LOCUS       NM_001402910            7739 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SR-related CTD-associated factor 11 (Scaf11),
            transcript variant 2, mRNA.
ACCESSION   NM_001402910 XM_006521430
VERSION     NM_001402910.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7739)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7739)
  AUTHORS   Butterfield,N.C., Curry,K.F., Steinberg,J., Dewhurst,H.,
            Komla-Ebri,D., Mannan,N.S., Adoum,A.T., Leitch,V.D., Logan,J.G.,
            Waung,J.A., Ghirardello,E., Southam,L., Youlten,S.E.,
            Wilkinson,J.M., McAninch,E.A., Vancollie,V.E., Kussy,F.,
            White,J.K., Lelliott,C.J., Adams,D.J., Jacques,R., Bianco,A.C.,
            Boyde,A., Zeggini,E., Croucher,P.I., Williams,G.R. and
            Bassett,J.H.D.
  TITLE     Accelerating functional gene discovery in osteoarthritis
  JOURNAL   Nat Commun 12 (1), 467 (2021)
   PUBMED   33473114
  REMARK    Erratum:[Nat Commun. 2021 May 28;12(1):3302. PMID: 34050183]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7739)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7739)
  AUTHORS   Roberts,J.M., Ennajdaoui,H., Edmondson,C., Wirth,B., Sanford,J.R.
            and Chen,B.
  TITLE     Splicing factor TRA2B is required for neural progenitor survival
  JOURNAL   J Comp Neurol 522 (2), 372-392 (2014)
   PUBMED   23818142
REFERENCE   5  (bases 1 to 7739)
  AUTHORS   Hagar,J.A., Powell,D.A., Aachoui,Y., Ernst,R.K. and Miao,E.A.
  TITLE     Cytoplasmic LPS activates caspase-11: implications in
            TLR4-independent endotoxic shock
  JOURNAL   Science 341 (6151), 1250-1253 (2013)
   PUBMED   24031018
  REMARK    GeneRIF: Priming the caspase-11 pathway in vivo resulted in extreme
            sensitivity to subsequent LPS challenge in both wild-type and
            Tlr4-deficient mice, whereas Casp11-deficient mice were relatively
            resistant.
REFERENCE   6  (bases 1 to 7739)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 7739)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 7739)
  AUTHORS   Aubert,J., Dunstan,H., Chambers,I. and Smith,A.
  TITLE     Functional gene screening in embryonic stem cells implicates Wnt
            antagonism in neural differentiation
  JOURNAL   Nat Biotechnol 20 (12), 1240-1245 (2002)
   PUBMED   12447396
REFERENCE   9  (bases 1 to 7739)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158769.2 and AC133578.12.
            
            On Mar 23, 2022 this sequence version replaced XM_006521430.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.16381.1,
                                           SRR10223971.15585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AC158769.2         107804-108016
            214-295             AC158769.2         122027-122108
            296-453             AC158769.2         124516-124673
            454-531             AC158769.2         133621-133698
            532-632             AC158769.2         136194-136294
