LOCUS       NM_175155               7183 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus SAM and SH3 domain containing 1 (Sash1), mRNA.
ACCESSION   NM_175155 NM_177258
VERSION     NM_175155.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7183)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7183)
  AUTHORS   Coulombe,P., Paliouras,G.N., Clayton,A., Hussainkhel,A., Fuller,M.,
            Jovanovic,V., Dauphinee,S., Umlandt,P., Xiang,P., Kyle,A.H.,
            Minchinton,A.I., Humphries,R.K., Hoodless,P.A., Parker,J.D.K.,
            Wright,J.L. and Karsan,A.
  TITLE     Endothelial Sash1 Is Required for Lung Maturation through Nitric
            Oxide Signaling
  JOURNAL   Cell Rep 27 (6), 1769-1780 (2019)
   PUBMED   31067462
  REMARK    GeneRIF: endothelial Sash1 regulates alveolar epithelial cell
            maturation and promotes pulmonary surfactant production through
            nitric oxide signaling.
REFERENCE   3  (bases 1 to 7183)
  AUTHORS   Dauphinee,S.M., Clayton,A., Hussainkhel,A., Yang,C., Park,Y.J.,
            Fuller,M.E., Blonder,J., Veenstra,T.D. and Karsan,A.
  TITLE     SASH1 is a scaffold molecule in endothelial TLR4 signaling
  JOURNAL   J Immunol 191 (2), 892-901 (2013)
   PUBMED   23776175
  REMARK    GeneRIF: SASH1 acts to assemble a signaling complex downstream of
            TLR4 to activate early endothelial responses to receptor
            activation.
REFERENCE   4  (bases 1 to 7183)
  AUTHORS   Thaisz,J., Tsaih,S.W., Feng,M., Philip,V.M., Zhang,Y., Yanas,L.,
            Sheehan,S., Xu,L., Miller,D.R., Paigen,B., Chesler,E.J.,
            Churchill,G.A. and Dipetrillo,K.
  TITLE     Genetic analysis of albuminuria in collaborative cross and multiple
            mouse intercross populations
  JOURNAL   Am J Physiol Renal Physiol 303 (7), F972-F981 (2012)
   PUBMED   22859403
REFERENCE   5  (bases 1 to 7183)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   6  (bases 1 to 7183)
  AUTHORS   Lindvall,J.M., Blomberg,K.E., Wennborg,A. and Smith,C.I.
  TITLE     Differential expression and molecular characterisation of Lmo7,
            Myo1e, Sash1, and Mcoln2 genes in Btk-defective B-cells
  JOURNAL   Cell Immunol 235 (1), 46-55 (2005)
   PUBMED   16137664
  REMARK    GeneRIF: Not expressed in the investigated haematopoietic cell
            lines, while transcripts were found in whole splenic B-cells from
            both wild type and Btk-defective mice.
REFERENCE   7  (bases 1 to 7183)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 7183)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 7183)
  AUTHORS   Zeller,C., Hinzmann,B., Seitz,S., Prokoph,H., Burkhard-Goettges,E.,
            Fischer,J., Jandrig,B., Schwarz,L.E., Rosenthal,A. and Scherneck,S.
  TITLE     SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is
            downregulated in breast cancer
  JOURNAL   Oncogene 22 (19), 2972-2983 (2003)
   PUBMED   12771949
REFERENCE   10 (bases 1 to 7183)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ125950.1, AJ507736.1 and BY770549.1.
