LOCUS       NM_009121               1168 bp    mRNA    linear   ROD 17-SEP-2023
DEFINITION  Mus musculus spermidine/spermine N1-acetyl transferase 1 (Sat1),
            transcript variant 1, mRNA.
ACCESSION   NM_009121
VERSION     NM_009121.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Xu L, Zhao J, Sun Q, Xu X, Wang L, Liu T, Wu Y, Zhu J, Geng L, Deng
            Y, Awgulewitsch A, Kamen DL, Oates JC, Raj P, Wakeland EK, Scofield
            RH, Guthridge JM, James JA, Hahn BH, McCurdy DK, Wang F, Zhang M,
            Tan W, Gilkeson GS and Tsao BP.
  TITLE     Loss-of-function variants in SAT1 cause X-linked childhood-onset
            systemic lupus erythematosus
  JOURNAL   Ann Rheum Dis 81 (12), 1712-1721 (2022)
   PUBMED   35977808
  REMARK    GeneRIF: Loss-of-function variants in SAT1 cause X-linked
            childhood-onset systemic lupus erythematosus.
REFERENCE   2  (bases 1 to 1168)
  AUTHORS   Sapir T, Kshirsagar A, Gorelik A, Olender T, Porat Z, Scheffer IE,
            Goldstein DB, Devinsky O and Reiner O.
  TITLE     Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the
            developing mouse cortex
  JOURNAL   Nat Commun 13 (1), 4209 (2022)
   PUBMED   35864088
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1168)
  AUTHORS   Zhao J, Wu Y, Liang S and Piao X.
  TITLE     Activation of SSAT1/ALOX15 Axis Aggravates Cerebral
            Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis
  JOURNAL   Neuroscience 485, 78-90 (2022)
   PUBMED   35090880
  REMARK    GeneRIF: Activation of SSAT1/ALOX15 Axis Aggravates Cerebral
            Ischemia/Reperfusion Injury via Triggering Neuronal Ferroptosis.
REFERENCE   4  (bases 1 to 1168)
  AUTHORS   Wagner A, Wang C, Fessler J, DeTomaso D, Avila-Pacheco J, Kaminski
            J, Zaghouani S, Christian E, Thakore P, Schellhaass B, Akama-Garren
            E, Pierce K, Singh V, Ron-Harel N, Douglas VP, Bod L, Schnell A,
            Puleston D, Sobel RA, Haigis M, Pearce EL, Soleimani M, Clish C,
            Regev A, Kuchroo VK and Yosef N.
  TITLE     Metabolic modeling of single Th17 cells reveals regulators of
            autoimmunity
  JOURNAL   Cell 184 (16), 4168-4185 (2021)
   PUBMED   34216539
REFERENCE   5  (bases 1 to 1168)
  AUTHORS   Zahedi K, Brooks M, Barone S, Rahmati N, Murray Stewart T, Dunworth
            M, Destefano-Shields C, Dasgupta N, Davidson S, Lindquist DM,
            Fuller CE, Smith RD, Cleveland JL, Casero RA Jr and Soleimani M.
  TITLE     Ablation of polyamine catabolic enzymes provokes Purkinje cell
            damage, neuroinflammation, and severe ataxia
  JOURNAL   J Neuroinflammation 17 (1), 301 (2020)
   PUBMED   33054763
  REMARK    GeneRIF: Ablation of polyamine catabolic enzymes provokes Purkinje
            cell damage, neuroinflammation, and severe ataxia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1168)
  AUTHORS   Takenaka M, Imai E, Kaneko T, Ito T, Moriyama T, Yamauchi A, Hori
            M, Kawamoto S and Okubo K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   7  (bases 1 to 1168)
  AUTHORS   Kuroiwa A, Watanabe T, Hishigaki H, Takahashi E, Namikawa T and
            Matsuda Y.
  TITLE     Comparative FISH mapping of mouse and rat homologues of twenty-five
            human X-linked genes
  JOURNAL   Cytogenet Cell Genet 81 (3-4), 208-212 (1998)
   PUBMED   9730605
REFERENCE   8  (bases 1 to 1168)
  AUTHORS   Pietila M, Alhonen L, Halmekyto M, Kanter P, Janne J and Porter CW.