            633-697             AC158769.2         136773-136837
            698-753             AC158769.2         143734-143789
            754-860             AC158769.2         143942-144048
            861-962             AC158769.2         145000-145101
            963-1069            AC158769.2         146566-146672
            1070-3476           AC158769.2         147772-150178
            3477-3844           AC133578.12        1-368
            3845-4185           AC133578.12        1251-1591
            4186-4404           AC133578.12        2493-2711
            4405-4524           AC133578.12        3289-3408
            4525-7739           AC133578.12        3524-6738
FEATURES             Location/Qualifiers
     source          1..7739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 52.44 cM"
     gene            1..7739
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /note="SR-related CTD-associated factor 11"
                     /db_xref="GeneID:72193"
                     /db_xref="MGI:MGI:1919443"
     exon            1..213
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            214..295
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..4653
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /note="isoform 2 is encoded by transcript variant 2;
                     splicing factor, arginine/serine-rich 2, interacting
                     protein; serine/arginine-rich splicing factor 2,
                     interacting protein"
                     /codon_start=1
                     /product="protein SCAF11 isoform 2"
                     /protein_id="NP_001389839.1"
                     /db_xref="GeneID:72193"
                     /db_xref="MGI:MGI:1919443"
                     /translation="MKKKSVYNQNVGDQECDDMEGEENSNTADASGLLYSEADRCPIC
                     LSCLLGKEVGFPESCNHVFCMACILKWAEILASCPIDRKPFQAVFELSAFEGCAKIQV
                     KRRLRETEDKENQRSFKKQLFYHESSKGNKRKRNTIREDLLCERSDGLKVLYRNISNK
                     MDGKKNATVKTNKVQRSNQCTDSCIRNEMSSVFSCGSHSWGPRTHRASCTESIEVNEI
                     SALIRQKRQELELSWFPNTLPGNGRVGSVPWSVETAFLSLASSGLPRTVFPASTTSLE
                     HFGTSHKGYALAHTQGGGEKKQTSGTSNTRGSRRKPAATAPTRRSTRNTRAETVSQSQ
                     KSPVSNYSECDAPGNSNSSVSISPPAESEKQTRQAPKRKSVRRGRKPPLLKKKLRRSV
                     PPAEKSSSDSVEEETVDSDTPPVLEKEQQSCVESSSICSVQTDEENHLHLESCSEQTE
                     ENEQANNHEIEEQTESLNSESCTQDPPGLVGEDTGIEAKEFCADHDISPDTSLRGRDS
                     AEHQEQLSGSSESEVQALVCTESPPEGSPTCPPSDIEHQPVSSPLGEVSDNTTPVVSD
                     ERAEESLTVESTDLNDERTGESLTVESTDLNDSAVNIEAFVESPKMESCEGETAQGLD
                     RHCVPSSDSELPEHIQTENTEIIPACEHIQTENTEIIPACEHIQTENTEIIPVCGTLE
                     NENSDAVQDCEDNLLKHNLDNSQSDKFLEETTESLVEHPIHAELPHKEVDQSEKHFSE
                     DNNESVPMECDSFCSDQNESEVESSANTDSKQLSENSVPHSSEDKLSSDPAVEKVETV
                     AQPAESLVDKAPKPRTRRSRFHSPSTTWSPNKDAAQEKRRAQSPSPKRETVVESQSSQ
                     SPSPKRESARGRRKSRSLSPKKDVARERRQSRSPKRENAREAKRSESGSPRRDTSREN
