LOCUS       NM_001403562            4582 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus SH3-binding kinase 1 (Sbk1), transcript variant 3,
            mRNA.
ACCESSION   NM_001403562 XM_030241968
VERSION     NM_001403562.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4582)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4582)
  AUTHORS   Hang,M., Tse,M.C.L., Pang,B.P.S., Bi,X., Jin,F., Lee,C.W.,
            Wong,A.O.L. and Chan,C.B.
  TITLE     Differential regulation of hepatic SH3 domain binding kinase 1
            (SBK1) expression in mouse and goldfish
  JOURNAL   Gen Comp Endocrinol 344, 114372 (2023)
   PUBMED   37652166
  REMARK    GeneRIF: Differential regulation of hepatic SH3 domain binding
            kinase 1 (SBK1) expression in mouse and goldfish.
REFERENCE   3  (bases 1 to 4582)
  AUTHORS   Ahuja,P., Bi,X., Ng,C.F., Tse,M.C.L., Hang,M., Pang,B.P.S.,
            Iu,E.C.Y., Chan,W.S., Ooi,X.C., Sun,A., Herlea-Pana,O., Liu,Z.,
            Yang,X., Jiao,B., Ma,X., Wu,K.K.L., Lee,L.T.O., Cheng,K.K.Y.,
            Lee,C.W. and Chan,C.B.
  TITLE     Src homology 3 domain binding kinase 1 protects against hepatic
            steatosis and insulin resistance through the Nur77-FGF21 pathway
  JOURNAL   Hepatology 77 (1), 213-229 (2023)
   PUBMED   35363898
  REMARK    GeneRIF: Src homology 3 domain binding kinase 1 protects against
            hepatic steatosis and insulin resistance through the Nur77-FGF21
            pathway.
REFERENCE   4  (bases 1 to 4582)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4582)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 4582)
  AUTHORS   Schilling,K. and Oberdick,J.
  TITLE     The treasury of the commons: making use of public gene expression
            resources to better characterize the molecular diversity of
            inhibitory interneurons in the cerebellar cortex
  JOURNAL   Cerebellum 8 (4), 477-489 (2009)
   PUBMED   19554387
REFERENCE   7  (bases 1 to 4582)
  AUTHORS   Nara,K., Akasako,Y., Matsuda,Y., Fukazawa,Y., Iwashita,S.,
            Kataoka,M. and Nagai,Y.
  TITLE     Cloning and characterization of a novel serine/threonine protein
            kinase gene expressed predominantly in developing brain
  JOURNAL   Eur J Biochem 268 (9), 2642-2651 (2001)
   PUBMED   11322885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135809.4.
            
            On Mar 31, 2022 this sequence version replaced XM_030241968.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1998258.1,
                                           SRR10662772.1815917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-954               AC135809.4         126156-127109
            955-1187            AC135809.4         143449-143681
            1188-1390           AC135809.4         144635-144837
            1391-4582           AC135809.4         145417-148608
FEATURES             Location/Qualifiers
     source          1..4582
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     gene            1..4582
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /note="SH3-binding kinase 1"
                     /db_xref="GeneID:104175"
                     /db_xref="MGI:MGI:2135937"
     exon            1..954
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1187
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /inference="alignment:Splign:2.1.0"
     CDS             962..2215
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /EC_number="2.7.11.1"
