LOCUS       NP_058578                806 aa            linear   ROD 27-APR-2025
DEFINITION  U4/U6.U5 tri-snRNP-associated protein 1 [Mus musculus].
ACCESSION   NP_058578
VERSION     NP_058578.3
DBSOURCE    REFSEQ: accession NM_016882.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 806)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 806)
  AUTHORS   Koh,M.Y., Gagea,M., Sargis,T., Lemos,R. Jr., Grandjean,G.,
            Charbono,A., Bekiaris,V., Sedy,J., Kiriakova,G., Liu,X.,
            Roberts,L.R., Ware,C. and Powis,G.
  TITLE     A new HIF-1alpha/RANTES-driven pathway to hepatocellular carcinoma
            mediated by germline haploinsufficiency of SART1/HAF in mice
  JOURNAL   Hepatology 63 (5), 1576-1591 (2016)
   PUBMED   26799785
  REMARK    GeneRIF: SART1(+/-) mice showed significant up-regulation of
            HIF-1alpha in circulating and liver-infiltrating immune cells
REFERENCE   3  (residues 1 to 806)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (residues 1 to 806)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (residues 1 to 806)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (residues 1 to 806)
  AUTHORS   Chen,Y.I., Maika,S.D. and Stevens,S.W.
  TITLE     Epitope tagging of proteins at the native chromosomal loci of genes
            in mice and in cultured vertebrate cells
  JOURNAL   J Mol Biol 361 (3), 412-419 (2006)
   PUBMED   16859702
REFERENCE   7  (residues 1 to 806)
  AUTHORS   Bolland,D.J. and Hewitt,J.E.
  TITLE     Intron loss in the SART1 genes of Fugu rubripes and Tetraodon
            nigroviridis
  JOURNAL   Gene 271 (1), 43-49 (2001)
   PUBMED   11410364
REFERENCE   8  (residues 1 to 806)
  AUTHORS   Makarova,O.V., Makarov,E.M. and Luhrmann,R.
  TITLE     The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP
            are essential for the assembly of mature spliceosomes
  JOURNAL   EMBO J 20 (10), 2553-2563 (2001)
   PUBMED   11350945
REFERENCE   9  (residues 1 to 806)
  AUTHORS   Gupta,M., Mungai,P.T. and Goldwasser,E.
  TITLE     A new transacting factor that modulates hypoxia-induced expression
            of the erythropoietin gene
  JOURNAL   Blood 96 (2), 491-497 (2000)
   PUBMED   10887110
REFERENCE   10 (residues 1 to 806)
  AUTHORS   Gotoh,M., Shichijo,S., Hoshino,T., Imai,Y., Imaizumi,T., Inoue,Y.,
            Takasu,H., Yamaoka,T. and Itoh,K.
  TITLE     Sequence analysis of genes encoding rodent homologues of the human
            tumor-rejection antigen SART-1
  JOURNAL   Jpn J Cancer Res 89 (8), 849-854 (1998)
   PUBMED   9765622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122861.4 and AB014721.1.
            
            On Jan 26, 2007 this sequence version replaced NP_058578.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF129931.1, AB014721.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..806
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.31 cM"
     Protein         1..806
                     /product="U4/U6.U5 tri-snRNP-associated protein 1"
                     /note="SART-1; mSART-1; hypoxia-associated factor"
                     /calculated_mol_wt=90755
     Region          1..121
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z315.1)"
     Region          118..137
                     /region_name="HIND"
                     /note="HIND motif; pfam19252"
                     /db_xref="CDD:466011"
     Region          165..759
                     /region_name="SART-1"
                     /note="SART-1 family; pfam03343"
                     /db_xref="CDD:460888"
     Site            189
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            321
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            348
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Region          418..504
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            430
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            480
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            492
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            527
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Region          578..610
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            597
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            602
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            604
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            627
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            701
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            767
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            770
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     Site            795
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O43290; propagated from
                     UniProtKB/Swiss-Prot (Q9Z315.1)"
     CDS             1..806
                     /gene="Sart1"
                     /gene_synonym="U5-110K"
                     /coded_by="NM_016882.3:77..2497"
                     /db_xref="CCDS:CCDS29460.1"
                     /db_xref="GeneID:20227"
                     /db_xref="MGI:MGI:1309453"
ORIGIN      
        1 mgsskkhrge keaagttaaa gtggtteqpp rhrehkkhkh rssgggssgg errkrsrerg
       61 sergsgrrga eaearsgahg rersqaepse rrvkrekrdd gyeaaasska ssgdasslsi
      121 eetnklrakl glkplevnav kkeagtkeep vaadvinpma lrqreelrek laaakekrll
      181 nqklgkiktl geddpwlddt aawiersrql qkekdlaekr aklleemdqe fgvstlveee
      241 feqrrqdlys ardlqgltve haidsfrege tvvltlkdkg vlqdgedvlv nvnmvdkera
      301 dknvelrkkk pdylpyaede svddlaqqkp rsilakydee legerphsfr leqggmadgl
      361 rereleeirt klrlqaqsls svgprlasey lspeemvtfk ktkrrvkkir kkekevimra
      421 ddllplgdqt qdgdfgsrlr grgrrrvpev eeealedeek dpvaqpppsd dtrvenmdis
      481 deedggalpp gspegleede aelelqkqle kgrrlrqlqq lqqlrdsgek vleivkkles
      541 rqrgweeeed perkgtivfn atsefcrtlg eiptyglagn reeqeelmdf erdeersang
      601 gsesdgeeni gwstvnldee kqhqdfsass ttildeepiv nrglaaalll cqnkgllett
      661 vqkvarvkap nkslpsavyc iedkmaiddk ysrreeyrgf tqdfkekdgy kpdvkieyvd
      721 etgrkltpke afrqlshrfh gkgsgkmkte rrmkkldeea llkkmsssdt plgtvallqe
      781 kqkaqktpyi vlsgsgksmn antitk
//