                     QRSQSRVKDSSSREKSRSRSRERESDREAQRRERDRERRARRWSRSRSRSRSPSRLRT
                     KSKSSSFGRNERDNYSPRWKERWTNDGWRCPRGNDRYRRNDSEKQNENTRNEKNDITA
                     DSNDPSSTDKHRSDCPSWVTEKINSGPDPRTRNPEKLKDSHWEENRNENSGNSWTKNF
                     GPGWMSSRGRGGRGKGAYRGNFACNDQSENRWQSRTPLSGSDSFKSAEQQPSKRKSEQ
                     ELSFGTAADRSGWTSASSWAVRKTLPADVQSYYSRRGRNSSGPQSGWMRQEEETPEQD
                     SNLKDQTNQVDGSQLPVNMMQPHMSVMQPPVNAPHPPVGVFPYPVGLPAPMMNMQRNP
                     FTMHPPMPLHLHTGVPLMQVAAPASIPQGPPPPPPPPPSQQVSYVASQPDGKQVQGLS
                     SASHVSNNMNTQVLPAPSAAPANTGSVQGPSSGNTSSSSHVQASNAAVKLAESKVSVR
                     VEASADSSRTDKKLQIQEKAAQEVKLAIKPFYQNKDITKEEYKEIVRKAVDKVCHSKS
                     GEVNSTKVANLVKAYVDKYRYSRKKALEEPGSTEKT"
     exon            296..453
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            454..531
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            532..632
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            633..697
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            698..753
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            754..860
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            861..962
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1069
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..3844
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            3845..4185
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4404
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            4405..4524
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..7739
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4848..4853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /note="hexamer: AACAAA"
     polyA_site      4865
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /note="major polyA site"
     regulatory      7718..7723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
                     /note="hexamer: AATAAA"
     polyA_site      7739
                     /gene="Scaf11"
                     /gene_synonym="1110061H03Rik; 2610510E10Rik; CASP11;
                     mKIAA3013; Sfrs2ip; SIP1; SRRP129; Srsf2ip"
ORIGIN      
        1 agcggcggtg gcgcaagcgg cgcggagcta gcgccgcctg cccgggtctc ctgctgcgtg
       61 gctgcctgcg tgctcccgac ccggccgtcc gagccagccc gcgggccgcg cgcgcttccg
      121 agcggccgga ggagtccatg gtgcagaact tagcggcgga ctgacggaga ccgggcctcc
      181 tgcgccggcg cggccgcggg acctcggcct caggaaattc cttcacaagg agagatgaag
      241 aagaaatctg tatataatca gaatgtgggt gatcaggagt gtgacgacat ggaaggtgaa
      301 gaaaacagca atactgccga tgcctctggc ttactgtaca gtgaagcgga cagatgtcca
      361 atatgtctca gttgcctgtt agggaaggaa gttggttttc cagaaagttg taatcatgtc
      421 ttctgtatgg cctgtattct taaatgggca gagatattgg cttcttgtcc aatcgatcgg
      481 aaaccttttc aggccgtgtt tgaactcagt gcatttgaag gttgtgctaa gattcaagtg
      541 aaaagacggt tgagagaaac agaggacaag gaaaatcaaa ggtcttttaa gaagcaactc