            
            On Aug 22, 2006 this sequence version replaced NM_175155.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ507736.1, SRR11927937.2980883.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-185               CJ125950.1         2-186
            186-1046            AJ507736.1         1-861
            1047-1128           BY770549.1         269-350
            1129-7183           AJ507736.1         944-6998
FEATURES             Location/Qualifiers
     source          1..7183
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.75 cM"
     gene            1..7183
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /note="SAM and SH3 domain containing 1"
                     /db_xref="GeneID:70097"
                     /db_xref="MGI:MGI:1917347"
     exon            1..347
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..3905
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /note="putative adapter and scaffold protein 1"
                     /codon_start=1
                     /product="SAM and SH3 domain-containing protein 1"
                     /protein_id="NP_780364.3"
                     /db_xref="CCDS:CCDS23692.1"
                     /db_xref="GeneID:70097"
                     /db_xref="MGI:MGI:1917347"
                     /translation="MEEDAGAASPAPEPEPEVDPARELEPEAGVSESISRLWTDVMGI
                     LDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLDVEKPDASPTSLQLRS
                     QIEESLGFCSAVSTPEVERKYPLHKSNSEDGCVGKGDWKKKNKYFWQNFRKNQKGIMR
                     QTSKGEDVGYVASEITMSDEERIQLMMMVKEKMITIEEALARLKEYEAQHRQSSTLDP
                     ADWPDGSYPTLDGSSTCNSREQSDDETEDSVKFKRLHKLVNSTRRVRKKLIRVEEMKK
                     PSTEGGEEHVFENSPVQDERSALYSGVHKKPFFYDGSPEKPPEDDADSLTPSPSSSSL
                     DTWGAGRKLVKTFSKGESRGLIKPPKKMGTFFSYPEEEKAQKVSRSLTEGEMKKGLGS
                     LSHGRTCSFGGFDLTNRSLHVGSNNSDPAGKEGDFVYKEVIKSPPAPRISLGKKVRSV
                     KETMRKRMSKKYSSPVSEQDSGLDGMPSSPASGKPDSEHVDKPKLKAGGSVESLRSSL
                     SGQSSMSGQTVSTTDSSTSNRESVKSEDGDDEEPPYRGPFCGRARVHTDFTPSPYDTD
                     SLKLKKGDIIDIISKPPMGTWMGLLNNKVGTFKFIYVDVLNEEEEKPKRPTRRRKKGR
                     PSQPKSVEDLLDRINLKEHMPTFLFNGYEDLDTFKLLEEEDLDELNIRDPEHRAVLLT
                     AVELLQEYDSNSDQSGSQEKLLVDNQGLSGRSPRDSGCYESSENLENAKTHKPSVLST
                     KSSTESNLKSFTRSQPGNYPTLPLMKSGEVRKQGEEGRLGRGLAPDTAKSCDVPSVTD
                     LSKNRRSLPVSICRSCETLEGPEPVESWPRSHSLDDLQGDADVGKNVPTEMPETCSQN
                     VPEVPQKTSACTSKALPRGRDPTADVMLLTQSKRFSDPPKTMAKKLDGSVVASNLGIA
                     PPQCIPRDFEAQPPVKPGLTRTSLEGLRKGHDHHPLGTKEGVDGEQSAPETRTQSRHP
                     SQPPPVPAKKSRERLANGLHLVPSPEAPILPLKKASPASPVSPSDCPSPREPRPSSGT
                     EPGSPACTRPPPWLAELPESTSLQEHGVKLGPVLSRKVSCVRGVDLEMLTENKLQAEG
                     IDLTEEPYSDKHGRCGIPEALVQRYAEDLEQPERDVATNMDQIRVKLLRKQHRMAIPS
                     GGLTEICRKPLSPGCVASMSDWLISIGLPMYTSTLSDAGFSTLSQVPSLSHSCLQEAG
                     ITEERHIRKLITAARLFKLPPSPEAM"
     exon            348..476
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            477..527
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            528..577
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            578..618
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            619..705
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            706..818
