LOCUS       NM_178778              10706 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus suppressor of cancer cell invasion (Scai), transcript
            variant 1, mRNA.
ACCESSION   NM_178778
VERSION     NM_178778.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10706)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10706)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   3  (bases 1 to 10706)
  AUTHORS   Hansen,R.K., Mund,A., Poulsen,S.L., Sandoval,M., Klement,K.,
            Tsouroula,K., Tollenaere,M.A., Raschle,M., Soria,R., Offermanns,S.,
            Worzfeld,T., Grosse,R., Brandt,D.T., Rozell,B., Mann,M., Cole,F.,
            Soutoglou,E., Goodarzi,A.A., Daniel,J.A., Mailand,N. and
            Bekker-Jensen,S.
  TITLE     SCAI promotes DNA double-strand break repair in distinct
            chromosomal contexts
  JOURNAL   Nat Cell Biol 18 (12), 1357-1366 (2016)
   PUBMED   27820601
  REMARK    GeneRIF: SCAI (suppressor of cancer cell invasion) is identified as
            a 53BP1-interacting chromatin-associated protein that promotes the
            functionality of several DNA double-strand breaks repair pathways
            in mammalian cells.
REFERENCE   4  (bases 1 to 10706)
  AUTHORS   Fintha,A., Gasparics,A., Fang,L., Erdei,Z., Hamar,P., Mozes,M.M.,
            Kokeny,G., Rosivall,L. and Sebe,A.
  TITLE     Characterization and role of SCAI during renal fibrosis and
            epithelial-to-mesenchymal transition
  JOURNAL   Am J Pathol 182 (2), 388-400 (2013)
   PUBMED   23178076
  REMARK    GeneRIF: SCAI is a novel transcriptional cofactor that regulates
            epithelial-to-mesenchymal transition and renal fibrosis.
REFERENCE   5  (bases 1 to 10706)
  AUTHORS   Brandt,D.T., Baarlink,C., Kitzing,T.M., Kremmer,E., Ivaska,J.,
            Nollau,P. and Grosse,R.
  TITLE     SCAI acts as a suppressor of cancer cell invasion through the
            transcriptional control of beta1-integrin
  JOURNAL   Nat Cell Biol 11 (5), 557-568 (2009)
   PUBMED   19350017
REFERENCE   6  (bases 1 to 10706)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928639.5, AL845350.6 and AL844588.17.
            
            On Jan 12, 2022 this sequence version replaced NM_178778.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044772.1, SRR7652917.1164683.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL928639.5         21505-21646         c
            143-187             AL928639.5         20904-20948         c
            188-319             AL845350.6         52501-52632         c
            320-415             AL845350.6         44636-44731         c
            416-502             AL845350.6         42550-42636         c
            503-601             AL845350.6         40657-40755         c
            602-698             AL845350.6         27853-27949         c
            699-797             AL845350.6         26754-26852         c
            798-950             AL845350.6         26466-26618         c
            951-1052            AL845350.6         23210-23311         c
            1053-1154           AL845350.6         22749-22850         c
            1155-1233           AL845350.6         21867-21945         c
            1234-1333           AL845350.6         18922-19021         c
            1334-1415           AL845350.6         14249-14330         c
