LOCUS       NM_026991                952 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus spermidine/spermine N1-acetyl transferase 2 (Sat2),
            transcript variant 1, mRNA.
ACCESSION   NM_026991 XM_001001037 XM_001001048 XM_001001059 XM_001001075
            XM_181304 XM_901865 XM_901869 XM_901870
VERSION     NM_026991.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 952)
  AUTHORS   Chen,X., Zheng,Y., Han,Y., He,H., Lv,J., Yu,J., Li,H., Hou,S.,
            Shen,C. and Zheng,B.
  TITLE     SAT2 regulates Sertoli cell-germline interactions via
            STIM1-mediated ROS/WNT/beta-catenin signaling pathway
  JOURNAL   Cell Biol Int 46 (10), 1704-1713 (2022)
   PUBMED   35819096
  REMARK    GeneRIF: SAT2 regulates Sertoli cell-germline interactions via
            STIM1-mediated ROS/WNT/beta-catenin signaling pathway.
REFERENCE   2  (bases 1 to 952)
  AUTHORS   Sandusky-Beltran,L.A., Kovalenko,A., Ma,C., Calahatian,J.I.T.,
            Placides,D.S., Watler,M.D., Hunt,J.B., Darling,A.L., Baker,J.D.,
            Blair,L.J., Martin,M.D., Fontaine,S.N., Dickey,C.A., Lussier,A.L.,
            Weeber,E.J., Selenica,M.B., Nash,K.R., Gordon,M.N., Morgan,D. and
            Lee,D.C.
  TITLE     Spermidine/spermine-N1-acetyltransferase ablation impacts
            tauopathy-induced polyamine stress response
  JOURNAL   Alzheimers Res Ther 11 (1), 58 (2019)
   PUBMED   31253191
  REMARK    GeneRIF: Spermidine/spermine-N(1)-acetyltransferase ablation
            impacts tauopathy-induced polyamine stress response.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 952)
  AUTHORS   Xian,Y., Wu,M., Liu,Y., Hao,J., Wu,Y., Liao,X. and Li,G.
  TITLE     Increased Sat2 expression is associated with busulfan-induced
            testicular Sertoli cell injury
  JOURNAL   Toxicol In Vitro 43, 47-57 (2017)
   PUBMED   28578006
  REMARK    GeneRIF: In testis tissue subjected to busulfan, increased
            expression of Sat2 can cause cellular injury and subsequent organ
            damage, which could lead to male infertility. Therefore, Sat2 may
            be a novel molecular target for treating busulfan-induced
            testicular toxicity.
REFERENCE   4  (bases 1 to 952)
  AUTHORS   Zahedi,K., Lentsch,A.B., Okaya,T., Barone,S., Sakai,N., Witte,D.P.,
            Arend,L.J., Alhonen,L., Jell,J., Janne,J., Porter,C.W. and
            Soleimani,M.
  TITLE     Spermidine/spermine-N1-acetyltransferase ablation protects against
            liver and kidney ischemia-reperfusion injury in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 296 (4), G899-G909 (2009)
   PUBMED   19164485
  REMARK    GeneRIF: These studies indicate that SAT2 deficient animals are
            protected against ischemia-reperfusion injuries (IRI) and suggest
            that SAT2 is an important mediator of the tissue damage in IRI.
REFERENCE   5  (bases 1 to 952)
  AUTHORS   Berger,F.G., Kramer,D.L. and Porter,C.W.
  TITLE     Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse
  JOURNAL   Biochem Soc Trans 35 (Pt 2), 336-339 (2007)
   PUBMED   17371273
  REMARK    GeneRIF: Sat2 acts as a tumor promoter in the adenomaatous
            polyposis coli mouse (Min/+) model.
REFERENCE   6  (bases 1 to 952)
  AUTHORS   Chen,Y., Vujcic,S., Liang,P., Diegelman,P., Kramer,D.L. and
            Porter,C.W.