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            819..920
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1053
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1400
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1475
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1619
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1755
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1925
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2135
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2286
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..2400
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            2401..3509
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            3510..3641
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..7183
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7065..7071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sash1"
                     /gene_synonym="1100001C18Rik; 2500002E12Rik;
                     A330076K04Rik; mKIAA0790"
ORIGIN      
        1 ggaaaagttt ctggagttgt caatcgcggt cgcccgggat cgaggtgcca gtcctggcag
       61 tggtgctcgt acccagcgga gcctggggca tgcgacgcgg gggcgcggcc cggtgacgcc
      121 gcgggcgggg aacttgcgcc ccgtcggccg acgcgctgct gcgagcggtg ggcagcgcgg
      181 ggacccggac gcggacgcac ggggacgcgg ccatggagga ggacgcggga gctgctagcc
      241 cggcgccgga gcctgagccg gaggtggatc ccgcccggga gctggagccc gaggccggtg
      301 tctccgagtc aatctcccgc ctctggaccg acgtgatggg catcctggat ggttccctgg
      361 gaaacattga tgacctggca cagcagtatg cagattatta caatacctgc ttttctgacg
      421 tgtgtgagcg gatggaggag ctccggaaac ggcgcgtttc ccaggacctg gatgtggaga
      481 aacccgacgc cagccccacg tcacttcagc tgcggtccca gatcgaagag tctctaggct
      541 tctgcagcgc cgtgtcaaca ccagaagtgg aaagaaagta ccctctccat aaatcaaact
      601 cagaagacgg ctgtgtaggc aaaggagatt ggaagaagaa aaataaatac ttctggcaga
      661 atttccgaaa gaaccaaaaa ggaataatga gacagacttc aaaaggagaa gatgtgggct
      721 atgtagccag cgagattacg atgagtgacg aggagcggat tcagctgatg atgatggtca
      781 aggagaaaat gatcaccatt gaagaagcgc tcgccaggct gaaggaatac gaggcccagc
      841 accgtcagtc atccaccttg gaccccgcag actggcccga tggctcctac ccgacattgg
      901 atggctcctc cacctgcaac tcaagagagc agtcggatga tgagacagag gactcggtga
      961 agtttaagag gttgcacaag ctggtaaact ctactcgaag agtcagaaag aaactaatta
     1021 gggtggaaga aatgaaaaag cccagcacag aaggtggaga ggaacatgta tttgagaatt
     1081 ccccagtcca agatgaaaga tctgcactct actctggagt gcacaaaaag ccatttttct
     1141 atgatggctc tcctgagaaa cctccagaag atgatgcaga ctctctcacc ccatctccat
     1201 catccagcag cctggatacg tggggagctg gccggaagtt ggtcaaaacc ttcagcaaag
     1261 gagagagtcg gggcctgatt aagcccccta agaagatggg gacattcttc tcctatccag
     1321 aagaagagaa ggcccagaaa gtgtcccgct ccctcacaga gggggaaatg aagaaaggtc
     1381 ttgggtcttt gagtcacggg agaacctgca gttttggtgg attcgacctg acaaaccgtt
     1441 ctctgcatgt tggcagtaat aattctgacc ctgcgggtaa agagggagat tttgtgtaca
     1501 aagaagtcat caaatcccct cctgcccccc gcatctctct cgggaaaaag gtgagatcag
     1561 tgaaagagac catgaggaag aggatgtcta aaaagtacag cagcccggtc tcagagcagg
     1621 actcggggct cgatggaatg cccagctccc ccgcctcagg aaagcctgac tccgaacacg
     1681 tggacaagcc taagctcaaa gccgggggct ctgtggaaag ccttcggagt tctctgagtg
     1741 gccagagctc aatgagtggt cagacagtga gcaccactga ttcctccacc agcaaccggg
