LOCUS       NM_001359635            4724 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus strawberry notch 2 (Sbno2), transcript variant 2,
            mRNA.
ACCESSION   NM_001359635 XM_006513496
VERSION     NM_001359635.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4724)
  AUTHORS   Syme,T.E., Grill,M., Hayashida,E., Viengkhou,B., Campbell,I.L. and
            Hofer,M.J.
  TITLE     Strawberry notch homolog 2 regulates the response to interleukin-6
            in the central nervous system
  JOURNAL   J Neuroinflammation 19 (1), 126 (2022)
   PUBMED   35624480
  REMARK    GeneRIF: SBNO2 provides negative feedback to the transcriptional
            response to IL-6
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4724)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4724)
  AUTHORS   Grill,M., Syme,T.E., Nocon,A.L., Lu,A.Z., Hancock,D., Rose-John,S.
            and Campbell,I.L.
  TITLE     Strawberry notch homolog 2 is a novel inflammatory response factor
            predominantly but not exclusively expressed by astrocytes in the
            central nervous system
  JOURNAL   Glia 63 (10), 1738-1752 (2015)
   PUBMED   25903009
  REMARK    GeneRIF: The findings of this study are consistent with SBNO2
            functioning as an acute inflammatory response gene in astrocytes as
            well as other cells in the CNS.
REFERENCE   4  (bases 1 to 4724)
  AUTHORS   Maruyama,K., Uematsu,S., Kondo,T., Takeuchi,O., Martino,M.M.,
            Kawasaki,T. and Akira,S.
  TITLE     Strawberry notch homologue 2 regulates osteoclast fusion by
            enhancing the expression of DC-STAMP
  JOURNAL   J Exp Med 210 (10), 1947-1960 (2013)
   PUBMED   23980096
  REMARK    GeneRIF: Strawberry notch homologue 2 regulates osteoclast fusion
            by enhancing the expression of DC-STAMP.
REFERENCE   5  (bases 1 to 4724)
  AUTHORS   El Kasmi,K.C., Smith,A.M., Williams,L., Neale,G., Panopoulos,A.D.,
            Watowich,S.S., Hacker,H., Foxwell,B.M. and Murray,P.J.
  TITLE     Cutting edge: A transcriptional repressor and corepressor induced
            by the STAT3-regulated anti-inflammatory signaling pathway
  JOURNAL   J Immunol 179 (11), 7215-7219 (2007)
   PUBMED   18025162
  REMARK    GeneRIF: The SBNO2 is component of the pathways that contribute to
            the downstream anti-inflammatory effects of IL-10.
            Erratum:[J Immunol. 2008 Mar 1;180(5):3612. Panopolous, Athanasia
            [corrected to Panopoulos, Athanasia D]]
REFERENCE   6  (bases 1 to 4724)
  AUTHORS   Baba,K., Dekimoto,H., Muraoka,D., Agata,K., Terashima,T. and
            Katsuyama,Y.
  TITLE     A mouse homologue of Strawberry Notch is transcriptionally
            regulated by Reelin signal
  JOURNAL   Biochem Biophys Res Commun 350 (4), 842-849 (2006)
   PUBMED   17045962
REFERENCE   7  (bases 1 to 4724)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4724)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149806.1, BC056369.1 and BC032886.1.
