LOCUS       NM_022028               2612 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus salvador family WW domain containing 1 (Sav1),
            transcript variant 1, mRNA.
ACCESSION   NM_022028 XM_916596
VERSION     NM_022028.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2612)
  AUTHORS   Moon,D., Padanilam,B.J., Park,K.M. and Kim,J.
  TITLE     Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive Repair
            after Ischemia and Reperfusion Injury
  JOURNAL   Int J Mol Sci 25 (9), 4610 (2024)
   PUBMED   38731829
  REMARK    GeneRIF: Loss of SAV1 in Kidney Proximal Tubule Induces Maladaptive
            Repair after Ischemia and Reperfusion Injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2612)
  AUTHORS   Su,D., Li,Y., Zhang,W., Gao,H., Cheng,Y., Hou,Y., Li,J., Ye,Y.,
            Lai,Z., Li,Z., Huang,H., Li,J., Li,J., Cheng,M., Nian,C., Wu,N.,
            Zhou,Z., Xing,Y., Zhao,Y., Liu,H., Tang,J., Chen,Q., Hong,L.,
            Li,W., Peng,Z., Zhao,B., Johnson,R.L., Liu,P., Hong,W., Chen,L. and
            Zhou,D.
  TITLE     SPTAN1/NUMB axis senses cell density to restrain cell growth and
            oncogenesis through Hippo signaling
  JOURNAL   J Clin Invest 133 (20), e168888 (2023)
   PUBMED   37843276
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2612)
  AUTHORS   Xia,H., Wu,Y., Zhao,J., Cheng,C., Lin,J., Yang,Y., Lu,L., Xiang,Q.,
            Bian,T. and Liu,Q.
  TITLE     N6-Methyladenosine-modified circSAV1 triggers ferroptosis in COPD
            through recruiting YTHDF1 to facilitate the translation of IREB2
  JOURNAL   Cell Death Differ 30 (5), 1293-1304 (2023)
   PUBMED   36828914
  REMARK    GeneRIF: N6-Methyladenosine-modified circSAV1 triggers ferroptosis
            in COPD through recruiting YTHDF1 to facilitate the translation of
            IREB2.
REFERENCE   4  (bases 1 to 2612)
  AUTHORS   Zhang,H., Yang,Z. and Nakamura,F.
  TITLE     Importance of the filamin A-Sav1 interaction in organ size control:
            evidence from transgenic mice
  JOURNAL   Int J Dev Biol 67 (2), 27-37 (2023)
   PUBMED   37548015
  REMARK    GeneRIF: Importance of the filamin A-Sav1 interaction in organ size
            control: evidence from transgenic mice.
REFERENCE   5  (bases 1 to 2612)
  AUTHORS   De Chiara,L., Conte,C., Semeraro,R., Diaz-Bulnes,P.,
            Angelotti,M.L., Mazzinghi,B., Molli,A., Antonelli,G., Landini,S.,
            Melica,M.E., Peired,A.J., Maggi,L., Donati,M., La Regina,G.,
            Allinovi,M., Ravaglia,F., Guasti,D., Bani,D., Cirillo,L.,
            Becherucci,F., Guzzi,F., Magi,A., Annunziato,F., Lasagni,L.,
            Anders,H.J., Lazzeri,E. and Romagnani,P.
  TITLE     Tubular cell polyploidy protects from lethal acute kidney injury
            but promotes consequent chronic kidney disease
  JOURNAL   Nat Commun 13 (1), 5805 (2022)
   PUBMED   36195583
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2612)
  AUTHORS   Lu,L., Li,Y., Kim,S.M., Bossuyt,W., Liu,P., Qiu,Q., Wang,Y.,
            Halder,G., Finegold,M.J., Lee,J.S. and Johnson,R.L.
  TITLE     Hippo signaling is a potent in vivo growth and tumor suppressor
            pathway in the mammalian liver
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1437-1442 (2010)
   PUBMED   20080689
  REMARK    GeneRIF: show using a conditional allele of sav1, that an adaptor
            that potentiates mst1 and mst2 activity is likewise required to
            suppress growth in the mature liver and to prevent tumor formation.
REFERENCE   7  (bases 1 to 2612)
  AUTHORS   Oh,S., Lee,D., Kim,T., Kim,T.S., Oh,H.J., Hwang,C.Y., Kong,Y.Y.,
            Kwon,K.S. and Lim,D.S.
