LOCUS       NM_007644               4729 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus scavenger receptor class B, member 2 (Scarb2), mRNA.
ACCESSION   NM_007644
VERSION     NM_007644.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4729)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4729)
  AUTHORS   Miwatashi,W., Ishida,M., Takashino,A., Kobayashi,K., Yamaguchi,M.,
            Shitara,H. and Koike,S.
  TITLE     Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice
  JOURNAL   J Virol 96 (15), e0056122 (2022)
   PUBMED   35867561
  REMARK    GeneRIF: Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal
            Mice.
REFERENCE   3  (bases 1 to 4729)
  AUTHORS   Zou,Y., Pei,J., Wang,Y., Chen,Q., Sun,M., Kang,L., Zhang,X.,
            Zhang,L., Gao,X. and Lin,Z.
  TITLE     The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted
            mTORC1-Dependent Mitochondrial OXPHOS
  JOURNAL   Int J Mol Sci 23 (15), 8634 (2022)
   PUBMED   35955761
  REMARK    GeneRIF: The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via
            Disrupted mTORC1-Dependent Mitochondrial OXPHOS.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4729)
  AUTHORS   Stojkovska,I., Wani,W.Y., Zunke,F., Belur,N.R., Pavlenko,E.A.,
            Mwenda,N., Sharma,K., Francelle,L. and Mazzulli,J.R.
  TITLE     Rescue of alpha-synuclein aggregation in Parkinson's patient
            neurons by synergistic enhancement of ER proteostasis and protein
            trafficking
  JOURNAL   Neuron 110 (3), 436-451 (2022)
   PUBMED   34793693
REFERENCE   5  (bases 1 to 4729)
  AUTHORS   Heybrock,S., Kanerva,K., Meng,Y., Ing,C., Liang,A., Xiong,Z.J.,
            Weng,X., Ah Kim,Y., Collins,R., Trimble,W., Pomes,R., Prive,G.G.,
            Annaert,W., Schwake,M., Heeren,J., Lullmann-Rauch,R., Grinstein,S.,
            Ikonen,E., Saftig,P. and Neculai,D.
  TITLE     Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved
            in lysosomal cholesterol export
  JOURNAL   Nat Commun 10 (1), 3521 (2019)
   PUBMED   31387993
  REMARK    GeneRIF: Study provides multiple lines of evidence that LIMP-2
            participates in lipid transport from lysosomes by transporting
            cholesterol (and possibly also other lipid species) through its
            luminal cavity to the lysosomal membrane and later to lipid
            droplets. Data indicate that LIMP-2 operates in parallel with
            Niemann Pick (NPC)-proteins, mediating a slower mode of lysosomal
            cholesterol export.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4729)
  AUTHORS   Kunjathoor,V.V., Febbraio,M., Podrez,E.A., Moore,K.J.,
            Andersson,L., Koehn,S., Rhee,J.S., Silverstein,R., Hoff,H.F. and
            Freeman,M.W.
  TITLE     Scavenger receptors class A-I/II and CD36 are the principal
            receptors responsible for the uptake of modified low density
            lipoprotein leading to lipid loading in macrophages
  JOURNAL   J Biol Chem 277 (51), 49982-49988 (2002)
   PUBMED   12376530
  REMARK    GeneRIF: SR-A and CD36 are responsible for the preponderance of
            modified LDL uptake in macrophages and that other scavenger
            receptors do not compensate for their absence
REFERENCE   7  (bases 1 to 4729)
  AUTHORS   Kuronita,T., Eskelinen,E.L., Fujita,H., Saftig,P., Himeno,M. and
            Tanaka,Y.
  TITLE     A role for the lysosomal membrane protein LGP85 in the biogenesis
            and maintenance of endosomal and lysosomal morphology
  JOURNAL   J Cell Sci 115 (Pt 21), 4117-4131 (2002)
   PUBMED   12356916
  REMARK    GeneRIF: Overexpression of LGP85 causes an enlargement of early
            endosomes and late endosomes/lysosomes. LGP85 may participate in
            reorganizing the endosomal/lysosomal compartments.
