LOCUS       NM_001289644             549 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus secretoglobin, family 3A, member 2 (Scgb3a2),
            transcript variant 2, mRNA.
ACCESSION   NM_001289644 XM_006525525
VERSION     NM_001289644.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 549)
  AUTHORS   Xu,L., Tan,C., Barr,J., Talaba,N., Verheyden,J., Chin,J.S.,
            Gaboyan,S., Kasaraneni,N., Elgamal,R.M., Gaulton,K.J., Lin,G.,
            Afshar,K., Golts,E., Meier,A., Crotty Alexander,L.E., Borok,Z.,
            Shen,Y., Chung,W.K., McCulley,D.J. and Sun,X.
  TITLE     Context-dependent roles of mitochondrial LONP1 in orchestrating the
            balance between airway progenitor versus progeny cells
  JOURNAL   Cell Stem Cell 31 (10), 1465-1483 (2024)
   PUBMED   39181129
REFERENCE   2  (bases 1 to 549)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 549)
  AUTHORS   Beppu,A.K., Zhao,J., Yao,C., Carraro,G., Israely,E., Coelho,A.L.,
            Drake,K., Hogaboam,C.M., Parks,W.C., Kolls,J.K. and Stripp,B.R.
  TITLE     Epithelial plasticity and innate immune activation promote lung
            tissue remodeling following respiratory viral infection
  JOURNAL   Nat Commun 14 (1), 5814 (2023)
   PUBMED   37726288
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 549)
  AUTHORS   Li,Q., Jiao,J., Heng,Y., Lu,Q., Zheng,Y., Li,H., Cai,J., Mei,M. and
            Bao,S.
  TITLE     Prmt5 promotes ciliated cell specification of airway epithelial
            progenitors via transcriptional inhibition of Tp63
  JOURNAL   J Biol Chem 299 (8), 104964 (2023)
   PUBMED   37364687
REFERENCE   5  (bases 1 to 549)
  AUTHORS   Zhou,Y., Yang,Y., Guo,L., Qian,J., Ge,J., Sinner,D., Ding,H.,
            Califano,A. and Cardoso,W.V.
  TITLE     Airway basal cells show regionally distinct potential to undergo
            metaplastic differentiation
  JOURNAL   Elife 11, e80083 (2022)
   PUBMED   36178196
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 549)
  AUTHORS   Heinzmann,A., Dietrich,H. and Deichmann,K.A.
  TITLE     Association of uteroglobulin-related protein 1 with bronchial
            asthma
  JOURNAL   Int Arch Allergy Immunol 131 (4), 291-295 (2003)
   PUBMED   12915772
  REMARK    GeneRIF: UGRP1 does not play a major role in the development of
            bronchial asthma in our Caucasian population.
REFERENCE   7  (bases 1 to 549)
  AUTHORS   Reynolds,S.D., Reynolds,P.R., Pryhuber,G.S., Finder,J.D. and
            Stripp,B.R.
  TITLE     Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in
            mouse and human airways
  JOURNAL   Am J Respir Crit Care Med 166 (11), 1498-1509 (2002)
   PUBMED   12406855
REFERENCE   8  (bases 1 to 549)
  AUTHORS   Porter,D., Lahti-Domenici,J., Torres-Arzayus,M., Chin,L. and
            Polyak,K.
  TITLE     Expression of high in normal-1 (HIN-1) and uteroglobin related
            protein-1 (UGRP-1) in adult and developing tissues
  JOURNAL   Mech Dev 114 (1-2), 201-204 (2002)
   PUBMED   12175512
  REMARK    GeneRIF: Highest HIN-1 and UGRP-1 expression is detected in the
            lung, while lower level HIN-1 expression is also detected in the
            stomach, heart, small intestine, uterine and mammary glands
REFERENCE   9  (bases 1 to 549)
  AUTHORS   Niimi,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Srisodsai,A.,
            Zimonjic,D.B., Keck-Waggoner,C.L., Popescu,N.C. and Kimura,S.
  TITLE     Cloning, expression, and chromosomal localization of the mouse gene
            (Scgb3a1, alias Ugrp2) that encodes a member of the novel
            uteroglobin-related protein gene family
  JOURNAL   Cytogenet Genome Res 97 (1-2), 120-127 (2002)
   PUBMED   12438750
REFERENCE   10 (bases 1 to 549)
  AUTHORS   Niimi,T., Keck-Waggoner,C.L., Popescu,N.C., Zhou,Y., Levitt,R.C.
            and Kimura,S.
  TITLE     UGRP1, a uteroglobin/Clara cell secretory protein-related protein,
            is a novel lung-enriched downstream target gene for the
            T/EBP/NKX2.1 homeodomain transcription factor
  JOURNAL   Mol Endocrinol 15 (11), 2021-2036 (2001)
   PUBMED   11682631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY120182.1, AK136373.1 and AF274960.1.
            
            On Jan 25, 2014 this sequence version replaced XM_006525525.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. This
            results in a shorter protein (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061046.1, AK136373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                BY120182.1         2-24
            24-537              AK136373.1         2-515
            538-549             AF274960.1         578-589
FEATURES             Location/Qualifiers
     source          1..549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 23.49 cM"
     gene            1..549
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /note="secretoglobin, family 3A, member 2"
                     /db_xref="GeneID:117158"
                     /db_xref="MGI:MGI:2153470"
     exon            1..172
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..393
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; pneumo secretory protein 1; uteroglobin related
                     protein 1"
                     /codon_start=1
                     /product="secretoglobin family 3A member 2 isoform 2
                     precursor"
                     /protein_id="NP_001276573.1"
                     /db_xref="CCDS:CCDS79640.1"
                     /db_xref="GeneID:117158"
                     /db_xref="MGI:MGI:2153470"
                     /translation="MKLVSIFLLVTIGICGYSATALLINRLPVVDKLPVPLDDIIPSF
                     DPLKMLLKTLGISVEHLVTGLKKCVDELGPEASEAVKKLLEALSHLV"
     exon            173..369
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..538
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /note="hexamer: AATAAA"
     polyA_site      538
                     /gene="Scgb3a2"
                     /gene_synonym="LuLeu1; Pnsp1; UGRP1; Utgrp1"
                     /note="major polyA site"
ORIGIN      
        1 agtacctctg aggaaaagca gccatcaggt gacagcgagc agaactattg acaccgtgat
       61 tttgttgggc tttctgactg cattccaaag tcccggaaaa catcacaggc accagctatg
      121 aagctggtat ctatctttct gctggtgacc attggtattt gtggttattc tgccactgcc
      181 cttctcatca accgtctccc tgttgttgac aaattacctg tacctttgga cgacattatt
      241 ccctcatttg atcccttgaa gatgcttctg aaaaccctgg gcatttctgt agaacatctg
      301 gtgacaggac tgaagaagtg tgtggacgag ctgggaccag aggcttccga ggccgtgaag
      361 aagcttctgg aggctctttc acacctggta taaaatcttc ataaagagat ttaaggaagg
      421 agtatgaaaa gaaggatttg ctcactctgg ctggctggat ctctcattct atcatttgta
      481 aactgaatgt cccagagttt aaggagtcta gaaaagtatg aataaagcaa tgaaaagaaa
      541 aaaaaaaaa
//
