LOCUS       NM_009128               5453 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus stearoyl-Coenzyme A desaturase 2 (Scd2), mRNA.
ACCESSION   NM_009128
VERSION     NM_009128.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5453)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   2  (bases 1 to 5453)
  AUTHORS   York,A.G., Skadow,M.H., Oh,J., Qu,R., Zhou,Q.D., Hsieh,W.Y.,
            Mowel,W.K., Brewer,J.R., Kaffe,E., Williams,K.J., Kluger,Y.,
            Smale,S.T., Crawford,J.M., Bensinger,S.J. and Flavell,R.A.
  TITLE     IL-10 constrains sphingolipid metabolism to limit inflammation
  JOURNAL   Nature 627 (8004), 628-635 (2024)
   PUBMED   38383790
REFERENCE   3  (bases 1 to 5453)
  AUTHORS   Lin,J.B., Mora,A., Wang,T.J., Santeford,A., Usmani,D., Ligon,M.M.,
            Mysorekar,I.U. and Apte,R.S.
  TITLE     Loss of stearoyl-CoA desaturase 2 disrupts inflammatory response in
            macrophages
  JOURNAL   mBio 14 (4), e0092523 (2023)
   PUBMED   37417745
  REMARK    GeneRIF: Loss of stearoyl-CoA desaturase 2 disrupts inflammatory
            response in macrophages.
REFERENCE   4  (bases 1 to 5453)
  AUTHORS   Sinha,S., Aizawa,S., Nakano,Y., Rialdi,A., Choi,H.Y., Shrestha,R.,
            Pan,S.Q., Chen,Y., Li,M., Kapelanski-Lamoureux,A., Yochum,G.,
            Sher,L., Monga,S.P., Lazaris,A., Machida,K., Karin,M., Guccione,E.
            and Tsukamoto,H.
  TITLE     Hepatic stellate cell stearoyl co-A desaturase activates
            leukotriene B4 receptor 2 - beta-catenin cascade to promote liver
            tumorigenesis
  JOURNAL   Nat Commun 14 (1), 2651 (2023)
   PUBMED   37156770
  REMARK    GeneRIF: Hepatic stellate cell stearoyl co-A desaturase activates
            leukotriene B4 receptor 2 - beta-catenin cascade to promote liver
            tumorigenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5453)
  AUTHORS   Kanno,T., Nakajima,T., Yokoyama,S., Asou,H.K., Sasamoto,S.,
            Kamii,Y., Hayashizaki,K., Ouchi,Y., Onodera,T., Takahashi,Y.,
            Ikeda,K., Hasegawa,Y., Kinjo,Y., Ohara,O., Nakayama,T. and Endo,Y.
  TITLE     SCD2-mediated monounsaturated fatty acid metabolism regulates
            cGAS-STING-dependent type I IFN responses in CD4+ T cells
  JOURNAL   Commun Biol 4 (1), 820 (2021)
   PUBMED   34188173
  REMARK    GeneRIF: SCD2-mediated monounsaturated fatty acid metabolism
            regulates cGAS-STING-dependent type I IFN responses in CD4(+) T
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5453)
  AUTHORS   Ntambi,J.M.
  TITLE     Regulation of stearoyl-CoA desaturase by polyunsaturated fatty
            acids and cholesterol
  JOURNAL   J Lipid Res 40 (9), 1549-1558 (1999)
   PUBMED   10484602
  REMARK    Review article
REFERENCE   7  (bases 1 to 5453)
  AUTHORS   Tabor,D.E., Xia,Y.R., Mehrabian,M., Edwards,P.A. and Lusis,A.J.
  TITLE     A cluster of stearoyl CoA desaturase genes, Scd1 and Scd2, on mouse
            chromosome 19
  JOURNAL   Mamm Genome 9 (4), 341-342 (1998)
   PUBMED   9530639
REFERENCE   8  (bases 1 to 5453)
  AUTHORS   Park,E.I., Paisley,E.A., Mangian,H.J., Swartz,D.A., Wu,M.X.,
            O'Morchoe,P.J., Behr,S.R., Visek,W.J. and Kaput,J.
  TITLE     Lipid level and type alter stearoyl CoA desaturase mRNA abundance
            differently in mice with distinct susceptibilities to
            diet-influenced diseases
  JOURNAL   J Nutr 127 (4), 566-573 (1997)
   PUBMED   9109606
REFERENCE   9  (bases 1 to 5453)
  AUTHORS   Diczfalusy,U., Eggertsen,G. and Alexson,S.E.
