LOCUS       NM_009127               4844 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus stearoyl-Coenzyme A desaturase 1 (Scd1), mRNA.
ACCESSION   NM_009127
VERSION     NM_009127.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4844)
  AUTHORS   He,H., Bell,S.M., Davis,A.K., Zhao,S., Sridharan,A., Na,C.L.,
            Guo,M., Xu,Y., Snowball,J., Swarr,D.T., Zacharias,W.J. and
            Whitsett,J.A.
  TITLE     PRDM3/16 regulate chromatin accessibility required for NKX2-1
            mediated alveolar epithelial differentiation and function
  JOURNAL   Nat Commun 15 (1), 8112 (2024)
   PUBMED   39284798
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4844)
  AUTHORS   Velez-delValle,C., Hernandez-Mosqueira,C.P., Castro-Rodriguez,L.I.,
            Vazquez-Sandoval,A., Marsch-Moreno,M. and Kuri-Harcuch,W.
  TITLE     Gene expression and characterization of clonally derived murine
            embryonic brown and brite adipocytes
  JOURNAL   FEBS Open Bio 14 (9), 1503-1525 (2024)
   PUBMED   38972757
REFERENCE   3  (bases 1 to 4844)
  AUTHORS   Mao,X., Wang,L., Chen,Z., Huang,H., Chen,J., Su,J., Li,Z., Shen,G.,
            Ren,Y., Li,Z., Wang,W., Ou,J., Guo,W. and Hu,Y.
  TITLE     SCD1 promotes the stemness of gastric cancer stem cells by
            inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling
            pathway
  JOURNAL   Int J Biol Macromol 275 (Pt 2), 133698 (2024)
   PUBMED   38972654
  REMARK    GeneRIF: SCD1 promotes the stemness of gastric cancer stem cells by
            inhibiting ferroptosis through the SQLE/cholesterol/mTOR signalling
            pathway.
REFERENCE   4  (bases 1 to 4844)
  AUTHORS   Mori,H., Peterson,S.K., Simmermon,R.C., Overmyer,K.A., Nishii,A.,
            Paulsson,E., Li,Z., Jen,A., Uranga,R.M., Maung,J.N., Yacawych,W.T.,
            Lewis,K.T., Schill,R.L., Hetrick,T., Seino,R., Inoki,K., Coon,J.J.
            and MacDougald,O.A.
  TITLE     Scd1 and monounsaturated lipids are required for autophagy and
            survival of adipocytes
  JOURNAL   Mol Metab 83, 101916 (2024)
   PUBMED   38492843
  REMARK    GeneRIF: Scd1 and monounsaturated lipids are required for autophagy
            and survival of adipocytes.
REFERENCE   5  (bases 1 to 4844)
  AUTHORS   Harris,J.C., Trigg,N.A., Goshu,B., Yokoyama,Y., Dohnalova,L.,
            White,E.K., Harman,A., Murga-Garrido,S.M., Ting-Chun Pan,J.,
            Bhanap,P., Thaiss,C.A., Grice,E.A., Conine,C.C. and Kambayashi,T.
  TITLE     The microbiota and T cells non-genetically modulate inherited
            phenotypes transgenerationally
  JOURNAL   Cell Rep 43 (4), 114029 (2024)
   PUBMED   38573852
REFERENCE   6  (bases 1 to 4844)
  AUTHORS   Kyriakis,J.M., App,H., Zhang,X.F., Banerjee,P., Brautigan,D.L.,
            Rapp,U.R. and Avruch,J.
  TITLE     Raf-1 activates MAP kinase-kinase
  JOURNAL   Nature 358 (6385), 417-421 (1992)
   PUBMED   1322500
REFERENCE   7  (bases 1 to 4844)
  AUTHORS   Ntambi,J.M.
  TITLE     Dietary regulation of stearoyl-CoA desaturase 1 gene expression in
            mouse liver
  JOURNAL   J Biol Chem 267 (15), 10925-10930 (1992)
   PUBMED   1350282
REFERENCE   8  (bases 1 to 4844)
  AUTHORS   Danciger,M., Kozak,C.A., Adamson,M.C. and Farber,D.B.
