LOCUS       NM_020255                780 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SCAN domain-containing 1 (Scand1), mRNA.
ACCESSION   NM_020255
VERSION     NM_020255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 780)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 780)
  AUTHORS   Eguchi,T., Csizmadia,E., Kawai,H., Sheta,M., Yoshida,K.,
            Prince,T.L., Wegiel,B. and Calderwood,S.K.
  TITLE     SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT) and
            Suppresses Prostate Cancer Growth and Migration
  JOURNAL   Cells 11 (24), 3993 (2022)
   PUBMED   36552758
  REMARK    GeneRIF: SCAND1 Reverses Epithelial-to-Mesenchymal Transition (EMT)
            and Suppresses Prostate Cancer Growth and Migration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 780)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 780)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   5  (bases 1 to 780)
  AUTHORS   Arimura,N., Horiba,T., Imagawa,M., Shimizu,M. and Sato,R.
  TITLE     The peroxisome proliferator-activated receptor gamma regulates
            expression of the perilipin gene in adipocytes
  JOURNAL   J Biol Chem 279 (11), 10070-10076 (2004)
   PUBMED   14704148
REFERENCE   6  (bases 1 to 780)
  AUTHORS   Collins,T., Stone,J.R. and Williams,A.J.
  TITLE     All in the family: the BTB/POZ, KRAB, and SCAN domains
  JOURNAL   Mol Cell Biol 21 (11), 3609-3615 (2001)
   PUBMED   11340155
  REMARK    Review article
REFERENCE   7  (bases 1 to 780)
  AUTHORS   Castillo,G., Brun,R.P., Rosenfield,J.K., Hauser,S., Park,C.W.,
            Troy,A.E., Wright,M.E. and Spiegelman,B.M.
  TITLE     An adipogenic cofactor bound by the differentiation domain of
            PPARgamma
  JOURNAL   EMBO J 18 (13), 3676-3687 (1999)
   PUBMED   10393183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR519910.1, AK009115.1 and CA451199.1.
            
            On Oct 27, 2007 this sequence version replaced NM_020255.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA451199.1, AK009115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               CR519910.1         215-350             c
            137-366             AK009115.1         1-230
            367-780             CA451199.1         196-609
FEATURES             Location/Qualifiers
     source          1..780
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 77.39 cM"
     gene            1..780
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /note="SCAN domain-containing 1"
                     /db_xref="GeneID:19018"
                     /db_xref="MGI:MGI:1343132"
     exon            1..203
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /inference="alignment:Splign:2.1.0"
     exon            204..760
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..686
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /note="peroxisome proliferative activated receptor, gamma,
                     coactivator 2; leucine-rich-domain inter-acting protein 1"
                     /codon_start=1
                     /product="SCAN domain-containing protein 1"
                     /protein_id="NP_064651.2"
                     /db_xref="CCDS:CCDS38298.1"
                     /db_xref="GeneID:19018"
                     /db_xref="MGI:MGI:1343132"
                     /translation="MAAPQPSQDPQSPAAPPEQQEGAGDCAAPSPDSGSSPAPELPGA
                     PAALNTAPYADAALRPGASRPGPETFRQRFRQFRYQDAAGPREAFRQLRELSRQWLRP
                     DIRTKEQIVEMLVQEQLQAILPEAARARRLRRRADVRITG"
     regulatory      733..738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /note="hexamer: AATAAA"
     polyA_site      760
                     /gene="Scand1"
                     /gene_synonym="2310003H23Rik; Leap1; PGC-2; Ppargc2"
                     /note="major polyA site"
ORIGIN      
        1 atcccgactc agatttcgac tctgtcgtgt ccgacttgtc cgccggctcc aatggggacc
       61 ttgcagtgcc gccatcctta gtgtcagtag agctgatgtc tacggacttc cccagatcaa
      121 acttcacgtg actggtagag gaggcggctt ccggattcgc ggatcggttc atttccggcc
      181 accgaggagc ttcgcgggtc gagacgcagg cgaggcgccg gactgcgaaa caaaggggga
      241 cgccaacagc cgtagtcatg gcggcgccgc agcccagcca ggacccccaa agccccgcgg
      301 cgcctcccga gcagcaggaa ggagccggcg actgtgcggc cccgtcgccc gattccggga
      361 gctccccggc cccggagctc cccggcgcgc ccgcagcttt gaacacggcg ccctacgctg
      421 acgccgccct gcggcccgga gcctctcggc ccggccccga gacctttcgc cagcgcttcc
      481 ggcagtttcg ctaccaggac gcggccgggc cccgggaagc cttccggcag ctgcgggagc
      541 tgtcccgcca gtggctgcgg ccggacatcc gcaccaagga gcagatcgtg gagatgctgg
      601 tgcaggagca gctgcaggcc attctaccgg aggcggcccg ggctcggcgg ctgcggcgcc
      661 gcgcggacgt gcgcatcacc ggctgagcgg cggagcctgg ggctccctgg actgacaccc
      721 tacccctgag ttaataaaag ttgaattttg acagctccca aaaaaaaaaa aaaaaaaaaa
//