REFERENCE   8  (bases 1 to 4729)
  AUTHORS   Belz,G.T., Vremec,D., Febbraio,M., Corcoran,L., Shortman,K.,
            Carbone,F.R. and Heath,W.R.
  TITLE     CD36 is differentially expressed by CD8+ splenic dendritic cells
            but is not required for cross-presentation in vivo
  JOURNAL   J Immunol 168 (12), 6066-6070 (2002)
   PUBMED   12055215
  REMARK    GeneRIF: CD36 is differentially expressed by CD8+ splenic dendritic
            cells but is not required for cross-presentation in vivo.
REFERENCE   9  (bases 1 to 4729)
  AUTHORS   Schulz,O., Pennington,D.J., Hodivala-Dilke,K., Febbraio,M. and Reis
            e Sousa,C.
  TITLE     CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for
            MHC class I cross-presentation of cell-associated antigen by CD8
            alpha+ murine dendritic cells
  JOURNAL   J Immunol 168 (12), 6057-6065 (2002)
   PUBMED   12055214
  REMARK    GeneRIF: CD36 is not essential for MHC class I cross-presentation
            of cell-associated antigen by CD8 alpha+ dendritic cells.
REFERENCE   10 (bases 1 to 4729)
  AUTHORS   Tabuchi,N., Akasaki,K., Sasaki,T., Kanda,N. and Tsuji,H.
  TITLE     Identification and characterization of a major lysosomal membrane
            glycoprotein, LGP85/LIMP II in mouse liver
  JOURNAL   J Biochem 122 (4), 756-763 (1997)
   PUBMED   9399579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD349164.1, AK083038.1,
            CV558446.1, BB851354.1, AK034388.1 and BE852231.1.
            
            On Aug 20, 2015 this sequence version replaced NM_007644.3.
            
            Summary: This gene encodes a CD36-like type III transmembrane
            glycoprotein that localizes to the lysosomal membrane. Mice lacking
            the encoded protein exhibit an increased postnatal mortality caused
            by an obstruction of the ureteropelvic junction, deafness,
            peripheral demyelinating neuropathy and tubular proteinuria.
            [provided by RefSeq, Aug 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144235.1, AK083038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-49                CD349164.1         1-49
            50-2159             AK083038.1         2-2111
            2160-2399           CV558446.1         321-560
            2400-2410           BB851354.1         139-149
            2411-4713           AK034388.1         2-2304
            4714-4729           BE852231.1         1-16                c
FEATURES             Location/Qualifiers
     source          1..4729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 46.82 cM"
     gene            1..4729
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /note="scavenger receptor class B, member 2"
                     /db_xref="GeneID:12492"
                     /db_xref="MGI:MGI:1196458"
     exon            1..466
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            467..624
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            625..772
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            773..961
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1053
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1173
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1343
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1462