      601 ttttatcatg agagttccaa aggcaacaag agaaaaagaa acaccataag agaagatctg
      661 ttatgtgaaa gatctgatgg cttgaaggtg ttgtatagaa acatttcaaa caaaatggat
      721 ggaaagaaaa atgctacagt aaagacaaat aaggttcaaa gatcaaatca gtgtacagat
      781 tcgtgtatta gaaatgagat gtccagtgtg ttttcatgtg gcagccacag ctggggacct
      841 cgcacccata gagcttcctg tacagaatct atagaagtca atgagatcag tgcattgatt
      901 agacaaaaac gacaggaact ggagttgtca tggtttccta atacattacc tggaaatgga
      961 agagttggct ccgtaccctg gagtgtagag acagccttcc tctctctggc ttcctcaggc
     1021 ttgccaagga cggttttccc agcaagtacc acgtcgctag agcattttgg tacttctcat
     1081 aagggatatg cattagcaca tacccaagga ggaggagaaa aaaagcaaac ttcaggcaca
     1141 tcaaacacca gaggatcgag acgaaaacct gcagcaactg ctcctacaag gaggtccacg
     1201 cgaaacactc gagccgagac agtcagtcag tcccagaagt ccccagtgtc aaactattct
     1261 gagtgtgatg ccccagggaa tagtaattcc tctgtaagta tttcccctcc agctgaatca
     1321 gaaaagcaaa caagacaggc tccaaaacgg aagtctgtaa ggagaggaag aaaaccacct
     1381 ttattgaaaa agaaacttag gagatctgta cctcccgctg aaaaatcatc tagcgattca
     1441 gtagaggaag aaactgtgga ctctgacact ccacccgtgt tggagaaaga gcaacaatcg
     1501 tgtgtagaaa gcagtagcat ttgctctgtt caaaccgatg aagagaatca tctgcatctt
     1561 gaaagttgca gtgaacaaac agaagaaaat gaacaagcca acaatcatga gattgaggag
     1621 caaacagaaa gtttaaattc tgaatcttgc actcaggacc ctcctgggct tgttggagaa
     1681 gatacaggga tagaggccaa ggagttctgt gcagaccatg atatttcgcc agatacttct
     1741 ctaagaggaa gggattcagc agaacaccaa gagcagctgt ctggaagctc ggagtcagag
     1801 gtccaggcac ttgtgtgtac ggagagtcct cctgaagggt ctcctacatg tccaccttcc
     1861 gacatcgaac accaacctgt gtccagtccc ctgggtgaag tatccgataa caccacacca
     1921 gtggttagcg atgaaagagc agaggagagt ctcactgtag aaagtactga cttgaacgat
     1981 gaaagaacag gggagagtct cactgtagaa agtactgact tgaacgattc tgcagtaaac
     2041 atagaagcat ttgtagagag ccccaaaatg gaatcttgtg agggtgaaac tgcacaggga
     2101 ctggacagac actgtgttcc cagctcagac tctgagttgc ctgagcatat tcaaacagaa
     2161 aatacagaaa taattccagc atgtgaacat attcaaacag aaaatacaga aataattcca
     2221 gcgtgtgagc atattcaaac agaaaataca gaaataattc cagtgtgtgg tactttagaa
     2281 aatgaaaatt ctgatgctgt tcaagattgt gaagataact tattaaaaca taatcttgac
     2341 aactcccaat cagataaatt cctagaagaa acgacagagt ctctggttga acatcccatc
     2401 catgcagagt tacctcacaa agaggttgac cagagtgaga aacatttcag tgaagataat
     2461 aatgaatcag tacctatgga gtgcgattcc ttctgtagtg accagaatga gtctgaagta
     2521 gagtcatccg caaatactga ctctaaacaa ttgagtgaaa attctgtgcc acacagttct
     2581 gaggacaagc tgtcttctga tcctgcagtt gagaaggttg aaactgtagc acaaccagct
     2641 gaaagcttag tggataaagc cccaaagcct cgtactcgaa gatctagatt ccattctcca
     2701 tctacaacgt ggtctcctaa taaagatgct gcacaagaaa agaggcgcgc tcagtctcca
     2761 tctccaaaaa gagagactgt agtagaaagt cagagttctc agtcaccgtc acccaagaga
     2821 gagtctgcca gaggacggag gaaatcgcgt tctctctcac cgaaaaaaga tgtagcaaga
     2881 gaaaggaggc agtctcgctc tccaaagaga gagaatgcta gggaagctaa aagatctgag
     2941 tcagggtccc caagaagaga tacttctaga gagaaccaga ggtctcagtc ccgagtgaaa
