LOCUS       NM_024450               3470 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus stearoyl-coenzyme A desaturase 3 (Scd3), mRNA.
ACCESSION   NM_024450 XM_915820
VERSION     NM_024450.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3470)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3470)
  AUTHORS   Gan,A.M., Tracz-Gaszewska,Z., Ellert-Miklaszewska,A.,
            Navrulin,V.O., Ntambi,J.M. and Dobrzyn,P.
  TITLE     Stearoyl-CoA Desaturase Regulates Angiogenesis and Energy
            Metabolism in Ischemic Cardiomyocytes
  JOURNAL   Int J Mol Sci 23 (18), 10459 (2022)
   PUBMED   36142371
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3470)
  AUTHORS   Bond,L.M., Burhans,M.S. and Ntambi,J.M.
  TITLE     Uncoupling protein-1 deficiency promotes brown adipose tissue
            inflammation and ER stress
  JOURNAL   PLoS One 13 (11), e0205726 (2018)
   PUBMED   30427862
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3470)
  AUTHORS   Bond,L.M. and Ntambi,J.M.
  TITLE     UCP1 deficiency increases adipose tissue monounsaturated fatty acid
            synthesis and trafficking to the liver
  JOURNAL   J Lipid Res 59 (2), 224-236 (2018)
   PUBMED   29203476
REFERENCE   5  (bases 1 to 3470)
  AUTHORS   Dahlhoff,M., Camera,E., Schafer,M., Emrich,D., Riethmacher,D.,
            Foster,A., Paus,R. and Schneider,M.R.
  TITLE     Sebaceous lipids are essential for water repulsion, protection
            against UVB-induced apoptosis and ocular integrity in mice
  JOURNAL   Development 143 (10), 1823-1831 (2016)
   PUBMED   26989175
REFERENCE   6  (bases 1 to 3470)
  AUTHORS   Maier,H., Meixner,M., Hartmann,D., Sandhoff,R., Wang-Eckhardt,L.,
            Zoller,I., Gieselmann,V. and Eckhardt,M.
  TITLE     Normal fur development and sebum production depends on fatty acid
            2-hydroxylase expression in sebaceous glands
  JOURNAL   J Biol Chem 286 (29), 25922-25934 (2011)
   PUBMED   21628453
REFERENCE   7  (bases 1 to 3470)
  AUTHORS   Horsley,V., O'Carroll,D., Tooze,R., Ohinata,Y., Saitou,M.,
            Obukhanych,T., Nussenzweig,M., Tarakhovsky,A. and Fuchs,E.
  TITLE     Blimp1 defines a progenitor population that governs cellular input
            to the sebaceous gland
  JOURNAL   Cell 126 (3), 597-609 (2006)
   PUBMED   16901790
REFERENCE   8  (bases 1 to 3470)
  AUTHORS   Miyazaki,M., Bruggink,S.M. and Ntambi,J.M.
  TITLE     Identification of mouse palmitoyl-coenzyme A Delta9-desaturase
  JOURNAL   J Lipid Res 47 (4), 700-704 (2006)
   PUBMED   16443825
  REMARK    GeneRIF: Results show that mouse stearoyl-coenzyme A desaturase
            (SCD)1, 2, and 4 desaturate both C18:0 and C16:0, whereas mouse
            SCD3 uses C16:0 but not C18:0.
REFERENCE   9  (bases 1 to 3470)
  AUTHORS   Zheng,Y., Prouty,S.M., Harmon,A., Sundberg,J.P., Stenn,K.S. and
            Parimoo,S.
  TITLE     Scd3--a novel gene of the stearoyl-CoA desaturase family with
            restricted expression in skin
  JOURNAL   Genomics 71 (2), 182-191 (2001)
   PUBMED   11161812
REFERENCE   10 (bases 1 to 3470)
  AUTHORS   Parimoo,S., Zheng,Y., Eilertsen,K., Ge,L., Prouty,S., Sundberg,J.
            and Stenn,K.
  TITLE     Identification of a novel SCD gene and expression of the SCD gene
            family in mouse skin
  JOURNAL   J Investig Dermatol Symp Proc 4 (3), 320-322 (1999)
   PUBMED   10674390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125101.3, AF272037.1 and AC123853.2.
