LOCUS       NP_058622                962 aa            linear   ROD 02-MAY-2024
DEFINITION  squamous cell carcinoma antigen recognized by T-cells 3 isoform 2
            [Mus musculus].
ACCESSION   NP_058622
VERSION     NP_058622.1
DBSOURCE    REFSEQ: accession NM_016926.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 962)
  AUTHORS   Whitmill,A., Liu,Y., Timani,K.A., Niu,Y. and He,J.J.
  TITLE     Tip110 Deletion Impaired Embryonic and Stem Cell Development
            Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2
  JOURNAL   Stem Cells 35 (7), 1674-1686 (2017)
   PUBMED   28436127
REFERENCE   3  (residues 1 to 962)
  AUTHORS   Liu,Y., Timani,K., Mantel,C., Fan,Y., Hangoc,G., Cooper,S., He,J.J.
            and Broxmeyer,H.E.
  TITLE     TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC
  JOURNAL   Blood 117 (21), 5643-5651 (2011)
   PUBMED   21447833
REFERENCE   4  (residues 1 to 962)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 962)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (residues 1 to 962)
  AUTHORS   Stanek,D., Rader,S.D., Klingauf,M. and Neugebauer,K.M.
  TITLE     Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to
            Cajal bodies
  JOURNAL   J Cell Biol 160 (4), 505-516 (2003)
   PUBMED   12578909
REFERENCE   7  (residues 1 to 962)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 962)
  AUTHORS   Harada,K., Yamada,A., Mine,T., Kawagoe,N., Takasu,H. and Itoh,K.
  TITLE     Mouse homologue of the human SART3 gene encoding tumor-rejection
            antigen
  JOURNAL   Jpn J Cancer Res 91 (2), 239-247 (2000)
   PUBMED   10761712
REFERENCE   9  (residues 1 to 962)
  AUTHORS   Yang,D., Nakao,M., Shichijo,S., Sasatomi,T., Takasu,H.,
            Matsumoto,H., Mori,K., Hayashi,A., Yamana,H., Shirouzu,K. and
            Itoh,K.
  TITLE     Identification of a gene coding for a protein possessing shared
            tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T
            lymphocytes in cancer patients
  JOURNAL   Cancer Res 59 (16), 4056-4063 (1999)
   PUBMED   10463607
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132939.23 and AK086398.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (2)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057156.1, AF172722.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..962
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.55 cM"
     Protein         1..962
                     /product="squamous cell carcinoma antigen recognized by
                     T-cells 3 isoform 2"
                     /note="SART-3; mSART-3; tumor-rejection antigen SART3"
                     /calculated_mol_wt=109488
     Region          1..92
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          2..352
                     /region_name="Mediates interaction with PRPF3.
                     /evidence=ECO:0000250|UniProtKB:Q15020"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          101..>461
                     /region_name="RNA14"
                     /note="Pre-mRNA 3'-end processing (cleavage and
                     polyadenylation) factor [RNA processing and modification];
                     COG5107"
                     /db_xref="CDD:227438"
     Site            216
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          325..357
                     /region_name="HAT 5. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          360..392
                     /region_name="HAT 6. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          395..431
                     /region_name="HAT 7. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          441..474
                     /region_name="HAT 8. /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          488..521
                     /region_name="Required for interaction with USP4.
                     /evidence=ECO:0000250|UniProtKB:Q15020"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          538..952
                     /region_name="Necessary and sufficient for U6 snRNA
                     binding. /evidence=ECO:0000250|UniProtKB:Q15020"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          591..696
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          601..670
                     /region_name="Required for nuclear localization.
                     /evidence=ECO:0000250|UniProtKB:Q15020"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Site            651
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          705..778
                     /region_name="RRM1_SART3"
                     /note="RNA recognition motif 1 (RRM1) found in squamous
                     cell carcinoma antigen recognized by T-cells 3 (SART3) and
                     similar proteins; cd12391"
                     /db_xref="CDD:409825"
     Site            795
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          799..879
                     /region_name="RRM2_SART3"
                     /note="RNA recognition motif 2 (RRM2) found in squamous
                     cell carcinoma antigen recognized by T-cells 3 (SART3) and
                     similar proteins; cd12392"
                     /db_xref="CDD:409826"
     Site            852
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Region          877..937
                     /region_name="LSM_int_assoc"
                     /note="LSM-interacting associated unstructured; pfam16605"
                     /db_xref="CDD:465192"
     Region          880..962
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JLI8.1)"
     Site            906
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q15020; propagated from
                     UniProtKB/Swiss-Prot (Q9JLI8.1)"
     CDS             1..962
                     /gene="Sart3"
                     /gene_synonym="mKIAA0156"
                     /coded_by="NM_016926.2:766..3654"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS19552.1"
                     /db_xref="GeneID:53890"
                     /db_xref="MGI:MGI:1858230"
ORIGIN      
        1 mattaassas epevepqagp eaegeedeak pagvqrkvls gavaaeaaea kgpgwdlqre
       61 gasgsdgdee damassaess agedeweyde eeeknqleie rleeqlsing ydynchveli
      121 rllrlegels rvraarqkms elfplteelw lewlhdeism amdgldrehv yelferavkd
      181 yicpniwley gqysvggigq kgglekvrsv feralssvgl hmtkglaiwe ayrefesaiv
      241 eaarlekvhs lfrrqlaipl yemeatfaey eewseepmpe svlqsyqkal gqlekykpye
      301 eallqaeapr laeyqayidf emkigdpari qliferalve nclvpdlwir ysqyldrqlk
      361 vkdlvlsvhs ravrncpwtv alwsryllam erhgldhqti satfenalsa gfiqatdyve
      421 iwqvyldylr rrvdfrqdss keleelrsmf traleylqqe veerfsesgd psclimqswa
      481 rvearlcnnm qkarelwdsi mtrgnakyan mwleyynler ahgdtqhcrk alhravqcts
      541 dypehvcevl ltmertegtl edwdlaiqkt etrlarvneq rmkaaekeaa lvqqeeekae
      601 qrkkvraekk alkkkkktrg adkrredede enewgeeeee qpskrrrten slasgeasam
      661 keetelsgkc ltidvgppsk qkekaaslkr dmpkvahdss kdsvtvfvsn lpysieepev
      721 klrplfevcg evvqirpifs nrgdfrgycy vefgeeksaq qaleldrkiv egrpmfvspc
      781 vdksknpdfk vfrysttlek hklfisglpf sctkeeledi ckahgtvkdl rlvtnragkp
      841 kglayveyen esqasqavmk mdgmtirenv ikvaisnppq rkvpekpevr tapgapmlpr
      901 qmygargkgr tqlsllpral qrqgaapqae ngpapgpava psvateapkm snadfaklll
      961 rk
//
