LOCUS       NM_009162               1227 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus secretogranin V (Scg5), mRNA.
ACCESSION   NM_009162
VERSION     NM_009162.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1227)
  AUTHORS   Jarvela TS, Womack T, Georgiou P, Gould TD, Eriksen JL and Lindberg
            I.
  TITLE     7B2 chaperone knockout in APP model mice results in reduced plaque
            burden
  JOURNAL   Sci Rep 8 (1), 9813 (2018)
   PUBMED   29955078
  REMARK    GeneRIF: brain 7B2 can impact Abeta disposition in a manner that
            facilitates plaque formation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1227)
  AUTHORS   Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L,
            Mai M, Beckers A, Kracht M and Gossler A.
  TITLE     Identification of FOXJ1 effectors during ciliogenesis in the foetal
            respiratory epithelium and embryonic left-right organiser of the
            mouse
  JOURNAL   Dev Biol 423 (2), 170-188 (2017)
   PUBMED   27914912
REFERENCE   3  (bases 1 to 1227)
  AUTHORS   Arnes L, Akerman I, Balderes DA, Ferrer J and Sussel L.
  TITLE     betalinc1 encodes a long noncoding RNA that regulates islet
            beta-cell formation and function
  JOURNAL   Genes Dev 30 (5), 502-507 (2016)
   PUBMED   26944677
REFERENCE   4  (bases 1 to 1227)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1227)
  AUTHORS   Kanaya T, Hase K, Takahashi D, Fukuda S, Hoshino K, Sasaki I, Hemmi
            H, Knoop KA, Kumar N, Sato M, Katsuno T, Yokosuka O, Toyooka K,
            Nakai K, Sakamoto A, Kitahara Y, Jinnohara T, McSorley SJ, Kaisho
            T, Williams IR and Ohno H.
  TITLE     The Ets transcription factor Spi-B is essential for the
            differentiation of intestinal microfold cells
  JOURNAL   Nat Immunol 13 (8), 729-736 (2012)
   PUBMED   22706340
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1227)
  AUTHORS   Chiannilkulchai N, Pasturaud P, Richard I, Auffray C and Beckmann
            JS.
  TITLE     A primary expression map of the chromosome 15q15 region containing
            the recessive form of limb-girdle muscular dystrophy (LGMD2A) gene
  JOURNAL   Hum Mol Genet 4 (4), 717-725 (1995)
   PUBMED   7633422
REFERENCE   7  (bases 1 to 1227)
  AUTHORS   Marcinkiewicz M, Touraine P and Chretien M.
  TITLE     Pan-neuronal mRNA expression of the secretory polypeptide 7B2
  JOURNAL   Neurosci Lett 177 (1-2), 91-94 (1994)
   PUBMED   7824189
REFERENCE   8  (bases 1 to 1227)
  AUTHORS   Paquet L, Rondeau N, Seidah NG, Lazure C, Chretien M and Mbikay M.
  TITLE     Immunological identification and sequence characterization of a
            peptide derived from the processing of neuroendocrine protein 7B2
  JOURNAL   FEBS Lett 294 (1-2), 23-26 (1991)
   PUBMED   1743287
REFERENCE   9  (bases 1 to 1227)
  AUTHORS   Mattei MG, Mbikay M, Sylla BS, Lenoir G, Mattei JF, Seidah NG and
            Chretien M.
  TITLE     Assignment of the gene for neuroendocrine protein 7B2 (SGNE1 locus)
            to mouse chromosome region 2[E3-F3] and to human chromosome region
            15q11-q15
  JOURNAL   Genomics 6 (3), 436-440 (1990)
   PUBMED   2328988
REFERENCE   10 (bases 1 to 1227)
  AUTHORS   Mbikay M, Grant SG, Sirois F, Tadros H, Skowronski J, Lazure C,
            Seidah NG, Hanahan D and Chretien M.
