LOCUS       NM_001045526            1055 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus SLP adaptor and CSK interacting membrane protein
            (Scimp), mRNA.
ACCESSION   NM_001045526 XM_001001775 XM_622576 XM_909698 XM_993977
VERSION     NM_001045526.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1055)
  AUTHORS   Pei,X., Liu,L., Wang,J., Guo,C., Li,Q., Li,J., Ren,Q., Ma,R.,
            Zheng,Y., Zhang,Y., Liu,L., Zheng,D., Wang,P., Jiang,P., Feng,X.,
            Jiang,E., Wang,Y. and Feng,S.
  TITLE     Exosomal secreted SCIMP regulates communication between macrophages
            and neutrophils in pneumonia
  JOURNAL   Nat Commun 15 (1), 691 (2024)
   PUBMED   38263143
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1055)
  AUTHORS   Liu,L., Lucas,R.M., Nanson,J.D., Li,Y., Whitfield,J.,
            Curson,J.E.B., Tuladhar,N., Alexandrov,K., Mobli,M., Sweet,M.J.,
            Kobe,B., Stow,J.L. and Luo,L.
  TITLE     The transmembrane adapter SCIMP recruits tyrosine kinase Syk to
            phosphorylate Toll-like receptors to mediate selective inflammatory
            outputs
  JOURNAL   J Biol Chem 298 (5), 101857 (2022)
   PUBMED   35337798
  REMARK    GeneRIF: The transmembrane adapter SCIMP recruits tyrosine kinase
            Syk to phosphorylate Toll-like receptors to mediate selective
            inflammatory outputs.
REFERENCE   4  (bases 1 to 1055)
  AUTHORS   Curson,J.E., Luo,L., Liu,L., Burgess,B.J., Bokil,N.J., Wall,A.A.,
            Brdicka,T., Kapetanovic,R., Stow,J.L. and Sweet,M.J.
  TITLE     An alternative downstream translation start site in the non-TIR
            adaptor Scimp enables selective amplification of CpG DNA responses
            in mouse macrophages
  JOURNAL   Immunol Cell Biol 100 (4), 267-284 (2022)
   PUBMED   35201640
  REMARK    GeneRIF: An alternative downstream translation start site in the
            non-TIR adaptor Scimp enables selective amplification of CpG DNA
            responses in mouse macrophages.
REFERENCE   5  (bases 1 to 1055)
  AUTHORS   Lucas,R.M., Liu,L., Curson,J.E.B., Koh,Y.W.H., Tuladhar,N.,
            Condon,N.D., Das Gupta,K., Burgener,S.S., Schroder,K., Ingley,E.,
            Sweet,M.J., Stow,J.L. and Luo,L.
  TITLE     SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to
            direct pro-inflammatory signaling in TLR-activated macrophages
  JOURNAL   Cell Rep 36 (10), 109662 (2021)
   PUBMED   34496234
REFERENCE   6  (bases 1 to 1055)
  AUTHORS   Luo,L., Tong,S.J., Wall,A.A., Khromykh,T., Sweet,M.J. and Stow,J.L.
  TITLE     Development of SH2 probes and pull-down assays to detect
            pathogen-induced, site-specific tyrosine phosphorylation of the TLR
            adaptor SCIMP
  JOURNAL   Immunol Cell Biol 95 (6), 564-570 (2017)
   PUBMED   28290451
REFERENCE   7  (bases 1 to 1055)
  AUTHORS   Luo,L., Bokil,N.J., Wall,A.A., Kapetanovic,R., Lansdaal,N.M.,
            Marceline,F., Burgess,B.J., Tong,S.J., Guo,Z., Alexandrov,K.,
            Ross,I.L., Hibbs,M.L., Stow,J.L. and Sweet,M.J.
  TITLE     SCIMP is a transmembrane non-TIR TLR adaptor that promotes
            proinflammatory cytokine production from macrophages
  JOURNAL   Nat Commun 8, 14133 (2017)
   PUBMED   28098138
  REMARK    GeneRIF: In macrophages, SCIMP is constitutively associated with
            the Lyn tyrosine kinase, is required for tyrosine phosphorylation
            of TLR4, and facilitates TLR-inducible production of the IL-6 and
            IL-12p40.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1055)
  AUTHORS   Kralova,J., Fabisik,M., Pokorna,J., Skopcova,T., Malissen,B. and
            Brdicka,T.