     1801 agagtgtcaa gtcagaagat ggggatgacg aagagccacc ctatcggggt cccttctgtg
     1861 ggcgtgcccg agtgcacact gacttcaccc ccagtcccta tgacacggac tctctgaagc
     1921 tcaagaaagg agatatcatt gacataatta gcaaaccacc catgggtacc tggatgggcc
     1981 tgctgaacaa caaagtcggc acgttcaagt tcatctacgt ggatgtgcta aatgaggaag
     2041 aggagaagcc caagcgccct accaggagga ggaagaaggg aagaccatct cagccgaagt
     2101 ctgtggagga tctcctggac cggatcaacc tgaaagaaca catgcccacc ttcctgttca
     2161 atggctatga agacctggac accttcaaac tcctggagga agaagactta gatgaattaa
     2221 atatcaggga cccagaacac agagcagttc ttctgactgc ggtggagctg ttgcaggaat
     2281 atgacagtaa cagtgaccag tccggttctc aggaaaagct gctggtggac aaccagggcc
     2341 tgagtggacg atccccacga gactccggat gctacgaaag cagcgagaac ttggaaaacg
     2401 ccaaaactca caaacccagc gttctgtcta ccaagtcgtc cacggagtcc aacttaaagt
     2461 ctttcaccag gagtcagcca ggcaactacc cgacattgcc tttaatgaaa tcaggggagg
     2521 tgcgcaagca gggagaggag ggcaggctgg gacgaggtct agccccggac actgccaaga
     2581 gctgtgacgt gccctctgtg actgatttga gtaaaaaccg aaggagcctc ccggtctcca
     2641 tctgtcgcag ctgtgaaacc ctggagggtc ctgagcctgt ggaaagttgg ccccgatccc
     2701 attccctgga tgaccttcag ggagatgctg atgttggcaa gaatgtgcct accgagatgc
     2761 cagaaacctg ttctcagaat gtaccagaag tgccgcagaa gacgtctgcc tgcacctcca
     2821 aggctctgcc acgaggccga gatcccacag cagatgtgat gcttctgacc caaagcaaga
     2881 gattttccga ccccccgaaa acaatggcta agaaactgga tggctccgtg gtggcctcca
     2941 accttgggat agctcctcct cagtgtatac ccagagattt cgaggcccag ccgcctgtta
     3001 aacccggctt aacaaggacg tctcttgagg gtctcagaaa aggacatgat caccaccccc
     3061 tgggcaccaa agaaggggta gacggggagc agagcgcccc tgagaccagg acacagtccc
     3121 gacatccgtc gcagccccct cctgtgccag ccaagaaaag ccgagagcgc ctggccaatg
     3181 gcctgcactt ggtccccagc ccagaggcac ccatcctgcc actgaagaaa gccagccctg
     3241 ccagcccagt cagtcccagc gactgcccct ctccccggga acccaggcct tcctccggga
     3301 ctgagccggg cagcccagcc tgtacgagac ctccaccctg gctggctgag ctgcccgaga
     3361 gcactagcct gcaggagcat ggtgtgaaac tgggcccagt gctgagcagg aaggtttcct
     3421 gtgtccgggg tgtggaccta gagatgctca cggagaacaa gctgcaggcg gagggcattg
     3481 atctcactga ggagccctac tctgataagc atggccgttg tgggatcccg gaagccctgg
     3541 tacagagata cgcagaggac ctagagcagc ctgagaggga tgttgccacc aacatggacc
     3601 agatccgggt gaagctgctt cggaagcaac atcggatggc gatcccgagt ggtgggctga
     3661 cggaaatctg cagaaagccc ctctctcccg gctgtgttgc gtccatgtcg gattggctca
     3721 tctctatcgg cctgcccatg tacacgagca ccctttctga cgcagggttc agcacgctga
     3781 gccaagtgcc ttccctgtcc cactcttgcc ttcaggaggc cggcatcacc gaggagagac
     3841 acataaggaa actcataacg gcagccagac tcttcaaact gccaccaagc cctgaggcta
     3901 tgtagccagg ccggcgtggc cctccctaga caagagccag cctctcactg tgcttaggaa
     3961 gccgatacaa tccctccacg tctgctgggg ttgaagaaaa gtattctctc ggggctcacg
     4021 aactgcagga ttgggactca gaaccgaggc ccctctcttc cggtaaagcc ctcctcccct
     4081 gcccctcgag gaaatcgagg tgattctctt tgatgcccaa aggcaagaca cgcacttagt
     4141 tccgttttca ggcactgaag agccaagaca ctacaaacag tgtgtgtcca gtctgtcttt
     4201 gtgctgtcag agggctagga ggacgaggca gccggctcgt gtctgatcgt gcccttgcgc
     4261 atctgttggt cacccgatgc ccgagcccga tgggcttagc taggccaaag caacagactc
     4321 tggagttact gtatactatt gaccatgctc atttgttcaa aagctacaac agctgactct
     4381 atcaagaaca gaacggtcct cctctcctgt agataaacga ccagagacat tttaattgct
     4441 ttctagcaat tagcttttat ttgccttaat ataaactttt aaccagttat ctatctagtg
