LOCUS       NM_153790               3356 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus scavenger receptor class F, member 2 (Scarf2), mRNA.
ACCESSION   NM_153790
VERSION     NM_153790.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3356)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3356)
  AUTHORS   Bildsoe,H., Fan,X., Wilkie,E.E., Ashoti,A., Jones,V.J., Power,M.,
            Qin,J., Wang,J., Tam,P.P.L. and Loebel,D.A.F.
  TITLE     Transcriptional targets of TWIST1 in the cranial mesoderm regulate
            cell-matrix interactions and mesenchyme maintenance
  JOURNAL   Dev Biol 418 (1), 189-203 (2016)
   PUBMED   27546376
REFERENCE   3  (bases 1 to 3356)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   4  (bases 1 to 3356)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3356)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3356)
  AUTHORS   Berwin,B., Delneste,Y., Lovingood,R.V., Post,S.R. and Pizzo,S.V.
  TITLE     SREC-I, a type F scavenger receptor, is an endocytic receptor for
            calreticulin
  JOURNAL   J Biol Chem 279 (49), 51250-51257 (2004)
   PUBMED   15371419
  REMARK    GeneRIF: SREC-I is a type F scavenger receptor and an endocytic
            receptor for calreticulin
REFERENCE   7  (bases 1 to 3356)
  AUTHORS   Tamura,Y., Osuga,J., Adachi,H., Tozawa,R., Takanezawa,Y.,
            Ohashi,K., Yahagi,N., Sekiya,M., Okazaki,H., Tomita,S., Iizuka,Y.,
            Koizumi,H., Inaba,T., Yagyu,H., Kamada,N., Suzuki,H., Shimano,H.,
            Kadowaki,T., Tsujimoto,M., Arai,H., Yamada,N. and Ishibashi,S.
  TITLE     Scavenger receptor expressed by endothelial cells I (SREC-I)
            mediates the uptake of acetylated low density lipoproteins by
            macrophages stimulated with lipopolysaccharide
  JOURNAL   J Biol Chem 279 (30), 30938-30944 (2004)
   PUBMED   15145948
  REMARK    GeneRIF: role of scavenger receptor expressed by endothelial cells
            I (SREC-I) in the uptake of modified lipoproteins as well as in the
            development of atherosclerosis
REFERENCE   8  (bases 1 to 3356)
  AUTHORS   Ishii,J., Adachi,H., Aoki,J., Koizumi,H., Tomita,S., Suzuki,T.,
            Tsujimoto,M., Inoue,K. and Arai,H.
  TITLE     SREC-II, a new member of the scavenger receptor type F family,
            trans-interacts with SREC-I through its extracellular domain
  JOURNAL   J Biol Chem 277 (42), 39696-39702 (2002)
   PUBMED   12154095
  REMARK    GeneRIF: binds to SRECI and has a similar tissue distribution
            pattern
REFERENCE   9  (bases 1 to 3356)
  AUTHORS   Lund,J., Chen,F., Hua,A., Roe,B., Budarf,M., Emanuel,B.S. and
            Reeves,R.H.
  TITLE     Comparative sequence analysis of 634 kb of the mouse chromosome 16
            region of conserved synteny with the human velocardiofacial
            syndrome region on chromosome 22q11.2
  JOURNAL   Genomics 63 (3), 374-383 (2000)
   PUBMED   10704284
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF522197.1, AC078895.34 and BC059226.1.