  TITLE     The Transmembrane Adaptor Protein SCIMP Facilitates Sustained
            Dectin-1 Signaling in Dendritic Cells
  JOURNAL   J Biol Chem 291 (32), 16530-16540 (2016)
   PUBMED   27288407
  REMARK    GeneRIF: SCIMP is strongly phosphorylated after Dectin-1
            stimulation and that it participates in signal transduction
            downstream of this important pattern recognition receptor.
REFERENCE   9  (bases 1 to 1055)
  AUTHORS   Draber,P., Vonkova,I., Stepanek,O., Hrdinka,M., Kucova,M.,
            Skopcova,T., Otahal,P., Angelisova,P., Horejsi,V., Yeung,M.,
            Weiss,A. and Brdicka,T.
  TITLE     SCIMP, a transmembrane adaptor protein involved in major
            histocompatibility complex class II signaling
  JOURNAL   Mol Cell Biol 31 (22), 4550-4562 (2011)
   PUBMED   21930792
REFERENCE   10 (bases 1 to 1055)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK138818.1.
            
            On Apr 6, 2007 this sequence version replaced NM_001045526.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK138818.1, BY751379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1055              AK138818.1         2-1056
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1055
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /note="SLP adaptor and CSK interacting membrane protein"
                     /db_xref="GeneID:327957"
                     /db_xref="MGI:MGI:3610314"
     exon            1..86
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            87..210
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..551
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /note="transmembrane protein C17orf87 homolog"
                     /codon_start=1
                     /product="SLP adapter and CSK-interacting membrane
                     protein"
                     /protein_id="NP_001038991.1"
                     /db_xref="CCDS:CCDS24967.1"
                     /db_xref="GeneID:327957"
                     /db_xref="MGI:MGI:3610314"
                     /translation="MSWWRDNFWIILAMSIIFISLVLGLILYCVCRWQLRQGRNWEIA
                     KPSKQDGRDEEKMYENVLNSSPGQLPALPPRGSPFPGDLAPQEAPRQPSAWYSSVKKV
                     RNKKVFAISGSTEPENDYDDVEIPATTETQHSKTTPFWQAEVGLHSSF"
     exon            211..274
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            275..348
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            349..1055
                     /gene="Scimp"
                     /gene_synonym="A430084P05Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcctctcc ccagttgtgc ttgagtaaca ccctcagtcc acagctgtct ccccagctgc
       61 ttccagtgaa caccccggca gtctaggctc ccacagcaat gagttggtgg agggacaact
      121 tctggatcat cttagctatg tccatcatct tcatctccct ggtcctgggt ctcatcctgt
      181 actgtgtctg caggtggcag cttagacaag gcaggaactg ggaaattgct aagccctcaa
      241 aacaggatgg aagagatgaa gaaaagatgt atgagaatgt tcttaattct tcaccaggcc
      301 agttacctgc tctgccaccc aggggttcac cttttccagg agacctagcc ccacaggaag
      361 ctccaagaca accctcagct tggtactcat cagtgaagaa agttaggaac aagaaggtct
      421 ttgctatctc gggctccacc gagccagaaa atgattatga tgatgttgag attccagcaa
      481 ccaccgaaac ccagcactct aaaaccacac ctttttggca agctgaagtg ggtttacaca
      541 gctcgtttta gaatactcta gaatagccgg attataacac aagcacttcc taatccccag
      601 aggaagccac ctcagccatg tgaaagctac agcagaagac aggacagctt gatgttcccg
      661 aggctccaga tgtttctgtt gctccagatg tttctgctgc tccagatgtt tctgttgctc
      721 caaatatttc tgctgctcca gatgtttctg ttgctccaga tgtttctgtt gctccagatg
      781 ctcctgttgc tccagatgct cctgatgttt ctgacactgc agaagctcta ccccaagatt
      841 ctgaggatgt ggccttggca cctttgtgga ggaagtttcc ttagtgcaga ccactgggcc
      901 tgtgagaact gactcatttc tcaacatttt ctttcgttcc ctgggtgaat gtagctgtaa
      961 ggcagtgact ctcaaccttc ctaatgcagg gatccttcaa tacaattcct tatttgtggt
     1021 gatcctcaac cataaaatta ttttgttgct acttc
//
