LOCUS       NM_001399625           10705 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus suppressor of cancer cell invasion (Scai), transcript
            variant 4, mRNA.
ACCESSION   NM_001399625
VERSION     NM_001399625.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10705)
  AUTHORS   Ghotbi,E., Tchegnon,E., Chen,Z., Li,S., Shipman,T., Wang,Y.,
            Raman,J., Zhang,Y., McKay,R.M., Liao,C.P. and Le,L.Q.
  TITLE     Transcription factor KROX20 marks epithelial stem cell ancestors
            for hair follicle formation
  JOURNAL   J Clin Invest 134 (23), e180160 (2024)
   PUBMED   39361422
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10705)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   3  (bases 1 to 10705)
  AUTHORS   Hansen,R.K., Mund,A., Poulsen,S.L., Sandoval,M., Klement,K.,
            Tsouroula,K., Tollenaere,M.A., Raschle,M., Soria,R., Offermanns,S.,
            Worzfeld,T., Grosse,R., Brandt,D.T., Rozell,B., Mann,M., Cole,F.,
            Soutoglou,E., Goodarzi,A.A., Daniel,J.A., Mailand,N. and
            Bekker-Jensen,S.
  TITLE     SCAI promotes DNA double-strand break repair in distinct
            chromosomal contexts
  JOURNAL   Nat Cell Biol 18 (12), 1357-1366 (2016)
   PUBMED   27820601
  REMARK    GeneRIF: SCAI (suppressor of cancer cell invasion) is identified as
            a 53BP1-interacting chromatin-associated protein that promotes the
            functionality of several DNA double-strand breaks repair pathways
            in mammalian cells.
REFERENCE   4  (bases 1 to 10705)
  AUTHORS   Fintha,A., Gasparics,A., Fang,L., Erdei,Z., Hamar,P., Mozes,M.M.,
            Kokeny,G., Rosivall,L. and Sebe,A.
  TITLE     Characterization and role of SCAI during renal fibrosis and
            epithelial-to-mesenchymal transition
  JOURNAL   Am J Pathol 182 (2), 388-400 (2013)
   PUBMED   23178076
  REMARK    GeneRIF: SCAI is a novel transcriptional cofactor that regulates
            epithelial-to-mesenchymal transition and renal fibrosis.
REFERENCE   5  (bases 1 to 10705)
  AUTHORS   Brandt,D.T., Baarlink,C., Kitzing,T.M., Kremmer,E., Ivaska,J.,
            Nollau,P. and Grosse,R.
  TITLE     SCAI acts as a suppressor of cancer cell invasion through the
            transcriptional control of beta1-integrin
  JOURNAL   Nat Cell Biol 11 (5), 557-568 (2009)
   PUBMED   19350017
REFERENCE   6  (bases 1 to 10705)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928639.5, AL845350.6 and AL844588.17.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144989.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AL928639.5         21505-21646         c
            143-187             AL928639.5         20904-20948         c
            188-288             AL845350.6         69860-69960         c
            289-420             AL845350.6         52501-52632         c
            421-516             AL845350.6         44636-44731         c
            517-603             AL845350.6         42550-42636         c
            604-702             AL845350.6         40657-40755         c
            703-799             AL845350.6         27853-27949         c
            800-898             AL845350.6         26754-26852         c
            899-1051            AL845350.6         26466-26618         c
            1052-1153           AL845350.6         23210-23311         c
