LOCUS       NM_028903               3809 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus scavenger receptor class A, member 5 (Scara5),
            transcript variant 1, mRNA.
ACCESSION   NM_028903
VERSION     NM_028903.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3809)
  AUTHORS   Yu,B., Cheng,C., Wu,Y., Guo,L., Kong,D., Zhang,Z., Wang,Y.,
            Zheng,E., Liu,Y. and He,Y.
  TITLE     Interactions of ferritin with scavenger receptor class A members
  JOURNAL   J Biol Chem 295 (46), 15727-15741 (2020)
   PUBMED   32907880
  REMARK    GeneRIF: Interactions of ferritin with scavenger receptor class A
            members.
REFERENCE   2  (bases 1 to 3809)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3809)
  AUTHORS   Lee,H., Lee,Y.J., Choi,H., Seok,J.W., Yoon,B.K., Kim,D., Han,J.Y.,
            Lee,Y., Kim,H.J. and Kim,J.W.
  TITLE     SCARA5 plays a critical role in the commitment of mesenchymal stem
            cells to adipogenesis
  JOURNAL   Sci Rep 7 (1), 14833 (2017)
   PUBMED   29093466
  REMARK    GeneRIF: This study demonstrates that SCARA5 is a positive
            regulator in adipocyte lineage commitment and early adipogenesis in
            mesenchymal stem cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3809)
  AUTHORS   Mendes-Jorge,L., Ramos,D., Valenca,A., Lopez-Luppo,M., Pires,V.M.,
            Catita,J., Nacher,V., Navarro,M., Carretero,A., Rodriguez-Baeza,A.
            and Ruberte,J.
  TITLE     L-ferritin binding to scara5: a new iron traffic pathway
            potentially implicated in retinopathy
  JOURNAL   PLoS One 9 (9), e106974 (2014)
   PUBMED   25259650
  REMARK    GeneRIF: Scara5 was downregulated, pointing out this receptor as a
            potential player implicated in retinopathy and also as a possible
            therapeutic target.
            Erratum:[PLoS One. 2017 Jun 22;12(6):e0180288. doi:
            10.1371/journal.pone.0180288.. PMID: 28640867]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3809)
  AUTHORS   Prabhudas,M., Bowdish,D., Drickamer,K., Febbraio,M., Herz,J.,
            Kobzik,L., Krieger,M., Loike,J., Means,T.K., Moestrup,S.K.,
            Post,S., Sawamura,T., Silverstein,S., Wang,X.Y. and El Khoury,J.
  TITLE     Standardizing scavenger receptor nomenclature
  JOURNAL   J Immunol 192 (5), 1997-2006 (2014)
   PUBMED   24563502
  REMARK    Review article
REFERENCE   6  (bases 1 to 3809)
  AUTHORS   Li,J.Y., Paragas,N., Ned,R.M., Qiu,A., Viltard,M., Leete,T.,
            Drexler,I.R., Chen,X., Sanna-Cherchi,S., Mohammed,F., Williams,D.,
            Lin,C.S., Schmidt-Ott,K.M., Andrews,N.C. and Barasch,J.
  TITLE     Scara5 is a ferritin receptor mediating non-transferrin iron
            delivery
  JOURNAL   Dev Cell 16 (1), 35-46 (2009)
   PUBMED   19154717
  REMARK    GeneRIF: Data show that the transferrin receptor TfR1 provided
            transferrin to the ureteric bud, but not to the capsule or the
            stroma, and that Scara5 bound serum ferritin and then stimulated
            its endocytosis from the cell surface with consequent iron
            delivery.
REFERENCE   7  (bases 1 to 3809)
  AUTHORS   Fujimoto,M., Oshima,K., Shinkawa,T., Wang,B.B., Inouye,S.,
            Hayashida,N., Takii,R. and Nakai,A.
  TITLE     Analysis of HSF4 binding regions reveals its necessity for gene
            regulation during development and heat shock response in mouse
            lenses
  JOURNAL   J Biol Chem 283 (44), 29961-29970 (2008)
   PUBMED   18755693
REFERENCE   8  (bases 1 to 3809)
  AUTHORS   Jiang,Y., Oliver,P., Davies,K.E. and Platt,N.
  TITLE     Identification and characterization of murine SCARA5, a novel class
            A scavenger receptor that is expressed by populations of epithelial
            cells
  JOURNAL   J Biol Chem 281 (17), 11834-11845 (2006)
   PUBMED   16407294
REFERENCE   9  (bases 1 to 3809)
  AUTHORS   Sarraj,M.A., McClive,P.J., Wilmore,H.P., Loveland,K.L. and
            Sinclair,A.H.
