LOCUS       NM_001114660            3680 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Sec1 family domain containing 2 (Scfd2), transcript
            variant a, mRNA.
ACCESSION   NM_001114660
VERSION     NM_001114660.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3680)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3680)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140246.1, AC115823.18 and AI850693.1.
            
            On Nov 5, 2013 this sequence version replaced NM_001114660.1.
            
            Transcript Variant: This variant (a) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140246.1, AK135666.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2360              AK140246.1         2-2361
            2361-3350           AC115823.18        51185-52174
            3351-3680           AI850693.1         1-330               c
FEATURES             Location/Qualifiers
     source          1..3680
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 39.44 cM"
     gene            1..3680
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /note="Sec1 family domain containing 2"
                     /db_xref="GeneID:212986"
                     /db_xref="MGI:MGI:2443446"
     exon            1..961
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2178
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /note="isoform a is encoded by transcript variant a; sec1
                     family domain-containing protein 2; neuronal Sec1;
                     syntaxin-binding protein 1-like 1"
                     /codon_start=1
                     /product="sec1 family domain-containing protein 2 isoform
                     a"
                     /protein_id="NP_001108132.1"
                     /db_xref="CCDS:CCDS51519.1"
                     /db_xref="GeneID:212986"
                     /db_xref="MGI:MGI:2443446"
                     /translation="MSAAGILAFAQQGWEQVLAKVKWSVVYLDAACAESLHWSCGSSR
                     LLEAVKGPACHLREFEPQAIGGGAKQPRAVFVLSSPLKGRIVDTLQSIICRSHFQHCV
                     VVTAVSHAVHLTANHVPAAAAAELEGQQPVFEQLEEKLCEWMGNENYTAEVLHVPLFL
                     APVASHLAFTPAFATLFPLLPQDVHALNSARPDKRRLSSLGEVDATALTPELLLYIRC
                     LVSGLSSLCEHLGVREECFAVGPLSRVIATDLANYAPAKNRKKTATGRASVVFVDRTL
                     DLTGAVGHHGDNLVEKIMSVLPQLPGHTHDVMVNMAELTAVQAVEENQNVIAPGCLAP
                     SNEASAKALWEALLNSKHKEAVMEVRRHLVEAASRENLPIKMSMGRVTPGQLMSYIQL
                     FKNNLRALRNHCGLLQLGMATVQTLKHPQTAKWDNFLAFERLLLQSLGDSTMAGVLNQ
                     LLPMIKSSSQRTSDDLNPEELLILLIYIYSVPGDVTLDRDLGDVEEKVKKALAHVLSE
                     ESELSPLLQKITGCDSAVDLTLPKSQIAVNDVFMALREIAGARNLMRQFKSVYVPGNN
                     THQASYKPLLKQVVEEIFNPEKSDPIDIEHMSSGLTDLLKTGFSMFMKVSRPHPSDHP
                     LLILFVVGGVTVAEAKMVKDLVASLKPGTQVMVLSTRLLKPLNIPELLFATDRLHPDL
                     GF"
     exon            962..1130
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1258
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1434
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1684
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1830
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1965
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2085
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..3665
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2363..2368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /note="hexamer: AATAAA"
     polyA_site      2392
                     /gene="Scfd2"
                     /gene_synonym="E430013M20Rik; STXBP1L1"
                     /note="major polyA site"
ORIGIN      
        1 agagacaggc ccacgtgtac tgtgttgact gtcaaagtac tcagtacccg gaagccctgc
       61 gttctgacct gagttcccgc ccgtacgccg gtgagacccc tggccagctg gcgatacggg
      121 atcatgagcg ccgcgggcat actggccttt gcccagcaag gctgggagca ggtgctggcc
      181 aaagtgaagt ggtccgtggt ctacctggac gctgcctgcg ccgagagcct gcactggagc
      241 tgcggatcca gccggcttct ggaggcggtg aagggtcctg cgtgtcacct gcgggaattt
      301 gaaccccagg ccattggcgg gggagccaag cagccccggg cggttttcgt tttgagcagc
      361 ccgctgaaag gccggatcgt agacactcta cagagtatca tttgccgcag tcactttcag
