LOCUS       NM_178653               1927 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus saccharopine dehydrogenase (putative) (Sccpdh),
            transcript variant 1, mRNA.
ACCESSION   NM_178653 XM_905846
VERSION     NM_178653.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1927)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1927)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113977.16.
            
            On Mar 6, 2023 this sequence version replaced NM_178653.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046033.1, AK077695.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-315               AC113977.16        137601-137915
            316-428             AC113977.16        139953-140065
            429-509             AC113977.16        145761-145841
            510-639             AC113977.16        147411-147540
            640-689             AC113977.16        148250-148299
            690-820             AC113977.16        148955-149085
            821-938             AC113977.16        149862-149979
            939-1058            AC113977.16        150803-150922
            1059-1115           AC113977.16        151021-151077
            1116-1227           AC113977.16        153575-153686
            1228-1309           AC113977.16        155066-155147
            1310-1927           AC113977.16        155942-156559
FEATURES             Location/Qualifiers
     source          1..1927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 83.62 cM"
     gene            1..1927
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /note="saccharopine dehydrogenase (putative)"
                     /db_xref="GeneID:109232"
                     /db_xref="MGI:MGI:1924486"
     exon            1..315
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1415
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /EC_number="1.5.1.9"
                     /note="isforom 1 is encoded by transcript variant 1;
                     probable saccharopine dehydrogenase; saccharopine
                     dehydrogenase-like oxidoreductase"
                     /codon_start=1
                     /product="saccharopine dehydrogenase-like oxidoreductase
                     isforom 1"
                     /protein_id="NP_848768.1"
                     /db_xref="CCDS:CCDS15563.1"
                     /db_xref="GeneID:109232"
                     /db_xref="MGI:MGI:1924486"
                     /translation="MATEQRPFHLVVFGASGFTGQFVTEEVAREQIASEQSSRLPWAV
                     AGRSKEKLQQVLEKAAQKLGRPSLSSEVGVIICDISNPASLDEMAKQAKLVLNCVGPY
                     RFYGEPVVKACIENGTSCIDICGEPQFLELMHAKYHEKAAEKGVYIIGSSGFDSIPAD
                     LGVLYTRNQMNGTLTAVESFLTINTGPEGLCIHDGTWKSAIYGFGDKGSLRKLRSVSC
                     LKPVPIVGTKLKRRWPVSYCRELNSYSIPFLGSDISVVKRTQRYLHENLEDSPVQYAA
                     YVTVGGITSVIKLMFAGLFFLFFVKFSIGRQLLIKFPWLFSFGYFSKQGPTQKQMDET
                     SFTMTFFGQGYSHGTCVEKNKPNIRICTQVKGPEAGYVATPIAMVQAAMTFLSDASDL
                     PKGGGVFTPGAAFSRTKLIDRLNKHGIEFSVISSSEV"
     exon            316..428
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            429..509
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            510..639
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            640..689
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            690..820
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            821..938
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1058
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1115
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1227
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1309
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1927
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /note="hexamer: ATTATA"
     polyA_site      1567
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /note="major polyA site"
     regulatory      1904..1909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1927
                     /gene="Sccpdh"
                     /gene_synonym="C330023F11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gctgtagccg cgccgacggc ggccaggaca gcggcggttg ctgcgcccgg tactggggtc
       61 ccggcctgag gcgcaggcgc ggtggactca gcccgccccg ggctgcagct cgctgtggac
      121 tcgtcatggc gacggagcag aggcctttcc acctggtggt gttcggcgcc tctggcttca
      181 ccggccagtt cgtgacggag gaggtggccc gggagcagat agcctcggag cagagctccc
      241 gcctgccctg ggccgtggcg ggtcgctcca aggagaagct gcagcaagtg ctggagaagg
      301 ctgcccagaa actgggaaga ccatcactat catctgaagt tggagtcata atctgtgata
      361 tcagtaatcc agcctcactt gatgaaatgg ctaaacaggc aaagcttgtc ctcaactgcg
      421 taggaccgta tcgattttat ggagaacctg tagtaaaagc atgtattgaa aatggaacaa
      481 gttgtattga catctgtggg gaacctcagt ttctggaact aatgcatgcg aagtatcatg
      541 agaaagctgc agagaagggg gtttatatca ttggaagcag tggctttgac tccatcccag
      601 cagatctagg agtgctatac accaggaacc agatgaacgg tactttgact gctgtagaaa
      661 gcttcctgac aataaataca ggacctgagg ggttgtgtat tcatgatgga acctggaagt
      721 cggcaattta tggttttggc gataagggta gtttaagaaa actacggagt gtatcatgtc
      781 tgaaacctgt cccaattgtt ggtacaaagt tgaaaagaag gtggccagtc agctattgta
      841 gagagctgaa ctcgtattcc attccttttt tgggatctga tatatctgtt gtgaaaagga
      901 ctcagcgtta cttacatgaa aatttagagg actcaccagt tcagtatgct gcttatgtga
      961 cggtgggagg catcacctct gtgattaagc tgatgtttgc aggactgttc tttttattct
     1021 ttgtgaagtt tagcattgga agacaacttc tcataaaatt cccatggctc ttttcctttg
     1081 gctatttttc aaaacaaggt ccaacacaaa aacagatgga tgagacatca tttacaatga
     1141 cattctttgg tcaaggatac agccatggca cttgtgttga aaagaacaaa ccaaatatcc
     1201 gaatctgcac tcaagtgaag ggaccagagg ctggctacgt ggctactccc atagccatgg
     1261 ttcaggctgc catgactttt ctgagtgacg cctctgacct tccaaaaggg ggcggtgtct
     1321 ttacacctgg agcagctttc tccagaacaa agttgattga cagactcaac aaacatggca
     1381 ttgaatttag tgtcattagc agctccgaag tctaaacgtt tgaagactaa ccgaatcata
     1441 aaatgcacaa accgcgtctg tatttgatat gtgaaattct tctataagcc tatctgactg
     1501 tatgtggact gtcaagtata aaatatctgt acattaaaag caggaaatta tactatctta
     1561 tcctaaactt catatctcag ctgtttttat gattttattg cttgtgagag gaaactaaca
     1621 ttctccttac gtttttattg acaagtgaac tggaaggtca gatggtgaag agagcccctg
     1681 ttggtgttgc tgacagcatt ccttagtgac ggagcgtggc tgctgttagg ctgtggcagt
     1741 agagtctgcc ttccctgccc tggtgttgtg gaatctcacc ctcctctaag ttcctctgcg
     1801 tagcatgtga gcgtttgcta agtgaaactg tacttctact tcagtctgct ttctcaccca
     1861 tctactccat ggactgatct tggattgttt aactcagttg aataataaag ggttatttat
     1921 tgagtga
//
