LOCUS       NP_033156                471 aa            linear   ROD 01-JUN-2024
DEFINITION  secretogranin-3 isoform 1 precursor [Mus musculus].
ACCESSION   NP_033156
VERSION     NP_033156.1
DBSOURCE    REFSEQ: accession NM_009130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 471)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 471)
  AUTHORS   Ji,L., Waduge,P., Wu,Y., Huang,C., Kaur,A., Oliveira,P., Tian,H.,
            Zhang,J., Stout,J.T., Weng,C.Y., Webster,K.A. and Li,W.
  TITLE     Secretogranin III Selectively Promotes Vascular Leakage in the Deep
            Vascular Plexus of Diabetic Retinopathy
  JOURNAL   Int J Mol Sci 24 (13), 10531 (2023)
   PUBMED   37445707
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 471)
  AUTHORS   Ji,L., Waduge,P., Wan,W., Tian,H., Li,J., Zhang,J., Chen,R. and
            Li,W.
  TITLE     Comparative ligandomics implicates secretogranin III as a
            disease-restricted angiogenic factor in laser-induced choroidal
            neovascularization
  JOURNAL   FEBS J 289 (12), 3521-3534 (2022)
   PUBMED   35038348
  REMARK    GeneRIF: Comparative ligandomics implicates secretogranin III as a
            disease-restricted angiogenic factor in laser-induced choroidal
            neovascularization.
REFERENCE   4  (residues 1 to 471)
  AUTHORS   Dai,C., Waduge,P., Ji,L., Huang,C., He,Y., Tian,H.,
            Zuniga-Sanchez,E., Bhatt,A., Pang,I.H., Su,G., Webster,K.A. and
            Li,W.
  TITLE     Secretogranin III stringently regulates pathological but not
            physiological angiogenesis in oxygen-induced retinopathy
  JOURNAL   Cell Mol Life Sci 79 (1), 63 (2022)
   PUBMED   35006382
  REMARK    GeneRIF: Secretogranin III stringently regulates pathological but
            not physiological angiogenesis in oxygen-induced retinopathy.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 471)
  AUTHORS   Ji,L., Waduge,P., Hao,L., Kaur,A., Wan,W., Wu,Y., Tian,H.,
            Zhang,J., Webster,K.A. and Li,W.
  TITLE     Selectively targeting disease-restricted secretogranin III to
            alleviate choroidal neovascularization
  JOURNAL   FASEB J 36 (1), e22106 (2022)
   PUBMED   34918375
  REMARK    GeneRIF: Selectively targeting disease-restricted secretogranin III
            to alleviate choroidal neovascularization.
REFERENCE   6  (residues 1 to 471)
  AUTHORS   Connor,F., Smith,A., Wooster,R., Stratton,M., Dixon,A.,
            Campbell,E., Tait,T.M., Freeman,T. and Ashworth,A.
  TITLE     Cloning, chromosomal mapping and expression pattern of the mouse
            Brca2 gene
  JOURNAL   Hum Mol Genet 6 (2), 291-300 (1997)
   PUBMED   9063750
REFERENCE   7  (residues 1 to 471)
  AUTHORS   Dopazo,A., Lovenberg,T.W., Danielson,P.E., Ottiger,H.P. and
            Sutcliffe,J.G.
  TITLE     Primary structure of mouse secretogranin III and its absence from
            deficient mice
  JOURNAL   J Mol Neurosci 4 (4), 225-233 (1993)
   PUBMED   7917832
REFERENCE   8  (residues 1 to 471)
  AUTHORS   Ottiger,H.P., Battenberg,E.F., Tsou,A.P., Bloom,F.E. and
            Sutcliffe,J.G.
  TITLE     1B1075: a brain- and pituitary-specific mRNA that encodes a novel
            chromogranin/secretogranin-like component of intracellular vesicles
  JOURNAL   J Neurosci 10 (9), 3135-3147 (1990)
   PUBMED   2204688
REFERENCE   9  (residues 1 to 471)
  AUTHORS   Kingsley,D.M., Rinchik,E.M., Russell,L.B., Ottiger,H.P.,
            Sutcliffe,J.G., Copeland,N.G. and Jenkins,N.A.
  TITLE     Genetic ablation of a mouse gene expressed specifically in brain
  JOURNAL   EMBO J 9 (2), 395-399 (1990)
   PUBMED   2303033
REFERENCE   10 (residues 1 to 471)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU058741.1 and AK139140.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148498.1, SRR1660817.100220.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..471
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 42.32 cM"
     Protein         1..471
                     /product="secretogranin-3 isoform 1 precursor"
                     /note="secretogranin-3"
                     /calculated_mol_wt=50942
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2403
     Region          20..471
                     /region_name="SGIII"
                     /note="Secretogranin-3; pfam15467"
                     /db_xref="CDD:464732"
     mat_peptide     23..471
                     /product="Secretogranin-3. /id=PRO_0000005462"
                     /note="propagated from UniProtKB/Swiss-Prot (P47867.1)"
                     /calculated_mol_wt=50942
     Region          24..45
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P47867.1)"
     Site            40
                     /site_type="glycosylation"
                     /note="O-linked (Xyl...) (chondroitin sulfate) serine.
                     /evidence=ECO:0000250|UniProtKB:Q8WXD2; propagated from
                     UniProtKB/Swiss-Prot (P47867.1)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P47867.1)"
     Region          89..108
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P47867.1)"
     Region          345..404
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P47867.1)"
     Site            365
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P47867.1)"
     CDS             1..471
                     /gene="Scg3"
                     /gene_synonym="1B1075; Chgd; SgIII"
                     /coded_by="NM_009130.3:332..1747"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS23347.1"
                     /db_xref="GeneID:20255"
                     /db_xref="MGI:MGI:103032"
ORIGIN      
        1 mgflwtgswi lvlvlnsgpi qafpkpegsq dkslhnrels aerplneqia eaeadkikka
       61 fpseskpses nyssvdnlnl lraiteketv ekerqsirsp pfdnqlnved adstknrkli
      121 deydstksgl dhkfqddpdg lhqldgtplt aedivhkiat riyeendrgv fdkivsklln
      181 lglitesqah tledevaeal qkliskeann yeetldkpts rtenqdgkip ekvtpvaavq
      241 dgftnrende tvsntltlsn glerrtnphr eddfeelqyf pnfyalltsi dsekeakeke
      301 tlitimktli dfvkmmvkyg tispeegvsy lenldetial qtknkleknt tdsksklfpa
      361 ppeksqeetd stkeeaakme keygslkdst kddnsnlggk tdeatgktea yleairknie
      421 wlkkhnkkgn kedydlskmr dfinqqaday vekgildkee anaikriyss l
//
