LOCUS       NM_172205               2310 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus suprabasin (Sbsn), transcript variant 1, mRNA.
ACCESSION   NM_172205
VERSION     NM_172205.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2310)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2310)
  AUTHORS   Zhou,Z., Zhang,Z., Chen,H., Bao,W., Kuang,X., Zhou,P., Gao,Z.,
            Li,D., Xie,X., Yang,C., Chen,X., Pan,J., Tang,R., Feng,Z., Zhou,L.,
            Wang,L., Yang,J. and Jiang,L.
  TITLE     SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling
  JOURNAL   Br J Cancer 127 (2), 211-222 (2022)
   PUBMED   35484216
  REMARK    GeneRIF: SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3
            signalling.
REFERENCE   3  (bases 1 to 2310)
  AUTHORS   Nakazawa,S., Shimauchi,T., Funakoshi,A., Aoshima,M.,
            Phadungsaksawasdi,P., Sakabe,J.I., Asakawa,S., Hirasawa,N., Ito,T.
            and Tokura,Y.
  TITLE     Suprabasin-null mice retain skin barrier function and show high
            contact hypersensitivity to nickel upon oral nickel loading
  JOURNAL   Sci Rep 10 (1), 14559 (2020)
   PUBMED   32884021
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2310)
  AUTHORS   Hubackova,S., Pribyl,M., Kyjacova,L., Moudra,A., Dzijak,R.,
            Salovska,B., Strnad,H., Tambor,V., Imrichova,T., Svec,J.,
            Vodicka,P., Vaclavikova,R., Rob,L., Bartek,J. and Hodny,Z.
  TITLE     Interferon-regulated suprabasin is essential for stress-induced
            stem-like cell conversion and therapy resistance of human
            malignancies
  JOURNAL   Mol Oncol 13 (7), 1467-1489 (2019)
   PUBMED   30919591
  REMARK    GeneRIF: SBSN expression was observed in human clinical specimens
            of colon and ovarian carcinomas, as well as in circulating tumour
            cells and metastases of the 4T1 mouse model. The association of
            SBSN expression with progressive stages of cancer development
            indicates its role in cancer evolution and therapy resistance.
REFERENCE   5  (bases 1 to 2310)
  AUTHORS   Alam,M.T., Nagao-Kitamoto,H., Ohga,N., Akiyama,K., Maishi,N.,
            Kawamoto,T., Shinohara,N., Taketomi,A., Shindoh,M., Hida,Y. and
            Hida,K.
  TITLE     Suprabasin as a novel tumor endothelial cell marker
  JOURNAL   Cancer Sci 105 (12), 1533-1540 (2014)
   PUBMED   25283635
  REMARK    GeneRIF: Findings suggest that SBSN is involved in the angiogenic
            potential of tumor endothelial cells (TEC) and may be a novel TEC
            marker.
REFERENCE   6  (bases 1 to 2310)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   7  (bases 1 to 2310)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2310)
  AUTHORS   Bazzi,H., Fantauzzo,K.A., Richardson,G.D., Jahoda,C.A. and
            Christiano,A.M.
  TITLE     Transcriptional profiling of developing mouse epidermis reveals
            novel patterns of coordinated gene expression
  JOURNAL   Dev Dyn 236 (4), 961-970 (2007)
   PUBMED   17330888
  REMARK    GeneRIF: Sbsn, Dmkn and Krtdap are coordinately expressed during
            epidermal morphogenesis.
REFERENCE   9  (bases 1 to 2310)
  AUTHORS   Moffatt,P., Salois,P., St-Amant,N., Gaumond,M.H. and Lanctot,C.
  TITLE     Identification of a conserved cluster of skin-specific genes
            encoding secreted proteins
  JOURNAL   Gene 334, 123-131 (2004)
   PUBMED   15256262
REFERENCE   10 (bases 1 to 2310)
  AUTHORS   Park,G.T., Lim,S.E., Jang,S.I. and Morasso,M.I.
  TITLE     Suprabasin, a novel epidermal differentiation marker and potential
            cornified envelope precursor
  JOURNAL   J Biol Chem 277 (47), 45195-45202 (2002)
   PUBMED   12228223
  REMARK    GeneRIF: These results indicate that the suprabasin protein
            potentially plays a role in the process of epidermal
            differentiation.
            GeneRIF: These results indicate that the suprabasin protein
            potentially plays a role in the process of epidermal
            differentiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167978.4, AA791703.1 and AI507307.1.
