LOCUS       NM_145399               1425 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus secretagogin, EF-hand calcium binding protein (Scgn),
            mRNA.
ACCESSION   NM_145399
VERSION     NM_145399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Wang,Q.W., Qin,J., Chen,Y.F., Tu,Y., Xing,Y.Y., Wang,Y., Yang,L.Y.,
            Lu,S.Y., Geng,L., Shi,W., Yang,Y. and Yao,J.
  TITLE     16p11.2 CNV gene Doc2alpha functions in neurodevelopment and social
            behaviors through interaction with Secretagogin
  JOURNAL   Cell Rep 42 (7), 112691 (2023)
   PUBMED   37354460
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Hamnett,R., Dershowitz,L.B., Sampathkumar,V., Wang,Z.,
            Gomez-Frittelli,J., De Andrade,V., Kasthuri,N., Druckmann,S. and
            Kaltschmidt,J.A.
  TITLE     Regional cytoarchitecture of the adult and developing mouse enteric
            nervous system
  JOURNAL   Curr Biol 32 (20), 4483-4492 (2022)
   PUBMED   36070775
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Biancolin,A.D., Srikrishnaraj,A., Jeong,H., Martchenko,A. and
            Brubaker,P.L.
  TITLE     The Cytoskeletal Transport Protein, Secretagogin, Is Essential for
            Diurnal Glucagon-like Peptide-1 Secretion in Mice
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   36036556
  REMARK    GeneRIF: The Cytoskeletal Transport Protein, Secretagogin, Is
            Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice.
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Chidananda,A.H., Khandelwal,R., Jamkhindikar,A., Pawar,A.D.,
            Sharma,A.K. and Sharma,Y.
  TITLE     Secretagogin is a Ca2+-dependent stress-responsive chaperone that
            may also play a role in aggregation-based proteinopathies
  JOURNAL   J Biol Chem 298 (9), 102285 (2022)
   PUBMED   35870554
  REMARK    GeneRIF: Secretagogin is a Ca(2+)-dependent stress-responsive
            chaperone that may also play a role in aggregation-based
            proteinopathies.
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Katoh,K., Omori,Y., Onishi,A., Sato,S., Kondo,M. and Furukawa,T.
  TITLE     Blimp1 suppresses Chx10 expression in differentiating retinal
            photoreceptor precursors to ensure proper photoreceptor development
  JOURNAL   J Neurosci 30 (19), 6515-6526 (2010)
   PUBMED   20463215
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Mulder,J., Zilberter,M., Spence,L., Tortoriello,G., Uhlen,M.,
            Yanagawa,Y., Aujard,F., Hokfelt,T. and Harkany,T.
  TITLE     Secretagogin is a Ca2+-binding protein specifying subpopulations of
            telencephalic neurons
  JOURNAL   Proc Natl Acad Sci U S A 106 (52), 22492-22497 (2009)
   PUBMED   20018755
  REMARK    GeneRIF: scgn is a marker of neuroblasts commuting in the rostral
            migratory stream. Terminally differentiated neurons in the
            olfactory bulb retain scgn expression, with scgn being present in
            periglomerular cells and granular layer interneurons.
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Arlotta,P., Molyneaux,B.J., Jabaudon,D., Yoshida,Y. and
            Macklis,J.D.
  TITLE     Ctip2 controls the differentiation of medium spiny neurons and the
            establishment of the cellular architecture of the striatum
  JOURNAL   J Neurosci 28 (3), 622-632 (2008)
   PUBMED   18199763
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Rogstam,A., Linse,S., Lindqvist,A., James,P., Wagner,L. and
            Berggard,T.