     3001 gattcttcct caagagaaaa gtcgaggtcc cggagcagag agagagaaag cgatagagaa
     3061 gctcagagga gagagcgaga cagagagagg agagctagaa gatggtcccg gtccagatcc
     3121 cgctctcgat cgccatcaag attaagaaca aaaagtaaga gttcatcgtt tggtagaaat
     3181 gagagagata attactctcc tcggtggaag gaaagatgga caaatgatgg ttggaggtgt
     3241 cccagaggaa atgaccggta ccggaggaat gattcagaga aacaaaatga aaatacaaga
     3301 aatgaaaaga atgacatcac tgcagatagt aatgatccaa gttccacaga taagcataga
     3361 agtgactgtc ccagttgggt aacagagaaa ataaactctg ggccagatcc aaggaccaga
     3421 aatccagaaa agttaaaaga ttcccactgg gaagaaaaca gaaatgaaaa ttcagggaat
     3481 tcttggacta aaaactttgg cccaggctgg atgtccagcc gtggtcgagg cggccgtggg
     3541 aaaggtgctt acagaggtaa ttttgcctgt aatgaccaga gcgagaacag gtggcaaagc
     3601 cgtacacccc tctcagggag cgactctttc aagtctgcgg agcagcagcc ctctaagcgc
     3661 aaaagtgagc aggagctgtc ctttggcaca gcggcagaca gatcagggtg gacgtctgca
     3721 tctagctggg cagtaagaaa gactctgccc gcagatgtgc agagctatta ctcgcggcgc
     3781 ggcaggaact cttcaggccc gcagtctggg tggatgagac aggaggagga gacacctgag
     3841 caggattcta acttaaaaga ccaaacaaac caagtcgatg gttctcagct gcctgtgaac
     3901 atgatgcagc cacacatgag tgtgatgcag cctccagtga acgccccgca cccgcctgtg
     3961 ggcgtcttcc catacccagt ggggctgccc gccccgatga tgaatatgca gcggaaccct
     4021 ttcaccatgc accctccgat gcccctgcat ctccacacag gagttcctct catgcaggta
     4081 gctgcccctg caagtatacc tcagggaccg ccgccaccac cccctccgcc accatcccag
     4141 caggtcagct acgtcgcctc acaaccagat gggaaacaag tgcagggcct ttcaagtgct
     4201 tctcatgtaa gtaataacat gaatacacaa gtgttgcctg ctccatcagc agccccagca
     4261 aacacgggat cagttcaggg accaagttct ggtaatactt cgtcatcaag tcacgtccaa
     4321 gcctctaacg ctgctgtaaa attggcagaa agcaaagtaa gtgttagagt ggaagccagc
     4381 gcagatagct cgaggacaga caagaaattg caaattcaag agaaagcagc acaggaggtg
     4441 aaactggcta ttaagccgtt ttatcagaat aaagacatca ctaaggaaga gtacaaagag
     4501 atcgtgcgga aggcagtgga caaagtttgt catagtaaga gtggagaagt aaactctacc
     4561 aaagtggcca atctggttaa ggcgtacgta gacaagtaca gatactcgcg gaagaaagct
     4621 ctggaagaac cggggtctac agaaaaaacc taggctgacc gggagcactg cccaggacac
     4681 tgtggagatg tttggagact gcactgcagc gtgcgccctt actgaatcac acacaactgt
     4741 gatggaaatc tggttttgat aaaattattt tttttattgt aggatatgtt ttgttcaaaa
     4801 tatagctgtg cactgcaact tctatatcta accctaaact ccaataaaac aaattccagg
     4861 gaaaaccaag ggtgtaatgg gatgtgcgtg tttatcagga gtgtgctctc acgtggatgc
     4921 tgaatgatgg aggacagcgg actgcataag ccagaaacct gtacgggtgc tggctgtgga
     4981 agacgtgtct gtctctatct atgtacaata gtttattctg tcaggctgaa aaagtatggt
     5041 ctttaggacc ttgcccctct aactatagaa acttaaacag tgtactgcta ttagatatat
     5101 ctgatattaa tagaacatgc caagtgcagg tcccaaatgc gtatttgtga agcacacatc
     5161 tgagtaaatg gcttagatgg aaagcaagtc atcatgagta aaaattagcc tcaaacctgc
     5221 cggtgctcct cacctctttg tcaccaggta aaggtcacac tgtgtgttgc ttttgttgtc
     5281 ttctctccta acctaggaaa aaataaatta gtggtttaat ttgctacatt acaactttgc