            
            On Jan 13, 2018 this sequence version replaced XM_006513496.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149806.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1994              AK149806.1         2-1995
            1995-1995           BC056369.1         1972-1972
            1996-3125           AK149806.1         1997-3126
            3126-3126           BC056369.1         3103-3103
            3127-3615           AK149806.1         3128-3616
            3616-3616           BC056369.1         3596-3596
            3617-3903           AK149806.1         3618-3904
            3904-4660           BC056369.1         3884-4640
            4661-4724           BC032886.1         1010-1073
FEATURES             Location/Qualifiers
     source          1..4724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..4724
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /note="strawberry notch 2"
                     /db_xref="GeneID:216161"
                     /db_xref="MGI:MGI:2448490"
     exon            1..116
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            117..292
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..4258
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein strawberry notch homolog 2"
                     /codon_start=1
                     /product="protein strawberry notch homolog 2 isoform 2"
                     /protein_id="NP_001346564.1"
                     /db_xref="GeneID:216161"
                     /db_xref="MGI:MGI:2448490"
                     /translation="MLAVEPTMDGDFPPHELPPPGGGIQLQNRLLHCPWWGSFSPSLY
                     PTFSSENQQFVGSTPFLGGQSCPETSYPTTATVPSFFSKSSDFPQDPSCLEDLSNASV
                     FSSSVDSLSDIPDTPDFLQADSLNEVPTIWDVSTTSTTHDKLFIPSGPFSAPEDPVTS
                     LSSTPLLISYQSHSQPEEEEGEEEEETEELGHAETYADYVPSKSKIGKQHPDRVVETS
                     TLSSVPPPDITYTLALPTSDNSTLSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAG
                     VGKGRTVAGIIVENYLRGRKKALWFSASNDLKYDAERDLRDIEAPGIAVHALSKIKYG
                     DNTTSEGVLFATYSALIGESQAGGQHRTRLRQILQWCGEGFDGVIVFDECHKAKNASS
                     TKMGKAVLDLQSKLPQARVVYASATGASEPRNMIYMSRLGIWGEGTPFRTFEEFLHAI
                     EKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLSPAFQQVYNRAARLWAEA
                     LSVFQQAADWIGLESRKSLWGQFWSAHQRFFKYLCIAAKVHRLVELAQQELSRDKCVV
                     IGLQSTGEARTREVLDENEGRLDCFVSAAEGVFLSLIQKHFPSTRRRRDRGGGKRKRR
                     PRGRGPKASRLSLEAAGVIRISDGSSTESDAGLDSDFNSSPESLVDDDVVIVDAPTHP
                     TDDRGSLYPLQRDLQGPGVVERVERLKQGLLAKVRALGRELPVNTLDQLIHQLGGPEC
                     VAEMTGRKGRVVSRPDGTVVFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSS
                     GVSLQADRRVQNQRRRVHMTLELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGE
                     RRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENKYGARALSRVLATIMGQTDNR
                     VPLPQGYPGGDTAFFRDMKQGLLSVGIGSRESRSGCLDVEKDCSITKFLNRILGLEVH
                     KQNALFQYFSDTFDHLIEIDKKEGRYDMGILDLAPGINEIHEESQQVFLAPGHPQDGQ
                     VVFYKISVDRGMKWEEALTRSLELKGPYDGFYLSYKVRGSKMSCLLAEQNRGEYFTVY
                     KPNIGRQSQLETLDSLCRKFHRVTVEEAREPWESSYALSLEHCSHTTWNQRCRLTQEG
                     KCCAQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKDKKKQVGIKIP
                     EGCVHRVLQELQLMDAEVKRRSTHGLAARPPTPRAITLPCGPGEVLDLTYSPPAEAFP
                     TPPRFAFPSLPPPDPSSLMLGARDPATNPVELAHQSCDINFREVLEDMLRSLRAGPTE
                     TPAPLVGVGGGGTERQSVIHFSPPFPNS"
     exon            293..366
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            367..478
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            479..640
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            641..724
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            725..821
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            822..976
