LOCUS       NM_020270               3247 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus secretory carrier membrane protein 5 (Scamp5),
            transcript variant 2, mRNA.
ACCESSION   NM_020270
VERSION     NM_020270.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3247)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3247)
  AUTHORS   Jin,L., Chen,Y., Crossman,D.K., Datta,A., Vu,T., Mobley,J.A.,
            Basu,M.K., Scarduzio,M., Wang,H., Chang,C. and Datta,P.K.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3247)
  AUTHORS   Zhang,D., Yuan,C., Liu,M., Zhou,X., Ge,S., Wang,X., Luo,G., Hou,M.,
            Liu,Z., Wang,Q.K., Wang,X., Li,H., Tan,Y., Jia,W., Wang,J., Wu,Y.,
            Wang,A., Yang,X. and Zhang,X.
  TITLE     Deficiency of SCAMP5 leads to pediatric epilepsy and dysregulation
            of neurotransmitter release in the brain
  JOURNAL   Hum Genet 139 (4), 545-555 (2020)
   PUBMED   32020363
REFERENCE   4  (bases 1 to 3247)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3247)
  AUTHORS   Castermans,D., Volders,K., Crepel,A., Backx,L., De Vos,R.,
            Freson,K., Meulemans,S., Vermeesch,J.R., Schrander-Stumpel,C.T., De
            Rijk,P., Del-Favero,J., Van Geet,C., Van De Ven,W.J.,
            Steyaert,J.G., Devriendt,K. and Creemers,J.W.
  TITLE     SCAMP5, NBEA and AMISYN: three candidate genes for autism involved
            in secretion of large dense-core vesicles
  JOURNAL   Hum Mol Genet 19 (7), 1368-1378 (2010)
   PUBMED   20071347
REFERENCE   6  (bases 1 to 3247)
  AUTHORS   Noh,J.Y., Lee,H., Song,S., Kim,N.S., Im,W., Kim,M., Seo,H.,
            Chung,C.W., Chang,J.W., Ferrante,R.J., Yoo,Y.J., Ryu,H. and
            Jung,Y.K.
  TITLE     SCAMP5 links endoplasmic reticulum stress to the accumulation of
            expanded polyglutamine protein aggregates via endocytosis
            inhibition
  JOURNAL   J Biol Chem 284 (17), 11318-11325 (2009)
   PUBMED   19240033
  REMARK    GeneRIF: exposure to ER stress increases SCAMP5 in the striatum,
            which positively regulates mtHTT aggregation via the endocytosis
            pathway
REFERENCE   7  (bases 1 to 3247)
  AUTHORS   Han,C., Chen,T., Yang,M., Li,N., Liu,H. and Cao,X.
  TITLE     Human SCAMP5, a novel secretory carrier membrane protein,
            facilitates calcium-triggered cytokine secretion by interaction
            with SNARE machinery
  JOURNAL   J Immunol 182 (5), 2986-2996 (2009)
   PUBMED   19234194
REFERENCE   8  (bases 1 to 3247)
  AUTHORS   Fernandez-Chacon,R. and Sudhof,T.C.
  TITLE     Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic
            vesicle-specific forms implicate SCAMPs in multiple
            membrane-trafficking functions
  JOURNAL   J Neurosci 20 (21), 7941-7950 (2000)
   PUBMED   11050114
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ148246.1 and BC018613.1.
            
            On Aug 26, 2014 this sequence version replaced NM_020270.2.
            
            Summary: This gene encodes a member of the Scamp (secretory carrier
            membrane protein) family. The encoded protein may be involved in
            neuronal vesicle trafficking. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018613.1, SRR1660813.83556.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                CJ148246.1         4-39
            37-3247             BC018613.1         1-3211
FEATURES             Location/Qualifiers
     source          1..3247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.05 cM"
     gene            1..3247
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /note="secretory carrier membrane protein 5"
                     /db_xref="GeneID:56807"
                     /db_xref="MGI:MGI:1928948"
     exon            1..128
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     exon            129..183
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..884
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /note="isoform 1 is encoded by transcript variant 2;
                     secretory carrier-associated membrane protein 5"
                     /codon_start=1
                     /product="secretory carrier-associated membrane protein 5
                     isoform 1"
                     /protein_id="NP_064666.1"
                     /db_xref="CCDS:CCDS40649.1"
                     /db_xref="GeneID:56807"
                     /db_xref="MGI:MGI:1928948"
                     /translation="MAEKVNNFPPLPKFIPLKPCFYQDFEADIPPQHLSLTKRLYYLW
                     MLNSVTLAVNLVGCLAWLIGGGGATNFGLAFLWLILFTPCSYVCWFRPIYKAFKTDSS
                     FSFMAFFFTFMAQLVISIIQAVGIPGWGVCGWIATISFFGTNIGSAVVMLIPTVMFTV
                     VAVFSFIALSMVHKFYRGSGGSFSKAQEEWTTGAWKNPHVQQAAQNAAMGAAQGAMNQ