            1416-1488           AL845350.6         3084-3156           c
            1489-1662           AL844588.17        140342-140515       c
            1663-1763           AL844588.17        140045-140145       c
            1764-10706          AL844588.17        126182-135124       c
FEATURES             Location/Qualifiers
     source          1..10706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..10706
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="suppressor of cancer cell invasion"
                     /db_xref="GeneID:320271"
                     /db_xref="MGI:MGI:2443716"
     exon            1..142
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1910
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SCAI; suppressor of cancer cell invasion protein"
                     /codon_start=1
                     /product="protein SCAI isoform 1"
                     /protein_id="NP_848893.2"
                     /db_xref="CCDS:CCDS38121.1"
                     /db_xref="GeneID:320271"
                     /db_xref="MGI:MGI:2443716"
                     /translation="MVRGARQSQQPRSRLAPRLSGTVEKPPRKRKSRTEFTLKETMSS
                     GGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLW
                     KFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQR
                     SYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNT
                     EDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLA
                     DALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGIQEPADKPTRRENPH
                     KYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDGEGPYDFGGVLTN
                     SNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIVVDSSNSVAYKNFTNLFGQ
                     PLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLR
                     KINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFVFCSATMRMHKAFRETRNYPES
                     YPQLPRDETVENPHLQKHILELASILDVRNIFFENSMDDY"
     exon            143..187
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            188..319
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..415
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..502
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            503..601
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            602..698
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..797
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            798..950
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1052
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1154
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1233
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1333
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1415
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1488
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1662
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1763
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..10706
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10686..10691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      10706
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcct actccagcct ccgccgcttc agcttcccga gcgagccctg cggccgccgg
       61 agcatctccc gcggcggagc aggagccgga tggtcagagg agcccggcag tcccagcagc
