     /db_xref="CCDS:CCDS49055.1"
                     /db_xref="GeneID:20259"
                     /db_xref="MGI:MGI:1306794"
                     /translation="MAQELQHPEFARAGQQAGLQVWRVEKLELVPVPQGAYGDFYVGD
                     AYLVLHTTKSSRGFSYRLHFWLGKECSQDESTAAAIFTVQMDDYLGGKPVQSRELQGY
                     ESTDFVGYFKGGLKYKAGGVASGLNHVLTNDLTAKRLLHVKGRRVVRATEVPLSWESF
                     NKGDCFIIDLGTEIYQWCGSSCNKYERLKASQVAIGIRDNERKGRSQLIVVEEGSEPS
                     ELMKVLGRKPELPDGDNDDDVVADISNRKMAKLYMVSDASGSMKVTLVAEENPFSMGM
                     LLSEECFILDHGAAKQIFVWKGKNANPQERKTAMKTAEEFLQKMKYSTNTQIQVLPEG
                     GETPIFKQFFKDWKDKDQSDGFGKVYITEKVAQIKQIPFDASKLHSSPQMAAQHNMVD
                     DGSGGVEIWRVENSGRVQIDPSSYGEFYGGDCYIILYTYPRGQIIYTWQGANATRDEL
                     TMSAFLTVQLDRSLGGQAVQVRVSQGKEPAHLLSLFKDKPLIIYKNGTSKKEGQAPAP
                     PTRLFQVRRNLASITRIVEVDVDANSLNSNDTFVLKLPRNNGFIWIGKGASQEEEKGA
                     EYVADVLKCKASRIQEGKEPEEFWNSLGGRGDYQTSPLLETRAEDHPPRLYGCSNKTG
                     RFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVEKKESVKSAKMYLETDP
                     SGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW"
     exon            320..474
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            475..636
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            637..786
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            787..879
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1012
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1101
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1317
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1439
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1530
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1701
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1879
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2001
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2079
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2140
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2999
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2981..2986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /note="hexamer: AATATA"
     polyA_site      2999
                     /gene="Scin"
                     /gene_synonym="adseverin"
                     /note="major polyA site"
ORIGIN      
        1 gcttctggcg agccgcttta aagccgggag agcaggttcg cggtcaccgg tcatcgggct
       61 cttccttggg ctcagggcac ggatcaagtc ctcggctcgc tcggccagca tcgcggcacc
      121 atggcgcagg agctgcagca ccccgagttc gcgcgcgcag gccagcaggc tgggctgcag
      181 gtgtggaggg tcgagaagct ggaactggta ccggtgcccc agggtgccta tggtgacttt
      241 tacgtcggag acgcctacct ggtgctgcac accaccaagt ccagcagggg cttctcctac
      301 cgcctgcatt tctggctggg aaaggagtgt tcccaggatg agagcacagc ggctgccatc
      361 tttacggtcc agatggacga ctatttgggt ggcaagccag tccagagcag agagcttcaa
      421 ggctatgagt cgactgattt tgtgggctat ttcaaaggcg gtctgaagta caaggctgga
      481 ggtgtggctt ctggactaaa ccatgtcctc accaatgatc tgactgcgaa aagacttctg
      541 cacgtgaagg gtcggagagt ggtcagagcc actgaagttc ccctcagctg ggagagcttc
