LOCUS       NM_054037                540 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1),
            transcript variant 1, mRNA.
ACCESSION   NM_054037
VERSION     NM_054037.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 540)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 540)
  AUTHORS   Yin,W., Liontos,A., Koepke,J., Ghoul,M., Mazzocchi,L., Liu,X.,
            Lu,C., Wu,H., Fysikopoulos,A., Sountoulidis,A., Seeger,W.,
            Ruppert,C., Gunther,A., Stainier,D.Y.R. and Samakovlis,C.
  TITLE     An essential function for autocrine hedgehog signaling in
            epithelial proliferation and differentiation in the trachea
  JOURNAL   Development 149 (3) (2022)
   PUBMED   35112129
REFERENCE   3  (bases 1 to 540)
  AUTHORS   Naizhen,X., Kido,T., Yokoyama,S., Linnoila,R.I. and Kimura,S.
  TITLE     Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1,
            SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia
  JOURNAL   J Histochem Cytochem 67 (6), 453-463 (2019)
   PUBMED   30768367
  REMARK    GeneRIF: Expression of Three Secretoglobin Proteins, SCGB1A1,
            SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia
REFERENCE   4  (bases 1 to 540)
  AUTHORS   Raffay,T.M., Locy,M.L., Hill,C.L., Jindal,N.S., Rogers,L.K.,
            Welty,S.E. and Tipple,T.E.
  TITLE     Neonatal hyperoxic exposure persistently alters lung secretoglobins
            and annexin A1
  JOURNAL   Biomed Res Int 2013, 408485 (2013)
   PUBMED   24187664
  REMARK    GeneRIF: Neonatal hyperoxia followed by RA recovery was associated
            with decreased lung CCSP and SCGB3A1 protein but not mRNA
            expression.
REFERENCE   5  (bases 1 to 540)
  AUTHORS   Yamada,A. and Kimura,S.
  TITLE     Induction of uteroglobin-related protein 2 (Ugrp2) expression by
            EGF and TGFalpha
  JOURNAL   FEBS Lett 579 (10), 2221-2225 (2005)
   PUBMED   15811345
  REMARK    GeneRIF: EGF-induced increase of Ugrp2 occurred at the
            transcriptional level that required the EGF receptor and the
            activation of the ERK-MAPK and phosphoinositide-3 kinase pathways
REFERENCE   6  (bases 1 to 540)
  AUTHORS   Reynolds,S.D., Reynolds,P.R., Pryhuber,G.S., Finder,J.D. and
            Stripp,B.R.
  TITLE     Secretoglobins SCGB3A1 and SCGB3A2 define secretory cell subsets in
            mouse and human airways
  JOURNAL   Am J Respir Crit Care Med 166 (11), 1498-1509 (2002)
   PUBMED   12406855
REFERENCE   7  (bases 1 to 540)
  AUTHORS   Porter,D., Lahti-Domenici,J., Torres-Arzayus,M., Chin,L. and
            Polyak,K.
  TITLE     Expression of high in normal-1 (HIN-1) and uteroglobin related
            protein-1 (UGRP-1) in adult and developing tissues
  JOURNAL   Mech Dev 114 (1-2), 201-204 (2002)
   PUBMED   12175512
  REMARK    GeneRIF: Highest HIN-1 and UGRP-1 expression is detected in the
            lung, while lower level HIN-1 expression is also detected in the
            stomach, heart, small intestine, uterine and mammary glands
REFERENCE   8  (bases 1 to 540)
  AUTHORS   Niimi,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A., Srisodsai,A.,
            Zimonjic,D.B., Keck-Waggoner,C.L., Popescu,N.C. and Kimura,S.
