LOCUS       NM_001358580            5377 bp    mRNA    linear   ROD 02-MAY-2023
DEFINITION  Mus musculus special AT-rich sequence binding protein 2 (Satb2),
            transcript variant 2, mRNA.
ACCESSION   NM_001358580 XM_017319630
VERSION     NM_001358580.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5377)
  AUTHORS   Romero DM, Zaidi D, Cifuentes-Diaz C, Maillard C, Grannec G,
            Selloum M, Birling MC, Bahi-Buisson N and Francis F.
  TITLE     A human dynein heavy chain mutation impacts cortical progenitor
            cells causing developmental defects, reduced brain size and altered
            brain architecture
  JOURNAL   Neurobiol Dis 180, 106085 (2023)
   PUBMED   36933672
REFERENCE   2  (bases 1 to 5377)
  AUTHORS   Zhang F, Yoon K, Zhang DY, Kim NS, Ming GL and Song H.
  TITLE     Epitranscriptomic regulation of cortical neurogenesis via
            Mettl8-dependent mitochondrial tRNA m3C modification
  JOURNAL   Cell Stem Cell 30 (3), 300-311 (2023)
   PUBMED   36764294
REFERENCE   3  (bases 1 to 5377)
  AUTHORS   Mun DJ, Goo BS, Suh BK, Hong JH, Woo Y, Kim SJ, Kim S, Lee SB, Won
            Y, Yoo JY, Cho E, Jang EJ, Nhung TTM, Triet HM, An H, Lee H, Nguyen
            MD, Park SY, Baek ST and Park SK.
  TITLE     Gcap14 is a microtubule plus-end-tracking protein coordinating
            microtubule-actin crosstalk during neurodevelopment
  JOURNAL   Proc Natl Acad Sci U S A 120 (8), e2214507120 (2023)
   PUBMED   36795749
REFERENCE   4  (bases 1 to 5377)
  AUTHORS   Cifuentes-Diaz C, Canali G, Garcia M, Druart M, Manett T,
            Savariradjane M, Guillaume C, Le Magueresse C and Goutebroze L.
  TITLE     Differential impacts of Cntnap2 heterozygosity and Cntnap2 null
            homozygosity on axon and myelinated fiber development in mouse
  JOURNAL   Front Neurosci 17, 1100121 (2023)
   PUBMED   36793543
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5377)
  AUTHORS   Parn A, Olsen D, Tuvikene J, Kaas M, Borisova E, Bilgin M, Elhauge
            M, Vilstrup J, Madsen P, Ambrozkiewicz MC, Goz RU, Timmusk T,
            Tarabykin V, Gustafsen C and Glerup S.
  TITLE     PCSK9 deficiency alters brain lipid composition without affecting
            brain development and function
  JOURNAL   Front Mol Neurosci 15, 1084633 (2023)
   PUBMED   36733269
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5377)
  AUTHORS   Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B,
            Farinas I, Karsenty G and Grosschedl R.
  TITLE     SATB2 is a multifunctional determinant of craniofacial patterning
            and osteoblast differentiation
  JOURNAL   Cell 125 (5), 971-986 (2006)
   PUBMED   16751105
  REMARK    GeneRIF: SATB2 acts as a molecular node in a transcriptional
            network regulating skeletal development and osteoblast
            differentiation.
REFERENCE   7  (bases 1 to 5377)
  AUTHORS   Britanova O, Akopov S, Lukyanov S, Gruss P and Tarabykin V.
  TITLE     Novel transcription factor Satb2 interacts with matrix attachment
            region DNA elements in a tissue-specific manner and demonstrates
            cell-type-dependent expression in the developing mouse CNS
  JOURNAL   Eur J Neurosci 21 (3), 658-668 (2005)
   PUBMED   15733084
  REMARK    GeneRIF: Satb2 may regulate differentiation of subsets of neurons
            at the level of higher order chromatin structure via binding to
            matrix attachment region DNA elements (MARs).
REFERENCE   8  (bases 1 to 5377)
  AUTHORS   Dobreva G, Dambacher J and Grosschedl R.
  TITLE     SUMO modification of a novel MAR-binding protein, SATB2, modulates
            immunoglobulin mu gene expression
  JOURNAL   Genes Dev 17 (24), 3048-3061 (2003)
   PUBMED   14701874
REFERENCE   9  (bases 1 to 5377)
  AUTHORS   FitzPatrick DR, Carr IM, McLaren L, Leek JP, Wightman P, Williamson
            K, Gautier P, McGill N, Hayward C, Firth H, Markham AF, Fantes JA
            and Bonthron DT.