            
            On Feb 3, 2006 this sequence version replaced NM_024450.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136277.1, AK078675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC125101.3         127895-127905
            12-1584             AF272037.1         1-1573
            1585-3470           AC123853.2         23480-25365
FEATURES             Location/Qualifiers
     source          1..3470
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..3470
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /note="stearoyl-coenzyme A desaturase 3"
                     /db_xref="GeneID:30049"
                     /db_xref="MGI:MGI:1353437"
     exon            1..260
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1313
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /note="delta(9)-desaturase 3; fatty acid desaturase 3;
                     palmitoyl-CoA desaturase; stearoyl-CoA desaturase 3"
                     /codon_start=1
                     /product="acyl-CoA desaturase 3"
                     /protein_id="NP_077770.1"
                     /db_xref="CCDS:CCDS29847.1"
                     /db_xref="GeneID:30049"
                     /db_xref="MGI:MGI:1353437"
                     /translation="MPGHLLQEEMTPSYTTTTTITAPPSGSLQNGREKVKTVPLYLEE
                     DIRPEMKEDIYDPTYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLVPSCKLYTCL
                     FAFVYYVISIEGIGAGVHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAH
                     HKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYY
                     KPGILLMCFILPTLVPWYCWGETFLNSFYVATLLRYAVVLNATWLVNSAAHLYGYRPY
                     DKNIDPRQNALVSLGSMGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAY
                     DRKRVSKATVLARIKRTGDGSHKSG"
     exon            261..543
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            544..674
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            675..880
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1113
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..3470
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1476
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /note="major polyA site"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2126
                     /gene="Scd3"
                     /gene_synonym="4930513N16Rik"
ORIGIN      
        1 cacacataca cgcttggggt gaggactcac acacgtacgc gcgtgcgcac atacacacac
       61 caagggtgaa cttggataac caccctgggt ggaaggcaca cgggaggggt ttgtgccaac
      121 acctagcttg ttttgcagaa acaggatctg caacagaagc ctcctctgcc ctgcagcccc
      181 aaacgccaca actttaaatc cttggaagat cttcccggcc tccaagaacc agcatgccag
      241 ggcacctgct gcaagaagag atgacgcctt cgtacacgac caccaccacc atcacagcgc
      301 ctccctctgg aagcctgcag aatggacgag agaaggtgaa gacggtgccc ctctacctgg
      361 aagaagacat ccgtcctgaa atgaaagaag atatatacga ccccacctat caggatgagg
      421 aggggccccc gcccaagctg gagtacgtct ggaggaacat cattctcatg gccctgctgc
      481 acgtgggagc cctgtacggg atcacactgg ttccctcctg caagctctac acctgcctct
      541 tcgcgtttgt ctactatgtg atcagtattg agggcattgg agccggagtc catcgcctgt
      601 ggagccacag aacgtacaag gcacgcctgc ccctgcggat cttcctcatc attgccaaca
      661 ccatggcgtt ccagaatgac gtgtatgaat gggcccgaga tcaccgagcc caccacaagt
      721 tctcagaaac acacgccgac cctcacaatt cccgccgtgg cttcttcttc tctcacgtgg