  TITLE     Novel scavenger receptor gene is differentially expressed in the
            embryonic and adult mouse testis
  JOURNAL   Dev Dyn 234 (4), 1026-1033 (2005)
   PUBMED   16245330
  REMARK    GeneRIF: Tesr is differentially expressed in the male vs. female
            embryonic and postnatal gonad, and may play a role in phagocytosis
            of apoptotic cells, cell-cell adhesion, and defense. [Tesr - testis
            expressed scavenger receptor]
REFERENCE   10 (bases 1 to 3809)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK133176.1 and BC016096.1.
            
            On Dec 1, 2009 this sequence version replaced NM_028903.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016096.1, AK133176.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3793              AK133176.1         2-3794
            3794-3809           BC016096.1         3770-3785
FEATURES             Location/Qualifiers
     source          1..3809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.35 cM"
     gene            1..3809
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /note="scavenger receptor class A, member 5"
                     /db_xref="GeneID:71145"
                     /db_xref="MGI:MGI:1918395"
     exon            1..344
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            345..462
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1826
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     testis expressed scavenger receptor; scavenger receptor
                     class A, member 5 (putative)"
                     /codon_start=1
                     /product="scavenger receptor class A member 5 isoform 1"
                     /protein_id="NP_083179.2"
                     /db_xref="CCDS:CCDS27214.1"
                     /db_xref="GeneID:71145"
                     /db_xref="MGI:MGI:1918395"
                     /translation="MDNKAMYLHTVSDRDNGSIFEEPFDGRSLSKLNLCEDGPCHKRR
                     AGGCCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLN
                     ESLRDMQLRLLQAPLQADLTEQVWKVQDALQNQTDSLLALAGLVQRLEGTLWGLHAQA
                     AQTEQAMALLRDRTGQQSDSAQLELYQLQVESNRSQLLLQRHAGLLDGLARRVGVLGE
                     ELADVGGALRGLNHSLSYDVALHSTWLQDLQVLVSNASADTRRMRLVHMDMEMQLKQE
                     LATLNVVTEDLRLKDWEHSIALRNITLAKGPPGPKGDQGNEGKEGKPGSPGLPGSRGL
                     PGERGDPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGERGERAGDMDFTMIRLV
                     NGSGPHQGRVEVFHDRRWGTVCDDGWDKKDGDVVCRMLGFHGVEEVYRTARFGQGTGR
                     IWMDDVNCKGTESSIFHCQFSKWGVTNCGHAEDAGVTCTVP"
     exon            463..591
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            592..1266
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1347
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1446
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1494
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1689
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..3794
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3771..3776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /note="hexamer: AATAAA"
     polyA_site      3794
                     /gene="Scara5"
                     /gene_synonym="4932433F15Rik; 4933425F03Rik; Tesr"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtacc tagcagagct gtgggtgact ccacagaata tctccggatc gctttctgag
       61 gctgaccgac gctgcaccaa gacaaggagt cccacgtgca gacctgttat tcagccactt
      121 tgttgaacgg atcctcccat agaagtgact ctgtggccct ggcctaaatc actaggtgac
      181 cctgaagact ctttctatat gactccatct ggatttggct ggctgtgggt acaagcttca
      241 agggactttc tgggtcttcg tggggcagca gtcagctctc tggctaccat ggcaatcgct
      301 gggaactgaa gggacagggc ccagcctcag cacggggcat acaggatacg atggacaaca
      361 aagccatgta cctgcacacc gtgagtgacc gtgacaacgg ctccatcttt gaagaaccct
      421 ttgatggcag gagcctgtcc aagctgaacc tgtgtgagga tggtccatgt cacaaacggc
      481 gggcgggagg ctgctgtaca cagctgggct ccctctcagc gctgaagcat gcagtcctgg
      541 ggctgtatct tctggtcttc ctgattcttg tgggtatctt catcttagca gtgtcccggc
