LOCUS       NM_009129               2724 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus secretogranin II (Scg2), transcript variant 1, mRNA.
ACCESSION   NM_009129
VERSION     NM_009129.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2724)
  AUTHORS   Lin,C., Zhao,P., Sun,G., Liu,N. and Ji,J.
  TITLE     SCG2 mediates blood-brain barrier dysfunction and
            schizophrenia-like behaviors after traumatic brain injury
  JOURNAL   FASEB J 38 (17), e70016 (2024)
   PUBMED   39225388
  REMARK    GeneRIF: SCG2 mediates blood-brain barrier dysfunction and
            schizophrenia-like behaviors after traumatic brain injury.
REFERENCE   2  (bases 1 to 2724)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2724)
  AUTHORS   Akkuratova,N., Faure,L., Kameneva,P., Kastriti,M.E. and Adameyko,I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2724)
  AUTHORS   Moreau,M.X., Saillour,Y., Cwetsch,A.W., Pierani,A. and Causeret,F.
  TITLE     Single-cell transcriptomics of the early developing mouse cerebral
            cortex disentangle the spatial and temporal components of neuronal
            fate acquisition
  JOURNAL   Development 148 (14) (2021)
   PUBMED   34170322
REFERENCE   5  (bases 1 to 2724)
  AUTHORS   Yap,E.L., Pettit,N.L., Davis,C.P., Nagy,M.A., Harmin,D.A.,
            Golden,E., Dagliyan,O., Lin,C., Rudolph,S., Sharma,N.,
            Griffith,E.C., Harvey,C.D. and Greenberg,M.E.
  TITLE     Bidirectional perisomatic inhibitory plasticity of a Fos neuronal
            network
  JOURNAL   Nature 590 (7844), 115-121 (2021)
   PUBMED   33299180
REFERENCE   6  (bases 1 to 2724)
  AUTHORS   Connor,F., Smith,A., Wooster,R., Stratton,M., Dixon,A.,
            Campbell,E., Tait,T.M., Freeman,T. and Ashworth,A.
  TITLE     Cloning, chromosomal mapping and expression pattern of the mouse
            Brca2 gene
  JOURNAL   Hum Mol Genet 6 (2), 291-300 (1997)
   PUBMED   9063750
REFERENCE   7  (bases 1 to 2724)
  AUTHORS   Mahata,S.K., Kozak,C.A., Szpirer,J., Szpirer,C., Modi,W.S.,
            Gerdes,H.H., Huttner,W.B. and O'Connor,D.T.
  TITLE     Dispersion of chromogranin/secretogranin secretory protein family
            loci in mammalian genomes
  JOURNAL   Genomics 33 (1), 135-139 (1996)
   PUBMED   8617499
REFERENCE   8  (bases 1 to 2724)
  AUTHORS   Schimmel,A., Braunling,O., Ruther,U., Huttner,W.B. and Gerdes,H.H.
  TITLE     The organisation of the mouse secretogranin II gene
  JOURNAL   FEBS Lett 314 (3), 375-380 (1992)
   PUBMED   1468571
REFERENCE   9  (bases 1 to 2724)
  AUTHORS   Kagotani,Y., Picart,R., Barret,A., Wiedenmann,B., Huttner,W.B. and
            Tixier-Vidal,A.
  TITLE     Subcellular localization of secretogranin II and synaptophysin by
            immunoelectron microscopy in differentiated hypothalamic neurons in
            culture
  JOURNAL   J Histochem Cytochem 39 (11), 1507-1518 (1991)
   PUBMED   1918927
REFERENCE   10 (bases 1 to 2724)
  AUTHORS   Eiden,L.E., Huttner,W.B., Mallet,J., O'Connor,D.T., Winkler,H. and
            Zanini,A.
  TITLE     A nomenclature proposal for the chromogranin/secretogranin proteins
  JOURNAL   Neuroscience 21 (3), 1019-1021 (1987)
   PUBMED   3627430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083887.15.