  TITLE     Clofibrate treatment increases stearoyl-CoA desaturase mRNA level
            and enzyme activity in mouse liver
  JOURNAL   Biochim Biophys Acta 1259 (3), 313-316 (1995)
   PUBMED   8541340
REFERENCE   10 (bases 1 to 5453)
  AUTHORS   Kaestner,K.H., Ntambi,J.M., Kelly,T.J. Jr. and Lane,M.D.
  TITLE     Differentiation-induced gene expression in 3T3-L1 preadipocytes. A
            second differentially expressed gene encoding stearoyl-CoA
            desaturase
  JOURNAL   J Biol Chem 264 (25), 14755-14761 (1989)
   PUBMED   2570068
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ110442.1, AK083922.1, CF168778.1, AK159413.1 and CJ242760.1.
            
            On May 15, 2008 this sequence version replaced NM_009128.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040384.1, AK147406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-407               CJ110442.1         4-410
            408-2860            AK083922.1         2-2454
            2861-3351           CF168778.1         107-597
            3352-3998           AK083922.1         2946-3592
            3999-5447           AK159413.1         717-2165
            5448-5453           CJ242760.1         431-436
FEATURES             Location/Qualifiers
     source          1..5453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..5453
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /note="stearoyl-Coenzyme A desaturase 2"
                     /db_xref="GeneID:20250"
                     /db_xref="MGI:MGI:98240"
     exon            1..736
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     CDS             713..1789
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /EC_number="1.14.19.1"
                     /note="delta(9)-desaturase 2; fatty acid desaturase 2;
                     Acyl-CoA desaturase 2 (Stearoyl-CoA desaturase 2) (Fatty
                     acid desaturase 2) (Delta(9)-desaturase 2)"
                     /codon_start=1
                     /product="stearoyl-CoA desaturase 2"
                     /protein_id="NP_033154.2"
                     /db_xref="CCDS:CCDS29848.1"
                     /db_xref="GeneID:20250"
                     /db_xref="MGI:MGI:98240"
                     /translation="MPAHILQEISGAYSATTTITAPPSGGQQNGGEKFEKSSHHWGAD
                     VRPELKDDLYDPTYQDDEGPPPKLEYVWRNIILMALLHLGALYGITLVPSCKLYTCLF
                     AYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHH
                     KFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYK
                     PGLLLMCFVLPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYD
                     KNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYD
                     RKRVSRAAVLARIKRTGDGSCKSG"
     exon            737..1019
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1150
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1356
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..1589
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..5453
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5431..5436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /note="hexamer: AATGAA"
     polyA_site      5453
                     /gene="Scd2"
                     /gene_synonym="mir-5114; Mir5114; Scd-2; swty"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctctgg aaatgcaaag accggatgga gttgcaagtg gtcggcgctc tagtggcttt