  TITLE     Crucial role for Mst1 and Mst2 kinases in early embryonic
            development of the mouse
  JOURNAL   Mol Cell Biol 29 (23), 6309-6320 (2009)
   PUBMED   19786569
REFERENCE   8  (bases 1 to 2612)
  AUTHORS   Lee,J.H., Kim,T.S., Yang,T.H., Koo,B.K., Oh,S.P., Lee,K.P.,
            Oh,H.J., Lee,S.H., Kong,Y.Y., Kim,J.M. and Lim,D.S.
  TITLE     A crucial role of WW45 in developing epithelial tissues in the
            mouse
  JOURNAL   EMBO J 27 (8), 1231-1242 (2008)
   PUBMED   18369314
  REMARK    GeneRIF: Mice lacking WW45 reveal a crucial role for WW45 in
            cell-cycle exit and epithelial terminal differentiation.
REFERENCE   9  (bases 1 to 2612)
  AUTHORS   Ohnishi,S., Guntert,P., Koshiba,S., Tomizawa,T., Akasaka,R.,
            Tochio,N., Sato,M., Inoue,M., Harada,T., Watanabe,S., Tanaka,A.,
            Shirouzu,M., Kigawa,T. and Yokoyama,S.
  TITLE     Solution structure of an atypical WW domain in a novel
            beta-clam-like dimeric form
  JOURNAL   FEBS Lett 581 (3), 462-468 (2007)
   PUBMED   17239860
  REMARK    GeneRIF: While typical WW domains function as monomeric modules
            that recognize proline-rich sequences, by using conserved residues
            that are solvent-exposed on the surface of the beta-sheet, this WW
            domain buries these residues in the dimer interface.
REFERENCE   10 (bases 1 to 2612)
  AUTHORS   Valverde,P.
  TITLE     Cloning, expression, and mapping of hWW45, a novel human WW
            domain-containing gene
  JOURNAL   Biochem Biophys Res Commun 276 (3), 990-998 (2000)
   PUBMED   11027580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166827.2.
            
            On Mar 9, 2023 this sequence version replaced NM_022028.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ292968.1, SRR13948564.4078890.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC166827.2         214065-214481       c
            418-861             AC166827.2         211600-212043       c
            862-1132            AC166827.2         203359-203629       c
            1133-1276           AC166827.2         196461-196604       c
            1277-2612           AC166827.2         192403-193738       c
FEATURES             Location/Qualifiers
     source          1..2612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.94 cM"
     gene            1..2612
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /note="salvador family WW domain containing 1"
                     /db_xref="GeneID:64010"
                     /db_xref="MGI:MGI:1927144"
     exon            1..417
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1484
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /note="isoform 1 is encoded by transcript variant 1; WW
                     domain-containing protein 4; protein salvador homolog 1;
                     45 kDa WW domain protein; WW domain-containing protein 3"
                     /codon_start=1
                     /product="protein salvador homolog 1 isoform 1"
                     /protein_id="NP_071311.1"
                     /db_xref="CCDS:CCDS25956.1"
                     /db_xref="GeneID:64010"
                     /db_xref="MGI:MGI:1927144"
                     /translation="MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTI
                     PRRTDLCLPDSSATAFSASGDGVVSRNQSFLRTAIQRTPHEVMRRESHRLSAPSYLVR
                     SLADVPRECGSSQSFLTEVNFAVENGDSGSRYFFSDNFFDGQRRRPLGDRAQEDYRYY
                     EYNHDLFQRMPQSQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYY
                     IDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQ
                     PPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLD
                     TYQGMLKLLFMKELEQIVKLYEAYRQALLTELENRKQRQQWYAQQHGKTFLS"
     exon            418..861