      781 gttggctgct tgtgcgcaaa cacccggctg tcaaagagaa gggcggaaaa ctggacatgt
      841 ctgacctgaa agccgagaag ctggtgatgt tccagaggag gtactacaag cctggcattc
      901 tgctgatgtg cttcatcctg cccacgctgg tgccctggta ctgctggggc gagacttttc
      961 taaacagttt ttatgttgcc actttactga gatacgctgt ggtgctcaac gccacttggc
     1021 tggtgaacag tgccgcccac ctctacgggt atcgccccta cgataagaac atcgatcccc
     1081 ggcagaatgc cctggtttcc ttgggaagta tgggcgaggg cttccacaac taccaccatg
     1141 ccttccccta cgactactct gccagtgagt accgctggca catcaacttc accacgttct
     1201 tcatcgactg catggctgca ctgggcctgg cttacgaccg gaagagagtg tccaaggcca
     1261 ctgtcttagc caggattaag agaactggag acgggagtca caagagtggc tgaatttgga
     1321 gtcagtctat tccaaaagcc agctggatag gggtttaata atgttttttc aaataccgaa
     1381 aagaagcacc catgttgtat agtgtcctac ttcaagacaa tattcttgta aaatattcaa
     1441 atattaaaag accaaaactt tcttttatga tgctaagcag aaattctcct gttcttagtc
     1501 ttgtatccga gggaccttct tattgcttaa cccttcttat tactttactg tcttttcagg
     1561 agagctgcag gtgagcaaca ggttggaata gacctttgaa aacgcggcaa atgttttaaa
     1621 ttaaagaacc ccaccaagag cactctttcc ttgatctctc ttgagcttca gggtaggtgt
     1681 ctcaagccaa atccaaccag ctcttcctgg atgttctctg ttaattccca tcaggccaca
     1741 ggaaagacaa cacacacaca cacacacaca cacacacaca cacacactac atacacaccc
     1801 accaccaaaa aaacaaccaa aaaccctaaa ctttccttgg cactgagctg gtgttgcatt
     1861 aagacatcat ggaggagcgc taccatgcca gggaggaccc tgaagcagag atggtgttgt
     1921 aaggaatgag ttctaaaaat gttctttctg gggctggaga gatggctcag tggttaagag
     1981 caccgactgc tcttccagag gtccggagtt caattcccag caaccacatg gtggctcata
     2041 accatctgta atgggatctg atgaactctt ctggtgtggc cgctgtgtac gcatatacat
     2101 aaaataaatc tttaaaaaaa taaaaatgtt ctttctgtga tcagacccag ctgcttccca
     2161 agcagacatg gagcccggca cacagcacac gccacacggc agccttcctt tctgtcttga
     2221 gcctcagagc ttggtaatga aactcttccc acttcaaggc agagatggag aggctggggg
     2281 atagatagca ttggtaggca gattgtgaga gataactttc tcagaaacag ctgtttgggt
     2341 tgaagatttc cttgatgtcc ttctgaaaca gtttcaaagc tgggttcctt tcttagtcca
     2401 gtttgttcct tgggttaata ggagtcaggg attcctgcat agcgtcctga tgcctattgc
     2461 ccagttcctt cctattaagt gtgaggttta tgactatctt aggtcagtga atctccgttg
     2521 catacgactg gtttaacgaa acagctgaaa gatgcaacac gggttggtta gttttcatca
     2581 attagttttc atcttcctca gctgtggacg ctgtattcaa caagcaagtg gtccggcaat
     2641 gtgcccacca gcatgagaga agcaagtctg gtaggagggt aacccactga ctcatgagtc
     2701 aatgcgagac ccactgtaat tccaatagac ctcggagtga tgggggcaca ggaaggagaa
     2761 cctcctagat gcttcctggc tagccaccta ggagtagccg ggcaagagag accctgcctc
     2821 aaaaacaagg taaaagaact cactcccaaa agttgtcctg tggcctgcac atgtgtaccc
     2881 cttgtgtata tgtaccccat atacaccaca cacacacaca cacacacaca cacacacatt
     2941 gctactaatt tttaaaaacg ctacagctgt ggagttccaa ggctttactg gggaagctat
     3001 tactgttgtt tcctatatgt aatatatcca tcgaattgct ttctgaacaa ctagttttgc
     3061 ccatagatta gtgttgcaag atatttgatc acaccgtgaa ccctgagatt gtgtaattta
     3121 ctgggggggg gggggggact gcttctaatc gtggtgtggc tcggccctag cactcatctt
     3181 taatccaaaa agctttctgt aaacagcttt aaataaagtc aaccataggt caagaggcag
     3241 agcaagcaac cagttgacag ggactgaaca taggagaaaa aaaaaagaga gagggagagg
     3301 gagccaggag gacggatgga gagacgcatt agaagtagaa gggagggaca ttcagtttga
     3361 gggggttttg agagggtgtg gaagagaact tgctcttttg ggatgttggc tatggaggaa
     3421 ggtcagctgg gtgctttctc tgcctctctg agctagcaga ctttcacccc
//