            1154-1232           AL845350.6         21867-21945         c
            1233-1332           AL845350.6         18922-19021         c
            1333-1414           AL845350.6         14249-14330         c
            1415-1487           AL845350.6         3084-3156           c
            1488-1661           AL844588.17        140342-140515       c
            1662-1762           AL844588.17        140045-140145       c
            1763-10705          AL844588.17        126182-135124       c
FEATURES             Location/Qualifiers
     source          1..10705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 24.42 cM"
     gene            1..10705
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="suppressor of cancer cell invasion"
                     /db_xref="GeneID:320271"
                     /db_xref="MGI:MGI:2443716"
     exon            1..142
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            143..187
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            188..288
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            289..420
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1909
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="isoform 3 is encoded by transcript variant 4;
                     protein SCAI; suppressor of cancer cell invasion protein"
                     /codon_start=1
                     /product="protein SCAI isoform 3"
                     /protein_id="NP_001386554.1"
                     /db_xref="GeneID:320271"
                     /db_xref="MGI:MGI:2443716"
                     /translation="MSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQK
                     QWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSE
                     TSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDL
                     VKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAET
                     GAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNK
                     PGIQELPANSVLLIYLSATGVFPTGRSDGEGPYDFGGVLTNSNRDIINGDAIHKRNQS
                     HKEMHCLHPGDLYPFTRKPLFIVVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQD
                     QSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSID
                     QAFLQFFGDEFLRLLLTRFVFCSATMRMHKAFRETRNYPESYPQLPRDETVENPHLQK
                     HILELASILDVRNIFFENSMDDY"
     exon            421..516
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            517..603
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..702
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            703..799
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..898
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1051
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1153
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1232
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1332
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1414
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1487
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1661
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1762
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..10705
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10685..10690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      10705
                     /gene="Scai"