  TITLE     Genomic identification and biochemical characterization of a second
            spermidine/spermine N1-acetyltransferase
  JOURNAL   Biochem J 373 (Pt 3), 661-667 (2003)
   PUBMED   12803540
REFERENCE   7  (bases 1 to 952)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011406.1, DV064807.1, AV097768.1 and AI413743.1.
            
            On Oct 5, 2017 this sequence version replaced NM_026991.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.399539.1, BU512250.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AK011406.1         2-8
            8-204               DV064807.1         69-265
            205-364             AK011406.1         66-225
            365-940             AK011406.1         227-802
            941-945             AV097768.1         164-168
            946-952             AI413743.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..952
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /note="spermidine/spermine N1-acetyl transferase 2"
                     /db_xref="GeneID:69215"
                     /db_xref="MGI:MGI:1916465"
     exon            1..281
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..728
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /EC_number="2.3.1.57"
                     /note="isoform 1 is encoded by transcript variant 1;
                     diamine acetyltransferase 2; polyamine N-acetyltransferase
                     2; spermidine/spermine N(1)-acetyltransferase 2;
                     thialysine N-epsilon-acetyltransferase"
                     /codon_start=1
                     /product="thialysine N-epsilon-acetyltransferase isoform
                     1"
                     /protein_id="NP_081267.1"
                     /db_xref="CCDS:CCDS36194.1"
                     /db_xref="GeneID:69215"
                     /db_xref="MGI:MGI:1916465"
                     /translation="MASTRIREARESDCGDIMRMIRELAEFEKLSHQVKISEEALRAD
                     GFGENPFFHCLVAEIIPAPGESQGSLVVGYGLYYFIYSTWTGRNVYLEDIYVMPQYRG
                     QGIGTKIIKKVAEVALNKGCSQFRLAVLDWNKKAVNLYKFLGAQDLTESEGWLSFRFE
                     GEAMRELAGR"
     exon            282..333
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..417
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            418..519
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..560
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            561..948
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      902..907
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /note="hexamer: AATAAA"
     polyA_site      948
                     /gene="Sat2"
                     /gene_synonym="2610016A03Rik; SSAT-2; SSAT2"
                     /note="major polyA site"
ORIGIN      
        1 agaatttaag gccttttctg gcagaagaga ccaccaggcc ggctaatcct cccagctgag
       61 accggttggt gccagaatct tgtctagaag cttctagcat ttcttctgcc cctcgctccc
      121 agcactttga gacctgagct ttgagaccag acctccgcgg ttctgcaaac gtgggagttg
      181 tctgtgatct ttgatttttg acagtgaggc tcggaatggc ttccacgcga atccgagagg
      241 ccagggagag cgattgtgga gacattatga ggatgatccg ggaactggca gagttcgaga
      301 aactgtccca tcaggtgaag atcagtgaag aagctctgcg agcagatggc tttggagaga
      361 accctttctt tcactgtttg gtggcagaga ttatcccagc acctggggag tcacaagggt
      421 cccttgtggt gggctatggg ctgtactact tcatctatag cacatggacc ggacgaaacg
      481 tttatctgga agacatctat gtgatgccgc aatatcgggg tcaagggatt ggtaccaaaa
      541 taatcaaaaa ggtggctgag gttgccctga ataagggttg ctcccagttc cgcctggcag
      601 ttctggattg gaacaagaag gccgtgaact tgtacaaatt tctaggggct caagatctga
      661 ctgaatcgga aggctggctc tcctttcgat ttgaaggcga ggcaatgagg gagttggcag
      721 gacgctgact tacgccctct ctctcctgcc tcttctttgg gatcaccata tcaagttttc
      781 ctaagaccat aaccataggc actgacccag acagacgctc gctcacccag aggcctccca
      841 gggtgcagac tcctgaagta cagaaagagt ggaagaggga gaagccttat taggaaccac
      901 aaataaaata cttgctttgc cctcatgggt agaggatgtg atgctgcaaa aa
//