  TITLE     Activation of polyamine catabolism profoundly alters tissue
            polyamine pools and affects hair growth and female fertility in
            transgenic mice overexpressing spermidine/spermine
            N1-acetyltransferase
  JOURNAL   J Biol Chem 272 (30), 18746-18751 (1997)
   PUBMED   9228047
REFERENCE   9  (bases 1 to 1168)
  AUTHORS   Fogel-Petrovic M, Kramer DL, Ganis B, Casero RA Jr and Porter CW.
  TITLE     Cloning and sequence analysis of the gene and cDNA encoding mouse
            spermidine/spermine N1-acetyltransferase--a gene uniquely regulated
            by polyamines and their analogs
  JOURNAL   Biochim Biophys Acta 1216 (2), 255-264 (1993)
   PUBMED   8241266
REFERENCE   10 (bases 1 to 1168)
  AUTHORS   de Meeus A, Alonso S, Demaille J and Bouvagnet P.
  TITLE     A detailed linkage map of subtelomeric murine chromosome 12 region
            including the situs inversus mutation locus IV
  JOURNAL   Mamm Genome 3 (11), 637-643 (1992)
   PUBMED   1360279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU699066.1, BC058696.1 and BX119986.8.
            
            [WARNING] On Dec 1, 2023 this sequence was replaced by NM_009121.5.
            
            On May 6, 2014 this sequence version replaced NM_009121.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058696.1, AK154445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BU699066.1         1-40
            41-1156             BC058696.1         1-1116
            1157-1168           BX119986.8         196758-196769       c
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.38 cM"
     gene            1..1168
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /note="spermidine/spermine N1-acetyl transferase 1"
                     /db_xref="GeneID:20229"
                     /db_xref="MGI:MGI:98233"
     exon            1..347
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            348..399
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            400..483
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            484..585
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            586..626
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
     exon            627..1168
                     /gene="Sat1"
                     /gene_synonym="Sat; SSAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcttcggcg ggctttcatc cttactggtc gcgatctctc cggctccccg tccagggagg
       61 agcttctgcg gacttaaaag gcaccgtctt gccacttctt agctgcgcag tttccccgaa
      121 gtaagtttgc cagttttctg tcttatactg aggttcgccg ggtcatggtg ccagcctgac
      181 tgagaagagg acgctcccgg gaaacgaatg aggaaccacc tcctcctgct gttcaagtac
      241 aggggcctgg tgcgcaaagg gaagaaaagc aaaagacgaa aatggctaaa tttaagatcc
      301 gtccagccac tgcctctgac tgcagtgaca tcctgcgact gatcaaggaa ctggctaaat
      361 atgaatacat ggaagatcaa gtcattttaa ctgagaaaga tctccaagag gatggctttg
      421 gagaacaccc cttctaccac tgcctggttg cagaagtgcc taaagagcac tggacccctg
      481 aaggacatag cattgttggg ttcgccatgt actattttac ctatgaccca tggattggca
      541 agttgctgta tcttgaagac ttcttcgtga tgagtgatta cagaggcttt ggtataggat
      601 cagaaatttt gaagaatcta agccaggttg ccatgaagtg tcgctgcagc agtatgcact
      661 tcttggtagc agaatggaat gaaccatcta tcaacttcta caaaagaaga ggtgcttcgg
      721 atctgtccag tgaagaggga tggaggctct tcaagattga caaagagtac ttgctaaaaa
      781 tggcagcaga ggagtgaggc gtgccggtgt agacaatgac aacctccatt gtgctttaga
      841 ataattctca gcttcccttg ctttctatct tgtgtgtagt gaaataatag agcgagcacc
      901 cattccaaag ctttattacc agtgacgttg ttgcatgttt gaaattcggt ctgtttaaag
      961 tggcagtcat gtatgtggtt tggaggcaga attcttgaac atcttttgat gaagaacaag
     1021 gtggtatgat cttactatat aagaaaaaca aaacttcatt cttgtgagtc atttaaatgt
     1081 gtacaatgta cacactggta cttagagttt ctgttttgat tctttttttt ttaaataaac
     1141 tactctttga tttaaatatt cagcctga
//