            
            On Mar 29, 2019 this sequence version replaced NM_009129.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3214714.1,
                                           SRR1660811.97301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                AC083887.15        101595-101665
            72-2724             AC083887.15        104603-107255
FEATURES             Location/Qualifiers
     source          1..2724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 40.89 cM"
     gene            1..2724
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="secretogranin II"
                     /db_xref="GeneID:20254"
                     /db_xref="MGI:MGI:103033"
     exon            1..71
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /inference="alignment:Splign:2.1.0"
     exon            72..2724
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1939
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; secretogranin-2; chromogranin-C"
                     /codon_start=1
                     /product="secretogranin-2 isoform 1 precursor"
                     /protein_id="NP_033155.1"
                     /db_xref="CCDS:CCDS15089.1"
                     /db_xref="GeneID:20254"
                     /db_xref="MGI:MGI:103033"
                     /translation="MAGAKAYRLGAVLLLIHLIFLISGAEAASFQRNQLLQKEPDLRL
                     ENVQKFPSPEMIRALEYIEKLRQQAHREESSPDYNPYQGVSVPLQLKENGEESHLAES
                     SRDALSEDEWMRIILEALRQAENEPPSAPKENKPYALNLEKNFPVDTPDDYETQQWPE
                     RKLKHMRFPLMYEENSRENPFKRTNEIVEEQYTPQSLATLESVFQELGKLTGPSNQKR
                     ERVDEEQKLYTDDEDDVYKTNNIAYEDVVGGEDWSPIEEKIETQTQEEVRDSKENTEK
                     NEQINEEMKRSGQLGLPDEENRRESKDQLSEDASKVITYLRRLVNAVGSGRSQSGPNG
                     DRAARLLQKPLDSQSIYQLIEISRNLQIPPEDLIEMLKAGEKPNGLVEPEQDLELAVD
                     LDDIPEADLDRPDMFQSKMLSKGGYPKAPGRGMVEALPDGLSVEDILNVLGMENVVNQ
                     KSPYFPNQYSQDKALMRLPYGPGKSRANQIPKVAWIPDVESRQAPYENLNDQELGEYL
                     ARMLVKYPELLNTNQLKRVPSPVSSEDDLQEEEQLEQAIKEHLGPGSSQEMERLAKVS
                     KRIPVGSLKNEDTPNRQYLDEDMLLKVLEYLNQEQAEQGREHLAKRAMENM"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="hexamer: AATAAA"
     regulatory      2348..2353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="hexamer: AATATA"
     polyA_site      2353
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="major polyA site"
     polyA_site      2368
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
     regulatory      2401..2406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
                     /note="hexamer: AATAAA"
     polyA_site      2419
                     /gene="Scg2"
                     /gene_synonym="Chgc; SgII"
ORIGIN      
        1 aaacggcccg agccctcact cagcggcaga gaggagcatg cttggagcct tccacataat
       61 ataagacaga ggaaatcttt aagacatggc tggagctaag gcgtaccgac ttggagcagt
      121 tctgcttctt atccacttaa ttttcctcat ctctggagcc gaagcagctt ccttccagcg
      181 aaaccagctg cttcagaaag aaccagacct cagattggag aatgtccaaa agtttcctag
      241 tccagaaatg atcagggctt tggagtacat agaaaagctc aggcagcaag ctcacagaga
