LOCUS       NM_016882               5091 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus squamous cell carcinoma antigen recognized by T cells
            1 (Sart1), mRNA.
ACCESSION   NM_016882
VERSION     NM_016882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5091)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5091)
  AUTHORS   Koh,M.Y., Gagea,M., Sargis,T., Lemos,R. Jr., Grandjean,G.,
            Charbono,A., Bekiaris,V., Sedy,J., Kiriakova,G., Liu,X.,
            Roberts,L.R., Ware,C. and Powis,G.
  TITLE     A new HIF-1alpha/RANTES-driven pathway to hepatocellular carcinoma
            mediated by germline haploinsufficiency of SART1/HAF in mice
  JOURNAL   Hepatology 63 (5), 1576-1591 (2016)
   PUBMED   26799785
  REMARK    GeneRIF: SART1(+/-) mice showed significant up-regulation of
            HIF-1alpha in circulating and liver-infiltrating immune cells
REFERENCE   3  (bases 1 to 5091)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 5091)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 5091)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 5091)
  AUTHORS   Chen,Y.I., Maika,S.D. and Stevens,S.W.
  TITLE     Epitope tagging of proteins at the native chromosomal loci of genes
            in mice and in cultured vertebrate cells
  JOURNAL   J Mol Biol 361 (3), 412-419 (2006)
   PUBMED   16859702
REFERENCE   7  (bases 1 to 5091)
  AUTHORS   Bolland,D.J. and Hewitt,J.E.
  TITLE     Intron loss in the SART1 genes of Fugu rubripes and Tetraodon
            nigroviridis
  JOURNAL   Gene 271 (1), 43-49 (2001)
   PUBMED   11410364
REFERENCE   8  (bases 1 to 5091)
  AUTHORS   Makarova,O.V., Makarov,E.M. and Luhrmann,R.
  TITLE     The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP
            are essential for the assembly of mature spliceosomes
  JOURNAL   EMBO J 20 (10), 2553-2563 (2001)
   PUBMED   11350945
REFERENCE   9  (bases 1 to 5091)
  AUTHORS   Gupta,M., Mungai,P.T. and Goldwasser,E.
  TITLE     A new transacting factor that modulates hypoxia-induced expression
            of the erythropoietin gene
  JOURNAL   Blood 96 (2), 491-497 (2000)
   PUBMED   10887110
REFERENCE   10 (bases 1 to 5091)
  AUTHORS   Gotoh,M., Shichijo,S., Hoshino,T., Imai,Y., Imaizumi,T., Inoue,Y.,
            Takasu,H., Yamaoka,T. and Itoh,K.
  TITLE     Sequence analysis of genes encoding rodent homologues of the human
            tumor-rejection antigen SART-1
  JOURNAL   Jpn J Cancer Res 89 (8), 849-854 (1998)
   PUBMED   9765622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122861.4 and AB014721.1.