                     /gene_synonym="9330112M16; A930041I02Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctctccgcct actccagcct ccgccgcttc agcttcccga gcgagccctg cggccgccgg
       61 agcatctccc gcggcggagc aggagccgga tggtcagagg agcccggcag tcccagcagc
      121 cgcggagtcg cctggccccc agactgtctg gcacagtgga gaaaccaccc cgaaaacgga
      181 aaagcagatt tcttaagcaa ctactgtctg actactgtct ggagatgaag aaattttaaa
      241 acgacgtctc tctcctcctg gagtttttgt tatatctgga gatagatgga ctgaatttac
      301 tcttaaagaa actatgtcct ctggaggtgc tgaagatgac atcccacagg gagagaggaa
      361 gacagttaca gatttttgtt atcttttgga taaatccaag caactgttca atggcttaag
      421 agatttgcct cagtatggac agaagcagtg gcagtcctac ttcggaagaa cttttgatgt
      481 ttacaccaaa ctctggaaat tccagcagca gcatcgacaa gtcttggata atcggtatgg
      541 cttgaagcgg tggcaaatag gggaaatcgc ttccaagatc gggcagctgt attaccacta
      601 ttatttacga acttctgaga ccagttatct gaatgaggct ttctccttct actctgcaat
      661 cagacagaga tcatactact ctcaagtcaa taaagaggac aggcctgagt tggttgttaa
      721 gaaactccga tactacgcaa gatttatagt agtttgcctt cttcttaaca aaatggacgt
      781 tgtgaaagac ctggtaaagg aattgtctga tgaaattgaa gattatactc atcgctttaa
      841 tactgaagat caagtcgagt ggaacctggt gcttcaagag gtagcagcat tcattgaggc
      901 agaccctgtg atggtgttaa atgatgataa cactattgtt atcacatcca atcgcctcgc
      961 tgagacagga gcccccttgc tggagcaagg catgattgtg ggacagttgt ctctggctga
     1021 tgcactcatt attggtaatt gtaataatca ggtcaaattc agcgaattaa ctgttgacat
     1081 gttccggatg ttgcaagcct tggagaggga gcctatgaat ttagcttccc agatgaataa
     1141 gccaggaata caggagctgc ctgccaatag tgtgcttctg atttacctgt cagccactgg
     1201 cgttttcccc acaggtcgtt ctgatggtga aggtccttat gactttggag gtgtacttac
     1261 taatagtaac cgggacatta tcaatggaga tgctatccac aagcgaaatc agtctcacaa
     1321 ggaaatgcac tgccttcatc ctggagatct ctatccattc acaaggaaac ccctgttcat
     1381 cgttgtggac tcctccaata gtgttgccta caagaatttt acaaatttgt ttggacagcc
     1441 actcgtctgc cttctttctc ccacggcata tccaaaagct ttgcaagatc agtctcagcg
     1501 aggtagcctc ttcacgctct ttttgaacaa tcctctaatg gccttcctat ttgtgtctgg
     1561 attgtcaagc atgcgtagag gcctgtggga aaagtgtcaa gaatatcttc gaaaaatcaa
     1621 ccgtgatatt gcccagctac tgacccattc acgttcaata gatcaggcct tcctccagtt
     1681 ttttggagat gaatttcttc gattgcttct cacaaggttt gtcttctgtt cagccaccat
     1741 gaggatgcac aaggcctttc gggaaacgcg aaattaccca gaatcctatc cacaactgcc
     1801 aagggatgaa accgtagaga atcctcacct tcagaagcac attttggaat tggcctccat
     1861 tctggatgtt cgaaacatct tctttgagaa ttctatggat gactattaaa accctcttgt
     1921 ttaacagttt ttcattttcc acagatttta aatggtgcaa ttttttaatg taatgacata
     1981 gtgtgttact tggtttttat ttttggattt aggaaacacc attttaaaag caaactgaaa
     2041 aaagttcaaa cttttagggt aacttttaaa atataatctt tcaagtcttt taaattctca
     2101 atcttgaaat ttttattttt ttggtcttgg cattagatac ttacctccaa catctacccc
     2161 cacattcaaa tagttactgt tgtcacctta agaagaacat atattgttta tttttccata
     2221 atgaggacaa tccataagtt aaacttggac ctggaagtgt ctggatttgg gaaataccta
     2281 attgttcata gaggtgaaac tggccacatg aaagtcaaga gcagagccct tctgtggagt
     2341 tgcttttcac ttcacactaa tcggtaggac ataagttact ctctgatgta caaactgatg
     2401 tcttgagatc tctgaatttc attaaatgat gttaaatttt tagaacctat ttagaattgt
     2461 ttgcatctgg aaattaaatt ttaaatagga actttaagat gacagatatt tagaatatga
     2521 gtactattat gatttgtttg catatttact tttctttgtg gtctatgaat gctaaaaatg
     2581 caaaggaaaa tacttttaag tatttcagcc aaaaatcaag tcattggttt catagttgga