  TITLE     cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell
            tumors of transgenic mice
  JOURNAL   Int J Pept Protein Res 33 (1), 39-45 (1989)
   PUBMED   2542174
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK019337.1, AK161556.1 and BB025018.1.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_009162.4.
            
            On Nov 13, 2006 this sequence version replaced NM_009162.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161579.1, AK017481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AK019337.1         2-63
            63-1171             AK161556.1         2-1110
            1172-1227           BB025018.1         247-302
FEATURES             Location/Qualifiers
     source          1..1227
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.45 cM"
     gene            1..1227
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /note="secretogranin V"
                     /db_xref="GeneID:20394"
                     /db_xref="MGI:MGI:98289"
     exon            1..93
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            94..326
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..739
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /note="neuroendocrine protein 7B2; secretogranin-5;
                     secretory granule endocrine protein I; secretory granule
                     neuroendocrine protein 1, 7B2 protein"
                     /codon_start=1
                     /product="neuroendocrine protein 7B2 precursor"
                     /protein_id="NP_033188.3"
                     /db_xref="CCDS:CCDS16561.1"
                     /db_xref="GeneID:20394"
                     /db_xref="MGI:MGI:98289"
                     /translation="MASRLVSAMLSGLLFWLMFEWNPAFAYSPRTPDRVSETDIQRLL
                     HGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDN
                     IPKDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGL
                     GKWNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEAE"
     exon            327..476
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..589
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..643
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1227
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1156..1161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /note="putative"
     polyA_site      1171
                     /gene="Scg5"
                     /gene_synonym="7B2; Sgne-1; Sgne1"
                     /note="putative"
ORIGIN      
        1 ccgaggtttc ggagggaggt gacgcaggag ctatccagca cgtcagctcc ctgttttggc
       61 ctagattgca agaagctcgc ccgcggccac acggttaaaa atggcctcaa ggctggtctc
      121 tgctatgcta tctggccttt tgttttggtt gatgtttgag tggaatccag cattcgctta
      181 tagtccacgg acccctgacc gggtctcaga gacagacatc cagaggctgc ttcatggggt
      241 tatggagcag ctgggcattg ccaggccacg cgtggagtac ccggctcacc aggccatgaa
      301 tcttgttggg ccacagagca tcgaaggggg agctcacgag ggtcttcagc atctgggtcc
      361 ttttggcaac atccccaaca tagtggcaga gttgactggt gacaacattc ctaaggactt
      421 cagtgaggat caaggctacc cagaccctcc aaatccctgt cctcttggga aaactgctga
      481 tgatggatgt ctagaaaacg cccccgacac tgcagagttc agccgagaat tccagttaga
      541 ccagcacctt tttgatccag aacatgacta cccaggtttg ggcaagtgga acaagaaact
      601 cctttatgag aaaatgaagg gaggacagag gcggaagcgg aggagtgtca atccctatct
      661 acaaggaaag aggttggaca atgttgtggc aaagaaatct gtcccccact tctcagaaga
      721 ggagaaggaa gcagaataaa gagaagacag tatgtagaaa cccatccaat gcttatgtgc
      781 atgttcatag agcccgtgag tgacagcatg cattttacat atttatggat gaaaagcagc
      841 tgtccttgcc tccataccaa tgcctgtgct ttctgctaca ttagaataaa agctccttct
      901 ctttggggga tttttttgat gtggatctgc aagaaacatt acaattaaaa tgtatatgtc
      961 aagtataata aaaacacgga tatgaaatac tcagatttct tgcagttttg ggttatgctg
     1021 tttgggccaa gtctgtaaaa cgctagcatt tgattttgat tatgtagtgt atctagccct
     1081 tgggccttgt tacacaccaa taaagaagtt tgtactcaag cagagggggt gacacatctc
     1141 actctgctgc ttcttaataa atgtatgtgc gagcattggc ttgggaagtt tttatataac
     1201 agtataaaat caatttcttt gcttaat
//