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1536
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1588
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1747
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..4721
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4702..4707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /note="hexamer: AAGAAA"
     polyA_site      4718
                     /gene="Scarb2"
                     /gene_synonym="9330185J12Rik; Cd36l2; LGP85; LIMP II;
                     LIMP-2; MLGP85"
                     /note="major polyA site"
ORIGIN      
        1 cgcttcccgg cgcagtcgcc agccgtcacc atcaccgccg ccgcggcttg ctggcgagcc
       61 ccaccagccc gcgtcaccgc tctgcgcgct ccctgcacct ccctggctgc agcagccgga
      121 gaaaacgaaa gccaggcggc cccggcactc gcgatcgcac cggctctgct gctcattccg
      181 gtatctactc cagggctgtg cgcactgcgc gggcagcggc tgaacacgca cggagaaggt
      241 gcgggagccg caggggcccc gggctttggg cggctgctgc tcggccttgg cggaggcttg
      301 ttccagctcg ccgttcggtc ccaggcctgg ccggtgagct gcgcgcagta tgggcagatg
      361 ctgcttctac acggcgggga cgctgtctct gctgctgctg gtgaccagcg tcacgctgct
      421 agtggctcga gtctttcaga aggcggtaga ccagacgatc gagaagaata tggtattaca
      481 aaatggcacc aaggtcttta attcctggga gaagccccct ctacctgtgt acatccagtt
      541 ttatttcttc aatgtcacca atcctgagga gatcctccaa ggagaaatcc ccctactaga
      601 agaagtgggg ccatacacct acagggagct ccggaacaag gcaaatattc agtttggaga
      661 aaatggaaca actatatctg ctgtcaccaa taaggcatat gtttttgaac gaaaccaatc
      721 tgttggagat cctaacgttg acttgattag aacaataaat attcctctgt tgactgtcgt
      781 ggatctggcc cagctgaccc tgctcaggga gcttatcgaa gccatgctga aagcctatca
      841 gcagaagttg tttgtgattc acaccgtgca cgaactgctc tggggctaca aagatgagat
      901 cttgtccctc gtccatattt tcaaacctga cgtctccccg aatttcggcc tgttctatga
      961 gagaaatgga acgaatgacg gggagtacgt gtttctgact ggagaggaca attaccttaa
     1021 cttttcaaaa atcgtggagt ggaatggaaa aacgtcgctg gactggtgga ccacagacac
     1081 atgcaatatg attaacggga cagacggaga ctcttttcat ccgctgataa gcaaggatga
     1141 ggtcctgtac ctcttcccgt cagacttgtg caggtcagta catatcactt tcagcagctt
     1201 tgagaacgta gaaggactgc ctgcttttcg gtataaggtg cctgcagaaa tactagccaa
     1261 cacctccgaa aacgctggct tctgtatacc cgagggaaac tgcatggact caggggtgtt
     1321 gaacatcagc atctgcaaga atggtgcacc cattatcatg tctttcccac acttttacca
     1381 agccgacgag aagttcgttt ctgccataaa aggcatgcat cccaacaagg aagagcatga
     1441 gtcgtttgtg gacattaatc ccttgactgg aattattttg agaggggcca agagattcca
     1501 gatcaacact tacgttagga aactggatga ctttgttgaa acgggagaca tcaggactat
     1561 ggttttccca gtgatgtatc tcaatgagag tgtcctcatt gacaaagaga ccgcaaatca
     1621 actgaagtct gtgattaaca cgactttggt tgtcaccaac ataccctaca tcattatggc
     1681 actgggtgtg ttctttggct tggttttcac gtggctggcg tgtcgaggac aggggtctat
     1741 ggatgaggga actgcagatg aaagagcacc cctcatacga acctaatggg acttacctgt
     1801 tgcctgagct tggtgagaga atgtgagagc tgccctgacc tggaccagga cagggggaac
     1861 cctgcatcct catgggctcc tggcctgtca agaaggaaac atagcactgg caagcgagaa
     1921 gcccctcctg gtcagaggga aatgagcagg gtgacatggc tggcaattct gctttataaa
     1981 atcgtgtctc taaaactgtg ttcatgtgtc taggaagtat ttaataaact tgtgtagaaa
     2041 ctttttgtgg ttgggccctg ggagctgagg ggacttcgtg accccctgtt gtagatacaa
