LOCUS       NM_001384100             834 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus spermine binding protein (Sbp), transcript variant 2,
            mRNA.
ACCESSION   NM_001384100 XM_030249611
VERSION     NM_001384100.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 834)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 834)
  AUTHORS   Joesting,M.S., Cheever,T.R., Volzing,K.G., Yamaguchi,T.P., Wolf,V.,
            Naf,D., Rubin,J.S. and Marker,P.C.
  TITLE     Secreted frizzled related protein 1 is a paracrine modulator of
            epithelial branching morphogenesis, proliferation, and secretory
            gene expression in the prostate
  JOURNAL   Dev Biol 317 (1), 161-173 (2008)
   PUBMED   18371946
REFERENCE   3  (bases 1 to 834)
  AUTHORS   Fischer,A., Sananbenesi,F., Pang,P.T., Lu,B. and Tsai,L.H.
  TITLE     Opposing roles of transient and prolonged expression of p25 in
            synaptic plasticity and hippocampus-dependent memory
  JOURNAL   Neuron 48 (5), 825-838 (2005)
   PUBMED   16337919
  REMARK    GeneRIF: Our data suggest a role for p25 in synaptic plasticity,
            synaptogenesis, learning, and memory and provide a model whereby
            deregulation of a plasticity factor can contribute to
            neurodegeneration.
REFERENCE   4  (bases 1 to 834)
  AUTHORS   Mills,J.S., Needham,M. and Parker,M.G.
  TITLE     Androgen regulated expression of a spermine binding protein gene in
            mouse ventral prostate
  JOURNAL   Nucleic Acids Res 15 (19), 7709-7724 (1987)
   PUBMED   3502715
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110262.12.
            
            On May 28, 2020 this sequence version replaced XM_030249611.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DV057869.1, DV057234.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC110262.12        157479-157609
            132-237             AC110262.12        157721-157826
            238-834             AC110262.12        160116-160712
FEATURES             Location/Qualifiers
     source          1..834
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.15 cM"
     gene            1..834
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /note="spermine binding protein"
                     /db_xref="GeneID:20234"
                     /db_xref="MGI:MGI:106021"
     exon            1..131
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..676
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /note="prostatic spermine-binding protein; major prostatic
                     secretory glycoprotein"
                     /codon_start=1
                     /product="prostatic spermine-binding protein precursor"
                     /protein_id="NP_001371029.1"
                     /db_xref="GeneID:20234"
                     /db_xref="MGI:MGI:106021"
                     /translation="MLLLLTLAFLASPTCRAQNVLGNAAGKYFYVQGEDQGQLKGMRI
                     FLSVFKFIKGFQLQFGSNWTDVYGTRSDNFIDFLLEDGEHVIKVEGSAVICLTSLTFT
                     TNKGRVATFGVRRGRYFSDTGGSDKHLVTVNGMHAPGLCVRGIGFKWGNINANGNDHY
                     NNKEDKADNKDADNKDADNKDDGDEDDDGNDDDDQKDES"
     exon            132..237
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /inference="alignment:Splign:2.1.0"
     exon            238..834
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /note="hexamer: AATAAA"
     polyA_site      832
                     /gene="Sbp"
                     /gene_synonym="p25"
                     /note="major polyA site"
ORIGIN      
        1 ttcttctcag agtgtcactg aaatcttacc attgtggcat ctaagtgcca gattgtacca
       61 caaaccctca ggagccatgc tgctgttgct gactttggct ttcctggcca gtcccacatg
      121 cagagcccag aatgtcctgg ggaatgctgc tggcaagtat ttctacgttc aaggtgaaga
      181 tcaggggcaa ctcaagggca tgcggatctt cttaagtgtt ttcaagttca tcaagggctt
      241 ccagctgcag tttggcagta actggactga tgtctatgga acccggtcag ataactttat
      301 agacttcctt ctggaggacg gagagcacgt gataaaggta gagggcagtg cagtgatctg
      361 cctgacttcc ctgaccttca ctacaaacaa ggggcgtgtg gccacctttg gtgttagaag
      421 gggtcgatac ttcagtgaca ctggaggttc agacaagcat ctagtgactg tcaatggaat
      481 gcatgcaccg ggcctctgcg tcagagggat tggcttcaaa tggggaaata tcaatgctaa
      541 tggcaatgac cattataata acaaggaaga taaggctgac aacaaagatg ctgacaacaa
      601 agatgctgac aacaaagatg atggagatga ggatgatgat ggaaacgatg atgatgacca
      661 gaaagatgaa agctgagtag catgctcaga gctcagtcct gcatctccac atggcagcgc
      721 ctcctctcag ccaagctctc ccactggagg aagtaatata ccaggagact ccaggctggg
      781 gggagcaaag cccaaatgcc tttatctctc tgtctaataa actatgtgca tcta
//