     5341 catttcaagg ctttgttgaa tttagaagac taacttgggg gaaaaaaacc aaaactatgt
     5401 tctttcatta taccttctat ttatcagtgg tagtaaatta tttgtgccaa ctggaaacat
     5461 gctacttggt ggtgaccttc ctttctgggg gactagcata gattacatga cctgctttgg
     5521 cagctccggg ttgcttttct tctgtcatgg tgtcagtgaa attcttctca cacttcagaa
     5581 gttccctaat ggggctggcg agatggctcg ccaggtaaga gcactaactg cgcttccaaa
     5641 ggtactcagt tcaaatccca gcaaccacat ggtggctcac acccaaccgt aatgagatct
     5701 gacgccctct tctggtgcgt ctgaagtcag ctacagtgta cttatttata ataataaata
     5761 aagaagttcc ctaatggtta cagtgaataa agtgttaatt tgttgattgg tagctctgct
     5821 gcataattct agatacaata actatgtctg acagaaggaa ggaaaattaa ataatgctat
     5881 ttttgcatag gtatcaggga ctagagtttg ttgttgctgt tgtttttaaa gcaccaagat
     5941 gttaatatgt tgatgttgat gcagagtggg ttcccagtgc ttgtgacact gctgctttca
     6001 ttgacatcta gaaaggagac tgataaactt ggactgcagt tacagttttc ccgttggtat
     6061 caaatagctg agaagatgtt cccataatac ggggatagag caggataaac actcagtgag
     6121 gcctacccat tcactgacaa gcacagtggt ctctgtgaga ctgtactttc tagagtgcag
     6181 gcaacctcgt tctcagttct gcataatgca ttccagccag ctttgaaagg aaggcgaatt
     6241 ttgtgatttt taacccatag tgattgcact aggtaaataa taggctttgt taggttatgc
     6301 ttatagtcct taagcatttc caaaaagttt ttgatcttct tttctacatt tctgtcattt
     6361 atgatgcaat attttacatt tttaattaaa gtctgtgtga acttatgatg gcagatgtgt
     6421 ggaagacagt tgtatacatc cgcggctcac cttgttcctt tcagttcagg ttcagtggtg
     6481 cacacttctg gtcctgcttt gacatttgtg tgtcagatgc tgtctgtcct cttcttctgc
     6541 agcagtgctc tgcctgcatt gttctactga cccctgggag taaatggcag tttaagttgt
     6601 gttttatact gtttagctct tgcaaagcaa gttttaaagt ttaggggaaa gtaggcgttg
     6661 tgtgaactgt taaggccccg tgctctggca gagctccact cttgctgaag ttctctgttc
     6721 tgtatctggt agggcaccgg gtcgagtgct tcagaatcct catttctaat atattctact
     6781 attagaatat actctggatt agaaatacat tagaaatgta ttcttactga gttagaaaac
     6841 gcatactttg tgttaaaaaa taccattgct tttacattct tggtttctca ttttttttct
     6901 tagaaatcca cattcgtttt gcacgtatat aaacttaaca cagtttggga gttgcaggtt
     6961 cctcttgatc atgactcagt atcaacttga cctttggcac catgggccct ttaacttggt
     7021 agtcacgttg acccatgttt caggttgtag aaatgcccag tagtacttac tcattatttt
     7081 aacattccag aggctttgca gttgtttgtt gctgttttgg tgatgaccac tacatcttcg
     7141 ccattctctt ccttcaaatg gccatggtgt gtttgctgac cgtccctgcc cacgccccac
     7201 ccccagacat gtggcctcaa gcgtggtggc tgccctgagt ttgagacatg gtagtataag
     7261 ttgcagtgct gtctgctgaa acaacactct aaaaccaggt tgtggtctgt aatatatcct
     7321 aataaatttt tttgctaaaa agtagtgtct ttaaaatttt attaagtttt ctgggaaatg
     7381 gtgactttta tatcagttta caccatttcc agtgtgttta agtatttctt ggatttttac
     7441 caaagtaatg agcatcatga caacattaat atctaggcaa taaaaaaggt cagagttagc
     7501 tataaacata tattttaata gtagttttcc taattatata atcactgtag cgaatttaaa
     7561 acattgagta atttctaaag atggaagaga ctgggaagca aaataaaaaa attatctgta
     7621 attctaccaa agttaacttc ttccaagctt ggcttcaatg cacattatat gttatgacct
     7681 attctcttca attaatgtat tgagaatatt ccattttaat aaaaattaat ttgacagca
//