                     /note="SH3 domain-binding kinase 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SBK1"
                     /protein_id="NP_001390491.1"
                     /db_xref="GeneID:104175"
                     /db_xref="MGI:MGI:2135937"
                     /translation="MSVGCPEPEPLHSLPCCGPGAAPVPGAGVPLLTEDMQALTLRTL
                     AASDVTKHYELVRELGKGTYGKVDLVAYKGTGTKMALKFVNKSKTKLKNFLREVSITN
                     SLSSSPFIIKVFDVVFETEECYVFAQEYAPAGDLFDIIPPQVGLPEDTVKRCVQQLGL
                     ALDFMHSRQLVHRDIKPENVLLFDRECRRVKLADFGMTRRVGCRVKRVSGTIPYTAPE
                     VCQAGRADGFAVDTGVDVWAFGVLIFCVLTGNFPWEAASGADAFFEEFVRWQRGRLPG
                     LPSQWRRFTEPALRMFQRLLALEPERRGPAKEVFRFLKHELTSELRRRPSHRARKPPG
                     DRLPGSLRLEAPGPLKRTVLTESGSGSRPSPPSVGPVVPVPVPVPVPVPEAGLAPPAP
                     PGRTDGRTDKSKGQVVLATAIEICV"
     exon            1188..1390
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..4582
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4562..4567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /note="hexamer: AATAAA"
     polyA_site      4582
                     /gene="Sbk1"
                     /gene_synonym="Sbk"
                     /note="major polyA site"
ORIGIN      
        1 gaggccgcga tggagcgcag cccgggcggg caccggcgct ggagcccgag tgccgggcgg
       61 agcgggagcc tcagccggag ccgcagcctc agcccgcgcc aggccggggc aggagcccgc
      121 agggccgggc tgctcgcagc ggcggcgccc gaacccccca gcggctgagc ggtgacctcc
      181 atcctcgcac gcggctgctg ggacgcagcg accgatccaa cccgggcccc ccaagatctg
      241 cttgctacaa ccgcacacct caagacacag agagacccag gcttggggcg ctagcctccc
      301 taatccgcta ctccggcaca cagggacccc aaacctagga cagcaagatc ctcttgctaa
      361 cgagaagccg cgggcacccc aaagcctcgg gacccgggcg accaagcccc ttgcgacgcc
      421 ttcagcgtcc cggctcatgg tggtagtggt gccctgagcc cctctcgggc cgggcagacg
      481 aagatcgaca cggcgcccag gccccctgcc gcggcgtccc cgcggcccca gcccaggtaa
      541 gtgggaccca ggtgaggggc ggcaggtgag tggtaccgag gtccctagag tcctgcaggt
      601 ggggaaggaa gtccagagtg cgcgctcccc ctcctcagcg tcgccatgga gccgaggctg
      661 aaggacgtct ctttgtgtct cgcttggagg agccgccccc tcctcctctc ccttccccca
      721 ccttccaccc caaccctgag atttgggcac agcttcggac cccgggagag aggagttgcg
      781 acgccctgga gaggggttag aaggtggaga gtctccccgg aatagcctgg agccttagac
      841 cttaggtcct ttgaagaata aagacacgta actatcatct cccaaagacc aagctgagtt
      901 cttaagtgac acccaccctc cccacaggaa agagaaaatt tggggcgccc aaagggagaa
      961 gatgagcgtg ggctgccctg agcctgaacc gctccactcc ctgccttgct gtgggccggg
     1021 ggccgcccct gtaccaggtg caggtgtgcc cctcctcaca gaagacatgc aagcgctgac
     1081 cctacgcaca ctggctgcca gcgatgttac caagcactat gagcttgtgc gggagctggg
     1141 caaagggacc tacgggaagg tcgacctggt ggcttacaag ggcacaggca ctaaaatggc
     1201 cctgaaattt gtgaataaga gtaagacaaa gctgaagaac tttctgcgtg aggtgagcat
     1261 caccaacagc ctgtcgtcta gccccttcat catcaaggtc tttgacgtgg tcttcgagac
     1321 cgaggagtgc tatgtctttg cccaggagta tgcacctgct ggggacctgt ttgacatcat
     1381 ccctcctcag gtggggctcc cagaggacac ggtgaagcgc tgtgtgcagc agctggggct
     1441 ggcgctggac ttcatgcaca gcaggcagct ggtgcaccgt gacatcaagc ccgagaatgt
     1501 gctgctgttt gaccgtgagt gccgccgtgt gaagctggct gacttcggca tgacgcggcg
     1561 cgtgggctgc cgtgtgaagc gcgtgagcgg cactataccg tacacagcac ccgaggtgtg
     1621 ccaggctggc cgcgccgatg gcttcgcggt ggacacgggc gtggacgtgt gggcctttgg
     1681 cgtgctcatc ttctgtgtgc tcactggcaa cttcccgtgg gaggctgcat cgggtgcgga
     1741 tgccttcttc gaggagttcg tgcgctggca gcggggtcgc ctgccggggc tgccatcgca
