LOCUS       NM_183216               3072 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus stearoyl-coenzyme A desaturase 4 (Scd4), mRNA.
ACCESSION   NM_183216
VERSION     NM_183216.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3072)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3072)
  AUTHORS   Paredes,A., Justo-Mendez,R., Jimenez-Blasco,D., Nunez,V.,
            Calero,I., Villalba-Orero,M., Alegre-Marti,A., Fischer,T.,
            Gradillas,A., Sant'Anna,V.A.R., Were,F., Huang,Z.,
            Hernansanz-Agustin,P., Contreras,C., Martinez,F., Camafeita,E.,
            Vazquez,J., Ruiz-Cabello,J., Area-Gomez,E., Sanchez-Cabo,F.,
            Treuter,E., Bolanos,J.P., Estebanez-Perpina,E., Ruperez,F.J.,
            Barbas,C., Enriquez,J.A. and Ricote,M.
  TITLE     gamma-Linolenic acid in maternal milk drives cardiac metabolic
            maturation
  JOURNAL   Nature 618 (7964), 365-373 (2023)
   PUBMED   37225978
  REMARK    Erratum:[Nature. 2023 Jul;619(7968):E24. doi:
            10.1038/s41586-023-06316-w.. PMID: 37322272]
REFERENCE   3  (bases 1 to 3072)
  AUTHORS   Gan,A.M., Tracz-Gaszewska,Z., Ellert-Miklaszewska,A.,
            Navrulin,V.O., Ntambi,J.M. and Dobrzyn,P.
  TITLE     Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy
            Metabolism in Ischemic Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (18), 10459 (2022)
   PUBMED   36142371
  REMARK    GeneRIF: Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy
            Metabolism in Ischemic Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3072)
  AUTHORS   Uijtdewilligen,P.J.E., Versteeg,E.M., van de Westerlo,E.M.A., van
            der Vlag,J., Daamen,W.F. and van Kuppevelt,T.H.
  TITLE     Dynamic Expression of Genes Involved in
            Proteoglycan/Glycosaminoglycan Metabolism during Skin Development
  JOURNAL   Biomed Res Int 2018, 9873471 (2018)
   PUBMED   30228991
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3072)
  AUTHORS   Escobedo,N., Contreras,O., Munoz,R., Farias,M., Carrasco,H.,
            Hill,C., Tran,U., Pryor,S.E., Wessely,O., Copp,A.J. and Larrain,J.
  TITLE     Syndecan 4 interacts genetically with Vangl2 to regulate neural
            tube closure and planar cell polarity
  JOURNAL   Development 140 (14), 3008-3017 (2013)
   PUBMED   23760952
REFERENCE   6  (bases 1 to 3072)
  AUTHORS   Miyazaki,M., Bruggink,S.M. and Ntambi,J.M.
  TITLE     Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
  JOURNAL   J Lipid Res 47 (4), 700-704 (2006)
   PUBMED   16443825
  REMARK    GeneRIF: Results show that mouse stearoyl-coenzyme A desaturase
            (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse
            SCD3 uses C16:0 but not C18:0.
REFERENCE   7  (bases 1 to 3072)
  AUTHORS   Miyazaki,M., Jacobson,M.J., Man,W.C., Cohen,P., Asilmaz,E.,
            Friedman,J.M. and Ntambi,J.M.
  TITLE     Identification and characterization of murine SCD4, a novel
            heart-specific stearoyl-CoA desaturase isoform regulated by leptin
            and dietary factors
  JOURNAL   J Biol Chem 278 (36), 33904-33911 (2003)
   PUBMED   12815040
  REMARK    GeneRIF: SCD4 demonstrates tissue-specific regulation by leptin and
            dietary factors.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123853.2.