     4501 tccacagccc ttacttaacc ctagttccag attttcagct tagactgcca tctaacgtgt
     4561 ttgggatgtt tccagcaaaa atagcctttt tttttaaaaa aacagtctca ttctaacatg
     4621 gcttatttta taagggtgac taccaggcac acgtttcatg ttgactttta gtttttgaac
     4681 taactataat ttagtaaaag tcgatcggga ctcacagagg ggcacgtgtg tgtgtagtga
     4741 ctgcccttca gtcttctgcc tttagtgaga ggctgtcaca gtggccatgg tgttgtgagt
     4801 ggctgtcacg gtggccatgg tgttgtgagt ggctgtcacg gtggccatgg tgttgtgagt
     4861 ggctgtcacg gtggccatgg tgttgtgaga ggctgtcacg gtggccatgg tgttgtgaga
     4921 ggctgtcaca gtggccatgg tgttgtgagt ggctgtcacg gtggccatgg tgttgcagta
     4981 tttatgtgaa atcctaacct catccatccc caaatccatt catcaactat cagatcacct
     5041 ttgcagaaag ccattgtaag ttgcatattt cagaaagatt tttttttcta aaaagggaag
     5101 tagtttactc atttaaagtt ctttttgttt gtttgttttt aatttttttt ccattttggc
     5161 cggttttatt atctctcatt tgttatgtag ataattattt taattcaagc aaaggttcat
     5221 tatggagcca gataaaccac atccgctggg tgttaaatat tgcatatttt caactggttt
     5281 ttccaacttt gatttccatg tgatctgccc tctttttgtc tggcgtctgg ttttctagca
     5341 gttggcacac ttagacaggt gtgcctgatc cattgcttac aaagtgtttt ttcttcatat
     5401 tcttgcaagc acgatgtgaa gtctccagtt atcgtggaag cattttgaat acaaggcccg
     5461 gatcagtcct ccgctagttc atttgggtta ttacaatttg attcccctca gaagagaagg
     5521 gcaagcggtt ttatgaataa caacgccatc ctggccttat ggtttatata gctggtccac
     5581 gtctctgagg aacatctcag gtgattcccc ccaccccaca cacattttag tgtgcgctaa
     5641 aaaataataa tattgcttgg tttcctcact tcccttcgcc tactataaaa tgccacgtgg
     5701 agaagttgag gcagtttaga atgagaagag taaaggcact gggttcctat tggactctta
     5761 ataaagagct cacggttagc ttccagggtc aggcataggc cacccaatgg gtgggggtgc
     5821 agggttctct gccagtccag gacccagtca catgctgttg tgggggttgg cattggaaaa
     5881 caggcttctt ctcttgcttt tgaagtaacc ctggcctgac cgtgcaacag actgcccttt
     5941 gattttagct gagcgaagag agagagacct cgcaaaagta acatcggagg taaccaggga
     6001 ggaggagaaa tcttttggga atttccaagt ttcagttcat tcttggtgta gggttttctg
     6061 ttttaagtca atcaaggagg tcttgagaat gtcaaacagt agcttttttc tctctggaaa
     6121 ttgtcgcctt tgcatggaga attaaattca gggaccacga gtttagtgtg aatgtctgat
     6181 ctgaaggggc tgaggcttct tatccctccc tccctccctc cctccctccc tccctccctc
     6241 cctccctccc tcccttcctt tcctttcctt gtatcatatt tgtttggttt tcttttgctt
     6301 tgaacgtttc atttggtctg agaaaagcct gaacattagc gtatgactct gaggagactc
     6361 ggggctgcct gtggctgtta gcggacaggc ggccggcttt agcaatagcc acttttgatc
     6421 ggttgcattt ggtacagaat tttgaatgac agtgaaaatt gttgtctttg caaagcacaa
     6481 aactaacctg gaaaggcgtt tcggctcagg tagctaccca gaatgtgtgt gattggtgtg
     6541 tctccgctgt ctgcagagaa agcagctgcc caaactacta tttacattcc cagatactga
     6601 gagcaaatag cttttcatgg ccttgcatat ttgggggccc ttttctctgt cccgacccca
     6661 ggtgcggatg gaactagaaa tgattcttct gtgagaaaag agtcctggac acggagtagt
     6721 gtgtttcaca actgcggtgg aacacaagta gattcccaag tcactgctgt gtgaggactg
     6781 agtgaggttc ccgaaaaatt ctgtcttgag tccatgttat cttgattttt aaaattgata
     6841 gggaagaaac cccacaaact gtcaagcaag ttatatgaca actaacaaca ttgcactttc
     6901 tgtatatgaa atcaatattt aaataactta tttttctcca ttgctattct taaacattgt
     6961 aagtagctgt aatataccaa taccaatacg ttcttgcaat tgcttcagcc cgagaaagct
     7021 gtgtattgtt ttaaaattgt aaaaaaaaaa aaaaatattg tgatgatcca tttaaaaaaa
     7081 aaaaaaagga aggtagacag aagggttttc ctgtgtatca aaacttgtct ataattatgt
     7141 cacctatgta cctaggggaa aggtaaataa aatgtcttca tcg
//