  TITLE     Chromosomal localization of the murine genes for the alpha- and
            beta-subunits of calcium/calmodulin-dependent protein kinase II
  JOURNAL   Mamm Genome 3 (2), 122-125 (1992)
   PUBMED   1319776
REFERENCE   9  (bases 1 to 4844)
  AUTHORS   Weiner,F.R., Smith,P.J., Wertheimer,S. and Rubin,C.S.
  TITLE     Regulation of gene expression by insulin and tumor necrosis factor
            alpha in 3T3-L1 cells. Modulation of the transcription of genes
            encoding acyl-CoA synthetase and stearoyl-CoA desaturase-1
  JOURNAL   J Biol Chem 266 (35), 23525-23528 (1991)
   PUBMED   1684180
REFERENCE   10 (bases 1 to 4844)
  AUTHORS   Josefowicz,W.J. and Hardy,M.H.
  TITLE     The expression of the gene asebia in the laboratory mouse. I.
            Epidermis and dermis
  JOURNAL   Genet Res 31 (1), 53-65 (1978)
   PUBMED   631559
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD544724.1, AK148103.1, BQ885468.1, BU053011.1, AK012370.1 and
            AA881780.1.
            
            On Apr 28, 2009 this sequence version replaced NM_009127.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.13448.1,
                                           SRR1660813.147170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CD544724.1         1-39
            40-1521             AK148103.1         3-1484
            1522-1871           BQ885468.1         358-707
            1872-2570           BU053011.1         3-701
            2571-4832           AK012370.1         550-2811
            4833-4844           AA881780.1         443-454
FEATURES             Location/Qualifiers
     source          1..4844
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 37.98 cM"
     gene            1..4844
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /note="stearoyl-Coenzyme A desaturase 1"
                     /db_xref="GeneID:20249"
                     /db_xref="MGI:MGI:98239"
     exon            1..324
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1368
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /EC_number="1.14.19.1"
                     /note="delta(9)-desaturase 1; fatty acid desaturase 1;
                     stearoyl-CoA desaturase 1; asebia"
                     /codon_start=1
                     /product="acyl-CoA desaturase 1"
                     /protein_id="NP_033153.2"
                     /db_xref="CCDS:CCDS29850.1"
                     /db_xref="GeneID:20249"
                     /db_xref="MGI:MGI:98239"
                     /translation="MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRP
                     EMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIF
                     YYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFS
                     ETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGL
                     LLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNI
                     QSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKK
                     VSKATVLARIKRTGDGSHKSS"
     exon            325..598
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..729
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            730..935
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1168