     2641 tctctacaca gattcttcgt tggttggttt taaacagtgt tgtaatggat tccttggtat
     2701 atccgctgca cagtttttct aatctttttt catattcaag tttccaaggc atggatgtta
     2761 gagagactct gtgtgagttg aggataactg ggtgttaagg aagtaaatcg tgagttaatt
     2821 ttgctttaac aatttggaag atattaaaac tccctgtgtt ttgttatttt atattcatgc
     2881 acaagttttg ttattttaaa taggactcaa tatgtaatat aaacgttttg tacatccttc
     2941 cctccatctc cttggtaatc tcaaaggtcc tagctgtgaa ggttcttcct tcctggcatc
     3001 ttttggttgc atggcattta aattcagaaa tctgtgaatt gtagggtctt ctgcctgtgt
     3061 ctacccctga cagtcctaga gaaatgaggt ggttgttttc agtacctctt tcctgtggcc
     3121 ctaaggaaat ttttgatatg gtattttaac ccagttaact ctcactagag catcacgtgg
     3181 gtgtaagttg tggccatatc tgctccagtg cacttacttt gtgaagtcca ggtcatggtt
     3241 gggtcaggga cttaggaagt ttcatttgct tttaaaattg tttgtatgtt ctttcagaca
     3301 gtatttttaa aagcttagaa aaaggttaat ctggaaagag cccttccaga tagaggtttt
     3361 tcctttttaa aaggcctact tccatttgtt tgcaaatcat gattttcctt ttataaactt
     3421 tcctcctgga atgtagcagt aaatattcct tagtagtctg gcctctgttc cagttccctt
     3481 aagtactgac caacaatgca tactttcctg ttccctgaca tctaaagtgg ccttgaccag
     3541 tgttttattc ttttttgcta agcctaagga ccagttgttt caaaagcaag aggtctgagt
     3601 tctaatcctg gcttttctag taatgagcat gatatccttt gacagacaaa taatctgttt
     3661 tttagcactc ttccatataa aatagagcga ctcggttaag atcctattcc tgtttgtgat
     3721 tctacagttt ggaacatttg ttccaaaagt gttgatttcc tccccattgc ttccaaaaaa
     3781 gttgatttgt gtggttttag cactataata tcctttctat atcgtgttta ctaaggtggt
     3841 tcaaaacaaa ccaaaaaatc ctaggtcata ctttgctgtt ttgagacttg cttaaagaga
     3901 ctttcctgga gaaattagac cttccatggt cagaaaaaaa atgtatgttg cagatgccag
     3961 tgtaaaacta gattataaca tgggttctta aactaataga aatacagttc ctaactcgtg
     4021 gttaaagata taaaatggac caaagctgtg gttgtagctt cttggtagag catttagcta
     4081 gtattcagaa atcctgtgtt tggtcttcat cactagggga aaaaaatata tttttaagaa
     4141 agaaaacaat agaaccaatt ttgagctggg tatggtggtg catgccttta atcccagtgc
     4201 ataagaggct aaggcaggaa ggttgcaagg tcagagctaa tctagattat atagcaaaag
     4261 tccacctcaa aaacaattgt taagagatct gaaatctttt gaaagcaaaa ctggagtagg
     4321 gaatttgaaa ctttaaaaaa aaaatctttg ccttaaaaaa taaaaacaaa catacgtcac
     4381 acataccaca ttattttttt aatggcattg aaatgtaagc agaggagact taaaaatctt
     4441 tgccttgagg attaagatcg ggcttagtat tagaaccttg cctagcatgc gtatatccct
     4501 ggtttccatc cctggtactt agaggtatag caagagcatc aggagttcaa ggccatcctt
     4561 agctatacag agtaagctct agaccagcct gcactacagt atgagaccct tttgcaaaaa
     4621 tagatttgcc tattttaagc tccatttaat cttagaattt ttaaaaactt aaatagtaag
     4681 actaaaaaaa gcaaagccaa gggagcaaca tttttgtact caaattgcac aaatttctct
     4741 gtagattctg ataaagtttc tggtgtctta agaatcacta taaacaaact aggaagaatc
     4801 agactgtaag agactggtta tgcacaaagc aaagtgaagc acaacaggat tttctttctg
     4861 tatccatgta tttctgatac taaaccttcc ctgtcttata ggaagcaagc tgagatgtca
     4921 gaagctactg gttatttggt gatagacata acaaacacga gctcatctca gcccagttgc
     4981 ttaaacttct ttctgtaata aacaggaggg aaatttttag agctgtataa tcttaacata
     5041 aaaattagga ttttgttctg ttttggaaat tcaaaccagt caagataagg ctcagtcata
     5101 gagtgcttgc ctagcatctg caaggctctg tggttaaatc ccagtataat gaatattctc
     5161 gccagtgaat cagccaccac tagcattttt tattaattat aaaatcagat tttttttctt
     5221 tgattttagg cagtatatat tctttgtaag tatatccctc ctaggaagcg gtgctctcaa
     5281 aaactttcaa agcacagaat ttattgtgcc ctttatactt tttaacaaag ttaaaatgtt