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1132
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1276
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1277..2612
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2595..2600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /note="hexamer: AATATA"
     polyA_site      2612
                     /gene="Sav1"
                     /gene_synonym="1700040G09Rik; Salv; Sav; WW45; Wwp3; Wwp4"
                     /note="major polyA site"
ORIGIN      
        1 gaaagtttac cggacgtagg cggtggccgc agcggtagcg gctccgggcg gcggaccatg
       61 gccctggtgg gcggccgcgg ccctgtccca aggcggcctc gggcggcgtc gttgagccgg
      121 ctgacttccc gggaggagct gccctgcgac tgagcggcgg cgggcgcgct tagcgcggcc
      181 aacatgcggc ggagcctgcg ggcgggcgcg ggcggcggag acccgaggcg aaggcggcgg
      241 cggcggcccg ggaggcggcg gcgggcggca ggctcgcggc cctagcgagg ctgctggggc
      301 ggcggcggga gtcgtccgcg aggatgctgt cccgcaagaa aaccaaaaac gaggtgtcta
      361 agccggccga ggtgcagggc aagtacgtga agaaggagac gtcgcccctg ctgcggaatc
      421 tcatgccttc attcattcgg cacggtccaa caattcccag acggactgac ctctgtcttc
      481 cagattcaag tgctactgct ttctcagctt ctggagatgg tgtagtttca agaaaccaga
      541 gtttcctgag aactgcaatt caaaggacac ctcatgaagt aatgagaaga gaaagccaca
      601 gactgtctgc cccttcttac cttgtcagga gcctagcaga tgtccctcga gagtgtggct
      661 catcacagtc atttttgaca gaagttaact ttgctgttga gaatggagac tctggctccc
      721 gatacttctt ctcagataac ttttttgatg gacagagaag gcggccactt ggagatcgtg
      781 cacaagaaga ttacagatat tatgaataca accatgatct cttccagagg atgccacaga
      841 gtcaggggag gcacacttca ggtattggga gagtcacggc tacatctcta gggaatttaa
      901 ctaaccatgg atctgaagat ttaccccttc ctcctggctg gtctgtggac tggacaatga
      961 gagggagaaa atactacata gatcataaca caaataccac tcactggagt catccccttg
     1021 aacgagaagg acttcctcct ggctgggaac gagtagagtc atcagaattt ggaacctatt
     1081 acgtggatca caccaataaa agggctcagt acaggcaccc ctgtgctccg agtgtacctc
     1141 ggtatgatca gcctccaccc atcacgtatc agccacaaca aactgaaaga aatcagtctc
     1201 tcctggtccc tgcaaatccc taccatactg cagaaattcc tgactggctt caggtttatg
     1261 cccgagcccc tgtgaaatat gaccacattc tgaagtggga gctcttccag ctggctgacc
     1321 tggacacgta ccagggaatg ctgaagttgc tcttcatgaa ggaactggag cagattgtga
     1381 agttgtacga ggcctacaga caggctcttc tcactgagtt ggaaaaccgc aagcagaggc
     1441 agcagtggta tgcccagcag catggcaaga cgttcttaag ttaacttatc acaagccaag
     1501 tttataagag ctttaaaata ttttcagata aatgactgca aacaagttct ttggttaata
     1561 aaggtaactt actatttgga agtataaaat tctagtttta catatatttt gttatcaatt
     1621 ttttttcttt tattgaacca agaaagtttt atcatttaaa aagccaatat ggcatatgct
     1681 accaaatgct gtattaggaa actgctggag actctggaca aaaagtagta caggaagaga
     1741 ttatcagcat aaacaggcat taaataggaa accgtcactc tctgactttt tatggacaca
     1801 cccttcttgt ttaggaaaca gaagaggatg agagtacatc tgtgatcagt tgctacgtgt
     1861 ggtgtcaagt gttttctgga atgagatggt ttgactatta ccataggtat agttcaaaat
     1921 acaaaacagg acttggaacc tttattgtaa caagcttgta cgtgtgtggt catctccccc
     1981 ccgccccctc agtcccccga cccccaatgt aaggaacacc tttgaaggag aaagatgaag
     2041 tctttgagga atacattcag aaatacagga ctataataaa tacatgcctc ttagtgcgca
     2101 actgttgcta atacggcttc cttcctttga ggcagagcac ataagtacag ttagcatggc
     2161 tctgagacac agcacaggct tcctgaccac atagaatact gccttccatc agggtgggct
     2221 aagttgccaa aaacgacaat cagggatcca ataagcaatc ttggtcactt aagtaaattt
     2281 tatattgcct tttttatctt tgagaagtat ttgtcataaa ggtgtagaaa caggctgtca
     2341 ttccttccta tttttcttgc tttgggttta atagttgttc ataattagtg ctgaacactt
     2401 gattacagat aaacttatgg aacttccagc tgtaaatcta gaattcttga gcttcatagc
     2461 tcttcagttg tgcttacaaa tgttgtgaat atgtatatat attagttctt ttcctaagta
     2521 taagcactcc atgttagaag tgactttgaa ttattgataa aatttcgcat ttgattttat
     2581 ataacaagtt attaaatata tttttgtgga aa
//