            
            On Jan 26, 2007 this sequence version replaced NM_016882.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF129931.1, AB014721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC122861.4         123167-123208       c
            43-2554             AB014721.1         1-2512
            2555-5091           AC122861.4         112028-114564       c
FEATURES             Location/Qualifiers
     source          1..5091
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.31 cM"
     gene            1..5091
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /note="squamous cell carcinoma antigen recognized by T
                     cells 1"
                     /db_xref="GeneID:20227"
                     /db_xref="MGI:MGI:1309453"
     exon            1..389
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..2497
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /note="SART-1; mSART-1; hypoxia-associated factor"
                     /codon_start=1
                     /product="U4/U6.U5 tri-snRNP-associated protein 1"
                     /protein_id="NP_058578.3"
                     /db_xref="CCDS:CCDS29460.1"
                     /db_xref="GeneID:20227"
                     /db_xref="MGI:MGI:1309453"
                     /translation="MGSSKKHRGEKEAAGTTAAAGTGGTTEQPPRHREHKKHKHRSSG
                     GGSSGGERRKRSRERGSERGSGRRGAEAEARSGAHGRERSQAEPSERRVKREKRDDGY
                     EAAASSKASSGDASSLSIEETNKLRAKLGLKPLEVNAVKKEAGTKEEPVAADVINPMA
                     LRQREELREKLAAAKEKRLLNQKLGKIKTLGEDDPWLDDTAAWIERSRQLQKEKDLAE
                     KRAKLLEEMDQEFGVSTLVEEEFEQRRQDLYSARDLQGLTVEHAIDSFREGETVVLTL
                     KDKGVLQDGEDVLVNVNMVDKERADKNVELRKKKPDYLPYAEDESVDDLAQQKPRSIL
                     AKYDEELEGERPHSFRLEQGGMADGLRERELEEIRTKLRLQAQSLSSVGPRLASEYLS
                     PEEMVTFKKTKRRVKKIRKKEKEVIMRADDLLPLGDQTQDGDFGSRLRGRGRRRVPEV
                     EEEALEDEEKDPVAQPPPSDDTRVENMDISDEEDGGALPPGSPEGLEEDEAELELQKQ
                     LEKGRRLRQLQQLQQLRDSGEKVLEIVKKLESRQRGWEEEEDPERKGTIVFNATSEFC
                     RTLGEIPTYGLAGNREEQEELMDFERDEERSANGGSESDGEENIGWSTVNLDEEKQHQ
                     DFSASSTTILDEEPIVNRGLAAALLLCQNKGLLETTVQKVARVKAPNKSLPSAVYCIE
                     DKMAIDDKYSRREEYRGFTQDFKEKDGYKPDVKIEYVDETGRKLTPKEAFRQLSHRFH
                     GKGSGKMKTERRMKKLDEEALLKKMSSSDTPLGTVALLQEKQKAQKTPYIVLSGSGKS
                     MNANTITK"
     exon            390..447
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            448..503
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            504..630
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            631..736
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            737..814
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            815..914
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1057
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1264
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1389
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1523
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1666
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1840
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1951
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2039
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2130
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2266
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2356
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..2478