       61 cccactttat gtacctctcc gcgtcttcct gccccggtag ccaaccccca ctgctagatt
      121 gggtcttctc ttccagagaa agcgctgaag cgcccccgtg gcagggtggg ggctgggtgg
      181 aggaccagcg ggggatgggt gagaagccag gagcagaaaa agaagggagg aggggggggc
      241 ggagctggag gcagagggaa cagcagattg tgcagagcca atgagagcag caggacgagg
      301 tggtaccaaa ttcccatcgg ccaatgacta gccagagttt acgaaggcct cattagcatc
      361 gcccccctcc gcttggctag ggatgggaca atgcggtgtt ggtgtctgca gtattctgac
      421 tcctggacac cggtggctgc aagctgcgat tttggcgtcc tctcattttc tatccttatc
      481 tccgcccgcg gctgccctgg ccagccagtt tttgattttt tatctggtca ttgatcaata
      541 taacgaacct aaggatatac aggacattaa taccccactg ccagctctgg cccagagctt
      601 gtaccgcgca gcgggctgca gaaacttagt catagcaccc tttgtcgctg aggtctgaag
      661 ctcgctgcac gttctcatcc ctgggaacgt gaccccagca tccgacgcca agatgccggc
      721 ccacatactg caagagatct ctggcgctta ctcagccacc accacaatca cagcgccacc
      781 ttctggggga cagcagaatg gaggcgagaa gtttgaaaag agttctcacc actggggagc
      841 agatgttcgc cctgaactaa aagatgatct atatgacccc acctatcagg atgatgaggg
      901 gcccccgccc aagctggagt acgtctggag gaacatcatt ctcatggccc tgctgcattt
      961 gggagccttg tacgggatca cactggttcc ctcctgcaag ctctacacct gtctcttcgc
     1021 gtatttgtac tatgtaatca gcgccctggg catcacagcc ggggctcatc gcctgtggag
     1081 ccacagaaca tacaaggcac ggctgcccct gaggctcttc ctcatcattg ccaacaccat
     1141 ggcgttccag aatgacgtgt atgaatgggc ccgagatcac cgcgcccacc acaagttctc
     1201 agaaacacac gccgaccctc acaattcccg ccgtggcttc tttttctctc acgtgggttg
     1261 gctgcttgtg cgcaaacacc cggctgtcaa agagaagggc ggaaaactgg acatgtctga
     1321 cctgaaagcc gagaagctgg tgatgttcca gaggaggtac tacaagcccg gcctcctgct
     1381 gatgtgcttc gtcctgccca cgctggtgcc ctggtactgc tggggcgaga cttttgtaaa
     1441 cagcctgtgc gttagcacct tcttgcgata cgccgtggtg ctcaacgcca cctggctggt
     1501 gaacagtgcc gcccacctct acggatatcg cccctacgac aagaacatta gctctcggga
     1561 gaacatcttg gtttccatgg gagctgtggg cgagggcttc cacaactacc accacgcctt
     1621 cccctacgac tactctgcca gtgagtaccg ctggcacatc aacttcacca cgttcttcat
     1681 cgattgcatg gctctcctgg gcctggctta cgaccggaag agagtgtcca gggctgctgt
     1741 cttggccagg attaagagaa ctggagacgg aagctgcaag agcggctgag tgtggggtct
     1801 tgcagttcct gttccagaag ccagcttggc agaggcttac tgttctgtta attaactact
     1861 gagtattgcc acccagatgc taaaatgatg actgacgtta acccattctg gtacagtatt
     1921 gtaaaacgga caaaaatcgg aagtcgacag ctcttccttc tatgctaagc tcatcttccc
     1981 ttctagtttc ttttcccgtt gtctttttct ttgctttgtc cctgatgacc tcgtttctca
     2041 ttgcttctcc caagccagcc gccgctcagc tataggtcag tgttcacctt ccagagtaca
     2101 ccaacttctc aagggtctac agtaaaggtt cgtgccccac ccccaactct tcttaagctg
     2161 ctctgagtta gaaatacaag aaaaatcttg agagatttct cctgttattt ttagcccagg
     2221 ctttgccaga tggaatgaaa aagaaaatag tttttatttg gcagggagcc tataaaagag
     2281 gtaaatctta aggggccaag ttcaacacgc aggctatgat tcatcaaagc cgtgggagag
     2341 ggggatctct tatgaacagg ctcagctccg tctggcagag ctaccgcagc ctttcaacat
     2401 agcgcgcctc ctctcctaat tcttagtagg tggcaactga ggaacttcgt gacactaaaa
     2461 tacagtaaca catcagtatc tcagtgtagt ttaggctgaa gatttaaaaa atatatatat
     2521 atatatatac tagtaaagtg aaaaacaatt tgtaggaaaa gtggtcttta ataaggattt
     2581 tcttttcctt taatgacaag gacccggggc caggtgtggt ggcttgcatc ttaaattgca
     2641 ggactggaga ggcagaggca ggtggatctc tgagttcaaa gccagccagg gctagatagt
     2701 gagaccttgt ctcaaattaa aaaaaacaac agttagcagg acatgcagag caagggaccc
