LOCUS       NM_001113421            2219 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus schwannomin interacting protein 1 (Schip1), transcript
            variant 3, mRNA.
ACCESSION   NM_001113421
VERSION     NM_001113421.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2219)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2219)
  AUTHORS   Martin,P.M., Cifuentes-Diaz,C., Devaux,J., Garcia,M., Bureau,J.,
            Thomasseau,S., Klingler,E., Girault,J.A. and Goutebroze,L.
  TITLE     Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a
            Multipartner Ankyrin- and Spectrin-binding Protein Involved in the
            Organization of Nodes of Ranvier
  JOURNAL   J Biol Chem 292 (6), 2441-2456 (2017)
   PUBMED   27979964
  REMARK    GeneRIF: work reveals that IQCJ-SCHIP1 interacts with several major
            nodal proteins, and we suggest that it contributes to a higher
            organizational level of the AnkG/betaIV-spectrin network critical
            for node integrity
REFERENCE   3  (bases 1 to 2219)
  AUTHORS   Li,A., Ma,S., Smith,S.M., Lee,M.K., Fischer,A., Borok,Z.,
            Bellusci,S., Li,C. and Minoo,P.
  TITLE     Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast
            cell fate
  JOURNAL   BMC Biol 14, 19 (2016)
   PUBMED   26984772
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2219)
  AUTHORS   Papandreou,M.J., Vacher,H., Fache,M.P., Klingler,E.,
            Rueda-Boroni,F., Ferracci,G., Debarnot,C., Piperoglou,C., Garcia
            Del Cano,G., Goutebroze,L. and Dargent,B.
  TITLE     CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1
            association with AnkG contributes to the maintenance of the axon
            initial segment
  JOURNAL   J Neurochem 134 (3), 527-537 (2015)
   PUBMED   25950943
  REMARK    GeneRIF: CK2-regulated IQJC-SCHIP-1 association with AnkG
            contributes to axon initial segment maintenance.
REFERENCE   5  (bases 1 to 2219)
  AUTHORS   Klingler,E., Martin,P.M., Garcia,M., Moreau-Fauvarque,C., Falk,J.,
            Chareyre,F., Giovannini,M., Chedotal,A., Girault,J.A. and
            Goutebroze,L.
  TITLE     The cytoskeleton-associated protein SCHIP1 is involved in axon
            guidance, and is required for piriform cortex and anterior
            commissure development
  JOURNAL   Development 142 (11), 2026-2036 (2015)
   PUBMED   25953347
  REMARK    GeneRIF: A new and early role for SCHIP1 during axon development
            and establishment of the anterior commissure, is identified.
REFERENCE   6  (bases 1 to 2219)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 2219)
  AUTHORS   Martin,P.M., Carnaud,M., Garcia del Cano,G., Irondelle,M.,
            Irinopoulou,T., Girault,J.A., Dargent,B. and Goutebroze,L.
  TITLE     Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late
            component of nodes of Ranvier and axon initial segments
  JOURNAL   J Neurosci 28 (24), 6111-6117 (2008)
   PUBMED   18550753
REFERENCE   8  (bases 1 to 2219)
  AUTHORS   Kwasnicka-Crawford,D.A., Carson,A.R. and Scherer,S.W.
  TITLE     IQCJ-SCHIP1, a novel fusion transcript encoding a
            calmodulin-binding IQ motif protein
  JOURNAL   Biochem Biophys Res Commun 350 (4), 890-899 (2006)
   PUBMED   17045569
REFERENCE   9  (bases 1 to 2219)
  AUTHORS   Miyamoto-Sato,E., Ishizaka,M., Horisawa,K., Tateyama,S.,
            Takashima,H., Fuse,S., Sue,K., Hirai,N., Masuoka,K. and Yanagawa,H.
  TITLE     Cell-free cotranslation and selection using in vitro virus for
            high-throughput analysis of protein-protein interactions and
            complexes
  JOURNAL   Genome Res 15 (5), 710-717 (2005)
   PUBMED   15867431
REFERENCE   10 (bases 1 to 2219)
  AUTHORS   Goutebroze,L., Brault,E., Muchardt,C., Camonis,J. and Thomas,G.