     2101 tgtctgaatc gcttgttaat gttccgtggc ctgacccgat tcagtgtgct tcattctcca
     2161 aactttgtgt tcagagtacg tatgtgtttc tgttgttgtt ccctgttcac ctccttacac
     2221 agaaagatgt ggtacccagg gtagaatcac agctccatac agtgtaccaa gcaaatgggg
     2281 ctgctttcct tctgtaaaac attacatttt gtgtctcgct ctaatcttca ggaaaataac
     2341 tcaagtcttt tgattggttt atagtgtgtt aggaatcaag taggggaagg gatggggtgg
     2401 ggtggggtgg tgtctgtaag tagacagcat tgagctcctg aggattttta gttgtgcttt
     2461 tgtgaagcaa gaggttgcac tgggaatgtt ggtgagggta aggcagatat ttcatttaga
     2521 atagagttca atgttagtta tggcatctag aggctaactg tcaattttag tcagagatgt
     2581 ctgggtgtag aatatgctgc tgagaggaca gaatcaatga cttctaaccc cctcccttca
     2641 ggcttctctg ccacatagga cagtgacacg gaatgacagt gtctgcaaat attgaggggt
     2701 tatttgtaaa atgacgaatg atggaagtcc atctgcccgt agcttacatt acagatagat
     2761 ccaggaagtg tgcacaggtt agagaggcat ttcttctgga cccagccggt gcttcgtggc
     2821 tccctgtcac taagtgctct ctgcttcctg tgacaatcac ttttctgaca gagcgagaaa
     2881 tgttagactg ctagtcagag gcacttcaga taaggagtcg agcagccagg ctgcttctct
     2941 ttggaaggca atggcttccg tgtaggacta aggacattag tgtcacagcc gtcagacctc
     3001 agctatcctg gagggcagag tccatgattc tcagagtcca ctattttggg gttgtttgtt
     3061 tgttttagtt tttatttttt tattttttat cttttggtgg cttagttttt aagacagggt
     3121 ttctctgtgt agccctggct gtcatggaac tcgctctata gaccagactg gcctcgaatt
     3181 cacagagatc tgacagcctc tgcctcctaa gtgctgggat taaaggctta caccattgat
     3241 tttttttttt tcaatgaacc ctatacatta tctggctagc tgtttataga attccctgaa
     3301 aactgaattt cagtatattt aaattttttt aaaaactgag atgtcacata catattagaa
     3361 gtaaaacatt gctttaatat acaggcccaa attttcctct attgacacaa agcaatacac
     3421 aatgtttccc ttttttaaaa aaattttggt agtttttgag accgggttgg tgtagtcttg
     3481 gctgttctgg aagtcactat gtaaactagg ctggccttga actcagagat cgcctgcctt
     3541 gtgtcatgag tgctgggatc cataagccac catgcttggc tgatgtttcc cttctagaga
     3601 gacagctctt taaattttca cctttcctac taatcaaagt aaaaaaatta gacaccccaa
     3661 atcaccaata tgtgaaacta aactgaaaat atctgacctt tagtaatgac aaatattttt
     3721 agactttgtc aatatttaac tcggtagttg gcacatctta gtcttcatgc ttcatgacag
     3781 ggtctcactc tgtagctcag gctatcttga aactcactat gtagcatagg ttgaccttga
     3841 atttatagtg agccggtctc agcctcccaa gtgctgctat tacaggcacg cactacacct
     3901 gtctgtgttt atgcaactac ttatccacac taataaattg ataagctagt gcatactaat
     3961 tggttcattc ctattttcag gatataatca tctctaagga gatttttaaa cacagaaact
     4021 atagcattta gtgatgtaca tagtagatag acatgatcgc acatagaaaa ggagaccaaa
     4081 aacagattga tcctttatta gtgccatggt tgtgaatagc agtggttcat ttggtgtttt
     4141 ctttctaaaa ggtccatggc aaacccacaa ggcacagtca gaattgtagg ttgattaaca
     4201 acaaatctac ccattcagtg cggggctgaa aatagcaagc tgttccctgt gttcgttctt
     4261 ctgagggcat tctcctggac gggccccaaa ggctgtggcc atcatccttc tcatgacaca
     4321 gagtggcagg gcactgggag tgcacagggt gggggatggg caggggatag gcatttccac
     4381 ataggctcta ggctctgccc agtagatttc acttccttgt gctttacaaa gatcactaac
     4441 ggtcaaatgg gacaagcact acacaactaa cccctattgg ggtttttgct taagggggat
     4501 aacttttaac ttgttgtttg cggtgtgaat tcttcaaaag gccctctgag cattgttact
     4561 ggtgtaaatt gcttgtgcct gcctggcttt aaaaagactg accagaatgc tcttcatgtg
     4621 gcttacagag ttggttcgtt gttgtgcttc ttgacctggt tttatttcta cccataatac
     4681 aatgaaatgt ttcactaatt aaagaaagtt tctataaagt taaaaaaaa
//