      121 cgcggagtcg cctggccccc agactgtctg gcacagtgga gaaaccaccc cgaaaacgga
      181 aaagcaggac tgaatttact cttaaagaaa ctatgtcctc tggaggtgct gaagatgaca
      241 tcccacaggg agagaggaag acagttacag atttttgtta tcttttggat aaatccaagc
      301 aactgttcaa tggcttaaga gatttgcctc agtatggaca gaagcagtgg cagtcctact
      361 tcggaagaac ttttgatgtt tacaccaaac tctggaaatt ccagcagcag catcgacaag
      421 tcttggataa tcggtatggc ttgaagcggt ggcaaatagg ggaaatcgct tccaagatcg
      481 ggcagctgta ttaccactat tatttacgaa cttctgagac cagttatctg aatgaggctt
      541 tctccttcta ctctgcaatc agacagagat catactactc tcaagtcaat aaagaggaca
      601 ggcctgagtt ggttgttaag aaactccgat actacgcaag atttatagta gtttgccttc
      661 ttcttaacaa aatggacgtt gtgaaagacc tggtaaagga attgtctgat gaaattgaag
      721 attatactca tcgctttaat actgaagatc aagtcgagtg gaacctggtg cttcaagagg
      781 tagcagcatt cattgaggca gaccctgtga tggtgttaaa tgatgataac actattgtta
      841 tcacatccaa tcgcctcgct gagacaggag cccccttgct ggagcaaggc atgattgtgg
      901 gacagttgtc tctggctgat gcactcatta ttggtaattg taataatcag gtcaaattca
      961 gcgaattaac tgttgacatg ttccggatgt tgcaagcctt ggagagggag cctatgaatt
     1021 tagcttccca gatgaataag ccaggaatac aggagccagc tgacaagccc accagacgag
     1081 aaaaccccca caagtatcta ctctacaaac cgactttcag ccaactgtat acatttttag
     1141 cagcatcttt taaggagctg cctgccaata gtgtgcttct gatttacctg tcagccactg
     1201 gcgttttccc cacaggtcgt tctgatggtg aaggtcctta tgactttgga ggtgtactta
     1261 ctaatagtaa ccgggacatt atcaatggag atgctatcca caagcgaaat cagtctcaca
     1321 aggaaatgca ctgccttcat cctggagatc tctatccatt cacaaggaaa cccctgttca
     1381 tcgttgtgga ctcctccaat agtgttgcct acaagaattt tacaaatttg tttggacagc
     1441 cactcgtctg ccttctttct cccacggcat atccaaaagc tttgcaagat cagtctcagc
     1501 gaggtagcct cttcacgctc tttttgaaca atcctctaat ggccttccta tttgtgtctg
     1561 gattgtcaag catgcgtaga ggcctgtggg aaaagtgtca agaatatctt cgaaaaatca
     1621 accgtgatat tgcccagcta ctgacccatt cacgttcaat agatcaggcc ttcctccagt
     1681 tttttggaga tgaatttctt cgattgcttc tcacaaggtt tgtcttctgt tcagccacca
     1741 tgaggatgca caaggccttt cgggaaacgc gaaattaccc agaatcctat ccacaactgc
     1801 caagggatga aaccgtagag aatcctcacc ttcagaagca cattttggaa ttggcctcca
     1861 ttctggatgt tcgaaacatc ttctttgaga attctatgga tgactattaa aaccctcttg
     1921 tttaacagtt tttcattttc cacagatttt aaatggtgca attttttaat gtaatgacat
     1981 agtgtgttac ttggttttta tttttggatt taggaaacac cattttaaaa gcaaactgaa
     2041 aaaagttcaa acttttaggg taacttttaa aatataatct ttcaagtctt ttaaattctc
     2101 aatcttgaaa tttttatttt tttggtcttg gcattagata cttacctcca acatctaccc
     2161 ccacattcaa atagttactg ttgtcacctt aagaagaaca tatattgttt atttttccat
     2221 aatgaggaca atccataagt taaacttgga cctggaagtg tctggatttg ggaaatacct
     2281 aattgttcat agaggtgaaa ctggccacat gaaagtcaag agcagagccc ttctgtggag
     2341 ttgcttttca cttcacacta atcggtagga cataagttac tctctgatgt acaaactgat
     2401 gtcttgagat ctctgaattt cattaaatga tgttaaattt ttagaaccta tttagaattg
     2461 tttgcatctg gaaattaaat tttaaatagg aactttaaga tgacagatat ttagaatatg
     2521 agtactatta tgatttgttt gcatatttac ttttctttgt ggtctatgaa tgctaaaaat
     2581 gcaaaggaaa atacttttaa gtatttcagc caaaaatcaa gtcattggtt tcatagttgg
     2641 atctctacac agattcttcg ttggttggtt ttaaacagtg ttgtaatgga ttccttggta
     2701 tatccgctgc acagtttttc taatcttttt tcatattcaa gtttccaagg catggatgtt