  TITLE     Cloning and characterization of SCHIP-1, a novel protein
            interacting specifically with spliced isoforms and naturally
            occurring mutant NF2 proteins
  JOURNAL   Mol Cell Biol 20 (5), 1699-1712 (2000)
   PUBMED   10669747
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093360.7, AK083464.1, BC060529.1 and BY616163.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c, also known as
            Schip-1a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU163407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-206               AC093360.7         133032-133237       c
            207-1790            AK083464.1         33-1616
            1791-2201           BC060529.1         1131-1541
            2202-2219           BY616163.1         406-423
FEATURES             Location/Qualifiers
     source          1..2219
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 31.44 cM"
     gene            1..2219
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /note="schwannomin interacting protein 1"
                     /db_xref="GeneID:30953"
                     /db_xref="MGI:MGI:1353557"
     exon            1..206
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1595
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /note="isoform c is encoded by transcript variant 3;
                     neurofibromatosis 2 interacting protein"
                     /codon_start=1
                     /product="schwannomin-interacting protein 1 isoform c"
                     /protein_id="NP_001106892.1"
                     /db_xref="CCDS:CCDS50926.1"
                     /db_xref="GeneID:30953"
                     /db_xref="MGI:MGI:1353557"
                     /translation="MERSEQRVRAAWDCDPGKQADRDYREDGMDLGSDAGSSSSSRAS
                     SQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEE
                     EEDDRGYRDDGCPAREPGDVSARIGSSGSGSRSAATTMPSPMPNGNLHPHDPQDLRHN
                     GNVVVAGRPNASRVPRRPIQKTQPPGSRRGGRNRASGGLCLQPPDGGTRVPEEPPAPP
                     MDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIY
                     TSCSKSGKPSLSARLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSS
                     SYSDRDTTEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPV
                     ADLLPHMPHISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRD
                     ELHTEQDAMLVDIEDLTRHAESQQKHMAEKMPAK"
     exon            207..890
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1009
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1127
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1325
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1449
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1543
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2219
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2173..2178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /note="hexamer: AATAAA"
     polyA_site      2201
                     /gene="Schip1"
                     /gene_synonym="Nf2ip; Schip-1"
                     /note="major polyA site"
ORIGIN      
        1 cacacctcgc ggcatgcgct gtagaaactc tctaggtaac tttacctgct aacaaagtgg
       61 ctctctatgg attcctttcc aaggcggttt cagtgaaccg ctcttccttc tcaaatggac
      121 gagggtagct cttcagcacc atggagaggt ctgagcagcg cgtaagggcc gcgtgggact
      181 gcgacccagg caagcaagct gacagagatt accgagagga tgggatggat ctaggcagtg
      241 acgccggcag cagcagcagc agccgcgcca gctcacaatc caactccacc aaagtgaccc
      301 cttgctccga gtgcaaatcc tcatcgtcgc cggggggtag cttggacttg gtgtctgctc
      361 tggaagacta tgaagagccc ttcccggtct accagaagaa ggtgattgat gagtgggctc
      421 cggaggagga cggggaggag gaggaagagg aggacgatcg agggtatcgg gatgacggct
      481 gtccggcccg ggagccgggg gacgtgagcg ccaggatcgg cagcagcggc agcgggagca
      541 ggagcgccgc caccaccatg ccgtccccga tgcctaacgg caacctccat ccgcacgacc
      601 ctcaagacct caggcacaat ggcaacgtgg tggtagctgg ccggccgaac gcctctcggg
      661 ttccccggcg acccatccag aagacccagc ctccagggag ccggcgcgga ggccgaaacc
      721 gggcatctgg gggcctctgc cttcagccac cggacggcgg gacgcgggtc ccggaagaac
      781 cccctgcgcc cccaatggac tgggaggcat tggaaaagca tctggccggg ctgcagttcc
      841 gggagcagga ggtgcgaaac cagggtcagg cgaggaccaa ctccacctct gcacagaaga
      901 atgagagaga gtctatcaga cagaagttgg cactcggaag cttctttgac gatggcccag
      961 gaatctatac cagctgcagc aaaagtggga agccaagcct ttctgcaaga ctacagagcg
     1021 ggatgaacct ccagatatgc tttgtcaatg acagcggcag tgacaaggac agcgatgcag
     1081 atgacagtaa gacggaaacc agcttggaca cgcccttgtc ccccatgagc aagcagagtt
     1141 cttcctattc ggatagagac acaactgagg aggagtctga atccctggat gacatggact
     1201 tcctcacaag gcaaaagaag ctacaagctg aagccaaaat ggctctggcc atggccaaac
     1261 caatggccaa aatgcaagta gaagtggaaa aacagaacag gaaaaagtct cccgtcgctg
     1321 atcttctccc acacatgcct cacataagcg aatgtttgat gaaaagaagc ttaaagccca
     1381 ccgacctgag agacatgact atcgggcagc tacaagtgat cgtcaatgac ctccactccc
     1441 agattgaaag tttgaatgaa gagttggtcc agctgctcct tattcgagat gagctgcaca
     1501 cagaacaaga tgccatgctg gtggacattg aagacttgac tagacacgct gagagtcagc
     1561 agaagcacat ggctgagaaa atgcccgcga agtgaaagag agccatccac cagagaacaa
     1621 gctagaattt attttgcttc tgtggtcgta aaaattgctg ttgctaaagg tggttccgaa
     1681 acagacatca gtgttagtca ttggtaacgt ccgagcttac tgtcccgtga ctggccttcg
     1741 cttcttaatt tattttaatt tctttctttc cttttttttt tttttttttt tactcttgcc
     1801 acttactatc aggcctttta ataaaacatt gttacaagaa ctgtacagta cttaaaccac
     1861 caacaaccgt ggataagcag agggtagttt tgactttgtt tttgtttaga gactttaagt
     1921 tggagcagta ttttaccatt gactgtttca ttcttcactg tagctttgaa gaggaactgt
     1981 aaatgacggt gctatacaag tcaaaataca tgcctgcctc gtagtgaagt cgtagctctc
     2041 catactacgt atattttaat cagttttcaa cattttgtga atgttgacta cctgaggttt
     2101 attcttagat gtgctattaa cattctgtcg gatccacatg gttccttggg agttttatgt
     2161 ataaatatgt aaaataaaaa ttaaaacttt gtttcatatg atacgtcctt ttgctcact
//
