LOCUS       NM_001205083            2196 bp    mRNA    linear   ROD 06-SEP-2023
DEFINITION  Mus musculus scavenger receptor class B, member 1 (Scarb1),
            transcript variant 3, mRNA.
ACCESSION   NM_001205083
VERSION     NM_001205083.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Kobayashi K, Iwasa K, Azuma-Suzuki R, Kawauchi T and Nabeshima YI.
  TITLE     Feto-maternal cholesterol transport regulated by beta-Klotho-FGF15
            axis is essential for fetal growth
  JOURNAL   Life Sci Alliance 6 (10), e202301916 (2023)
   PUBMED   37541847
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Guilbaud E, Barouillet T, Ilie M, Borowczyk C, Ivanov S, Sarrazy V,
            Vaillant N, Ayrault M, Castiglione A, Rignol G, Brest P, Bazioti V,
            Zaitsev K, Lebrigand K, Dussaud S, Magnone V, Bertolotto C,
            Marchetti S, Irondelle M, Goldberg I, Huby T, Westerterp M, Gautier
            EL, Mari B, Barbry P, Hofman P and Yvan-Charvet L.
  TITLE     Cholesterol efflux pathways hinder KRAS-driven lung tumor
            progenitor cell expansion
  JOURNAL   Cell Stem Cell 30 (6), 800-817 (2023)
   PUBMED   37267915
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Zhang M, Salbaum JM, Jones S, Burk D and Kappen C.
  TITLE     Aberrant lipid accumulation in the mouse visceral yolk sac
            resulting from maternal diabetes and obesity
  JOURNAL   Front Cell Dev Biol 11, 1073807 (2023)
   PUBMED   36936697
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Dunigan-Russell K, Yaeger MJ, Hodge MX, Kilburg-Basnyat B, Reece
            SW, Birukova A, Guttenberg MA, Novak C, Chung S, Ehrmann BM,
            Wallace ED, Tokarz D, Majumder N, Xia L, Christman JW, Shannahan J,
            Ballinger MN, Hussain S, Shaikh SR, Tighe RM and Gowdy KM.
  TITLE     Scavenger receptor BI attenuates oxidized phospholipid-induced
            pulmonary inflammation
  JOURNAL   Toxicol Appl Pharmacol 462, 116381 (2023)
   PUBMED   36681128
  REMARK    GeneRIF: Scavenger receptor BI attenuates oxidized
            phospholipid-induced pulmonary inflammation.
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Rosales C, Yelamanchili D, Gillard BK, Liu J, Gotto AM Jr and
            Pownall HJ.
  TITLE     Serum opacity factor rescues fertility among female Scarb1-/- mice
            by reducing HDL-free cholesterol bioavailability
  JOURNAL   J Lipid Res 64 (2), 100327 (2023)
   PUBMED   36596339
  REMARK    GeneRIF: Serum opacity factor rescues fertility among female
            Scarb1[-/-] mice by reducing HDL-free cholesterol bioavailability.
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Rigotti A, Edelman ER, Seifert P, Iqbal SN, DeMattos RB, Temel RE,
            Krieger M and Williams DL.
  TITLE     Regulation by adrenocorticotropic hormone of the in vivo expression
            of scavenger receptor class B type I (SR-BI), a high density
            lipoprotein receptor, in steroidogenic cells of the murine adrenal
            gland
  JOURNAL   J Biol Chem 271 (52), 33545-33549 (1996)
   PUBMED   8969220
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Wang N, Weng W, Breslow JL and Tall AR.
  TITLE     Scavenger receptor BI (SR-BI) is up-regulated in adrenal gland in
            apolipoprotein A-I and hepatic lipase knock-out mice as a response
            to depletion of cholesterol stores. In vivo evidence that SR-BI is
            a functional high density lipoprotein receptor under feedback
            control
  JOURNAL   J Biol Chem 271 (35), 21001-21004 (1996)
   PUBMED   8798380
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Acton S, Rigotti A, Landschulz KT, Xu S, Hobbs HH and Krieger M.