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..5091
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2532..2537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /note="hexamer: AATAAA"
     polyA_site      2555
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /note="major polyA site"
     regulatory      5064..5069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /note="hexamer: AATAAA"
     polyA_site      5091
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
ORIGIN      
        1 gcgcgacccg gaagcgttcc catttcgcgt cgtctgggct agggtagcgg cccggctcca
       61 ggcggacgca ataatcatgg ggtcgtcaaa gaagcaccgt ggcgagaagg aggcggccgg
      121 gacgacggct gcggccggga ctgggggcac gaccgagcag ccgccacggc atcgcgagca
      181 taagaaacac aagcaccgga gcagcggcgg cggcagcagc ggcggcgaac gacggaagcg
      241 gagccgggag cgtgggagtg agcgcgggag cgggcggcgt ggggcggaag ccgaggcccg
      301 cagcggcgcg cacggtcgcg aacgaagcca agcggagccc tcggagcggc gcgtgaagcg
      361 ggagaaacgc gatgacggct acgaggccgc tgccagctcc aaagccagct ctggcgatgc
      421 ctcatccctc agcattgagg agaccaataa actccgagca aagttggggc tgaagccctt
      481 ggaggtcaat gctgttaaga aagaggcggg caccaaggag gagcccgtgg cagccgatgt
      541 tatcaacccc atggccttgc gacagcggga agaactgcgg gagaagctgg cagctgccaa
      601 ggaaaaacgc ttgctgaacc aaaaattggg gaaaataaag acactggggg aggatgaccc
      661 ctggctggat gatactgcag cctggataga gaggagccgg cagctacaga aagagaagga
      721 cctggcagag aagcgggcta agctactaga ggagatggac caagagtttg gtgtgagcac
      781 tttagtggag gaggagtttg agcagaggcg acaggacctg tacagtgccc gggacctgca
      841 aggcctcact gtggaacatg ccatcgattc ttttcgagaa ggggagactg tggtcctcac
      901 cctcaaggac aaaggggtac tgcaggacgg ggaggacgtg ctggtgaatg tgaacatggt
      961 ggacaaggag cgggcggaca agaacgtgga gcttcggaaa aagaagcctg actacctgcc
     1021 ctatgcggaa gatgagagtg tggacgattt ggcacagcaa aaacctcgtt ctatcctggc
     1081 caaatatgat gaggaactgg agggcgagcg accacattcc ttccgtctgg agcagggtgg
     1141 gatggccgat ggcctgaggg aacgagagtt agaagaaatc cgcaccaagc tacggctgca
     1201 ggctcagtct ctgagctccg tagggccccg gcttgcctct gagtacctca gtcccgagga
     1261 gatggtgacc ttcaagaaga ccaaacggag agtgaagaaa atccgaaaga aggagaagga
     1321 ggtgataatg cgggcagatg acttgctgcc cctgggcgac cagactcagg atggggactt
     1381 tggatccagg ctccggggcc ggggtcggcg ccgagttcct gaggtggagg aggaggccct
     1441 tgaggatgag gagaaggacc ctgtggccca gccgccacca tcggatgaca ctcgagtaga
     1501 gaacatggac atcagtgatg aagaggatgg gggagctctt ccgccagggt ccccagaggg
     1561 gctggaggaa gacgaggcag agctggagct gcagaagcag ctggagaagg ggcgccggct
     1621 gcggcagctg cagcaactgc agcagctccg agacagtggt gagaaggtgc tggagattgt
     1681 gaagaaactg gagtctcgcc agcgcggctg ggaggaggag gaggaccctg agaggaaggg
     1741 gaccatcgtg ttcaatgcca cttctgaatt ctgccgcacg ctgggggaga tccccaccta
     1801 cgggttggct ggcaaccgcg aggagcagga agagctcatg gactttgaaa gggatgagga
     1861 gcgctcggcc aacggtggct ctgaatcaga tggggaagag aacattggct ggagcaccgt
     1921 caacctggat gaggagaagc agcatcagga tttctctgct tcctctacca ccatcctgga
     1981 tgaggagccc atcgtgaaca gagggctggc tgctgccctg ctcctgtgtc agaacaaagg
     2041 actgctggag accacagtac aaaaggtggc ccgggtgaag gctcccaata agtcactgcc
     2101 ctcagcagtg tactgcatcg aggataagat ggccattgat gacaagtaca gccgacggga
     2161 ggagtacagg ggcttcaccc aggacttcaa ggagaaagat ggctacaagc ctgatgttaa
     2221 gattgaatac gtggatgaga cgggcaggaa actgactccc aaggaggcat tccggcagct
     2281 gtcccaccgc ttccacggaa agggctcagg caagatgaag actgagcggc ggatgaagaa