     5341 tcacagtttg ggaattgaag tgtaatttgt tatttgaggt tttcctgact cgaggtctgg
     5401 gtttagagtt tggttttgtt tcttctcctc catcatgtaa tagaattccc ttaaataggt
     5461 aatgatactg aatttcatta gtgtcaagga agaagtccag ctcagacttc cgaatcagac
     5521 acaggtcctt ctgaagcatt cttctccaag ttcagtctct gtctatgtct gaggtggggt
     5581 ttcaacctag ttgaaaagtc tcacttatcc gtggagactt ataatcacct caataacaag
     5641 agaatgttct ggactggaga tgcattaagg tgccaatgtc tgcatacttg gccactgcca
     5701 gaatcatccg tccactcggt gtgagtggaa ggcttaatat gaatatgaat ttgaatgcct
     5761 tgagtctcct ggagatttgg gagtattttc tgttctcatg tttatttgga gaagtttaag
     5821 agtgtttagg ttgaaggctc tttttagaac ttatttattt gaaattctta ttttaatggc
     5881 atgtgtatat ttttgtgatg ctatatgaaa tctctgtaaa ctttttgtat atatgtgtac
     5941 atatttttaa atatcttggt atgcagtgat gcagtgtgtg catattatat acctataccc
     6001 attgtgggct gatttatttt agttctgtga ggacatcaga gtggcattgt tcatgctact
     6061 ataattaggt tgtggctgga tatccttcac aagcctcaat tttaaggggc ttgtgctgag
     6121 ataaaatggg ctcctttgga gttgaaatta agatatgaag atactaagag taggctgcat
     6181 attctcagct ttaaagtcat ctacaaactt ccatttaaat tgatatattt gctagaaacc
     6241 tgaaaaacta tgattgtgaa tctgagacac cagcagtgtc ttacttaatc tattagttct
     6301 ttatttttct tagcccatat ttgagtgtta gtactgagta ggactttgag ggctattgaa
     6361 aaaaattact ttgctctcac ttgaaaatag aaaatgtctt ttaagttgaa atagccatgt
     6421 ttatcattat aatatctgat gctaaatttt aatttctgag tttttttcca tcagtctgct
     6481 cattctataa gtgtctctgt gaggcagaag ggacattagc aaaaaaaggc caaacctcag
     6541 tgggctggat agaggggaac tgggttgttg atgtgtgtgt gtctacagca gctgtctggc
     6601 taagtaaact tttcttgctg gcattgcata tcaaagataa gtccattcat ctgaaaaatg
     6661 cttccagcaa attcagagcc tttactttta ttgctgagtt ccctgggaat acttttactg
     6721 tacaatttaa ccatacattc acacacaaag tagatttctt aatatgaagt gcctaagagg
     6781 ctataaaatc ctaggcttct agctgagcac aatgtgtggg gcagggaggg tatctataat
     6841 cccagttctt aggaggggga gttagaagtt tgaggccagc ttctggtgca tagtaagttt
     6901 cagattagca tgggccacag gaaaccctgg ctcaaaaatc ctaatagact tgggatgata
     6961 atgttggaga cagtaaaatt acagaaaata tgtacggtgc caatttgtct gggttttgca
     7021 gcatatcaat atttttagtt catgtgctta tttgcatgaa tgaatgtaag ggatatttag
     7081 acacttggat aactttacta taaagaataa agttatttct gcattgtaaa ataactccag
     7141 ggcaactttc tactgtattc ttccaaagac caaatctctc ttattacttt ttccaaagag
     7201 aaaaatcagt ttgagtcaat tttaccactt ctaaaattat tgcatttgcc cctaccccat
     7261 tgttaataaa acatccagct attcataaca cttttcaatt atactcttaa ggttatcttt
     7321 ttcctgaaat aaattaaggt acattaatgt gatttttttt ttcctgagaa atcctatcaa
     7381 aaaatgttca cagactctaa tgttgtttta acaaccaaac ttttttgaag aaggcagatc
     7441 atatattatg tttaaaattc ataaaactgg ggctggagag aggtctgggc agttaataag
     7501 aacctctttg tgttttgctt atctgagaca ggatctcttt atgtagccct ggctgtcctg
     7561 gagcttccta tatagaacag gctgaactca cagagatcct cctacctcca ctttctgagt
     7621 catggaccac ccaccacgcc taggtttaat tcctagcaca cacacagctg ctcacaacct
     7681 tcagttccag agcatctgat acattcttct ggcctctgtg ggcactacat gcatgtgcac
     7741 tgcctgcatg tgaggcatag gcatataata cacctatgtg tttattttct tttaaaaaaa
     7801 aaaaaaaacc tagtagggca aagttgctac tgtgcctgta acttctcccc aaacagtaac
     7861 aaagctggta actttgcagt tcagcaaaat atgaattgct gggacaacca cgcctttccc
     7921 ccacattctc ctgaatgctt atgcacacat agtcaactcc tagtctttcc tcaacactgg
     7981 atactacatg agttaataaa agtaagatga ttcatcttcc tcaaactagg ccttccatcc