  TITLE     Identification of scavenger receptor SR-BI as a high density
            lipoprotein receptor
  JOURNAL   Science 271 (5248), 518-520 (1996)
   PUBMED   8560269
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Dissen E and Fossum S.
  TITLE     Chromosomal localization of the genes encoding rat CD4, CD8alpha,
            and CD8beta
  JOURNAL   Immunogenetics 44 (4), 312-314 (1996)
   PUBMED   8753864
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Acton SL, Scherer PE, Lodish HF and Krieger M.
  TITLE     Expression cloning of SR-BI, a CD36-related class B scavenger
            receptor
  JOURNAL   J Biol Chem 269 (33), 21003-21009 (1994)
   PUBMED   7520436
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY018765.1, AK145588.1 and AK143368.1.
            
            [WARNING] On Sep 27, 2023 this sequence was replaced by
            NM_001205083.2.
            
            Transcript Variant: This variant (3) differs at the 3' end compared
            to variant 1. This results in a frame-shift and a longer isoform
            (3) with a distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145588.1, SRR13422600.1393776.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                BY018765.1         2-76
            76-2157             AK145588.1         2-2083
            2158-2196           AK143368.1         2686-2724
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 64.11 cM"
     gene            1..2196
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /note="scavenger receptor class B, member 1"
                     /db_xref="GeneID:20778"
                     /db_xref="MGI:MGI:893578"
     exon            1..338
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1775
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /note="isoform 3 is encoded by transcript variant 3;
                     scavenger receptor class B type I; scavenger receptor
                     class B1; HDL QTL 1"
                     /codon_start=1
                     /product="scavenger receptor class B member 1 isoform 3"
                     /protein_id="NP_001192012.1"
                     /db_xref="GeneID:20778"
                     /db_xref="MGI:MGI:893578"
                     /translation="MGGSSRARWVALGLGALGLLFAALGVVMILMVPSLIKQQVLKNV
                     RIDPSSLSFGMWKEIPVPFYLSVYFFEVVNPNEVLNGQKPVVRERGPYVYREFRQKVN
                     ITFNDNDTVSFVENRSLHFQPDKSHGSESDYIVLPNILVLGGSILMESKPVSLKLMMT
                     LALVTMGQRAFMNRTVGEILWGYDDPFVHFLNTYLPDMLPIKGKFGLFVGMNNSNSGV
                     FTVFTGVQNFSRIHLVDKWNGLSKIDYWHSEQCNMINGTSGQMWAPFMTPESSLEFFS
                     PEACRSMKLTYNESRVFEGIPTYRFTAPDTLFANGSVYPPNEGFCPCRESGIQNVSTC
                     RFGAPLFLSHPHFYNADPVLSEAVLGLNPNPKEHSLFLDIHPVTGIPMNCSVKMQLSL
                     YIKSVKGIGQTGKIEPVVLPLLWFEQSGAMGGKPLSTFYTQLVLMPQVLHYAQYVLLG
                     LGGLLLLVPIICQLRSQVSRRGGHASDSARVSADLCFLQLALVLPPLSHPAVTFLYKS
                     WKAQDPPRSGLG"
     exon            339..496
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            497..638
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            639..842
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            843..938
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1054
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1221