            
            On Nov 24, 2015 this sequence version replaced NM_153790.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF522197.1, AB024432.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1728              AF522197.1         2-1729
            1729-1729           AC078895.34        180565-180565       c
            1730-3302           AF522197.1         1731-3303
            3303-3356           BC059226.1         3440-3493
FEATURES             Location/Qualifiers
     source          1..3356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.03 cM"
     gene            1..3356
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /note="scavenger receptor class F, member 2"
                     /db_xref="GeneID:224024"
                     /db_xref="MGI:MGI:1858430"
     exon            1..246
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..2599
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /note="scavenger receptor type F; scavenger receptor
                     expressed by endothelial cells 2 (acetyl LDL receptor
                     like)"
                     /codon_start=1
                     /product="scavenger receptor class F member 2 precursor"
                     /protein_id="NP_722485.1"
                     /db_xref="CCDS:CCDS28010.1"
                     /db_xref="GeneID:224024"
                     /db_xref="MGI:MGI:1858430"
                     /translation="MEGAGSRGAGPARRQGARGLGLLLLLWLLPGLAAPQDLNPRGRN
                     VCRTPGSQVLTCCAGWRQLGDECGIAVCEGNSTCSENEVCVRPGECRCRHGYFGANCD
                     TKCPRQFWGPDCKERCSCHPHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRSG
                     ACRCEPGWWGAQCASACYCSATSRCDPQTGACLCHVGWWGRSCNNQCACNSSPCEQQS
                     GRCQCRERMFGARCDRYCQCSHGRCHPVDGTCACDPGYRGKYCREPCPAGFYGPGCRR
                     RCGQCKGQQPCTVVEGRCLTCEPGWNGTKCDQPCATGFYGEGCGHRCPPCRDGHACNH
                     VTGKCTHCNAGWIGDRCETKCSNGTYGEDCAFVCSDCGSGHCDFQSGRCLCSPGVHGP
                     HCNVTCPAGLHGVDCAQACSCHEESCDPVTGACHLETNQRKGVMGAGALLTLLLGLLL
                     SLLGCCCACRGKDSARRELTLGRKKAPQRFCGSFSRISMKLPRIPLRRQKLPKVVVAH
                     HDLDNTLNCSFLDPPSGLEQPSPSWSSRASFSSFDTTDEGPVYCVPHEEATADSRDLE
                     ATAALTEVAAVSLEPTGTSTPGEEAAVLPASSDSERSASSVEGPSGALYARVARREAR
                     PARTRNEAGGLSLSPSPERRKPPPPDPATKPKVSWIHGKHSAAAAAPSPPPAGRKAAP
                     SPSGRKRTPSNSSVQPPGLTEEAPGPASPTPPRARARGRGLGLSEPTDAGGPPRSAPE
                     AASMLAAELRDKTRSLGRAEKPPPPQKAKRSVLPAATVRTASASEASGSEKAAASAPA
                     PETPRKKTPIQKPPRKKSREAAGEPSRAGTAPGAS"
     exon            247..305
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..407
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            408..927
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1146
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1275
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1379
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1497
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1613
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1766
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..3308
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3290..3295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3308
                     /gene="Scarf2"
                     /gene_synonym="NSR1; Scatf1; SREC-II; Srec2; SrecII;
                     SRECRP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcccctcc tgccgccccc cgcccggcct cgcactccgc ttccggccgc ccttgccgcg
       61 gccgcacccg cgcccacccg cgcctgcccc gcgcctcatg gagggcgcag ggtcccgggg
      121 ggccgggccg gcgcggcgcc agggagcccg agggctggga ctgctgctgc tgctctggct
      181 gctgcccggt ctcgcggcgc cccaggactt gaacccgcga ggccgcaacg tgtgccgcac
      241 gcccggttcc caggtgctca cgtgttgcgc tggctggagg cagctggggg atgagtgtgg