  TITLE     Identification of SATB2 as the cleft palate gene on 2q32-q33
  JOURNAL   Hum Mol Genet 12 (19), 2491-2501 (2003)
   PUBMED   12915443
REFERENCE   10 (bases 1 to 5377)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101777.8 and AC131072.13.
            
            [WARNING] On May 6, 2023 this sequence was replaced by
            NM_001358580.2.
            
            On Dec 2, 2017 this sequence version replaced XM_017319630.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.215496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849389, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AC101777.8         70392-70622
            232-314             AC101777.8         76319-76401
            315-542             AC101777.8         80760-80987
            543-719             AC101777.8         102385-102561
            720-846             AC131072.13        179077-179203       c
            847-970             AC131072.13        178032-178155       c
            971-1073            AC131072.13        171249-171351       c
            1074-1546           AC131072.13        151398-151870       c
            1547-1759           AC131072.13        130257-130469       c
            1760-1915           AC131072.13        125662-125817       c
            1916-2113           AC131072.13        111525-111722       c
            2114-5377           AC131072.13        74067-77330         c
FEATURES             Location/Qualifiers
     source          1..5377
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..5377
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /note="special AT-rich sequence binding protein 2"
                     /db_xref="GeneID:212712"
                     /db_xref="MGI:MGI:2679336"
     exon            1..231
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            232..314
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            315..542
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2575
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /note="two cut domains-containing homeodomain protein;
                     KIAA1034-like DNA binding protein"
                     /codon_start=1
                     /product="DNA-binding protein SATB2"
                     /protein_id="NP_001345509.1"
                     /db_xref="CCDS:CCDS14965.1"
                     /db_xref="GeneID:212712"
                     /db_xref="MGI:MGI:2679336"
                     /translation="MERRSESPCLRDSPDRRSGSPDVKGPPPVKVARLEQNGSPMGAR
                     GRPNGAVAKAVGGLMIPVFCVVEQLDGSLEYDNREEHAEFVLVRKDVLFSQLVETALL
                     ALGYSHSSAAQAQGIIKLGRWNPLPLSYVTDAPDATVADMLQDVYHVVTLKIQLQSCS
                     KLEDLPAEQWNHATVRNALKELLKEMNQSTLAKECPLSQSMISSIVNSTYYANVSATK
                     CQEFGRWYKKYKKIKVERVERENLSDYCVLGQRPMHLPNMNQLASLGKTNEQSPHSQI
                     HHSTPIRNQVPALQPIMSPGLLSPQLSPQLVRQQIAMAHLINQQIAVSRLLAHQHPQA
                     INQQFLNHPPIPRAVKPEPTNSSVEVSPDIYQQVRDELKRASVSQAVFARVAFNRTQG
                     LLSEILRKEEDPRTASQSLLVNLRAMQNFLNLPEVERDRIYQDERERSMNPNVSMVSS
                     ASSSPSSSRTPQAKTSTPTTDLPIKVDGANVNITAAIYDEIQQEMKRAKVSQALFAKV
                     AANKSQGWLCELLRWKENPSPENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSE
                     RMQHVVQLPPEPVQVLHRQQSQPTKESSPPREEAPPPPPPTEDSCAKKPRSRTKISLE
                     ALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGS
                     AVDVAEYKDEELLTESEENDSEEGSEEMYKVEAEEENADKSKAAPAETDQR"
     exon            543..719
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            720..846
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            847..970