            
            On Nov 17, 2006 this sequence version replaced NM_183216.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY430080.1, BC141234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC123853.2         114675-114864
            191-458             AC123853.2         115343-115610
            459-589             AC123853.2         118850-118980
            590-795             AC123853.2         120259-120464
            796-1028            AC123853.2         122570-122802
            1029-3072           AC123853.2         126049-128092
FEATURES             Location/Qualifiers
     source          1..3072
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..3072
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /note="stearoyl-coenzyme A desaturase 4"
                     /db_xref="GeneID:329065"
                     /db_xref="MGI:MGI:2670997"
     exon            1..190
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1228
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /EC_number="1.14.19.1"
                     /note="delta(9)-desaturase 4; fatty acid desaturase 4;
                     acyl-CoA desaturase 4"
                     /codon_start=1
                     /product="stearoyl-CoA desaturase 4"
                     /protein_id="NP_899039.2"
                     /db_xref="CCDS:CCDS29849.1"
                     /db_xref="GeneID:329065"
                     /db_xref="MGI:MGI:2670997"
                     /translation="MTAHLPQEISSRCSTTNIMEPHSRRQQDGEEKMPLQAEDIRPEI
                     KDDLYDPSYQDEEGPPPKLEYVWRNIIFMALLHVGALYGITLVPSCKVYTWLLGVFYN
                     VVAGLGITAGAHRLWSHRTYKARLPLRIFLIMANTMAFQNDVYEWARDHRAHHKFSET
                     HADPHNSRRGFFFSHVGWLLVRKHPAVKEKGKNLDMSDLKAEKLVMFQRRYYKLAVTL
                     MFIILPTLVPWYLWGETFQHSLCVSNFLRYAVLLNFTWLVNSAAHLYGYRPYDRGIGA
                     RENPFVSMASLGEGFHNYHHTFPYDYSVSEYRWHINFTTFFIDCMAALGLAYDRKKVS
                     KAVVLARIKRTGDGSHKSS"
     exon            191..458
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            459..589
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..795
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1028
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..3072
                     /gene="Scd4"
                     /gene_synonym="ACOD4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagcagaac tgactggtga cacctgcaca gttagccggg catcaacgca gtacacacag
       61 cgcacagtgg gctctggact caacgcttca ccgatcctca gtcgctgcag acctggacct
      121 tgctctctct gccttcacaa gaggatctag gcttccaagg agcaagatga cggcccactt
      181 gccacaagag atctccagca ggtgtagcac taccaacatc atggaacccc actcccggag
      241 acagcaggat ggagaagaga agatgcccct ccaggcagaa gatatccggc ctgaaataaa
      301 agatgatctg tatgacccca gctaccagga tgaggaggga cccccgccca agctggagta
      361 cgtctggagg aacatcatct tcatggccct gctgcacgtg ggagccctgt acgggatcac
      421 actggttccc tcctgcaagg tctacacctg gctcttggga gtattctaca acgtggttgc
      481 cggtttgggc atcacagccg gagcgcatcg cttgtggagc caccgaacct ataaagcaag
      541 gctgccccta cgcatcttcc tcatcatggc caataccatg gctttccaga atgacgtgta