      301 gatagcggtg tgcgaaggca attccacgtg ctcagaaaac gaggtgtgcg tgcggccagg
      361 cgaatgccgc tgccgacatg gctactttgg tgccaactgc gacacaaagt gcccgcgcca
      421 gttctggggc cctgactgca aggagaggtg cagttgccac ccgcacggac agtgcgagga
      481 cgtgaccgga cagtgtacgt gtcacgcgcg ccgctggggt gcgcgctgcg agcatgcttg
      541 ccaatgccag catggcacgt gccacccgcg gagcggcgcg tgccggtgcg agccgggctg
      601 gtggggtgcg caatgcgcta gcgcttgcta ttgcagcgct acttcccggt gcgatccaca
      661 gacaggcgcc tgcctgtgcc acgtaggctg gtggggccgc agctgtaaca accagtgcgc
      721 ctgcaactcg tcgccctgcg agcagcagag tggccgctgc cagtgtcgcg agcgcatgtt
      781 tggcgcccgc tgtgatcgct attgccagtg ctctcacggt cgctgccacc cggtggacgg
      841 cacgtgtgcc tgcgatcctg gctaccgggg caagtattgt cgcgagccat gccccgctgg
      901 attctatggc ccgggctgtc gccgtcggtg tggccaatgc aaaggccagc agccgtgcac
      961 ggtagtcgaa ggccgctgtc tgacatgcga gcccggctgg aacggaacca aatgtgacca
     1021 accctgcgcc accggtttct acggcgaagg ttgtggccac cgctgcccac cctgccgcga
     1081 cgggcatgcc tgcaaccatg tcaccggcaa gtgtacgcac tgcaatgcgg gctggatcgg
     1141 cgaccggtgc gagactaagt gcagtaatgg cacttacggt gaggactgtg ccttcgtgtg
     1201 ctctgattgc ggcagcggcc actgtgactt ccagtccggg cgctgccttt gcagccctgg
     1261 tgttcacgga cctcactgta atgtaacttg cccggccggg ctccacggcg tggactgcgc
     1321 ccaggcctgc agctgtcacg aggaatcatg cgacccggtc accggtgcct gccacctgga
     1381 gaccaatcag cgcaaaggtg tgatgggcgc gggcgctctg ctcacgctgc tcctcggcct
     1441 gctgctctcg ctgctcggtt gttgctgcgc ctgccggggc aaggactcgg cgcgccggga
     1501 gctcaccctt ggaaggaaga aggcgcctca acgtttttgt ggaagcttca gccgcatcag
     1561 catgaagctg ccccgaatcc cgcttcgcag gcagaagctg cccaaagtcg tagtggccca
     1621 tcatgaccta gacaacacac tcaactgcag ttttctggac ccaccctcag ggctggagca
     1681 gccctctcca tcatggtcct ccagggcctc cttctcatca ttcgacacca cagatgaagg
     1741 ccctgtgtac tgtgtgcccc acgaggaagc gactgccgac agccgagacc tggaagcgac
     1801 tgccgctctc actgaggtgg ccgctgtgtc cttagagccc acgggcacct cgacgcccgg
     1861 ggaggaggca gcggtcctcc ctgcatcctc agacagcgag cgctccgcat caagcgtgga
     1921 ggggccgagc ggggcgctgt acgcgcgtgt ggcccggcgc gaggcccggc cggcccggac
     1981 ccgaaatgag gctgggggct tgtcactgtc cccatcgccc gagcgcagga agccgccacc
     2041 accagaccct gccaccaagc ctaaggtgtc ctggatccac ggcaagcaca gcgccgctgc
     2101 cgctgcaccg tcgcctccgc ctgcaggccg caaggctgcg ccgagcccta gcgggaggaa
     2161 acggaccccc agcaactcgt cggtgcagcc ccccggactg accgaggagg cccccggccc
     2221 ggcttcaccc acgccacccc gcgcccgagc gcgcggccgc ggcctggggc tctcggagcc
     2281 aacggacgcg ggaggtcccc cgcgcagcgc gcccgaggcc gcctctatgc tggcagctga
     2341 gctgcgcgac aagactcgca gcttaggccg cgccgagaag ccgccgccgc cgcagaaggc
     2401 caagcgctcc gtgctccccg ccgcgacggt ccgcacagcc tcggcgtccg aggcctcggg
     2461 gtcagagaag gcggcggcca gcgcacctgc gcccgagacc cctcggaaga aaacccccat
     2521 ccagaaaccg cctcggaaga agagcaggga ggcagcgggg gagccgagta gggcgggcac
     2581 ggcccccgga gcttcctaag ctcgcagccc caggaggctt tctcaccacc atttccccgc
     2641 gcggccgcag cgaaggcatt tcattggccc ccaaagccca gcgcccgccc aagcctgcgt
     2701 ctggttggcc taggctcaag cagccgcggc ctggttggat ctgctctcgg gcctcgcaga
     2761 cacttagctg gctacccgct cccactagca aagttgtgga gcttttctag taatctctgt
     2821 ctcgttggcc atggcttgga gagcctacag acttcttact ggccaagaag agtgttcttg
     2881 gcagggctac cttgtcactg gccgatgcca gcagcgcttc tgcctcttgg ctgcctctca
     2941 tttgccaagg cctggtgcct atggctgaag ggtctttttc tctgaagaca aaaagaggtt
     3001 gcgtccataa actgggctcc agagtatctg gttggcccga acctggggag aagagctggt
     3061 ctcttcttcg cagggggctc agcccatgtt ggcttgtccc cttcccacgc acgccagccc
     3121 tggtctctca gccatcaagc tggttttgat ggcctcctat caccccacga gggaacccca
     3181 gggcctactc tggtggcttt agatgtattt ataggccctg ggcagggctt ctctcatccc
     3241 atctgggacc ttctggatgg gctcctcata gcaggccaaa gctttcttta ataaaatgct
     3301 tctccccaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