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1073
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1546
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1759
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1915
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2113
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..5377
                     /gene="Satb2"
                     /gene_synonym="BAP002; mKIAA1034"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttccaac tttgcctggc acttcctcaa aatcacacac cagcaggaga atactccatt
       61 ccttgacaat ggccggccaa tgcagagaga acaaagatga ctcacactga gatccttgga
      121 cacaggcact gcactgtcct ggttgctgga gaagaaggtg atgagtgttt tcaggaacct
      181 gatggagagc caatggaaag gaaagttgtt tgccagtaac cctctttgaa gaagtcctca
      241 agtcctaata tcatcaattc ttcttagttc gtggacattg ggccggaggt ggattctgta
      301 gttccaacac caaggtccct gcgcgtttta ttgcgacctg ccggtgggaa ctttgtctcc
      361 aaatcggagc agcatggagc ggcggagcga gagcccgtgt cttcgggaca gccccgaccg
      421 aagaagcggc agccccgacg tcaaggggcc tcccccggtg aaggtggccc ggctggagca
      481 gaacggcagc cccatgggag cccgcgggag gcccaacggc gccgtggcca aggccgtggg
      541 aggtttgatg attccagttt tctgtgtggt ggagcagttg gatggctctc ttgaatacga
      601 caaccgagaa gagcacgctg agttcgtctt ggtgcggaaa gatgtgcttt ttagccagct
      661 ggtggagacc gcgctcctgg ccctggggta ttcccacagc tctgcagcgc aggcccaagg
      721 aataatcaag ctagggaggt ggaaccccct ccccctcagt tatgtgacag acgcccctga
      781 tgcgactgtg gccgacatgc tgcaagatgt ctatcacgtt gtgacgctga agatccaatt
      841 acaaagttgt tcaaagttgg aagacttgcc tgcggagcaa tggaaccacg ccaccgtccg
      901 caatgcctta aaggaactgc tcaaagaaat gaaccagagc acattagcca aagaatgccc
      961 tctctcccag agtatgattt catccattgt aaatagcaca tactatgcca atgtgtcagc
     1021 aaccaagtgc caggagtttg ggagatggta caaaaagtat aagaagataa aagtggaaag
     1081 agtggagcga gagaaccttt cagactattg tgttctgggc cagcggccaa tgcatttacc
     1141 aaatatgaac cagctggcat ccctgggcaa aaccaacgaa cagtctcctc atagccaaat
     1201 ccaccacagt actccaatcc gaaaccaagt gcccgcactc cagcccatca tgagccctgg
     1261 tcttctctca ccgcagctca gtcctcagct tgtcaggcag caaatagcca tggcccatct
     1321 gataaaccaa cagatagccg ttagccgact cctggctcac cagcatcctc aagccatcaa
     1381 ccagcagttc ttgaaccacc cacccattcc cagagcagtt aagccagagc caacaaactc
     1441 ctctgtggaa gtctctcctg atatctacca gcaagttaga gatgagttga agagggctag
     1501 tgtgtctcaa gctgtctttg caagagtggc attcaaccgc acacagggat tattgtcaga
     1561 gatactgcgt aaggaagaag atcccaggac tgcgtctcag tctcttctag taaacctgag
     1621 ggccatgcag aacttcctca acctgcctga agtggagcgt gatcgcattt accaggatga
     1681 gcgagagagg agcatgaacc ccaatgtgag catggtctcc tctgcctcta gcagtcccag
     1741 ctcctcccga accccacagg ccaaaacctc gacaccgaca acagacctcc ctattaaggt
     1801 ggacggcgcc aacgtcaaca tcacagctgc catttatgac gagatccaac aggagatgaa
     1861 aagagccaag gtgtctcaag ccctgtttgc caaagtggct gcaaacaaaa gtcagggctg
     1921 gctttgcgaa ctgcttcgtt ggaaggagaa ccccagccca gaaaaccgca ccctttggga
     1981 gaatctctgc accatccgcc gtttcctgaa tcttccccaa catgagcggg atgtgatcta
     2041 tgaggaagaa tctcgacatc accacagtga acgcatgcag catgtggtcc agctcccacc
     2101 tgagcccgtg caggtccttc atcgacagca gtcccagcca actaaggaga gctcccctcc
     2161 cagagaagaa gcacccccac cgcctcctcc aacagaagac agctgtgcca aaaagcctcg
     2221 gtctcgcaca aagatctctt tggaagccct gggcatcctt caaagcttca tccatgatgt
     2281 aggcctctat cccgaccagg aagccatcca cacactctcc gcccagctgg atctccccaa
     2341 acacaccatc atcaagttct tccagaacca gaggtaccac gtgaagcacc atggcaagct
     2401 gaaggagcac ctgggctccg ccgtggacgt ggcagagtat aaggacgagg agctgctgac
     2461 cgagtccgag gagaatgaca gtgaggaagg ctcggaggag atgtacaagg tggaggccga