     1801 gtggcgccgt tttaccgagc ctgcgctgcg tatgttccag cggcttctgg cgctagagcc
     1861 tgagcggcgt gggcccgcca aggaggtctt tcgcttcctc aagcacgagc tcacatccga
     1921 gctgcggcgg cggccttccc accgcgcacg caagccgcct ggggaccgcc tgccagggtc
     1981 cctgcgcctt gaggctcccg ggccactcaa gcgcactgtg ctcaccgaga gtggcagcgg
     2041 ctcgcggcct tccccaccca gcgtagggcc cgtggtaccc gtgccagtgc cagttccagt
     2101 acccgtgcct gaggctggtc tggctccgcc tgcacccccg ggcaggaccg acggccgcac
     2161 ggacaagagt aaagggcagg tggtactggc cacggccatc gagatctgcg tctgagccgc
     2221 tgcagcgcag ctgctgcggg gaagccgcgc gctctaaccc gtactgggga caaggagcag
     2281 tctctgcgcg gcagtgggaa ggagtagcgt agactaggag gcccagacac cccggtcggt
     2341 ggtgggctgg tgacatagct agtaaatgac catgcgtacg gccggcctca gcctagagga
     2401 gccgaggccc ctgacaaagg ctgggagctt gtgggccaga ctctgagctc tggaacctga
     2461 acactcctgg cgcttcatac cccttggcag ataaccctac agtattccat ccaaacctgg
     2521 gcacagaaag ggggctttgg tgtcgggcag atatgggcat gagatcgatc cttagaaact
     2581 ggcaaaggac aggcactggg ttgataacag tggtctccag gaggtcagag gaagaggcca
     2641 agccctttaa atgtagcaaa agttgtgtgc aggaacagac ccgattatct agtgataccc
     2701 ctcacttctt cctgctgatg ggaactttga acccaggagg gagagctatt actgcagcca
     2761 cgaggctttt gggaacagag ctccaatgtg tgcccctcct gggagtaagg gagcagatgg
     2821 ctggggaaca ggaggctcgg cactcctgtg tccccagggc aatggagtcc atgcacagcc
     2881 cagctgctcc ctccagagca ctccacaagc agggaaacag ttgtgacagc tactcctggg
     2941 tttctgttgc cgtcacatgt cagcctgggt tctaggccag taccctttca ggggcagagc
     3001 aggtcactga agtgaggagg gagtgtgatg tgtgtctaag tgtccagaca cctcaccagg
     3061 cagctgccaa gagccaggcc tctgttttag cacactcctc agggaacccc aggaggtacc
     3121 tgctgttggc tccggttctt aggcagcaaa gcagggatcc accctgcccc ggctctcctt
     3181 tgggacccta cacaagaggc ttgagggacc cttgcaataa cctcaacaca ggcaggctgt
     3241 gccttctgcc tggcgccacc caactggcca gcctgggctg cctctcctag ggtccctcca
     3301 aaaagttccg ggtcattcaa ggaggttcca tcttggggct ggctggctag ctagctacaa
     3361 ggggcaccaa ccacccctca gcctggagcc ccccacctct acacaccccc ttactcccac
     3421 cacaaagggc tataggtctc cctgccctgc ctgagtccag tttacaaact gtggttgctc
     3481 cagggcctgg tcctactctc ctggggtgcc accacttccc tagtggacac agggccacat
     3541 atgccaggta agtagcaaac ccctcctcct gccaagagcc gagtctcaga aggcccccat
     3601 cactgccctg gcccacctgg ggccattagg ccctccttcc cagccgctgc ctctcctctt
     3661 gccttaggcc tctccaccct gatctgcaat aacaaggaag cgagattcca cggtagacat
     3721 cccgcatccc acaagcgccc ctctctgttg agatcctgtg tgggaggctt ctcccttgta
     3781 gtatctagga tggtagtcct cagaagagac cttaggtacg tagcccagcc ccattgttta
     3841 gaggcagcaa ccagcctgac ctggaacagg actcggactg ggtcagcctc tgctcttgcc
     3901 accgctggta ctgtctctgt cggttgggtt gggacccttt gccccttagg agaggtgttg
     3961 gttacagatg tttacctcag tttgaagaaa caaaactgtt gaagaaacaa ataataataa
     4021 tagcaaaaaa ttagtaacac ggtagacatg gaggcttaga agacaaacca cagaggaaac
     4081 ctcccccttt acaagttttc tgtgaagtac agtttgttca cgtacgcaca catatgtgtg
     4141 catctctgtc tcaccccagg gcaggccaaa tcatctattg acacctgtcc cagcctgtgt
     4201 gtccctcaca ctgccccctg tcctttggtg cttcccaggg gcccctttga gctggcttgt
     4261 ggggtatagg agagctcccc ggatgggaag tgaggcctcg ggttagctag aggtctccca
     4321 ccaggttctg tgagcagaga gccctatgac tgtgatgttc cctgagccca caggacagtc
     4381 ctggtggctg gcaacagtgt ccagttctgg ggcagagcct gggttgttct cacgcagtag
     4441 agcctcacac ccctgtctcg cctctcctac cccatgtgtt tgtaaatact ctggcttcct
     4501 ttggccctga ggaggttttt aaatgtgtta tttacttctc taactatgac aattgctata
     4561 aaataaaaat ttagaaaaat ga
//