      301 agaaagcagc ccagactaca atccctacca aggcgtctct gttcctcttc aactcaaaga
      361 aaacggagaa gaaagccact tggcagagag ctcaagggat gcactgagtg aagacgagtg
      421 gatgcggata atactcgagg ctctgaggca ggctgaaaat gagccgccat ctgcccccaa
      481 agagaacaag ccctatgcct tgaatctgga gaagaacttc ccagtggaca cgcctgatga
      541 ctatgagact caacagtggc ctgagaggaa actcaagcac atgcggttcc ctctcatgta
      601 tgaagagaat tccagagaaa accccttcaa acgcacaaat gaaatagtcg aggaacaata
      661 cacaccccaa agtcttgcta ccctggagtc tgtgttccaa gagcttggga aactgacagg
      721 gccaagcaac cagaagcgtg agagggttga cgaggaacaa aagctgtaca cagatgatga
      781 agacgacgtg tacaagacca acaacattgc ctatgaagat gtcgtggggg gagaagactg
      841 gagccccata gaggagaaaa tagagactca aacccaggaa gaggtgagag acagcaaaga
      901 gaacacagaa aaaaatgaac aaatcaatga agagatgaaa cgttcagggc agttggggct
      961 cccagatgaa gaaaaccgga gagagagtaa agaccaactc tcagaggatg cctccaaagt
     1021 tatcacctac ctgagaaggt tagtgaatgc tgtgggcagt gggaggtcac agagtgggcc
     1081 aaatggggac agggcagccc ggcttcttca gaagcccctt gattctcagt ctatttatca
     1141 gctgattgaa atctccagga atttgcagat accccctgaa gatttaattg agatgctcaa
     1201 agctggagag aagccaaatg ggttggtgga gccagagcag gatctggagc ttgctgttga
     1261 cctagatgac atcccagagg ctgacctaga ccgtccagac atgtttcaaa gtaagatgct
     1321 ctccaagggt gggtatccca aggcacctgg tcgtggtatg gtagaggcct tgcctgatgg
     1381 gctgagtgtc gaggacattt taaatgtttt agggatggag aatgtagtaa atcagaagtc
     1441 cccatatttt cccaaccaat atagccaaga caaggctctg atgaggctcc cttatggtcc
     1501 tgggaaatct agagccaacc agattcccaa agtagcctgg atccctgatg ttgaaagcag
     1561 acaagcacct tatgaaaatc tgaatgacca agaattggga gagtacttag ccaggatgct
     1621 agttaagtac cctgagctcc tgaataccaa ccagctgaag agagtgccca gtccagtctc
     1681 ctcagaggat gacctccaag aagaagagca gctcgagcag gccatcaagg aacatctggg
     1741 gccaggaagc tcccaggaaa tggagagact ggccaaggtg agcaaaagga tccccgtagg
     1801 atccctgaag aatgaggaca ccccaaacag acagtacctg gatgaagata tgctcctgaa
     1861 agtgctggag tacctcaacc aagagcaggc agagcagggg agggagcatc ttgccaagcg
     1921 ggccatggaa aacatgtaaa cagctttaat gcccaatttc ccttctttcc cccaagtaag
     1981 ccccctacat ttctcttaag tgtgttgatc tctatcctgt tgacagtgta atatctttaa
     2041 agtgatgtat aggcagatga ctccaggtca ttttggggga tctgcttcac ttattctgag
     2101 ctgttacgtt gtgtgtggat gtgtgtaaat gttatgattc ccagattgaa aaaaaatgtt
     2161 ctttattcaa gaaagatatc tatgatagtg ttggctaatg tatctaatgg tcatggaatt
     2221 gatgatgctc acatatgata aagagtatcc tataattatc ttggaagttt ttaacattta
     2281 ttgaattatt ttgttactgt ctgtagtgtt ttgtggagtt ctggagcaaa accaataaag
     2341 cattataaat atatagtttt acttataagg ccttttctat tgtgtgtttt attgttgatt
     2401 aataaatgtt atttctggat acctttggac tttttattct ggaaaccaga gacaactggt
     2461 atggatcaag cagcatggag ccagaggaga aaattattac tgtccacagg caacccaggt
     2521 aagagatgaa tcttatatgt gatcatattt tctgcctaca ggatgttgtg aacattcccg
     2581 aacagcctta catcttttca tgttttccat atacctcatt aacaaaacga gactttgggt
     2641 ataattctta cacttcacat tgattcatat aagtaaaaga tattaaactt tccccactca
     2701 tcacaatttg aaaatgaaag aaaa
//