     2521 ggaagagaat gccgacaaga gcaaggctgc accggccgaa accgaccaga gataatgtga
     2581 actccgcagg cagagcaata gatgggtcca aggactttct gttttagttt ctttcaagtt
     2641 cctctcggct ttgttttatt ttgttttggt tttgtctgtt ttatttttct tacccttaat
     2701 ggcattcctc tgttgcacag gatagcctat agactgagta agctcagagt ttctgaatca
     2761 gacgtcacct tggcaaagac actaagtgtt aaacttttac aattgactcg accatagtaa
     2821 ttctagtcac gggcgaccct gccgtcattc ctgccaactt atggaagcga taccaggcaa
     2881 attccaggat gggaagaccc acgagataaa tgaaggaagc tgcaagtgtg tatatgtata
     2941 tgtacatatc tctatattta catatatata ttaaaattgc atgggacaga gaactttaca
     3001 atccgaagga ctagactgtg aaatgagttc ttaaagaaaa gacttgttta tgtataaaaa
     3061 ctaataccac ttcacagtga gtcactttga ctttgagaaa ctgcagcctg ctctcagggc
     3121 gggataacta tttttgaatt cctatttatt ttgtgtgttt gtccctgatt tttttttttt
     3181 taattctatg gcttcctatc tggcagcttt taatgggtaa tttctgaggt atgtatttaa
     3241 caaaataaca ctgccaaaaa gatgagagac aggaggaaag aagagagtaa agtgggagaa
     3301 aatcagggca tgtcaaaaaa accaacataa gaccaattcc tccagaggac ataatgcaca
     3361 ccttaagaca aggactcagc gccgtgaccc tccacactcc attcccgagc atgccagcac
     3421 tgtatcgagc ggatgccttc tgtggaatcc cgagcccagt tcagtgcaga ggaaacttga
     3481 cctttagcgc agtctcaatg agtgacgttt tgacgttgga cctatggaat ccatgctatg
     3541 agccacattt tgttgtgaag tttatttact cgcttgtggc ttcaaatctt aaaattatta
     3601 agcctgctca tttaatattg ttagggtgtt accctttcct tcctttcctt tctttctttc
     3661 tttctttctt tctttctttc tttctttctt tctttctttc tttctttttt tttttctgga
     3721 tttcttttgt tcttgttctt gttttggttt tggtttggtt tgttttaaat agaacatagt
     3781 ttaatgtaat gttaggttag agaaagaagt ttctgcccgg ttagaggggc tcccgctcag
     3841 ataactccac cctgccctct ccccgagtgt tcctactctg cttccgttta gacttcctct
     3901 tcttcacaaa tccccttcac tttagccaga cctctgcaga ccctgagctc acgcgtctcc
     3961 acccttcccc tgccacgaca gccctggcag gaacctggtt tggaatcatg cacctccagg
     4021 caataaagta agtgaagcga tttcagcaga gtcacctact catcggaaaa ggaaataatt
     4081 gtcccagtgc cccacatagc gcttacctta cgtaaagcag aactaatgcc aacgggctgt
     4141 tttgtggaac aagcgttaaa gctgcaatct accacagttt gccaaatctc ctccagtttc
     4201 ctattagaaa cagtagcatt accttccagt tccagtgaca gcgattgcaa gaggagacct
     4261 cccttccttc gggaccggcc tccggaaccc actccaggct tgagatggcc actcagcagt
     4321 cccgcacggt tggattttat tttcttttgt tttgtttttg agttgtatcc tcatgcaacc
     4381 ttgtcaaaga cctcatgcaa tatcactttg aaatttattt tctgtttact acacaaacat
     4441 tgtaatataa ctgttaatac tatttatata tttgaaaggt ataagaggta ggagtttaaa
     4501 aaaaaaacct ctatgtgtag atattaactc agagcttaca ctatacaggg agaagacacg
     4561 ttgcaataca agctaattct agctgcttag taacctctgg agttttcaaa gggacatttt
     4621 tcctgtactt tttcaaataa tgatgtttaa aacagttacc cttgacatga gcgtcatgca
     4681 gctttgcaaa aggatggctg tttgcaactg aggcctgggc ccgcccgtcc cctttctgta
     4741 gatgctgcag ctttaatccg agagtccaca gttgctgctt cctgatctcc gagttactct
     4801 ttccaaattg tcttctgacg ctgttgctga agtcactctg tacacatcct agacaccgat
     4861 ttttttgcca agctcttaca ggtggttcat cgatcgatgg catccgcatt tggtatcttt
     4921 tacacttcaa ccaaaaattt attaggtatt tttcaatgct aagtcttgcc ttttattttt
     4981 taatttcact gccaagtttg cagtggttct aagtgaatct gtgggcattt tagcctgtgg
     5041 tcttgccaga tctttgcgaa ttacaatgca tatatgtcta tttattcaat atctgtcata
     5101 taatatctat ttggaagaag aaactttctc ttgtagtgcc tcttgacaaa gcacaatttc
     5161 ccgccttttt tttttttttt gtgaaatgaa gaaaaaaaca aattgtgttt tattgcagta
     5221 tcaataatgt gaataaggat taacatattg taaatgttcc tttttccatg taaatcaact
     5281 atctttgtta tcactaagtg ataattttta acttatgtgc attgttaggc tgttagaatt
     5341 ttttggttgt taaataaaac gcattcaata aatctga
//