     2761 agagagactc tgtgtgagtt gaggataact gggtgttaag gaagtaaatc gtgagttaat
     2821 tttgctttaa caatttggaa gatattaaaa ctccctgtgt tttgttattt tatattcatg
     2881 cacaagtttt gttattttaa ataggactca atatgtaata taaacgtttt gtacatcctt
     2941 ccctccatct ccttggtaat ctcaaaggtc ctagctgtga aggttcttcc ttcctggcat
     3001 cttttggttg catggcattt aaattcagaa atctgtgaat tgtagggtct tctgcctgtg
     3061 tctacccctg acagtcctag agaaatgagg tggttgtttt cagtacctct ttcctgtggc
     3121 cctaaggaaa tttttgatat ggtattttaa cccagttaac tctcactaga gcatcacgtg
     3181 ggtgtaagtt gtggccatat ctgctccagt gcacttactt tgtgaagtcc aggtcatggt
     3241 tgggtcaggg acttaggaag tttcatttgc ttttaaaatt gtttgtatgt tctttcagac
     3301 agtattttta aaagcttaga aaaaggttaa tctggaaaga gcccttccag atagaggttt
     3361 ttccttttta aaaggcctac ttccatttgt ttgcaaatca tgattttcct tttataaact
     3421 ttcctcctgg aatgtagcag taaatattcc ttagtagtct ggcctctgtt ccagttccct
     3481 taagtactga ccaacaatgc atactttcct gttccctgac atctaaagtg gccttgacca
     3541 gtgttttatt cttttttgct aagcctaagg accagttgtt tcaaaagcaa gaggtctgag
     3601 ttctaatcct ggcttttcta gtaatgagca tgatatcctt tgacagacaa ataatctgtt
     3661 ttttagcact cttccatata aaatagagcg actcggttaa gatcctattc ctgtttgtga
     3721 ttctacagtt tggaacattt gttccaaaag tgttgatttc ctccccattg cttccaaaaa
     3781 agttgatttg tgtggtttta gcactataat atcctttcta tatcgtgttt actaaggtgg
     3841 ttcaaaacaa accaaaaaat cctaggtcat actttgctgt tttgagactt gcttaaagag
     3901 actttcctgg agaaattaga ccttccatgg tcagaaaaaa aatgtatgtt gcagatgcca
     3961 gtgtaaaact agattataac atgggttctt aaactaatag aaatacagtt cctaactcgt
     4021 ggttaaagat ataaaatgga ccaaagctgt ggttgtagct tcttggtaga gcatttagct
     4081 agtattcaga aatcctgtgt ttggtcttca tcactagggg aaaaaaatat atttttaaga
     4141 aagaaaacaa tagaaccaat tttgagctgg gtatggtggt gcatgccttt aatcccagtg
     4201 cataagaggc taaggcagga aggttgcaag gtcagagcta atctagatta tatagcaaaa
     4261 gtccacctca aaaacaattg ttaagagatc tgaaatcttt tgaaagcaaa actggagtag
     4321 ggaatttgaa actttaaaaa aaaaatcttt gccttaaaaa ataaaaacaa acatacgtca
     4381 cacataccac attatttttt taatggcatt gaaatgtaag cagaggagac ttaaaaatct
     4441 ttgccttgag gattaagatc gggcttagta ttagaacctt gcctagcatg cgtatatccc
     4501 tggtttccat ccctggtact tagaggtata gcaagagcat caggagttca aggccatcct
     4561 tagctataca gagtaagctc tagaccagcc tgcactacag tatgagaccc ttttgcaaaa
     4621 atagatttgc ctattttaag ctccatttaa tcttagaatt tttaaaaact taaatagtaa
     4681 gactaaaaaa agcaaagcca agggagcaac atttttgtac tcaaattgca caaatttctc
     4741 tgtagattct gataaagttt ctggtgtctt aagaatcact ataaacaaac taggaagaat
     4801 cagactgtaa gagactggtt atgcacaaag caaagtgaag cacaacagga ttttctttct
     4861 gtatccatgt atttctgata ctaaaccttc cctgtcttat aggaagcaag ctgagatgtc
     4921 agaagctact ggttatttgg tgatagacat aacaaacacg agctcatctc agcccagttg
     4981 cttaaacttc tttctgtaat aaacaggagg gaaattttta gagctgtata atcttaacat
     5041 aaaaattagg attttgttct gttttggaaa ttcaaaccag tcaagataag gctcagtcat
     5101 agagtgcttg cctagcatct gcaaggctct gtggttaaat cccagtataa tgaatattct
     5161 cgccagtgaa tcagccacca ctagcatttt ttattaatta taaaatcaga ttttttttct
     5221 ttgattttag gcagtatata ttctttgtaa gtatatccct cctaggaagc ggtgctctca
     5281 aaaactttca aagcacagaa tttattgtgc cctttatact ttttaacaaa gttaaaatgt
     5341 ttcacagttt gggaattgaa gtgtaatttg ttatttgagg ttttcctgac tcgaggtctg