  TITLE     Binding of calcium ions and SNAP-25 to the hexa EF-hand protein
            secretagogin
  JOURNAL   Biochem J 401 (1), 353-363 (2007)
   PUBMED   16939418
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC016093.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016093.1, AK148468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.01 cM"
     gene            1..1425
                     /gene="Scgn"
                     /note="secretagogin, EF-hand calcium binding protein"
                     /db_xref="GeneID:214189"
                     /db_xref="MGI:MGI:2384873"
     exon            1..263
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..1012
                     /gene="Scgn"
                     /codon_start=1
                     /product="secretagogin"
                     /protein_id="NP_663374.1"
                     /db_xref="CCDS:CCDS26375.1"
                     /db_xref="GeneID:214189"
                     /db_xref="MGI:MGI:2384873"
                     /translation="MDNARRKTPARLDAACFWQIWQRFDKEEKGYIRETELDAFFDHL
                     LAKSGTEDTLMEENVQKVKEQLMTSHNVSKEGRILMKELASMFLSEDENFLLFFRLET
                     PLDNSVEFMQIWRKYDADSSGFISAAELCNFLRDLFLHHKKNISEAELEEYTSTMMKI
                     FDKNKDGRLDLNDLARILALQENFLLQFKMDASSTEERKRDFEKIFAHYDVSKTGALE
                     GPEVDGFVKDMMELVQPSISGVDLDKFREILLRHCDVNKDGKIQKSELALCLGLKINP
                     "
     exon            264..334
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            335..427
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            428..517
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            518..574
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            575..652
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            653..708
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            709..754
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            755..814
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            815..883
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1412
                     /gene="Scgn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1000..1005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scgn"
                     /note="hexamer: AATAAA"
     polyA_site      1022
                     /gene="Scgn"
                     /note="major polyA site"
     regulatory      1389..1394
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scgn"
                     /note="hexamer: AATAAA"
     polyA_site      1412
                     /gene="Scgn"
ORIGIN      
        1 gcaggaggac gcctgcgggt tgcctcctgg agcctgacat ctagactgaa gactgctcag
       61 cgacaccaac gagcccggac gccctcgagc ttgccttgcc cactggtacc tagctagaga
      121 gggaggaagt ggaccgaaga gtcgggaaat actgctaggc gagtttaccc acatcagcac
      181 catggacaac gcacgcagaa aaactccagc tcggctggat gctgcctgct tctggcagat
      241 ctggcagcgc ttcgacaagg aagaaaaagg ttacataaga gagacagagc tggatgcctt
      301 ctttgatcat ttgctggcaa aatctggcac tgaggacact cttatggaag aaaatgtgca
      361 gaaagtgaaa gaacagttga tgaccagcca caacgtctct aaggaaggcc gcatactgat
      421 gaaagagctt gccagtatgt tcttatctga agatgaaaat ttcctcctgt tctttcgcct
      481 ggaaactccc ttggataaca gtgtagagtt tatgcagatt tggcgcaaat acgatgcgga
      541 cagcagtggt ttcatatcag ctgctgagct ttgtaacttt cttcgagacc ttttcctcca
      601 ccacaaaaag aacatttccg aggctgaact ggaagagtat actagcacca tgatgaagat
      661 ctttgacaaa aataaagatg gacgtttgga tcttaatgac ttggcaagga ttctggcgct
      721 ccaggaaaac ttccttcttc agtttaaaat ggatgcttct tctactgaag aaaggaagag
      781 ggactttgag aaaatctttg cccattacga tgttagtaaa actggagccc tggaaggccc
      841 agaagtggat ggatttgtca aagatatgat ggagctggtc cagcccagca tcagtggtgt
      901 ggatctggat aagttccggg agattctgct tcgccattgc gatgtcaaca aggatggaaa
      961 gatccagaag tctgagctgg cactgtgtct tgggctaaaa ataaacccct gatccccaac
     1021 tactctgctc tccacttaag tgtctgtgtt cctgctgtga gaagtgtgtt tgtgctttgc
     1081 tcttggggac ccagttaatg gaccttctcc ctgacagttt ggtactcttg atggagggag
     1141 tggccctagg gtgctgcttc cagaggcagc catgatcttg tcccatggga agccccatac
     1201 agcttcttcc atgtttgttc cttgaccttg gtctatctcc tcaagggcct cattttacct
     1261 gctctgttca accttcccta tcgcctggtg atccattcta ccatcttctg cttgtccttg
     1321 agctttctgc tcagttagag tgtcacctgt atcgtgctgt cacatgtaca aatatgtctt
     1381 cttgtggaaa taaagctgtg gtcaagaata aaaaaaaaaa aaaaa
//