      601 aacaagggcg actgcttcat cattgacctt ggcaccgaaa tttaccagtg gtgtggttcc
      661 tcctgcaaca aatatgagcg tctgaaagca agccaggtgg ccattggcat ccgggacaat
      721 gagaggaaag gaagatctca actcattgtg gtggaagaag gaagtgaacc atcagagctc
      781 atgaaggttt tagggagaaa gcctgagctt ccagatgggg acaatgatga cgatgtcgta
      841 gcagacataa gtaacaggaa gatggcgaag ctctacatgg tttcagatgc aagtgggtcc
      901 atgaaagtaa cactggtggc tgaagaaaac ccgttctcca tgggaatgtt gctttctgaa
      961 gaatgcttca ttttggacca tggtgctgca aaacaaattt ttgtatggaa aggtaaaaat
     1021 gctaacccac aggagaggaa gactgccatg aagacagctg aggagttttt acagaaaatg
     1081 aagtattcta ctaatactca aattcaggtt cttccggaag gcggtgaaac accaattttc
     1141 aaacagttct ttaaggactg gaaggataaa gaccagagtg atggctttgg gaaggtgtac
     1201 atcacggaga aagtggctca gataaagcag attccgtttg atgcctcaaa actgcacagt
     1261 tctccgcaga tggcagccca gcacaacatg gtggacgatg gctctggcgg ggtggagatc
     1321 tggcgtgtag agaacagtgg tagagtccag attgacccaa gctcctatgg cgagttctat
     1381 ggcggtgact gctacattat cctctacact tatcccagag gacagatcat ctacacatgg
     1441 caaggagcaa atgctaccag agatgaactg accatgtccg cgtttctgac tgtccagttg
     1501 gaccggtccc ttggagggca ggctgtgcag gtccgtgtct ctcaaggcaa agagcctgct
     1561 cacctgctga gtttgttcaa agacaaacca ctcattattt ataagaatgg gacatccaag
     1621 aaagaagggc aggcaccggc tccccctaca cgcctttttc aagtccggag gaacctggca
     1681 tctatcacca gaattgtgga ggttgacgtt gatgcaaatt cattaaattc taatgacact
     1741 tttgtcctaa aactgccacg aaacaatggc ttcatctgga taggaaaagg tgctagccag
     1801 gaggaggaga aaggagcaga gtatgtggct gatgtcctca agtgcaaagc ttcaagaatt
     1861 caagaaggca aggaaccaga ggaattctgg aactctcttg gagggagggg agactaccag
     1921 acttcaccat tgctagaaac tcgggctgaa gaccatccac ctcggcttta tggttgctcc
     1981 aacaaaactg gaagattcat tattgaagaa gttccgggag agttcaccca ggatgacctg
     2041 gcagaagatg atgtcatgct acttgatgcg tgggaacaga tctttatttg gattggcaaa
     2101 gatgccaatg aagttgagaa aaaggaatca gtgaagtctg ccaaaatgta cctggagaca
     2161 gacccttctg gaagagacaa gaggacaccg attgtcatca tcaagcaagg gcacgagccc
     2221 cccacattca caggctggtt tctgggctgg gactccagca ggtggtaaaa ccagcaacta
     2281 tcctggctgc attggggcag ctgccccact ttgttgttgg ggaattgttt actttttgtt
     2341 attggctttt gaagataaac tcctgccaaa tggatatata tctatatcta tatctatatc
     2401 tatatctata tctatatcta tatctatatc tatatctatc tatatctaat ctatatctat
     2461 ctatctatct atctatctat ctatctatct atctatctat ctatctatct atatgctcct
     2521 cttttccttc tctttcaaag ggaattgctg tatgttacta tactgaaata acctaaagca
     2581 accatttgtt ttcgagcaat tttgcaatct ggggacctct gaggaagtaa ttttgtcatt
     2641 cagccactgc tagccaaact tgtcttttcc catagagagg aaggagagcc acagtgcttc
     2701 taagcatttc cccgtctgct actctgtttg cagtgagctt tactttatgt atggctttaa
     2761 caatgccttg ctgtttccca tctcaagtca atgccacttg gatgccattc actcccaagt
     2821 gtccttacat aggatgaact tctttagctt ttttagaaaa ctaaaatcat gtcttttatg
     2881 ataaaacaca ttttatttct ataagtttaa ctttatatat ttgatagcac atgctcaata
     2941 gcataaagaa tatgcattga atgatgtttt tcataattaa aatatatcct tttggaaaaa
     3001 aaaaaaaa
//