      421 cactgtgtgg tggtcacagc cgtgagccac gcagtccacc tcactgctaa ccacgtaccg
      481 gccgctgcag cggccgagct cgaggggcag cagccggtgt tcgaacagct ggaggagaag
      541 ctctgtgagt ggatgggcaa cgagaactat acggccgagg tgctccacgt cccgttgttt
      601 ctcgcccctg ttgcctccca tctcgctttt actccagcct ttgctaccct cttcccactg
      661 ctacctcagg atgtccacgc tcttaacagt gccagacccg acaagaggag gctgagcagc
      721 ttgggtgagg tggatgccac tgccctaacc ccagagctgc tgctgtacat cagatgcctc
      781 gtgtcaggcc tcagttctct gtgtgaacat ctaggggtac gagaggagtg tttcgccgtg
      841 ggtcccctca gtcgggtcat cgctacagat ctggcaaatt atgcccccgc caagaacagg
      901 aaaaagactg ctacaggcag ggcttctgtg gtctttgtgg atagaactct ggatctcaca
      961 ggagcggttg gacaccacgg agacaactta gtagagaaga tcatgtcagt gcttccacag
     1021 cttccaggcc acacccacga cgtgatggtc aacatggccg agctcactgc tgtccaggct
     1081 gtggaggaaa accagaacgt gattgcacca ggctgccttg ccccatccaa tgaggcctca
     1141 gccaaggccc tgtgggaagc cttactgaac tccaagcaca aagaggcagt gatggaagtt
     1201 cggagacatc tagtggaagc agccagcaga gagaacctgc ccatcaagat gagtatggga
     1261 agagtcactc cagggcagct catgtcctat attcaactct tcaagaacaa cctcagagct
     1321 cttagaaatc actgtgggct tctacagctt gggatggcca cagttcaaac tctgaagcac
     1381 ccacagactg ccaagtggga taacttcctg gcatttgaaa ggctccttct acagagcctt
     1441 ggggattcaa ccatggctgg tgtgctaaat cagctgctgc caatgattaa gtcctcaagc
     1501 cagagaacca gtgacgacct caaccctgag gaactgctga tcctgctcat atacatttac
     1561 tctgtccctg gagacgtcac gctggacaga gacctgggag acgtggaaga aaaggtgaag
     1621 aaagcattgg cccatgtcct ctctgaggag tctgagctgt cccctttgct gcagaaaatc
     1681 acaggctgtg actctgcagt tgacctgacg ttgcccaaat cccaaattgc tgtgaatgat
     1741 gtcttcatgg ctctccggga gatcgctgga gctaggaatc tcatgagaca gtttaagtct
     1801 gtgtatgttc ctggaaataa cacccatcag gcatcctata agccgctgtt gaagcaggtt
     1861 gtggaggaaa tatttaatcc tgagaagtca gatcctattg acattgaaca tatgtcctca
     1921 ggcctcactg atctcctgaa aactggattc agcatgttca tgaaggtgag ccggccccat
     1981 cccagtgacc atcccctctt gatcctcttt gtggtgggcg gcgtcacagt cgctgaagcc
     2041 aaaatggtca aagaccttgt agcatctctg aagccaggaa cccaggtgat ggtgctgtcc
     2101 acaagactcc tgaagccgct taacattccc gagctgctct ttgcaactga ccggctacac
     2161 ccagacctcg gcttctgaca cctagagaag ataagacctg tttgagctgg aaataccaat
     2221 gcccattggt caccactcca gatatgcctc caaagccagt gtccccatta ctaattatag
     2281 gtatgactta attctaccag agaggtcttc atgactgcat ggaaggcagt ttgtttggac
     2341 tggactgggt cttcaacagc aaaataaaga cttgcattct cgttcttcta aaggtgtcaa
     2401 gctgtcgcta gctgacttcg ccagctgtca tgttcattta cccttagcca cttattgtac
     2461 tcttcccaga gatccctgga agttctagct ctagataaaa gcctgttggc aagtggtggc
     2521 agatatgagc gttgtggtga agttagccat ggaaagttca gtgcacttag aatccccagc
     2581 tagaggaagg ctacgttttc tttgtgatta taggagtggg gcggggatgt cacagacaga
     2641 gcctgagact ttgtttctct ttgacaccaa aacatttctg aaagacaagg agggggaggc
     2701 atggcctggg tagcactggg ctggtggcct tcgtgagtgg taaatcaccc cacgagtgac
     2761 aaagggctgc tttgttccag ctggttcaag gactggggca gcccgctact tggaacagca
     2821 gtgggaggga caaagcaggg tgactggaga gctgtctttg ctagcaatgg tttcatcctg
     2881 tgcagaggaa gcccgtgtag aagagatctc ctcccgggga ctctgggttg taaccacaac
     2941 ccctcgatgg cctttgtgat ttcaaattcc tactgaaata gaaagctttc ttctgggggt
     3001 ttatattttc ttttggtcag agcagaaaaa cccagatgca cctagtgaaa ttatatgaga
     3061 actctgggga gaaagaaagg aagagagaga gagagggagg gagggaagga gggagggagg
     3121 gggaggaaga aagaaaggaa ggaaggaagg aaggaaggaa ggaaggaagg aaggaaggaa
     3181 ggaaggaagg aagagaaaga gagaaagaaa agaaaaacaa actggttaga catccatgtg
     3241 tggccggtgg ccgttcccag cctaagtaat gaatgtctga aatgggaaaa agctgaagaa
     3301 tagtttccag agtggattta acaggaagat gaaatgaaat gtaaaccaag acataactat
     3361 acattttact tctctattaa atactgtgca ttttggagaa gaaggaaaaa aaaaaaagct
     3421 gaacttggag tcactttcac atgctgaagc tgagtttcat gagaccagat gttcttgttc
     3481 atgcccaagt ccttctttgc cttcaccgat tctctgatgg tgctgaactg taaggcagct
     3541 ctttttaaaa atcccatgaa tctaaaaatc ttacatttga ataaggggaa aaaacagaat
     3601 tagctgcaga caaattatat gtaagcagag ataagtactt tctaaaataa agaaatgtaa
     3661 agtaaaaaaa aaaaaaaaaa
//