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1110
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1201
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1345
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1463
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1569
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1723
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1900
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1998
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2078
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2270
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2440
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2441..2572
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2573..2708
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2821
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2822..2893
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..3002
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3077
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3078..3221
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3222..3316
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3317..3409
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3541
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3618
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3619..3809
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     exon            3810..4682
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4657..4662
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /note="hexamer: AATATA"
     polyA_site      4660
                     /gene="Sbno2"
                     /gene_synonym="F730040C21; Sno; Stno"
                     /note="major polyA site"
ORIGIN      
        1 gagtcccgcc cgctcgggag cggctgcctt cctgccttgg ctgtctggtg cgggccactg
       61 aaccctgtga ttggggagtg acggggagcc tggccttggg ggtggcacga ctgctggata
      121 tgacattaca actgccgctg ccagcaccac agagtaagca gtccagatag ccgccacccg
      181 agggtcgcgg agcgctgcct ccacttgcct gatgctggca gtggaaccca ccatggatgg
      241 ggacttccct ccacatgagc tcccaccccc tggaggtggc atccagctac agaaccgact
      301 cctgcactgt ccttggtggg gcagtttctc accgtctttg taccccacct tctccagtga
      361 aaaccaacag ttcgtgggtt ccaccccatt ccttggtggc cagtcttgcc ctgaaaccag
      421 ctaccccacc acagccaccg tccccagctt cttctccaag agcagcgact ttcctcagga
      481 cccctcatgc ctcgaggacc tctccaatgc ctctgtcttc tcttcatctg tggattccct
      541 gtcagacatc ccagacacac ctgacttcct gcaggctgac agcctcaacg aggtgcctac
      601 catctgggat gtcagcacca cctcaactac ccatgacaag ctgttcatac ctagtgggcc
      661 attctcggct cctgaagacc cggtgacttc gctctccagc actccacttc tcatcagcta
      721 tcagtcacac agccagcctg aggaggaaga aggggaggaa gaggaggaga ctgaggaact
      781 gggccatgct gagacctatg ctgactatgt accatctaag tccaagattg gaaagcaaca
      841 cccagaccgt gtggttgaga ccagcacact gtccagtgtt ccacccccgg acatcaccta
      901 caccctagcg ctacccacct cagacaacag caccctgtct gccctacagc tggaagccat
      961 cacctatgcc tgccagcaac acgaggtcct gctgcccagt gggcagcgtg ctggttttct
     1021 gattggggat ggggccggcg tgggcaaggg ccgcacagtg gctggcatca tagtggagaa
     1081 ctacctgcgg ggccggaaga aggcattgtg gttcagtgcc tccaatgacc tcaagtatga
     1141 tgcggaacgg gacctgagag acattgaggc cccaggcatt gcagtgcatg cattgagcaa
     1201 gatcaagtac ggtgacaaca ctacctcaga gggtgtcctc tttgccacct actctgccct
     1261 gattggagaa agccaggcag gtgggcagca tcgcacacgc ctccgccaga tcctgcagtg
     1321 gtgtggtgag ggcttcgatg gtgtgattgt gtttgacgag tgccacaaag ccaagaacgc
     1381 cagttccact aagatgggca aggccgtgct ggacctgcag agcaaactgc cccaggctag
     1441 ggtggtgtac gccagtgcca caggtgcctc tgagccccgc aacatgatat acatgagccg
     1501 gctgggcatt tggggtgagg gcacaccctt ccggaccttt gaggagttcc tgcatgccat
     1561 tgagaagagg ggcgtgggtg ccatggagat cgtggcgatg gacatgaagg tcagcggcat