     2761 tcgagtgagg catgtttgga atccgtaggg cagtcgctca tggtttcgag cgtcccgtga
     2821 gctgcacccc cagggtcttt ttaattcctg ttcttccatc tttaagatga tggtcgtgcc
     2881 cacaaattga ggatagctgt ggcgtttcca tacatctaac agtggaagga tttcaagagt
     2941 tgaacttgag tcacagttaa aactgaaaag tcgtaaagtc tgtcctggat ccttacaaac
     3001 actccgtgag tgcttccctc agaagacgat gctgcgcgcc ttctccctcc cactgtcggg
     3061 cagtggacgg gcacgttgga agtcgctgtg ggcgcctcct aatgacttct caaaggaaag
     3121 cttctgaggg ccccttacca ggggacttca cggctttggg gtgttctagt ggagcaggtt
     3181 aggttttttt tagccccttt cagtcccgct gctgtttgtg gcaaggcagt actgactcat
     3241 gcctcactag ctctgtgacc aggtaggact ctgcctggga tacatggttg aaatctctca
     3301 gctctaccac acctgcctct tttcccctac ccattttttg tgttttgggg tgggtttttt
     3361 tgttgtattt cttttttcct ctttgacatt tagtcttggt ctaggcagaa atgtcctgga
     3421 tatttccagg cagtaaagat gtgtggtcct ggcaccttcc tcactcagag atacaacctc
     3481 tatctgcagt aggtagagac ggctatcctt ttctggtggg tttcagattc tccacctctt
     3541 atccctccca ggcttctgac actctcttca gctctaaaga aaaagtttgg ccaactttct
     3601 agaaacatcc ctggctcaga gagactcttt gtcagtcatt ccaaaacaaa tggtttggtg
     3661 gcacacatgc cggcgagtca gggcggacag agcatgcacc gtgctcccgg cacttggcaa
     3721 agcttcggca aagcttcgcg ggctaatcag ccctcctggg tgatgctgtg gttaagtggg
     3781 aagcacagca ctcgaggttg tgttcttaag tgcctctgtt tgaaagcttt gggtagggta
     3841 ggagagctga gatgccatga atttcacaga aaggctctcg tgcagcagtg cagaagcctg
     3901 gccgcgtcgg ctgtacagca taccaggtgc tgtgcttcga ggggacagtc ttcctgggct
     3961 agttgaatag agagaggctt tagggccttc ctgtgcccac ttgaaagtag ccttaccctt
     4021 cagctgtttg ctaaaagaga attcttgggc gaatccaagg tatttgctga gctgtggccc
     4081 tattctattc cttggatatg ccttttgagt gatttcagtt ccgctggtta tggtgcccac
     4141 ttaaacaaat gtgaaaaata aaagcagctc tcttcttagc ctgccccgtg gatctgaacc
     4201 atgctgtggc taaggacccc gtaaaataac atctgtcgtt aagggtgtac cagctcacta
     4261 agaaacactg ctatcaagat ttttaaagct caaaccaagt gacactttta ataagagact
     4321 aagatctgat tgagggagtt ttctaacagt ccttgcctcg tggacacgct aaagtttgac
     4381 ttgggtgcct tacctctttt ctaaccagtg ttgctcgtga gcctgtggcg ctcgcttgct
     4441 cgctcgctcg ctcgctccgt ggattcctta aaaccagaga gcctgtaagt gtggcaagat
     4501 caaaactggc ctggctggag ggttagctgg acatggatct gcaggattgc ctctggggac
     4561 ctcgttttgg gaacttttct tggggctgtt ttgctcaagt gcccgtagct gatggatggg
     4621 tgaagtaatt ttgaacgtac gcgatttgta ggttttgtta tttgttttaa gatttaaaag
     4681 ctggttatag gattttaagt gaaagctttt cttcctggtt tgctagtgtt cttgagtgtc
     4741 ttctttagtt gaaataggtt agtaggaaat ttaagaaagt ggtggccgtg ttacactggt
     4801 ggtgaaggcc agggccgcct accaactctc agttttttgt aacagtccca ctctgacgat
     4861 aatgagttca ctccttggat aaggatgtta atgagggaag agccttcccg acctgaccta
     4921 atcagctctt actggaccca gctgtcaaca ctgttgcatt ggggatttaa gtttccaacc
     4981 catgacttat gggacagatt caaaccgtag cactgggcat ttcgcctaac aatactgtga
     5041 ctcagtattc tgtgaaactg ggataatatt cctgacctac ctccacgggt aggtgtgagc
     5101 atgagaaaat gctctttata aaacatttgg ggatcctctg cagaggagta tttaagtcct
     5161 gcacattttt gtagtaactg tccatcgtgg acttgacatg tgcctatgtc ccagatgacg
     5221 ttgttaatct acatcattct cagaggttga atggatgcgt cagataatgt atactcactg
     5281 ctatgaaaac atgcaggact ccgtttcctt ccttgggtgg gatttttcct ttattatgtg
     5341 caactgtagt tatttgtaat ctaataattt tcattaatac caactccgaa agtatttcta
     5401 ctcatctgag gttgtgtttg ttcataataa aatgaaatga tctgactgca aaa
//