     2341 gctggatgag gaggcgctcc tgaagaaaat gagctccagt gacacgcccc tgggcaccgt
     2401 ggcactgctc caggagaagc agaaggccca gaagacaccg tatatcgtgc tcagtggcag
     2461 tggcaagagc atgaatgcga acaccatcac caaatgaagc cgccctcctc cctggcccag
     2521 atgtagtgtt aaataaagtt ccctccttat ttttcctctt ggttgtgctg ctgtctaagg
     2581 ttagacctag gcaaggcctc tgtcacggtc agttctgcca tctggcaagt cgctgagcct
     2641 cctcgccctt ctgtgttgcc ttccgagtgg tcagaacacc tgcttcatgc gtgaggcgcc
     2701 ggtgagctct ttcgttcact ctctggttat ccaggagcgg atgggcctga tccttgaacc
     2761 tgtgtgattt aaagtctgat ctctgcctgt aagactggcc atttaatgaa cagaggaggt
     2821 gagaaaccag cctggtccct cagaggacat tcctctgtga gctgactcca ttgtaacaga
     2881 agccctccac ccagtggcgt gtacctgtca cactgcggtc aaattggctt cttgatccca
     2941 aatcattgct gttttcagac tggtcacatg cgtgttgcta ggccttagag agccactaac
     3001 caccctgtgt tgtcctggtt acagttttca gggtactaag taaggattgc ctaggctctc
     3061 tggaagggta gagatgttac ctcctgtccc ctgtgttact gtggcatttg tggaggcatg
     3121 agggtcatcc caggactggg gtaggggtta cctcgagtgc acttatatac gaggactgag
     3181 ccaccctgct aggtgcctgc aactgtgcct ggaaagatgg gctttctagg aaggcgctgt
     3241 ggaagaagcc ctgctgagcc acaggctgtg ggaggaccct gccccacagg tggctacttt
     3301 gaatcagaag atgagtgccc tgtgtcagtt actgaagcta gccccatgtg ggtctctggt
     3361 gagtgtatca aataactaga aaaaagcaag agacaggaaa cccagttgtt tataagtgat
     3421 actaggtagc agttcctgag acactgacca taaaagaggt gaggtcagtt ggtgttctcg
     3481 gctgtgcctg tggatcttgg ctagtgatgg ttgtgcagga gtgtccattt ctctaagtct
     3541 caggtgcttg attatggtgt ctactggcta tggccattgg tcagaggtca ctttttttgt
     3601 ttcctttttt gagacagggt ttctctgtgt agccctggct gtcatggaac tctgtagaac
     3661 agtctggcct tgaactcaag gatccacctg cttctgcctc ttgggtgctg gtattagagg
     3721 tgtgtgccac caccacctaa ctaaaagctc acacttattt tcaggaaatt gggttggtgc
     3781 tgttgctgcc acaccttagg gagagcaggg cctaggggct accaagtagc aggagacttg
     3841 atgccaaggg cagacaggaa cccaggttcg ctgtcagcgg gtggagaagg ttagcgactt
     3901 aggtttgtat ttgggacatt ggtctaatgt cgcatatttg gttactgagt ttcactcact
     3961 gctgaatgat taccacaggc aagtcactga cttgggttct gagctgcaga ggcgtgtgat
     4021 ctctgactcc cactcgggct ttgctgagaa tcgcctcttg ttacctctag ccctctccta
     4081 acatggagag ggaagggagg gctgttctcc atccacatgg acaccatagg catatcttag
     4141 ctctcggagt gtggtcatga gaaccccaga agtctgacgc cagctgtgcc ttagcccttg
     4201 ctctggggtc ctcatccctt caggccatgc ctgtgtcttg ctgaggtccc cagaggtcat
     4261 cttccagctt gagactctcc aggtttggcc cacatgccta gtaggtggat gtggcactac
     4321 ctgggctctc taccccacca taagtcaaaa ccaggagcaa gagaggagac agtgcactgg
     4381 gctcagtagc aagtgtgagg gagtccttcc gtctgtttct gaatattgtg aaatgtccca
     4441 ttgtagaaca gaccacgttg gcttagcaat gaaagtgccc ttttgtcagc tcagtacatg
     4501 aagagggatg tatctaacag cactaatgcc acacccattg acagaatggg tcaataactt
     4561 ctgtgaccga atgaaaaatg tggtttgcat cttatggatg aggaggtagc cagacccaaa
     4621 attgttcctg cttccaatct gcaacctaat agacaaattt aattactgtc agaggtcaga
     4681 accatatcgt agttggggat ggatttaaaa aggtagcaga ttagttctct aactccagaa
     4741 atgcctctgg gaccaagaat ggcccacaaa ataggttttc tgttggaaca cttactatca
     4801 ggtaataatt tctgtttgtc ctgtgttttg ttaacagttt ttcttccgtt ttgaattgag
     4861 gttttaaaat ttttaatgtt tatgggtgtt ttatctgcct gtgtctagtc acattcatat
     4921 caaggcaaca gagccagaag agggtggcag atgccctgga actaaagtga cagatggtta
     4981 tgagctgtca tgttcaccat gctgggtatt gaaacttggc tcataatcac tgagccatct
     5041 cttcagctcc cctgccccaa agcaataaag tttgagttta ttaaaagatt a
//