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1340
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1414
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1466
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..2196
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2176
                     /gene="Scarb1"
                     /gene_synonym="CD36; Cd36l1; Chohd1; Cla-1; Cla1;
                     D5Ertd460e; Hdlq1; Hlb398; mSR-BI; SR-B1; SR-BI; Srb1;
                     SRBI"
ORIGIN      
        1 ggaatcccgc gccgaactcg ggggcgggct gcccgggcca tggcgcataa agcctctggc
       61 cacctgcagg gctactgctg ctccggccac cgccaggcac acaccttgct gctgagggag
      121 tctcggcttc tgtcatctct gtggcctccg tcacctctgt ctccgtctcc ttcaggtcct
      181 gagccccgag agccccttcc gcgcacgcgg acatgggcgg cagctccagg gcgcgctggg
      241 tggccttggg gttgggcgcc ctggggctgc tgtttgctgc gctcggcgtt gtcatgatcc
      301 tcatggtgcc ctccctcatc aagcagcagg tgctcaagaa tgtccgcata gacccgagca
      361 gcctgtcctt cgggatgtgg aaggagatcc ccgtcccttt ctacttgtct gtctacttct
      421 tcgaagtggt caacccaaac gaggtcctca acggccagaa gccagtagtc cgggagcgtg
      481 gaccctatgt ctacagggag ttcagacaaa aggtcaacat caccttcaat gacaacgaca
      541 ccgtgtcctt cgtggagaac cgcagcctcc atttccagcc tgacaagtcg catggctcag
      601 agagtgacta cattgtactg cctaacatct tggtcctggg gggctcgata ttgatggaga
      661 gcaagcctgt gagcctgaag ctgatgatga ccttggcgct ggtcaccatg ggccagcgtg
      721 cttttatgaa ccgcacagtt ggtgagatcc tgtggggcta tgacgatccc ttcgtgcatt
      781 ttctcaacac gtacctccca gacatgcttc ccataaaggg caaatttggc ctgtttgttg
      841 ggatgaacaa ctcgaattct ggggtcttca ctgtcttcac gggcgtccag aatttcagca
      901 ggatccatct ggtggacaaa tggaacggac tcagcaagat cgattattgg cattcagagc
      961 agtgtaacat gatcaatggg acttccgggc agatgtgggc acccttcatg acacccgaat
     1021 cctcgctgga attcttcagc ccggaggcat gcaggtccat gaagctgacc tacaacgaat
     1081 caagggtgtt tgaaggcatt cccacgtatc gcttcacggc ccccgatact ctgtttgcca
     1141 acgggtccgt ctacccaccc aacgaaggct tctgcccatg ccgagagtct ggcattcaga
     1201 atgtcagcac ctgcaggttt ggtgcgcctc tgtttctctc ccacccccac ttttacaacg
     1261 ccgaccctgt gttgtcagaa gctgttcttg gtctgaaccc taacccaaag gagcattcct
     1321 tgttcctaga catccatccg gtcactggga tccccatgaa ctgttctgtg aagatgcagc
     1381 tgagcctcta catcaaatct gtcaagggca tcgggcaaac agggaagatc gagccagtag
     1441 ttctgccgtt gctgtggttc gaacagagcg gagcaatggg tggcaagccc ctgagcacgt
     1501 tctacacgca gctggtgctg atgccccagg ttcttcacta cgcgcagtat gtgctgctgg
     1561 ggcttggagg cctcctgttg ctggtgccca tcatctgcca actgcgcagc caggtaagta
     1621 ggaggggcgg ccacgcctcg gactcggctc gggtttcagc cgacctctgt ttcctgcagc
     1681 tagctcttgt tctacctcct ctctcgcacc ctgcagtaac ttttctctac aagtcctgga
     1741 aggcccagga ccctcccagg tcggggctag gctgaggcta ggtacccagt catttggcca
     1801 acaagtgggt gccacttggt gcccgctctg gaaagtgcct gccgaaggta gaggtggggg
     1861 gtcagggctg ggctggttag agaagcaaag gaaagccagg ttaaaccaaa cagagaagat
     1921 agtttttccc aaggaaaatg ctctgggctg gagttgggtg tgagatggaa gtgggaggag
     1981 ccacgtgtgg aaccatgaac ttagattttc taagtccaga gaaaaaagtg aaagaaatta
     2041 gttataaatt ttgcttgacc caaatatatc agcatatgag gctgaagttt tacatcagcc
     2101 atagagcact tgtttagcca gtgtgaggcc ttgtattcag gcctcagcgc tgacaggaaa
     2161 aaaaaataat caaaaataat gaaaatattt aaaaaa
//