     8041 tcactgagtt ctgagcacaa gaatgtaatt ttcaacatgc attatattaa atggagaata
     8101 atttatgtga cgatggaatc aatcacctac ttacaggaaa ggaataacat agaagaatat
     8161 acaattaggt aaggataaat gcattaagta taactaattt ggtaccatac aagtattttc
     8221 tttggaattt tgtatgtttt cttaagtgaa aatcaagagt ttcattttta cacaatactg
     8281 ttattcataa ctataacatc atttcataat tttaaaatat ttttcttttt gtgcttttca
     8341 aatttaagtt tgcagactac tcaaagcagt ggttttgagg gtgttttgtt gttgttgttg
     8401 tttgttttgt tttgtttata atattggcag tagattccgt tttaaaaaca gtttaaagta
     8461 tattacatcg catttgacag atttgcttac aggctcagtc tggatttggt cacaaaacaa
     8521 tctacaaatt gcaaatattt ttccttttaa gtggacaatt ctagtctgtc acctaagaca
     8581 atcacctttt tatatgtagt atttgtggca atatcactaa tttcaaattt tacttttttc
     8641 agatcctaga tttaactttc taaattttca ttcttatgaa atgaaaatta atgaactgag
     8701 ttacatcact ttcaaattga agagaggagt tatggttagt ttttttttta taagtttgaa
     8761 gtgaaaggta actaaatttt tatacttttg tatatatcac tgtttttccc ccttgtttaa
     8821 aactgtcatg aatgtccatt tttccctggt tcaaaagttg atttataaac attagtttga
     8881 actatgaatt tttcatagca tgaaaattcc aagcatgaaa ctagcattag taaccattat
     8941 aaaatgtcaa atgatgttat ccctttccct ggtaaacatt tccaaaccac agagaaaggc
     9001 cactgatttt ttttccccta aattaaaaga tacagtggtg tattttaaag tctttatggg
     9061 aaaaaaaact acttataagt tctgttaccg tttcctaagg aatgggtttg ttttttaaga
     9121 gttattatat cgttaaatta cattgtgttg ttcaacacag taatttagaa cttgatttat
     9181 gtggccattt gtagttgcat agaaatactc tttttaccgc atagactata atcgctagtt
     9241 ttccaaactt tttttttata agccttgctc ttcagctcga gtcctgtatg ttgtaggatt
     9301 cttaaaattg aggcaggaag gtcttacaga gtaggaaatg cttatagaga ttacaagaga
     9361 aggaatttcc ccaaaaaagt taccctcatt ttgtagcacc aatataagta gtagttgcat
     9421 ttgtcactga atcagatgaa gtagttagaa gtcatatatt tttactttgc tgtaaagatt
     9481 agtataacta atttaagaga actttgttat tttctgagca gtttccattt taagacttag
     9541 tgtcaattag ctttattcaa agtatcacta aaagttaatt aaatcaaggg ttttgggtgg
     9601 tttttttttt aaaaagttct gttgatcttc ttttaccctg aaactaatgg tgaatctgtt
     9661 gtctacacta tgttaggcag aaatgcactt gttgaaatag cagaaactat acttgacttt
     9721 ctaatagtgt gaaacacttt ttttttaaat gtgcttgtct gtaactgaaa tgttatagaa
     9781 ttgtaaccct gtagggatta tagagttata tttattagct ctcaacagat tgaagcacaa
     9841 cagttctcat gtaacaatcc ttattcaagt gctctctgtc gtacaaataa agctgattgc
     9901 ctatctagtt gttcacacat cactattatc ctgtatgaga cagtcttgtt catttgtatt
     9961 aaaatttggg tattgtgagt taatactttc aaataaacct gtcagtcagc tctgatatgc
    10021 agtagattgt ttagattcac aaattttatg tgttactggt caattttgaa gagactttac
    10081 cacagtgact aaggggaaaa ttctattgta tcatttgact tgaacatttg taaaagtctt
    10141 gtctgtggtg tttctaaatt gcttaaacca tacattctct taaggatttt aatttgcttt
    10201 tgttcttttc caacagtcat tttctggttt tgtctgttac agtaaacatt ttatagacct
    10261 taggaattgt caagttcttg aacatttatt ttcttgagtt gatcacttaa ctcttgtgta
    10321 tgtgatttgt cataaacaat tagagccttt cacttcttca ctacatgaat ttcagagtaa
    10381 acactgtgat tctacagagc agattccata ggcgttccaa tattcttaac tgttacacag
    10441 tgcctgtcac tttgagggca cataaatact aggatggaaa ataaaacgtt gttttgatgt
    10501 ttgttaaata acaagattac agaatatctg tggggttttt tttgtttttt gtggtcagtg
    10561 taataaagaa ttttgcattg ataaatattc tctaggaatg tgtatacatt catctagtgt
    10621 gaactcttgt aaatgaattt tgtatcttga atcacgtata tattaagtgt atcatcaata
    10681 taaaaataaa cattatttgc ttaaa
//