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..4837
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4806..4811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /note="hexamer: AATAAA"
     polyA_site      4832
                     /gene="Scd1"
                     /gene_synonym="ab; Scd; Scd-1"
                     /note="major polyA site"
ORIGIN      
        1 cacctccacg cctggcttcc ttggctagct atctctgcgc tctttaccct ttgctggcag
       61 ccgataaaag ggggctgagg aaatactgaa cacggtcatc ccatcgcctg ctctaccctt
      121 taaaatccca gcccagggag atctgtgcac agccagaccg ggctgaacac ccatcccgag
      181 agtcaggagg gcaggtttcc aagcgcagtt ccgccactcg cctacaccaa cgggctccgg
      241 aaccgaagtc cacgctcgat ctcagcactg ggaaagtgag gcgagcaact gactatcatc
      301 atgccggccc acatgctcca agagatctcc agttcttaca cgaccaccac caccatcact
      361 gcacctccct ccggaaatga acgagagaag gtgaagacgg tgcccctcca cctggaagaa
      421 gacatccgtc ctgaaatgaa agaagatatt cacgacccca cctatcagga tgaggaggga
      481 cccccgccca agctggagta cgtctggagg aacatcattc tcatggtcct gctgcacttg
      541 ggaggcctgt acgggatcat actggttccc tcctgcaagc tctacacctg cctcttcggg
      601 attttctact acatgaccag cgctctgggc atcacagccg gggctcatcg cctctggagc
      661 cacagaactt acaaggcacg gctgcccctg cggatcttcc ttatcattgc caacaccatg
      721 gcgttccaga atgacgtgta cgaatgggcc cgagatcacc gcgcccacca caagttctca
      781 gaaacacacg ccgaccctca caattcccgc cgtggcttct tcttctctca cgtgggttgg
      841 ctgcttgtgc gcaaacaccc ggctgtcaaa gagaagggcg gaaaactgga catgtctgac
      901 ctgaaagccg agaagctggt gatgttccag aggaggtact acaagcccgg cctcctgctg
      961 atgtgcttca tcctgcccac gctggtgccc tggtactgct ggggcgagac ttttgtaaac
     1021 agcctgttcg ttagcacctt cttgcgatac actctggtgc tcaacgccac ctggctggtg
     1081 aacagtgccg cgcatctcta tggatatcgc ccctacgaca agaacattca atcccgggag
     1141 aatatcctgg tttccctggg tgccgtgggc gagggcttcc acaactacca ccacaccttc
     1201 cccttcgact actctgccag tgagtaccgc tggcacatca acttcaccac gttcttcatc
     1261 gactgcatgg ctgccctggg cctggcttac gaccggaaga aagtttctaa ggctactgtc
     1321 ttagccagga ttaagagaac tggagacggg agtcacaaga gtagctgagc tttgggcttc
     1381 tgagttcctg tttcaaacgt tttctggcag agatttaata ttctgttgat taactaacaa
     1441 ctggatattg ctatcggggt gttaatgatg catttaacct attccggtac agtattctta
     1501 taaaatgaga aagctttgat cacgttttga ggtaataaat attttattta gctaggatta
     1561 accatgccac aagacattat atatttctaa gcacacatga taaatgcata tacaattttg
     1621 cacaacagct ttaaataata acaataaatt tgaacattct atacagagag gatcaaagcc
     1681 aaggaacatg ctgttttgat gctagggtga gcatggtgct cagtccctgt ttgtttgcat
     1741 ggtgtccagc tttgtttctt ctctgtcatc accaccttca ggcaaatagt tgaccaacca
     1801 ctggcctgtg tctgtccacc ctccaaagcc caggccacct ttctgttttc tgaaatactg
     1861 atccttcctc ctgaatacat ccctccttgt tcctagcttc aagactgctg cctcaaacta
     1921 gggatagagc aagtccccgc tgatgaagtt cactgcaggt tgtgctagat gggatggaga
     1981 aattatcttc atttgataca gagcaagtag attgtctcga gagaaaagtt agcatgcgtg
     2041 gtatgatttg taagtaaaga tggaagagag agagagagag agagagagag agagagagag
     2101 agaggtagcc atatctaaca gcctacttac caaagacccc aggcctctct gcttggcatg
     2161 cctcctttct gtccatcctc tgaaccccag agattagtga gatttgaata attaaatcat
     2221 tttcagagtg aagggggtta atgcagggtc tgtgctaggg gagggtttta gcttttggta
