LOCUS       NM_009130               2207 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus secretogranin III (Scg3), transcript variant 1, mRNA.
ACCESSION   NM_009130
VERSION     NM_009130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Ji,L., Waduge,P., Wu,Y., Huang,C., Kaur,A., Oliveira,P., Tian,H.,
            Zhang,J., Stout,J.T., Weng,C.Y., Webster,K.A. and Li,W.
  TITLE     Secretogranin III Selectively Promotes Vascular Leakage in the Deep
            Vascular Plexus of Diabetic Retinopathy
  JOURNAL   Int J Mol Sci 24 (13), 10531 (2023)
   PUBMED   37445707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Ji,L., Waduge,P., Wan,W., Tian,H., Li,J., Zhang,J., Chen,R. and
            Li,W.
  TITLE     Comparative ligandomics implicates secretogranin III as a
            disease-restricted angiogenic factor in laser-induced choroidal
            neovascularization
  JOURNAL   FEBS J 289 (12), 3521-3534 (2022)
   PUBMED   35038348
  REMARK    GeneRIF: Comparative ligandomics implicates secretogranin III as a
            disease-restricted angiogenic factor in laser-induced choroidal
            neovascularization.
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Dai,C., Waduge,P., Ji,L., Huang,C., He,Y., Tian,H.,
            Zuniga-Sanchez,E., Bhatt,A., Pang,I.H., Su,G., Webster,K.A. and
            Li,W.
  TITLE     Secretogranin III stringently regulates pathological but not
            physiological angiogenesis in oxygen-induced retinopathy
  JOURNAL   Cell Mol Life Sci 79 (1), 63 (2022)
   PUBMED   35006382
  REMARK    GeneRIF: Secretogranin III stringently regulates pathological but
            not physiological angiogenesis in oxygen-induced retinopathy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Ji,L., Waduge,P., Hao,L., Kaur,A., Wan,W., Wu,Y., Tian,H.,
            Zhang,J., Webster,K.A. and Li,W.
  TITLE     Selectively targeting disease-restricted secretogranin III to
            alleviate choroidal neovascularization
  JOURNAL   FASEB J 36 (1), e22106 (2022)
   PUBMED   34918375
  REMARK    GeneRIF: Selectively targeting disease-restricted secretogranin III
            to alleviate choroidal neovascularization.
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Connor,F., Smith,A., Wooster,R., Stratton,M., Dixon,A.,
            Campbell,E., Tait,T.M., Freeman,T. and Ashworth,A.
  TITLE     Cloning, chromosomal mapping and expression pattern of the mouse
            Brca2 gene
  JOURNAL   Hum Mol Genet 6 (2), 291-300 (1997)
   PUBMED   9063750
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Dopazo,A., Lovenberg,T.W., Danielson,P.E., Ottiger,H.P. and
            Sutcliffe,J.G.
  TITLE     Primary structure of mouse secretogranin III and its absence from
            deficient mice
  JOURNAL   J Mol Neurosci 4 (4), 225-233 (1993)
   PUBMED   7917832
REFERENCE   8  (bases 1 to 2207)
  AUTHORS   Ottiger,H.P., Battenberg,E.F., Tsou,A.P., Bloom,F.E. and
            Sutcliffe,J.G.
  TITLE     1B1075: a brain- and pituitary-specific mRNA that encodes a novel
            chromogranin/secretogranin-like component of intracellular vesicles
  JOURNAL   J Neurosci 10 (9), 3135-3147 (1990)
   PUBMED   2204688
REFERENCE   9  (bases 1 to 2207)
  AUTHORS   Kingsley,D.M., Rinchik,E.M., Russell,L.B., Ottiger,H.P.,
            Sutcliffe,J.G., Copeland,N.G. and Jenkins,N.A.
  TITLE     Genetic ablation of a mouse gene expressed specifically in brain
  JOURNAL   EMBO J 9 (2), 395-399 (1990)
   PUBMED   2303033
REFERENCE   10 (bases 1 to 2207)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU058741.1 and AK139140.1.