            
            On Apr 11, 2007 this sequence version replaced NM_172205.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1). The protein contains
            a repetitive central domain rich in glycine and alanine.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AI507307.1, CK020675.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1756              AC167978.4         1773-3528           c
            1757-2123           AA791703.1         1-367
            2124-2310           AI507307.1         1-187               c
FEATURES             Location/Qualifiers
     source          1..2310
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 19.24 cM"
     gene            1..2310
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /note="suprabasin"
                     /db_xref="GeneID:282619"
                     /db_xref="MGI:MGI:2446326"
     exon            1..1999
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2000..2071
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2116
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2286
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2258..2263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2286
                     /gene="Sbsn"
                     /gene_synonym="1110005D19Rik"
                     /note="major polyA site"
ORIGIN      
        1 atgaggggtg gggaagaggg agggaggtga aggataaata gcggcctcgc tccctggctc
       61 ctctctgcat cctccctgcc ttcccaacaa catgtatctt gtcagtttgc tcagctcctg
      121 ctgcctctta gtgctcctgg ggactctgcc tgcccgggca gcccatgagg atcccgttga
      181 gaaggtcata gaagggttca gccgagggct gagcaatgct gagagagagg tgggcaaggc
      241 ccttgaaggc atcaataacg gaatcactca agctggaagg gaagtggaaa aaatttttgg
      301 tgaactcagc aacatgggca gccaggctgg caagaacgtg gaacatggct tggacaaagt
      361 agcccacgac atcaacagtg gcatcggaca cgcaggaaag gaagcagaga agtttgccca
      421 tggggtcaac cacgccgctg gacaggttgg gaaggagaca aacaaaatca tccatcatgg
      481 ggtcagccag gggggcagtg aagcagggaa gtttggtcag gggtcccacc atgcttttgg
      541 tcagggtggg aatgtggcag acaagttagg tcatgaaacc caccatgctt ttggtcaggg
      601 tgggaatgtg gcagacaagt taggtcatga aacccaccat gcttttggtc agggtgggaa
      661 tgtggcagac aagttaggtc atggagggaa tgtggcagac aagctaggtc atggaaccca
      721 ccatgctttt ggtcagggtg ggaatgtggc agacaagtta ggtcatgaaa cccaccatgc
      781 ttttggtcag ggtgggaatg tggcagacaa gttaggtcat ggaacccacc atgcttttgg
      841 tcagggtggg aatgtggcag acaagttagg tcatgaaacc caccatgctt ttggtcaggg
      901 tgggaatgtg gcagagaagt taggtcatga aacccaccat gcttttggtc agggcggaaa
      961 tatggcagac aagtttggtc agggggccca ccatgctttt ggtcagggcg gaaatatggc
     1021 agacaagttt ggtcaggggg cccaccatgc ttttggtcag ggcggaaata tggcagacaa
     1081 gtttggtcag ggggcccacc atgcttttgg tcagggcgga aatatggcag acaagtttgg
     1141 tcagggggcc caccatgctt ttggtcaggg cggaaatatg gcagacaagt ttggtcaggg
     1201 ggcccaccat gcttttggtc agggcaggga tatggcagag acatttgatc agggggccca
     1261 ccatgctttt ggtcagggtg ggagagaggg aggcagactg gtgcaagggg ctggtcaggg
     1321 acttagccat gctgcaaagg aggcacagca gtttggtcat ggtcacgggc atggttatta
     1381 tgctgcgggg cagacttggc aagaaggaga caaagtaatt cgtcccgggg tcagccaggc
     1441 tggggaggag atggagcagt ttggccaggg tgtccgccat actattaaac aggctgaaaa
     1501 ggaagcagaa aaagtggccc atggggtaca gaatggagtc aaccaggctc aaaaggaagc
     1561 agaaaaagtg gcccatgggg tacagaatgg agtcaaccag gctcaaaagg aagcagaaaa
     1621 agtggcccat ggggtacaga atggagtcaa ccaggctcaa aaggaagcag aaaaagtggc
     1681 ccacggtgtc caaactgggg tcaaccaggc cgggaaggag acacagagag ttggccaagg
     1741 ggtccaaact gggttcaacc agggtcaaaa ggaagcagaa aaagtggccc atggggtcca
     1801 aactggggtc aaccaggccg ggaaggagac acagaaagct ggccaagggg tcaactatgc
     1861 tgctggccag gccgagaagg aagcggagaa gcttggccaa ggtgtccacc atgctgctgg
     1921 ccaggaaatg aacaggttgc agcaagatgt tcataatggg gtcaaccaac ccagcaagga
     1981 ggccaaccag ctgctgaatg ggtctcatca aggtcaaggc gggtacggag gccagcacgg
     2041 aggggccgca accactacag tagtatctgg ggcctcggtc aacaagccat ttatcaactt
     2101 cccagctctg tggaggagta tcgccgccac catgccctaa actgatgccc aggcaacaga
     2161 atgttccggt tgtcacacca gctgaaccga cccagaggag cgggggcttg gggagagctt
     2221 cctgggtgcc cttgagaggg ctgctttgag ctttgtgaat aaacttgaac atactctccc
     2281 ttttcaaaaa aaaaaaaaaa aaaaaaaaaa
//