  TITLE     Cloning, expression, and chromosomal localization of the mouse gene
            (Scgb3a1, alias Ugrp2) that encodes a member of the novel
            uteroglobin-related protein gene family
  JOURNAL   Cytogenet Genome Res 97 (1-2), 120-127 (2002)
   PUBMED   12438750
  REMARK    GeneRIF: genomic structure and expression patterns of Ugrp2 and its
            alternative spliced form were characterized
REFERENCE   9  (bases 1 to 540)
  AUTHORS   Niimi,T., Keck-Waggoner,C.L., Popescu,N.C., Zhou,Y., Levitt,R.C.
            and Kimura,S.
  TITLE     UGRP1, a uteroglobin/Clara cell secretory protein-related protein,
            is a novel lung-enriched downstream target gene for the
            T/EBP/NKX2.1 homeodomain transcription factor
  JOURNAL   Mol Endocrinol 15 (11), 2021-2036 (2001)
   PUBMED   11682631
REFERENCE   10 (bases 1 to 540)
  AUTHORS   Krop,I.E., Sgroi,D., Porter,D.A., Lunetta,K.L., LeVangie,R.,
            Seth,P., Kaelin,C.M., Rhei,E., Bosenberg,M., Schnitt,S.,
            Marks,J.R., Pagon,Z., Belina,D., Razumovic,J. and Polyak,K.
  TITLE     HIN-1, a putative cytokine highly expressed in normal but not
            cancerous mammary epithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 98 (17), 9796-9801 (2001)
   PUBMED   11481438
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV578532.1 and AF313456.1.
            
            On Jan 17, 2013 this sequence version replaced NM_054037.1.
            
            Summary: This gene encodes a small secreted protein that may
            function in the inhibition of cell growth. Expression of the
            related gene in humans is downregulated via DNA methylation in
            breast cancers and other tumor types. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1, also known as type A)
            represents the shorter transcript and encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF313456.1, W20910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AV578532.1         1-15
            16-540              AF313456.1         1-525
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.75 cM"
     gene            1..540
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /note="secretoglobin, family 3A, member 1"
                     /db_xref="GeneID:68662"
                     /db_xref="MGI:MGI:1915912"
     exon            1..121
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..381
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; uteroglobin related protein 2; pneumo secretory
                     protein 2; cytokine HIN-1; high in normal 1"
                     /codon_start=1
                     /product="secretoglobin family 3A member 1 isoform a
                     precursor"
                     /protein_id="NP_473378.1"
                     /db_xref="CCDS:CCDS24619.1"
                     /db_xref="GeneID:68662"
                     /db_xref="MGI:MGI:1915912"
                     /translation="MKLTTTFLVLCVALLSDSGVAFFMDSLAKPAVEPVAALAPAAEA
                     VAGAVPSLPLSHLAILRFILASMGIPLDPLIEGSRKCVTELGPEAVGAVKSLLGVLTM
                     FG"
     exon            122..357
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            358..508
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      488..493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /note="hexamer: AATAAA"
     polyA_site      508
                     /gene="Scgb3a1"
                     /gene_synonym="HIN-1; LuLeu2; Pnsp2; UGRP2; Utgrp2"
                     /note="major polyA site"
ORIGIN      
        1 tcggagccag gcttcaggaa gattgtctta taggtcctgg gagcatcttc tgagactcat
       61 tctaccatga agcttaccac cacctttcta gtgctctgtg tggctctgct cagtgactct
      121 ggtgttgctt tcttcatgga ctcattggcc aagcctgcgg tagaacccgt ggccgccctt
      181 gctccagctg cagaggctgt ggcaggggct gtgcctagcc taccattaag ccacttggcc
      241 atcctgaggt tcatcctggc cagcatgggc atcccattgg atcctctcat agagggatcc
      301 aggaagtgtg tcaccgagct gggccctgag gctgtaggag ctgtgaagtc actgctgggg
      361 gtcctgacaa tgttcggttg aggggaacct gggaaaattc tgcctgacga gatgcctgac
      421 gagatatttt tctttaacaa gagctggaaa ccctgctgct cacacctttc tccttcctct
      481 gtaccttaat aaacccagct agaacagcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