     5401 ggtttagagt ttggttttgt ttcttctcct ccatcatgta atagaattcc cttaaatagg
     5461 taatgatact gaatttcatt agtgtcaagg aagaagtcca gctcagactt ccgaatcaga
     5521 cacaggtcct tctgaagcat tcttctccaa gttcagtctc tgtctatgtc tgaggtgggg
     5581 tttcaaccta gttgaaaagt ctcacttatc cgtggagact tataatcacc tcaataacaa
     5641 gagaatgttc tggactggag atgcattaag gtgccaatgt ctgcatactt ggccactgcc
     5701 agaatcatcc gtccactcgg tgtgagtgga aggcttaata tgaatatgaa tttgaatgcc
     5761 ttgagtctcc tggagatttg ggagtatttt ctgttctcat gtttatttgg agaagtttaa
     5821 gagtgtttag gttgaaggct ctttttagaa cttatttatt tgaaattctt attttaatgg
     5881 catgtgtata tttttgtgat gctatatgaa atctctgtaa actttttgta tatatgtgta
     5941 catattttta aatatcttgg tatgcagtga tgcagtgtgt gcatattata tacctatacc
     6001 cattgtgggc tgatttattt tagttctgtg aggacatcag agtggcattg ttcatgctac
     6061 tataattagg ttgtggctgg atatccttca caagcctcaa ttttaagggg cttgtgctga
     6121 gataaaatgg gctcctttgg agttgaaatt aagatatgaa gatactaaga gtaggctgca
     6181 tattctcagc tttaaagtca tctacaaact tccatttaaa ttgatatatt tgctagaaac
     6241 ctgaaaaact atgattgtga atctgagaca ccagcagtgt cttacttaat ctattagttc
     6301 tttatttttc ttagcccata tttgagtgtt agtactgagt aggactttga gggctattga
     6361 aaaaaattac tttgctctca cttgaaaata gaaaatgtct tttaagttga aatagccatg
     6421 tttatcatta taatatctga tgctaaattt taatttctga gtttttttcc atcagtctgc
     6481 tcattctata agtgtctctg tgaggcagaa gggacattag caaaaaaagg ccaaacctca
     6541 gtgggctgga tagaggggaa ctgggttgtt gatgtgtgtg tgtctacagc agctgtctgg
     6601 ctaagtaaac ttttcttgct ggcattgcat atcaaagata agtccattca tctgaaaaat
     6661 gcttccagca aattcagagc ctttactttt attgctgagt tccctgggaa tacttttact
     6721 gtacaattta accatacatt cacacacaaa gtagatttct taatatgaag tgcctaagag
     6781 gctataaaat cctaggcttc tagctgagca caatgtgtgg ggcagggagg gtatctataa
     6841 tcccagttct taggaggggg agttagaagt ttgaggccag cttctggtgc atagtaagtt
     6901 tcagattagc atgggccaca ggaaaccctg gctcaaaaat cctaatagac ttgggatgat
     6961 aatgttggag acagtaaaat tacagaaaat atgtacggtg ccaatttgtc tgggttttgc
     7021 agcatatcaa tatttttagt tcatgtgctt atttgcatga atgaatgtaa gggatattta
     7081 gacacttgga taactttact ataaagaata aagttatttc tgcattgtaa aataactcca
     7141 gggcaacttt ctactgtatt cttccaaaga ccaaatctct cttattactt tttccaaaga
     7201 gaaaaatcag tttgagtcaa ttttaccact tctaaaatta ttgcatttgc ccctacccca
     7261 ttgttaataa aacatccagc tattcataac acttttcaat tatactctta aggttatctt
     7321 tttcctgaaa taaattaagg tacattaatg tgattttttt tttcctgaga aatcctatca
     7381 aaaaatgttc acagactcta atgttgtttt aacaaccaaa cttttttgaa gaaggcagat
     7441 catatattat gtttaaaatt cataaaactg gggctggaga gaggtctggg cagttaataa
     7501 gaacctcttt gtgttttgct tatctgagac aggatctctt tatgtagccc tggctgtcct
     7561 ggagcttcct atatagaaca ggctgaactc acagagatcc tcctacctcc actttctgag
     7621 tcatggacca cccaccacgc ctaggtttaa ttcctagcac acacacagct gctcacaacc
     7681 ttcagttcca gagcatctga tacattcttc tggcctctgt gggcactaca tgcatgtgca
     7741 ctgcctgcat gtgaggcata ggcatataat acacctatgt gtttattttc ttttaaaaaa
     7801 aaaaaaaaac ctagtagggc aaagttgcta ctgtgcctgt aacttctccc caaacagtaa
     7861 caaagctggt aactttgcag ttcagcaaaa tatgaattgc tgggacaacc acgcctttcc
     7921 cccacattct cctgaatgct tatgcacaca tagtcaactc ctagtctttc ctcaacactg
     7981 gatactacat gagttaataa aagtaagatg attcatcttc ctcaaactag gccttccatc