      601 tgaatgggcc cgagatcacc gcgcccacca caagttctca gaaacacacg ccgaccctca
      661 caattcccgc cgtggcttct tcttctctca cgtgggttgg ctgcttgtgc gcaaacatcc
      721 ggctgtcaaa gagaagggca aaaacctgga catgtctgac ctgaaagccg agaagctggt
      781 gatgttccag aggaggtact acaagctagc tgtcacgctc atgttcatca ttctgcccac
      841 actggtaccc tggtacttgt ggggtgagac ttttcaacac agcttatgcg tctcgaattt
      901 cctgcggtat gctgtgcttc taaacttcac ttggctggtg aacagtgcgg cccacctcta
      961 cggataccgg ccctatgaca ggggcattgg tgcccgggag aatcccttcg tttcaatggc
     1021 atctttaggc gagggcttcc acaactacca tcacacgttc ccctacgatt actctgtcag
     1081 tgagtaccgc tggcacatca acttcaccac gtttttcatc gactgcatgg ctgccctggg
     1141 cctggcttac gaccggaaga aagtatctaa ggccgttgtc ttagccagga ttaagagaac
     1201 tggagatggg agtcacaaga gtagctgagt gtggggtcat ctgggtctct gttccataaa
     1261 acaactgggc caacatttaa ttttctgtta actactgaat aatgctacca aagccctctc
     1321 ctgaactttt ttttttaggg ggaggggagg gtacatggtc tctctgtctc tctgtcttgt
     1381 ctgtatctct gtgtctctgt gtctgtctct gtctctctct ctctagtcta tactatagac
     1441 caggctggct tcgaactcac agagatcttc ctgcctccgc ctcccaattg ttgggattaa
     1501 aggggtgtat cactgtgccc agctctgcga agtcttgtca aatgttcaag gcaactctcc
     1561 tttatgaccc ctttgtcctc tagtcccatc cccacccttc gttcctacta tgcttgtctt
     1621 tcttttctcc ttctctaaga agcagccagt gagtgcttgg ccaacctccc caaggcttca
     1681 cagcctttct gttgtctcaa agtaaggacc ttcatcatgg acagttctct gcctaggtat
     1741 ttgtctaaag ctatcagtac aacaaaacct tttagggaat gtcttcttaa ttgccgttag
     1801 ttcatgcttt tctgaagaaa agggggaaaa tagcatcagt tgtcatagaa gtgctaaagg
     1861 tggagaatcc tcaggtggga aagcatgcag agtatgactc agaagcaggg ggaccatcaa
     1921 ggtaggaagt gactcagtag ggagtactca ccaaaataag acctcccaca gacagagccc
     1981 agacacagag caggaaacgg ccgttgaaag tggccatgct agaacacaat agaatgtctc
     2041 tgcagctcag tctggtccaa gccagaagta aaggaaaaac aattcagtta gtaggaaaag
     2101 agatttctcc tgagacaggg tttttgtttg tttgtttgtt tgtttgttgt tgttttctgt
     2161 attgacaagg aacattgtta tgccacagaa caagaaggct tcggcttggt taaaaaaaaa
     2221 cagaaaactc atagattcca caagctacac atccaatctg ttttacactt ctcttctgcc
     2281 tgccttgcgt tgtcaatgtt atttatgttc tgctctcata gtgattgggt aactatagca
     2341 accccaaaca tcccaactgg aaggattgta ggcaaagttg ggtcaaacct aaaatcatgt
     2401 agacgattgt ttagagcagg gagggaggtg tttcactgag tcctctgaga aggttccaga
     2461 agctttagaa cagagggtta cttgggtttc ctgtagctcc cacccctgag aagagaggga
     2521 agtctgatgg ccagtatcag tagtcacttc agaagaaata gctttgcaaa gagagagagc
     2581 tctgagaaca cattgtgctg tgggggctcc agaagttact gagttactaa gtattgagag
     2641 agtagcaaac tcagtgctcc aaggtatgct agtcataaaa cagagagcga cattcctcca
     2701 cccaccgctt cctgggttca aggagtgttc attcaaagaa agtcaccctg acccaccctg
     2761 accattgctg gaacccgcta tgcaaaggtg ctattgttag gggctcttag aaactgtctt
     2821 gagaaataac cctcacaatt accaggtatt ccttgtgaca cctgtgactt tgtacttcct
     2881 tgtgactctt gactggtatt tttggtattt tccaacaacg cccttcccac ctccttgagt
     2941 tgtggtttct tcctttaaat acccccttat ccagctactt ggggtgcccc cttatccagc
     3001 tacttggggt acttggggta cttgtatgat cgtggacccg agagcgctct tgaataaaaa
     3061 aatcctcttg ca
//