            
            On Sep 18, 2009 this sequence version replaced NM_009130.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148498.1, SRR1660817.100220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BU058741.1         1-60
            61-2207             AK139140.1         1-2147
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.32 cM"
     gene            1..2207
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="secretogranin III"
                     /db_xref="GeneID:20255"
                     /db_xref="MGI:MGI:103032"
     exon            1..422
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1747
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secretogranin-3"
                     /codon_start=1
                     /product="secretogranin-3 isoform 1 precursor"
                     /protein_id="NP_033156.1"
                     /db_xref="CCDS:CCDS23347.1"
                     /db_xref="GeneID:20255"
                     /db_xref="MGI:MGI:103032"
                     /translation="MGFLWTGSWILVLVLNSGPIQAFPKPEGSQDKSLHNRELSAERP
                     LNEQIAEAEADKIKKAFPSESKPSESNYSSVDNLNLLRAITEKETVEKERQSIRSPPF
                     DNQLNVEDADSTKNRKLIDEYDSTKSGLDHKFQDDPDGLHQLDGTPLTAEDIVHKIAT
                     RIYEENDRGVFDKIVSKLLNLGLITESQAHTLEDEVAEALQKLISKEANNYEETLDKP
                     TSRTENQDGKIPEKVTPVAAVQDGFTNRENDETVSNTLTLSNGLERRTNPHREDDFEE
                     LQYFPNFYALLTSIDSEKEAKEKETLITIMKTLIDFVKMMVKYGTISPEEGVSYLENL
                     DETIALQTKNKLEKNTTDSKSKLFPAPPEKSQEETDSTKEEAAKMEKEYGSLKDSTKD
                     DNSNLGGKTDEATGKTEAYLEAIRKNIEWLKKHNKKGNKEDYDLSKMRDFINQQADAY
                     VEKGILDKEEANAIKRIYSSL"
     exon            423..475
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            476..521
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            522..737
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            738..880
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1030
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1208
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1325
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1409
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1547
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1628
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..2207
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1906..1911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="hexamer: CATAAA"
     polyA_site      1929
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="major polyA site"
     regulatory      2179..2184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /note="major polyA site"
ORIGIN      
        1 ggagcatgcg cctcctcctc atttcctctc ctggagctag tggagtaaag ctacgcccag
       61 gcccgcgtcc gctggcggcg caggaacttc agcacccgcg gggcggacag cgcctaccgc
      121 acctgctcac ctgctctggg cgccagaaga gcctgcatcc tccttccagc ccggagcaac
      181 tgcgccggag gcgcccagac cctctccctt cccgcaccca ggctcctgtc ccttccagct
      241 tcttaactcc ccttctcatt cataacaaaa gctacagctc aggggcccag cgccaagctc
      301 tttccagcaa agcacagaag agcaagaaag aatggggttc ctttggaccg gctcttggat
      361 actggtgttg gtgctcaaca gcggcccaat tcaagctttc cccaaacccg aaggcagcca
      421 agacaaatcc ctgcataata gagaattaag tgcagaaaga cctttgaatg aacagatcgc
      481 tgaggcagag gcagacaaga ttaaaaaggc attcccttca gaaagcaagc cgagtgaaag
      541 caattattct tctgtcgata acttgaatct gctgagggca ataacagaaa aggaaaccgt
      601 tgagaaagag agacaatcca taagaagccc cccgtttgat aaccaactga acgtggaaga
      661 cgctgattca accaaaaatc ggaaactgat cgatgagtac gattccacca agagtggact
      721 ggaccacaag tttcaagatg acccagacgg ccttcatcaa ctggatggaa ctcctttaac
      781 tgctgaagac atcgtccata agattgccac caggatttat gaggagaacg acagaggagt
      841 gtttgacaaa attgtttcta aactgctgaa tcttggcctg atcactgaaa gccaggcaca
      901 tactctggaa gatgaagtag cagaagcttt acaaaaactg atttcaaaag aggccaacaa
      961 ttatgaggag accctggata aacccacaag caggaccgag aatcaggatg ggaaaatacc
     1021 agagaaagtg actccggtgg cagcagtcca agatggcttc actaaccgtg aaaacgatga
     1081 gacggtgtct aacaccttga ccttgtccaa tggcttggaa aggagaacta acccccacag
     1141 ggaagacgac tttgaggaac tccagtattt ccccaacttc tatgcactac tgacaagcat
     1201 cgactcagaa aaagaagcaa aagagaaaga aaccctgatc accatcatga agacattgat
     1261 tgacttcgtg aaaatgatgg tgaaatacgg tacgatatct ccagaggaag gcgtgtccta
     1321 ccttgaaaac ttggatgaaa caattgctct gcagaccaag aacaagctag aaaaaaatac
     1381 tactgatagc aaaagtaagc tattcccagc tccaccagag aagagtcagg aagaaacaga
     1441 cagtaccaag gaagaagccg ccaagatgga aaaggaatac ggaagcctaa aagactctac
     1501 aaaagatgat aactccaacc taggaggaaa gacagatgaa gccacaggga agacagaagc
     1561 ctacttggaa gccattagaa aaaacatcga atggctgaag aaacataaca agaagggcaa
     1621 caaagaagat tacgaccttt caaagatgag ggactttatc aaccaacaag ctgacgctta
     1681 tgtggagaag ggcatcctcg acaaggaaga agccaacgcc atcaaacgca tctacagcag
     1741 cctgtgaaaa tggcgggcag cttgagcctt cctgttgttc cagcaaaaac aatatagctt
     1801 acaaactaat tcggcggtta aagggttacc agcccagaag tattaggatg tgctgaattt
     1861 atagtagtta atcccttaga aatgagtaaa atagagctct cttgccataa ataccttatg
     1921 aaaagcaaag ctgtagagaa gccgaggttt ttctatatag aatccttatt tcctcttgaa
     1981 tttacatttt gtaatcagag atgtgctgct ctggaaaaga ctctaatggg ttgaacataa
     2041 gtctgaacct actccccact gtcctcagcc ccctgaagct ctgagaggcc ctgtctcggc
     2101 atgctagaca cctgagcacc tcactggatg tttgtcatag gatgtcgttt ccactagtcg
     2161 atctctgttg ggcacggaaa taaacccacg tctcttcata tccttga
//