      601 ctcgaagctc cccagatgac ttgaaggcgc tgactcggaa cgtcaaccgg ctgaatgaga
      661 gcctccggga catgcagctg cggctgctgc aggctccatt gcaggcagac ctgacagagc
      721 aggtgtggaa ggttcaggat gcgctgcaga accagacaga ctcgttgttg gccctggccg
      781 gcttggtgca gaggctggag ggcacgctgt gggggctgca cgcgcaggcg gcacagactg
      841 agcaggcgat ggccctgctg cgggaccgaa caggacagca gagtgactcc gcacagctgg
      901 aactctacca gctgcaggtg gaaagcaatc gaagccagct actgctgcag cgccacgcgg
      961 gcctgctgga tgggctagca cgcagggtgg gggtcctggg ggaggagctg gctgacgtgg
     1021 gcggtgcgct ccgtggtctc aaccacagcc tgtcctatga cgtggccctg cacagcacgt
     1081 ggctacagga cctgcaggtg ctggtgagca atgccagcgc agacactcgc cgtatgcggc
     1141 tggtgcacat ggacatggag atgcagctca agcaggagct ggccacactc aacgtggtga
     1201 ccgaggacct gcgtctgaag gactgggaac actccatcgc cttgaggaac atcacccttg
     1261 ccaaagggcc accgggaccc aaaggtgacc aaggaaatga agggaaggag ggaaagccag
     1321 gtagccctgg acttcctgga tctcgaggtc tgccaggaga gagaggtgac ccaggactgc
     1381 ctggtcccaa gggtgatgat gggaagctag gggctacggg ccccatgggc atgcgcggat
     1441 tcaaaggtga tcgaggccca aaaggagaga aaggagagag aggagagaga gctggtgaca
     1501 tggatttcac aatgattcgc ctggtgaatg gctccggccc acaccagggc cgggtggagg
     1561 tgttccatga tcgtcgttgg ggcacagtgt gtgacgacgg ctgggacaag aaggacgggg
     1621 acgtggtgtg ccgcatgctg ggcttccacg gggttgagga ggtgtaccgg acagctcgtt
     1681 ttgggcaagg cacagggagg atttggatgg acgatgtgaa ctgcaaggga accgagagct
     1741 ccatcttcca ctgccagttc tccaaatggg gggtgacaaa ctgtgggcat gctgaggatg
     1801 ctggggtgac ttgtactgtc ccctgagagt ggccgcagcc caaggccagg gcactgctgt
     1861 tgagccacgt tcctgtgtct ctctagggga gggggaattg cttggagcca cctaaccatg
     1921 gctcatgcct gatccaacac caccccaccc ttgctgccag ttggccctac tctggttcga
     1981 aggtgaccgg atgtcactct ctttgcagac aactgctcca aagtgctcag tgggacctac
     2041 attctgtctt tcccttccac caaggtttct acatggggag tcctagtcat ttgaaccagc
     2101 agtttgttga gctctctgaa gaagattcat aagggcctgg ggatccatat tccctttggt
     2161 ctcttggtta cagatggatg ctgatatgat atgatgtcat aggcaagcgc agcaatggag
     2221 gtgggaggtg ttatgggtca tttactttgc agataattct caaatcccac agtttcacca
     2281 tccacctccc cagcaagtag aaacccttaa tgactctgtt tccctctttt cctctgcctc
     2341 atcacaccat gttatttaga ggaaggagca gtggagaaac caatgggaga cataagaaaa
     2401 tggcagatac ctgataaacc cagctggagc tgggaatgga gggaaataac taccatgctg
     2461 tgctacatca tatcttgggt gctggaatca cttatccata ttgctgtgct aataaggcaa
     2521 ggcatgtccc tcagggcagg actctgcctc ctgggagtgc tcacctgacc cgttcatctg
     2581 gcttccaagt tagaagacca agaatgagca agactgagac caggttccca tgtgaatctt
     2641 agcgtgctct tgttaggcct gcctgagcaa caaacttggg ctgtagacat tccttcttag
     2701 aaggttgtat gtcccaaatc ctacagcaag cacatgtaag atcagacata atgggtttct
     2761 aagtacacgc aggagggctg atttgaaagg tgacatggga gctatccaca ttaacctgag
     2821 tccatcagtc gttagactgt gtctcagggt tcttggtgac attgtacctt ccaggcctct
     2881 ctaaatagaa tcctgtgatc caaggaatgc aatcctggta aacccctaaa gggtagaaag
     2941 aagtatgaaa ttcctataac cttcccatgg gaaatgagag gcctcggaac tcctcaagcc
     3001 tttagttgca cttccccctg cttacaaaga gaacataatt tgctcttgac ccagggagga
     3061 ggttgaacta gattgtacat gtgttctaga accggggagc tgcagggcag caactgagtg
     3121 cagacctgtc tggctaaaat agagtcacag acacaatcac atatcctatg aagtgagcat
     3181 tatcctgctc acagtcaaga aaaactatgt acatccaggt atagttgccc caaagatcct
     3241 gactggccac tcagccaata tttgatcttg gtcattcttg cttgcaatat gtgttattca
     3301 ctactgttct catgatctga ccaactgtta tgtttacata acatgcatgt gctcatgcac
     3361 tttcttccag agccgatgta tgtatccctg tacaagcgta gcactcctat tacattgccc
     3421 attgctcagc acgtcataat ggttacattt taaaagatag gctaacggcg gtatttttta
     3481 gaaaggtgtt ttaaaggtgc ctaaacatca ctttgaaaat tatgggaaaa aatccagtta
     3541 ccccagtgat gaagactcag caactttctc acttggtctt tacatggagg aaacacaagt
     3601 ttggctttat gtctataaaa gcaatgttaa aagtatttta agcataaaaa caagagtcgg
     3661 ctagtttaca gacctaccta cgagggcatg gaaatgacca tggcctggat ttcagggact
     3721 aatggaaact aggcctagaa tacttcagat gttttgtaag aaagaatctc aataaagtac
     3781 acatttgaaa tagaaaaaaa aaaaaaaaa
//