     8041 ctcactgagt tctgagcaca agaatgtaat tttcaacatg cattatatta aatggagaat
     8101 aatttatgtg acgatggaat caatcaccta cttacaggaa aggaataaca tagaagaata
     8161 tacaattagg taaggataaa tgcattaagt ataactaatt tggtaccata caagtatttt
     8221 ctttggaatt ttgtatgttt tcttaagtga aaatcaagag tttcattttt acacaatact
     8281 gttattcata actataacat catttcataa ttttaaaata tttttctttt tgtgcttttc
     8341 aaatttaagt ttgcagacta ctcaaagcag tggttttgag ggtgttttgt tgttgttgtt
     8401 gtttgttttg ttttgtttat aatattggca gtagattccg ttttaaaaac agtttaaagt
     8461 atattacatc gcatttgaca gatttgctta caggctcagt ctggatttgg tcacaaaaca
     8521 atctacaaat tgcaaatatt tttcctttta agtggacaat tctagtctgt cacctaagac
     8581 aatcaccttt ttatatgtag tatttgtggc aatatcacta atttcaaatt ttactttttt
     8641 cagatcctag atttaacttt ctaaattttc attcttatga aatgaaaatt aatgaactga
     8701 gttacatcac tttcaaattg aagagaggag ttatggttag tttttttttt ataagtttga
     8761 agtgaaaggt aactaaattt ttatactttt gtatatatca ctgtttttcc cccttgttta
     8821 aaactgtcat gaatgtccat ttttccctgg ttcaaaagtt gatttataaa cattagtttg
     8881 aactatgaat ttttcatagc atgaaaattc caagcatgaa actagcatta gtaaccatta
     8941 taaaatgtca aatgatgtta tccctttccc tggtaaacat ttccaaacca cagagaaagg
     9001 ccactgattt tttttcccct aaattaaaag atacagtggt gtattttaaa gtctttatgg
     9061 gaaaaaaaac tacttataag ttctgttacc gtttcctaag gaatgggttt gttttttaag
     9121 agttattata tcgttaaatt acattgtgtt gttcaacaca gtaatttaga acttgattta
     9181 tgtggccatt tgtagttgca tagaaatact ctttttaccg catagactat aatcgctagt
     9241 tttccaaact ttttttttat aagccttgct cttcagctcg agtcctgtat gttgtaggat
     9301 tcttaaaatt gaggcaggaa ggtcttacag agtaggaaat gcttatagag attacaagag
     9361 aaggaatttc cccaaaaaag ttaccctcat tttgtagcac caatataagt agtagttgca
     9421 tttgtcactg aatcagatga agtagttaga agtcatatat ttttactttg ctgtaaagat
     9481 tagtataact aatttaagag aactttgtta ttttctgagc agtttccatt ttaagactta
     9541 gtgtcaatta gctttattca aagtatcact aaaagttaat taaatcaagg gttttgggtg
     9601 gttttttttt taaaaagttc tgttgatctt cttttaccct gaaactaatg gtgaatctgt
     9661 tgtctacact atgttaggca gaaatgcact tgttgaaata gcagaaacta tacttgactt
     9721 tctaatagtg tgaaacactt tttttttaaa tgtgcttgtc tgtaactgaa atgttataga
     9781 attgtaaccc tgtagggatt atagagttat atttattagc tctcaacaga ttgaagcaca
     9841 acagttctca tgtaacaatc cttattcaag tgctctctgt cgtacaaata aagctgattg
     9901 cctatctagt tgttcacaca tcactattat cctgtatgag acagtcttgt tcatttgtat
     9961 taaaatttgg gtattgtgag ttaatacttt caaataaacc tgtcagtcag ctctgatatg
    10021 cagtagattg tttagattca caaattttat gtgttactgg tcaattttga agagacttta
    10081 ccacagtgac taaggggaaa attctattgt atcatttgac ttgaacattt gtaaaagtct
    10141 tgtctgtggt gtttctaaat tgcttaaacc atacattctc ttaaggattt taatttgctt
    10201 ttgttctttt ccaacagtca ttttctggtt ttgtctgtta cagtaaacat tttatagacc
    10261 ttaggaattg tcaagttctt gaacatttat tttcttgagt tgatcactta actcttgtgt
    10321 atgtgatttg tcataaacaa ttagagcctt tcacttcttc actacatgaa tttcagagta
    10381 aacactgtga ttctacagag cagattccat aggcgttcca atattcttaa ctgttacaca
    10441 gtgcctgtca ctttgagggc acataaatac taggatggaa aataaaacgt tgttttgatg
    10501 tttgttaaat aacaagatta cagaatatct gtggggtttt ttttgttttt tgtggtcagt
    10561 gtaataaaga attttgcatt gataaatatt ctctaggaat gtgtatacat tcatctagtg
    10621 tgaactcttg taaatgaatt ttgtatcttg aatcacgtat atattaagtg tatcatcaat
    10681 ataaaaataa acattatttg cttaaa
//