     1621 gtacatcgct cgccagctca gcttctcagg ggtcaccttc cgaatcgagg agatcccgct
     1681 gtcccctgcc ttccagcagg tctataatcg ggcagcccgg ctgtgggccg aggccctgag
     1741 cgtgttccag caggcagctg actggatcgg cctggagtct cgcaagtccc tgtggggtca
     1801 gttctggtca gcgcaccagc gcttctttaa gtacctgtgc atcgcagcca aagtgcaccg
     1861 gctagtggag ctggcacagc aggagctgag cagggacaag tgtgtggtca tcgggctgca
     1921 gtccacaggg gaggcacgga ctcgagaggt gctggatgag aacgagggcc gcctggactg
     1981 cttcgtctcc gcagcagaag gtgtcttcct gtccctgatc cagaagcact tcccttccac
     2041 caggcggagg cgtgaccgcg gaggaggaaa gaggaaacgg cggcctcggg gtcgtggccc
     2101 caaggcttcc agactgtcac tggaggcagc aggagttatc cgtattagtg atggcagcag
     2161 cacagagtca gatgctggcc tggatagcga cttcaattca tccccagaat ccctggtaga
     2221 cgatgatgtg gtcattgtag acgcccccac acaccccaca gatgaccgag gttccctgta
     2281 cccacttcag agagacctgc agggccctgg tgtcgtggaa cgggtagaac ggctgaaaca
     2341 gggtctgctt gccaaggtgc gagcgctggg ccgggagctg ccagtcaaca cgttggacca
     2401 gctcatccac caacttgggg gtcctgagtg tgtggccgag atgaccggca ggaaaggccg
     2461 agtggtatcg aggcctgatg ggacagtggt ctttgagtcc agagcagaac agggcctgtc
     2521 catcgaccat gtgaacctca gggagaagca gcgcttcatg agcggcgaga agctcgtggc
     2581 tattatctct gaggcctcca gctcaggtgt ctccctccaa gccgaccgtc gagtccagaa
     2641 ccagcggcgc cgggtacaca tgaccctgga gctgccttgg agtgcagacc gtgccattca
     2701 acagtttggc cgcacccaca ggtccaacca ggtctcagca cccgagtacg tcttccttat
     2761 ctcagaactg gcaggggagc gcaggtttgc ctccattgtg gccaagcggc tcgaaagtct
     2821 gggtgccctc acccatggag atcgccgcgc cactgagtcc cgagacctga gcaagtacaa
     2881 ctttgagaac aagtatggcg cccgtgcgct cagccgcgtc cttgctacaa tcatgggcca
     2941 gacggacaac agggtgcccc tgccccaggg ctatccagga ggggataccg ccttctttcg
     3001 ggacatgaag cagggcctgc tgtctgtggg catcggcagc cgggagtcac gctcgggctg
     3061 cttggatgtg gagaaggact gctccatcac caagttcctg aaccgcatcc ttgggctgga
     3121 ggtgcacaag cagaacgccc tgttccaata cttctccgac accttcgacc acctcatcga
     3181 gatcgacaag aaggagggca gatacgacat gggcatccta gacctggccc ctggcatcaa
     3241 cgagatacat gaagaaagcc agcaggtgtt cctggcacct gggcacccac aggatgggca
     3301 agtggtcttc tacaagatta gcgtggaccg cggtatgaag tgggaagagg cattaactag
     3361 gtcgctggag ctcaaaggtc cctatgatgg cttctacctc tcctacaagg tacgaggcag
     3421 caaaatgagc tgcctcctgg cagaacagaa tcgcggcgag tatttcaccg tgtacaagcc
     3481 aaacatcggc agacagagcc agctggagac cctggacagc ctgtgccgga agtttcaccg
     3541 ggtcactgtg gaagaggccc gggaaccctg ggagagcagc tatgccctgt ccttggagca
     3601 ctgcagtcac accacctgga accagcgctg cagactgaca caggagggca agtgctgcgc
     3661 ccagggcctg cgcctccgcc accactacat gctgtgtggg gcgctgctgc gtgtgtgggg
     3721 ccgcatcgcc gctgtcatgg cggatgtcag cagtagcagc tacctacaga ttgtgcgcct
     3781 taagaccaag gacaagaaga agcaagtggg catcaagatc cccgagggat gcgttcaccg
     3841 cgtactgcag gaactgcagc tgatggatgc agaagtgaag cgccgcagca cccatgggtt
     3901 ggcagcgcgc ccacccactc cacgtgcgat tacgcttcct tgcggtccgg gtgaggtgct
     3961 ggacttgacc tacagtcccc cagctgaggc tttcccaaca cctccgcgct tcgccttccc
     4021 ttcgctgccg cccccagacc ccagctctct gatgctgggt gctagagacc ctgctaccaa
     4081 ccctgtggag ctggcacacc agagctgcga catcaatttc agggaagtgt tggaagacat
     4141 gctccgctct ttgcgcgcgg gacccaccga aacccctgca cctctggtgg gcgtgggtgg
     4201 cgggggcaca gagcgacaga gcgtcatcca cttcagccca cccttcccaa actcttaggc
     4261 tgctacttca gcctctggat tacaactgta ctgggcagca aggcctatgg gctcctctgc
     4321 aagcagaggc tcccatgact actgaggtgc ctggccacag tgccttccca gccagtgggg
     4381 agtggggcct ctctgtgcct cacctgctac agctgcgcag cctagaagcc gtggggcttg
     4441 gttgtcccag agagctggta actcaggaaa tcggtgctcg ggccccgctg gctatggggg
     4501 ctccacgggg cagaccccgt taatatatgc aatcccctgc tccctaaatt attgtcaccc
     4561 gcctctcccc agccccggag tctgtgggca gccggcgggc cctggtttct atgtatttat
     4621 aatgaactcg tgtacatatg taaagatctt ttttaaaata tatgtgcctt ttgcttactt
     4681 tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