                     PQTQYSATPNYTYSNEM"
     exon            184..312
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     exon            313..469
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     exon            470..571
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     exon            572..689
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     exon            690..3227
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /note="hexamer: AATAAA"
     polyA_site      3227
                     /gene="Scamp5"
                     /gene_synonym="Sc5"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcgcac gctccccgcc cccaatccgg gagccgctcg cggcccgctc cgcgcctgat
       61 cgcccggtgc agcgcagctc agcgcggcgc agcgcgacta cctttctgca gccgagcggt
      121 cggggctggt caggacaaag aggtgtgagc aggcttactg agctggctga tccatcatgg
      181 cggagaaagt gaacaacttc ccaccattgc ccaaattcat cccactgaag ccatgtttct
      241 accaagactt cgaggcagac atccctcctc agcatctcag cttgaccaag cgcctctact
      301 acctctggat gttgaacagc gtcacgctgg ccgtgaacct ggtgggctgt ctcgcgtggc
      361 tgatcggagg cgggggagcc accaactttg gcctggcctt tctctggctc atcctcttca
      421 caccttgctc ctacgtctgc tggtttcggc ccatttacaa ggccttcaag acagacagtt
      481 ccttcagctt catggcattc ttcttcacct tcatggctca gctggtcatc agcatcatcc
      541 aggctgtggg aattccaggc tggggtgtct gcggctggat tgccaccatt tccttcttcg
      601 ggacgaacat cggctcagca gtggtgatgc tcattcccac ggtcatgttc acagttgtgg
      661 ccgtcttttc cttcattgct cttagcatgg ttcataagtt ctaccggggt agcggaggca
      721 gtttcagcaa ggctcaggag gaatggacca ctggagcgtg gaagaaccca catgtgcagc
      781 aggcagccca gaatgcagcc atgggggctg ctcagggtgc catgaatcaa ccgcagactc
      841 agtattctgc cactcccaac tacacgtact ccaatgagat gtgagccagc caagcccacc
      901 aggaggcagg gctgggggcc agtgggacag ggggcttaag ccacatcttc tgtgtggtga
      961 ccaagcaggg ttcccccttc ccttttctcc tccccaactt tgtacaaaga atcagagtta
     1021 tatatatata tatatatatg tgtgtacgta tatgtatatg tctatccctg cccccacctt
     1081 tgggtcctct gggaactttg cactgcacaa gaagtgtttt ctgtgcattg gtagccaagc
     1141 ctatgtcccc ttgtgagata atgtacagtg gcgatctctt gttgtggtgc tagatgtatg
     1201 tttagaacta aaccagcccc ctccatccat caggttgtcc cctctgaccc tggcccagag
     1261 actccacagg ccagggggag gcctagcagg gagccagata ccttgtgcag ggtgatgagc
     1321 ctaagctatt tctgccttta gtcccattgg gaagcaacag tattagtgtt catggtgata
     1381 ggcaggttct aggcgatggg acagagagga tgtccccttg ctccctgtag tcctccctcc
     1441 acctcctctt cccctcgttc ctccctcatt gtgagattct ttgtgctcat ttccctagct
     1501 ggctcctccg tgatcttttt cctccccatg tagcttttcg ttgtcttcct aaagcggggt
     1561 gtctcagtta tgtctgcttt taagactacc cagatacccc caatccgctc cccagttcca
     1621 ggaagctgac atgggagctc agccaaccct gacgtggaag gggcacccag cttggggatt
     1681 ctgagcccat ttggtacttg atacggggga ggggggggaa tggaaatgca gagctgatct
     1741 ccttgattct gcaagcctgg cccgcagagg caggcatctc cttttccctc tcctggcttc
     1801 caccccttgc tgcccagatc caccttgagc cgctctgcat ttcccgctgg cttgtatgag
     1861 gcacttgcca ggtgtaaagg ccgtggtgga acagagggca tcattggtcg ctgggggagg
     1921 tgtggctggc cccagctcag aagggcttct agcttctcaa agtgaccact ggattcctgg
     1981 aaggagtagc tgttctaatt gagtctggca gaaaggatag aggtcagaag gttaggtctg
     2041 aagggggaag atctgaggag aagtcaaata ggacccattg agagggtagt tcacctctcc
     2101 agtctccctt gtcctggcta caggacacat tctgcagaga tgctcccagg cccagttcaa
     2161 gctgcaagca caatgtcctg agtaggattc ctggttggca ggaggaaggg caggatggct
     2221 ctgcctttag tttttagttt agtgttctgt ccttccctcc tcttccattc acgagaacga
     2281 caggattcga ttccaggcct ttccttagtt ctcttagaac cctcatctct ctctagactg
     2341 atcttagttc ctgggactgt atctttcaag cagggtgtgg acattgtctg gtatcttatt
     2401 cctctgcatg aggcctgagg tgggtaggcc ttaccaagga gcagctggct gtttctcatc
     2461 tccttgcaac agaaacccac ctaggctagg gagactggaa aaccatacca cattggtttg
     2521 ccttggaccc taagacttgg tttcaggcca ccttgagctt tgatttttca gcttcttcct
     2581 tgtaagagaa tccaagagtg tctggaaagt tcctttcctg ttgactccct aggcttagtt
     2641 gattctctcc cctactgttt tctctatgga gagcagttgt catagctcct gctaccctga
     2701 gagattctag ggctaggctc ttcctcctct tcccttctcc cagctccctt tctcttagtc
     2761 ctctgttact tccaggaaag ctgtgatcca gctgccagcc tagcatccac agctgttggg
     2821 tgttaccccc agtcaacttc ctgtcctatc ggcctctcct ctttcctggc tcacacctat
     2881 tggccatgcc tggcactgcc cttgggaaag cctgtcacca gtgtctggcc cagctgctca
     2941 ggcactggga tgctgcatct tcaggcaact atgcactttg atgaggagag agtgagagag
     3001 atggggccgg gcacagatgg tttgcttgag gggtgggagg gcctggtgga tgctgggagt
     3061 cctcctgtct gtcgccagcc agtgacctgc ttttgcattc tcctggtgcc cactgcccct
     3121 tgtttctgag agacacaaac tatcccctca ttggcagttg acctgcccga gccagtgtct
     3181 atctgtgtaa ctggatgaat ataataaagg gatcatttga ccctgtaaaa aaaaaaaaaa
     3241 aaaaaaa
//