     2281 actgaagatt ttttcatgga aaaagtcttc gtgttcaatg tgcctagaac tgataactaa
     2341 acagctgaca tttgtcgggg acagatatgg tgtgaaacta tgaaaatata agcaaaatct
     2401 tcacttggaa catgaaacta tttcacttag aaaataatcg aaggacccga ggtgttgcct
     2461 gggttgccag tttctttcgt ggctgggcag gaactagtga ggttgagggg cagtgtctgt
     2521 aagtagctgc taagaggtgc atttccagat gaagcccttg gggaacatct gccagggatc
     2581 cgcatggtgt tggctccatc cattgcttta gtttcctcct tggattgtgt agaaacttgg
     2641 cttcccatgg ttttgaacct tccatgcctt ctttgctttg tggccaccca gcctgcctag
     2701 tgctgcctag gaagctctta cccacctgat ttcttctgac atttctttct ttggcctttt
     2761 tttctttctc cggacatgca gctagttgcc tgagtgtatc aagagcaccc aggacttgct
     2821 gctgtccagg cctgttcctc ccccagtatc cgtgggtgtg gaagagctgt gtagcttcag
     2881 gaagcagagc caggtgccac ctttctgtgg cttccagatc ctccctacct ccaactcatg
     2941 tgcctctgtc acagtgattt caggaaagct tggtagaccc tctagcaaca tctcggttca
     3001 gaaagtctct ctggtttgtg agttaacagc tcagctaagt gctgttttgt ctcagtgagt
     3061 taaccactga atgcgagggt tggttgttga tctgtctcgg tgtgtgtcgg agtagacagc
     3121 atatgcactt ctccctgtgc gctttgcaag gtaatgtggc tttggctgat ccatgcaggc
     3181 aggtagtggt acagtgctgc tgaaaggaag aagttcccca ttttatctgt taaaacacca
     3241 gagacatggg caagtgctaa tggacctcac ttcaggaaga gggtctgctt cctgaagcca
     3301 gtgtgtgatg aaaagtgact gagacctgat atctaaggtg agacctgata cctaacactc
     3361 tgtcacacag tccagggcca acagtgctat aggaaagtct agaagaaaac atcacatcag
     3421 tattttagaa ccatcaacca tctcttgtcc ctatagccca atccagaggc ctggttttta
     3481 gaactggctg tgtaaggtgc caaacactca gttcacttgt agaatcagag ccttttttcc
     3541 cccctatgtt aattgaacac gcgctctgag ctgttttgtt gaagtagaaa atctcataga
     3601 aaaatcactg tagatctact gacctatagc cctctggaaa tgcctttgag atggttttac
     3661 ttttctaggt catagatgcc tgatttataa gatgaacaat aaaatcagct ttctttcttt
     3721 ctcttctgat cttattcccc agatctgatt caggccatgt tccaaagcaa ggctacattg
     3781 aggtcctggt gtctttaagt aaaggacatc tttcagatcc tctcaaagaa ggatttataa
     3841 cagtttccag atgaatgtac taatagcttt gggtgcctta tctctttcct aatctgtagt
     3901 gcctgtgagc tcagtctcac tccttccctt agcccggaga ccccttagat cgagtgggaa
     3961 tagtcaagag gctggctgga gagtcatcag tacattggtt tgcagaaatc ttttacaggc
     4021 tacattttgg aatttttttt tttttagtaa gtgatcaaat ttggtgggaa gtaattcgag
     4081 tgtattcgat tgtattgtcg tcctcgttat cattgtcaaa catgttatag acggcagttg
     4141 gcactggggc tgctaatctc tgggtgtagt ctctgaaact gtagctccag tgaggtggtg
     4201 tgaaaggtta gcaaagccac catctgctgg tggctccagc caaggtgcct cttagccact
     4261 gaattgctat gttatccttt ctcttgtaac aaacccaccc cagagataaa gcctttaatc
     4321 aacccaagaa actcctgggc taagtatctg acagtctcac atctcaacag tgtgaattaa
     4381 gtgtccatag catcagctca ggaggacact ctgggagagt gctgacaaaa aagggttatt
     4441 aatactgacc tactacttca agggcagttc tgaggtgatt agagcttttt ttaaaaacca
     4501 agtatttggg gatcctcagc agaggtattc atacagactc ccaaagaact atatatgttc
     4561 ctgagaccat cgtttagtct acattgctct tcccagagac tgacagatat gaccagtcaa
     4621 agtgcaagac tacctaccca ctgccatgaa aaccattgca ggaaaccttt cccttccctg
     4681 aatgagattt tttttttccc tttttatgtg gggtaattat ttgtgaccca agtgtaattt
     4741 ggatgatttc cattaatatc aactcttgaa gcctacttgt actgattgag attgtatttg
     4801 ttcctaataa aagtggatct ggttgtactg tctgggaaaa aaaa
//
